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Variability in Durations of Therapy for Gram-Negative Bloodstream Infections and Factors Associated With Prolonged Durations.

Data on treatment durations for gram-negative bloodstream infections in clinical practice are limited. In this study of 4240 gram-negative bloodstream infection episodes during 2019 from 24 US hospitals, the median duration of therapy was 12 days (IQR, 9-15); 59% were treated for >10 days. There was marked variability in treatment durations across hospitals.

Adult-Onset Hyperammonemia: Case Report and Review of Literature.

INTRODUCTION: Hyperammonemia is a life-threatening condition most associated with liver disease, though non-cirrhotic causes are increasingly recognized. CASE PRESENTATION: We report an 18-year-old female presenting with 1 week of progressive confusion, abdominal pain, and nausea. Initial evaluation showed normal routine laboratories but markedly elevated ammonia and respiratory alkalosis. She rapidly deteriorated, requiring intubation and intensive care. Ammonia peaked at 795 µg/dL and improved rapidly after urgent venous hemofiltration and medical therapy, with full neurological recovery by

Evaluation of bloodstream infections in febrile neutropenic patients with hematological malignancy: a retrospective cohort study.

BACKGROUND: Patients with hematological malignancies (HMs) are at high risk of bloodstream infections (BSIs) during episodes of febrile neutropenia (FN). However, empirical treatment initiated before isolation of the causative agent from blood cultures is crucial. The aim of this study was to determine the distribution and antimicrobial resistance profile of microorganisms isolated from BSIs in patients with HMs, and to evaluate the association with the need for intensive care unit (ICU) and mortality at 30 days. METHODS: Single-centre data from patients with HMs who were admitted to the hema

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… Other Gram-negative bacteria include Stenotrophomonas maltophilia , Enterobacter spp., Serratia spp., Proteus mirabilis , Morganella morganii , Salmonella spp., and Sphingomonas paucimobilis . Other Gram-positive bacteria include Streptococcus pneumoniae and alpha-hemolytic streptococci. … Other Gram-negative bacteria include Stenotrophomonas maltophilia , Enterobacter spp., Serratia spp., Proteus mirabilis , Morganella morganii , Salmonella spp., and Sphingomonas paucimobilis . Other Gram-positive bacteria include Streptococcus pneumoniae and alpha-hemolytic streptococci. …

Belantamab mafodotin, pomalidomide, and dexamethasone in Japanese patients with RRMM in the phase 3 DREAMM-8 trial.

The phase 3 DREAMM-8 (NCT04484623) trial assessed belantamab mafodotin + pomalidomide + dexamethasone (BPd) vs bortezomib + Pd (PVd) in lenalidomide-exposed patients with relapsed/refractory multiple myeloma (RRMM) and ≥ 1 prior therapy. Here, we present findings from Japanese patients (data cutoff: 27-May-24). The primary endpoint was progression-free survival (PFS). Secondary endpoints included overall response rate (ORR), duration of response (DoR), and safety. Overall, 21 patients were randomized 1:1 to BPd (N = 10) and PVd (N = 11). Median follow-up was 13.8 months (range 0.23-26.71). For

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… The sepsis was caused by an infection with Morganella morganii that started prior to day 1 of study treatment. This was felt to be possibly related to high-dose cytotoxic chemotherapy that the patient had received in the month preceding the start of the study treatment. … In the BPd group, grade ≥ 3 infections were pneumonia (2 patients), cytomegalovirus chorioretinitis (1 patient), and Morganella morganii infection (1 patient). In the PVd group, grade ≥ 3 infections were pneumonia and influenza (1 patient, each). …

Bloodstream Infections in Patients with Hematologic Diseases: Causative Organisms and Factors Associated with Resistance.

BackgroundPatients with hematologic diseases are at high risk of bloodstream infections (BSIs). This study aimed to analyze clinical features and distributions of microorganisms in patients with hematologic diseases presenting at a tertiary care university-affiliated hospital in Korea.Materials and methodsWe retrospectively reviewed all BSI episodes recorded in patient medical records at two hematologic wards of the Catholic Hematology Hospital from January to December 2020. Our aim was to analyze demographic and clinical characteristics relevant to BSIs. We also described the antimicrobial re

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… (n = 1), Leptotrichia trevisanii (n = 1), and Morganella morganii (n = 1). b Enterococcus gallinarum (n = 5) and Enterococcus avium (n = 1). c All Streptococcus species other than viridans streptococci such as Streptococcus agalactiae (n = 2), Streptococcus dysgalactiae (n = 1), and Streptococcus pneumoniae …

Development and validation of a nomogram for predicting PICC catheter-related bloodstream infection among patients with hematologic malignancies.

PurposeTo identify risk factors for PICC-related bloodstream infections (PICC-CRBSI) in patients with hematologic malignancies and to develop and validate a predictive nomogram for clinical risk assessment.MethodsThis retrospective cohort study included 764 patients with hematologic malignancy who had PICC from a tertiary center (2021-2024). LASSO regression identified key predictors after addressing class imbalance via SMOTE-NC in the training set (n = 534). A multivariate logistic regression was used to construct a predictive nomogram, subsequently validated in a validation set (n = 230). Mo

Host impairments in patients with neoplastic diseases.

Healthy individuals possess an immune system comprising physical barriers, innate and acquired immunity as well as the indigenous microflora that populate the body surfaces. The immune system maintains constant vigilance over the body at the cellular level as well as at the interface between the host integument and the resident microflora. However, neoplastic diseases and their treatment often lead to impaired immunity resulting in an increased risk of infections due to viruses, bacteria, fungi, and protozoa. This chapter explores the various aspects of host impairment focusing on the componen

Клиническое представление лептоспироза: ретроспективное исследование 34 Пациенты поступили в одно учебное заведение во Франции.

Лептоспироз имеет весьма изменчивое клиническое представление, которое может быть связано с различными заражающими сероварами, факторами хост-компьютеров или их комбинацией. Это исследование проводилось ретроспективно 34 Число пациентов с серологическим подтвержденным лептоспирозом, принятых в течение отчетного периода 1992-2002. Наиболее частыми симптомами при поступлении в школу были лихорадка (см.100%), головная боль75%), миальгии55%), артхальгии45%) и рвотой (т.е.39%). Применяемые лабораторные исследования включали в себя лимфопенцию (см.85%), тромбоцитопенсия75%), повышенные ферменты пече

P941 – P1197

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Proceedings of Réanimation 2020, the French Intensive Care Society International Congress.

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ESCP 36th European Symposium on Clinical Pharmacy ‘Implementing Clinical Pharmacy in Community and Hospital Settings: Sharing the Experience’, Istanbul, Turkey 25–27 October 2007; Abstracts

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Р

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