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Case Report with Literature Review: Tumor-induced osteomalacia from a soft-tissue phosphaturic mesenchymal tumor of the trunk.

BACKGROUND: Tumor-induced osteomalacia (TIO), a type of acquired hypophosphatemic osteomalacia, is brought on by tumors producing excessive levels of fibroblast growth factor 23, which raises renal phosphorus excretion. METHODS: Through a review of the literature, we have outlined the clinical characteristics of 33 patients with soft-tissue TIO of the trunk and described a case of TIO brought on by a soft-tissue tumor on the back. RESULTS: A 63-year-old woman who had been experiencing generalized bone pain for approximately three years visited the hospital. Physical examination revealed a ro

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… The concept of PMT was first introduced by Weidner and Cruz ( 50 ) in 1987, who classified four morphological subtypes: PMTMCT, osteoblastoma-like, non-ossifying fibroma-like, and ossifying fibroma-like tumors ( 51 ). …

Interventional Procedures for Vertebral Diseases: Spinal Tumor Ablation, Vertebral Augmentation, and Basivertebral Nerve Ablation-A Scoping Review.

Low back pain is consistently documented as the most expensive and leading cause of disability. The majority of cases have non-specific etiologies. However, a subset of vertebral diseases has well-documented pain generators, including vertebral body tumors, vertebral body fractures, and vertebral endplate injury. Over the past two decades, specific interventional procedures targeting these anatomical pain generators have been widely studied, including spinal tumor ablation, vertebral augmentation, and basivertebral nerve ablation. This scoping review summarizes safety and clinical efficacy and

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… Treatment goals of STA may be a reduction in large tumor burden or as a definitive treatment for benign small tumors, such as osteoid osteomas or osteoblastomas [ 74 ]. …

Rare Diseases of the Orbit.

This article provides an overview of rare orbital diseases. Congenital malformations, inflammatory diseases, benign and malignant neoplasias are described. Although it represents a relatively small area of the body the orbit contains multiple different tissues. Therefore, a great variety of diseases can be found within the orbital space. That is the reason, why both the completeness and the level of detail in the description of particular diseases must be somewhat limited. Nevertheless, clinical manifestations, important aspects of diagnosis, treatment strategies, and, when specific data are a

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… scintigraphy: focus with increased uptake histology: lesions with osteoblastic/osteoclastic remodeling, granulomatous infection infiltrates with giant cells biopsy of involved bone needed for confirmation of diagnosis and exclusion of differential diagnoses (e. g., Langerhans cell histiocytosis, osteoblastoma …

Craniovertebral Junction Instability after Oncological Resection: A Narrative Review.

The craniovertebral junction (CVJ) is a complex transition area between the skull and cervical spine. Pathologies such as chordoma, chondrosarcoma and aneurysmal bone cysts may be encountered in this anatomical area and may predispose individuals to joint instability. An adequate clinical and radiological assessment is mandatory to predict any postoperative instability and the need for fixation. There is no common consensus on the need for, timing and setting of craniovertebral fixation techniques after a craniovertebral oncological surgery. The aim of the present review is to summarize the an

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… Primary neoplasms of extradural origin include chordomas, nerve sheath tumors, paragangliomas, osseous benign neoplasms (fibrous dysplasia, osteoid osteoma, osteoblastoma, aneurysmal bone cyst, giant cell tumors, osteochondroma, chondroma and eosinophilic granuloma), osseus malignant neoplasms (chondrosarcoma …

A Critical Appraisal of the Application of Frailty and Sarcopenia in the Spinal Oncology Population.

Study designSystematic review and clinimetric analysis.ObjectivesFrailty and sarcopenia predict worse surgical outcomes among spinal degenerative and deformity-related populations; this association is less clear in the context of spinal oncology. Here, we sought to identify frailty and sarcopenia tools applied in spinal oncology and appraise their clinimetric properties.MethodsA systematic review was conducted from January 1st, 2000, until June 2022. Study characteristics, frailty tools, and measures of sarcopenia were recorded. Component domains, individual items, cut-off values, and measurem

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… carcinoma) PLVI Charest-morin 2019 JNS spine Ambispective 113 59% (n = 67) Institutional database None 49 SD 19 Both Metastatic tumors: 13%, primary tumors: 87%; proportion of primary tumors: Malignant (66%) and benign (34%); primary bone tumor types: Chordoma (34%), chondrosarcoma (12%), GCT (8%), osteoblastoma … Charest-morin | 2019 | JNS spine | Ambispective | 113 | 59% (n = 67) | Institutional database | None | 49 | SD 19 | Both | Metastatic tumors: 13%, primary tumors: 87%; proportion of primary tumors: Malignant (66%) and benign (34%); primary bone tumor types: Chordoma (34%), chondrosarcoma (12%), GCT (8%), osteoblastoma …

miR-135b: A key role in cancer biology and therapeutic targets.

miR-135b, a microRNA, is consistently up-regulated in various cancer tissues and cells, promoting cancer progression. By inhibiting one or more target genes, miR-135b regulates phenotypes such as cancer growth, apoptosis, migration, invasion, drug resistance, and angiogenesis, establishing it as a critical driver of cancer progression. Additionally, miR-135b is regulated by various oncogenes and therapeutic drugs, highlighting its complexity and therapeutic potential. Significant progress has been made in understanding miR-135b's impact on cancer cell behavior, establishing it as a promising b

Interventional Radiology in the Management of Metastases and Bone Tumors.

Interventional Radiology (IR) has experienced an exponential growth in recent years. Technological advances of the last decades have made it possible to use new treatments on a larger scale, with good results in terms of safety and effectiveness. In musculoskeletal field, painful bone metastases are the most common target of IR palliative treatments; however, in selected cases of bone metastases, IR may play a curative role, also in combination with other techniques (surgery, radiation and oncology therapies, etc.). Primary malignant bone tumors are extremely rare compared with secondary bone

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… On the other hand, in case of benign lesions (osteoid osteoma OO, osteoblastoma OB, etc.) only the area covered by the lesion is treated. Indications: Benign tumors (OO, OB, desmoid tumors, chondroblastoma, and gigantocellular tumors of the bones GCTs [ 31 , 32 , 33 , 34 ]). …

Обязательный экзамен по патологии: лишний или необходимый?

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Электронные постеры

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From post-war reconstruction to the twenty-first century - ophthalmic pathology in Freiburg 1945-2015. Part 2: review of 43,169 histological diagnoses from 39,256 specimens collected over 71 years at a large German tertiary eye care centre.

BACKGROUND: Ophthalmic pathology is essential for diagnosing ocular diseases, correlating clinical and histopathological findings, and advancing research. The Eye Center at the University of Freiburg, Germany, has archived histopathological specimens since 1945, offering a unique resource to analyse long-term diagnostic trends. This study examines 43,169 diagnoses from 39,256 specimens over 71 years (1945–2015), providing insights into the evolution of ophthalmic pathology at a major tertiary care centre. METHODS: We performed a retrospective analysis of all archived ophthalmic pathology repor

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… (3.3%) | SCC | 4 (3.9%) | Granuloma | 3 (2.1%) | Hemangioma | 2 (2.4%) | Metastasis | 1 (7.1%) | Fat tissue | 1 (3.0%) | Meningeoma | 2 (3.1%) | Rhabdo-myosarcoma | 3 (3.3%) | Connective tissue | 3 (2.9%) | Lymphangioma | 3 (2.1%) | Langerhans cell histiocytosis | 2 (2.4%) | Necrosis | 1 (7.1%) | Osteoblastoma …

A Comprehensive Review of the Role of the Latest Minimally Invasive Neurosurgery Techniques and Outcomes for Brain and Spinal Surgeries.

Minimally invasive neurosurgical techniques offer reduced surgical trauma, lower complication rates, and faster recovery compared to traditional open procedures. Approaches such as keyhole craniotomy, endoscopic skull base surgery, endovascular neurosurgery, and percutaneous spinal techniques have advanced the management of cranial and spinal pathologies. These methods aim to minimize tissue disruption, blood loss, and hospital stay while maintaining surgical efficacy. This narrative review explores their evolution, applications, and advantages in modern neurosurgery.

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… Moreover, in 2019, two patients with osteoblastoma and granuloma received a subtotal resection, and three others with cholesteatoma, cholesterol granuloma, and schwannoma had a total resection. …

Rare Diseases of the Nose, the Paranasal Sinuses, and the Anterior Skull Base.

Due to their low incidence and thus resulting limited diagnostic criteria as well as therapeutic options, rare diseases of the nose, the paranasal sinuses, and the anterior skull base are a significant challenge. The value as of which a disease has to be considered as rare amounts to a maximum of 5 patients per 10 000 people. Within these diseases, however, there are extreme differences. Some rare or orphan diseases like for example the inverted papilloma belong to regularly diagnosed and treated diseases of larger departments of oto-rhino-laryngology whereas other rare diseases and malformati

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… Suppression of the osteoblastoma activity, however, could not be found 176 . In cases of asymptomatic course, wait-and-see is the preferred strategy. Functional impairment and complaints such as cephalgia justify surgical procedure depending on the location of the manifestation. …

Exploring the promising potential of induced pluripotent stem cells in cancer research and therapy.

The advent of iPSCs has brought about a significant transformation in stem cell research, opening up promising avenues for advancing cancer treatment. The formation of cancer is a multifaceted process influenced by genetic, epigenetic, and environmental factors. iPSCs offer a distinctive platform for investigating the origin of cancer, paving the way for novel approaches to cancer treatment, drug testing, and tailored medical interventions. This review article will provide an overview of the science behind iPSCs, the current limitations and challenges in iPSC-based cancer therapy, the ethical

Е-постеры.

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34th Европейский конгресс патологии - резюме.

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Oral Presentations

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Rapid Fire Presentations

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Устные доклады

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Электронные постеры

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Е-постеры.

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