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An open-label phase II trial of sotrovimab (VIR-7831) prophylaxis against COVID-19 infection in immunocompromised individuals with impaired SARS-CoV-2 humoral immunity.

BACKGROUND: Immunocompromised individuals have a limited humoral immune response to SARS-CoV-2 vaccination and are at higher risk of severe COVID-19. Sotrovimab is a monoclonal antibody (mAb) targeting a conserved SARS-CoV-2 spike protein epitope. METHODS: This phase II open-label study evaluated the safety and tolerability of sotrovimab pre-exposure prophylaxis in immunocompromised adults with impaired vaccine response. Between February and June 2022 in the northeastern region of the USA, participants received sotrovimab 500 mg IV on Treatment Day (TD) 1 and 2000 mg IV on TD2 due to the spre

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… General disorders and administration site conditions Any event | 0 | 0 | 0 | 0 | 2 (3) | 0 | 0 | 2 (3) Chest Pain | 0 | 0 | 0 | 0 | 1 (1) | 0 | 0 | 1 (1) Non-Cardiac Chest Pain | 0 | 0 | 0 | 0 | 1 (1) | 0 | 0 | 1 (1) Infections and infestations Any event | 3 (3) | 0 | 0 | 3 (3) | 9 (11) | 0 | 0 | 9 (11) Empyema …

Intrathoracic manifestations of hematologic malignancies: a narrative review.

BACKGROUND AND OBJECTIVE: Although the global incidence of hematologic malignancies is decreasing, the risk of developing these cancers is increasing due to increased lifespan and modern treatments including targeted therapy, chemotherapy, and radiation. Intrathoracic manifestations of hematologic malignancies may be the presenting sign leading to diagnosis or result from various treatment toxicity. The most common respiratory manifestation of hematologic malignancies is infectious, but up to half of pulmonary findings are from non-infectious etiologies. We aim to summarize the current literat

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… A single center study that reviewed 172 patients with hematologic malignancies with IPC placement showed a rate of IPC related complications of 9.5%, and the incidence of empyema was 2.9% and major bleeding was 1.7%. The median time to removal of IPCs was 81 days after placement ( 24 ). …

Ixazomib with cyclophosphamide and dexamethasone in relapsed or refractory myeloma: MUKeight phase II randomised controlled trial results.

The all-oral combination of ixazomib, cyclophosphamide, and dexamethasone (ICD) is well tolerated and effective in newly diagnosed and relapsed multiple myeloma (MM). We carried out MUKeight, a randomised, controlled, open, parallel group, multi-centre phase II trial in patients with relapsed MM after prior treatment with thalidomide, lenalidomide, and a proteasome inhibitor (ISRCTN58227268), with the primary objective to test whether ICD has improved clinical activity compared to cyclophosphamide and dexamethasone (CD) in terms of progression-free survival (PFS). Between January 2016 and Dece

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… Three serious adverse reactions (SARs) in the ICD arm resulted in death (pneumonia, intracranial haemorrhage and pleural empyema). No SARs resulted in death in the CD arm. …

Yellow nail syndrome: a review.

Yellow nail syndrome (YNS; OMIM 153300, ORPHA662) is a very rare disorder that almost always occurs after 50 years of age but a juvenile or familial form has also been observed. YNS is diagnosed based on a triad associating yellow nail discoloration, pulmonary manifestations (chronic cough, bronchiectasia, pleural effusion) and lower limb lymphedema. Chronic sinusitis is frequently associated with the triad. YNS etiology remains unknown but a role of lymphatic impairment is usually evoked. YNS is more frequently isolated but may be associated in rare cases with autoimmune diseases, other clini

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… of more than 150 patients described in publications identified with the search terms “pleural effusion” and “YNS”, Valdés et al. recently reported the characteristics of these pleural effusions [ 32 ]: 68.3% were bilateral; the fluid appeared serous in 75%, milky (chylothorax) in 22% and purulent (empyemas …

Pathology Competencies in Medical Education and Educational Cases: Update 2023.

Pathology is a core component of medical school curricula because understanding the pathogenesis of the disease is foundational both for diagnostic efficiency and optimal use of ancillary resources in patient care. The Pathology Competencies for Medical Education (PCME) were developed as a national resource of expectations of pathology knowledge for medical students. The PCME are composed of three competencies: disease mechanisms and processes, organ system pathology, and diagnostic pathology and therapeutic pathology. The learning goals and learning objectives of the PCME that were first publ

Drug Treatment of Neuromyelitis Optica Spectrum Disorders: Out with the Old, in with the New?

IntroductionNeuromyelitis optica spectrum disorders (NMOSD) are rare neuroinflammatory demyelinating diseases of the CNS, mainly affecting optic nerves, spinal cord and brainstem regions. The diagnosis depends on clinical symptoms, MRI findings and the detection of autoantibodies against the water channel aquaporin 4 (AQP4-Ab). This autoantibody is particularly important for diagnostic sensitivity and specificity and further sets the course for major therapeutic decisions. Due to a relapsing course with the accumulation of disability, relapse prevention by immunotherapy is crucial in NMOSD. Un

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… There was one death in the eculizumab group due to pulmonary empyema. Two patients discontinued the study due to adverse events - both of them receiving placebo. CD19 B-Cell Depletion Besides the pivotal role of AQP4-Ab, B-cells contribute to NMOSD pathology by B-cell T-cell collaboration. …

Systemic complications of rheumatoid arthritis: Focus on pathogenesis and treatment.

As a systemic autoimmune disease, rheumatoid arthritis (RA) usually causes damage not only to joints, but also to other tissues and organs including the heart, kidneys, lungs, digestive system, eyes, skin, and nervous system. Excessive complications are closely related to the prognosis of RA patients and even lead to increased mortality. This article summarizes the serious complications of RA, focusing on its incidence, pathogenesis, clinical features, and treatment methods, aiming to provide a reference for clinicians to better manage the complications of RA.

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… Rheumatoid arthritis increases the risk of pleural empyema. Open Med (Wars) (2020) 15(1):1012–8. doi: 10.1515/med-2020-0225 80. Kadura S, Raghu G. Rheumatoid arthritis-interstitial lung disease: manifestations and current concepts in pathogenesis and management. …

Ход работы 34th Симпозиум ESVN-ECVN 23rd-24th сентябрь 2022.

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Vaccination Against Respiratory Infections in Adults with Cancer: A Concise Guide for Clinicians.

Global cancer incidence reached 20 million new cases across 185 countries in 2022, with approximately 10 million cancer-related deaths annually. Among adults with solid tumors and hematological malignancies, infections are a major contributor to morbidity and mortality, with respiratory infections playing a particularly significant role. These infections not only reduce life expectancy but can also delay cancer therapy, negatively affect treatment outcomes, and increase healthcare costs. In recent years, the burden of respiratory infections in this population has been driven by influenza virus

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… Additional complications, such as lung abscess and empyema, may require prolonged antibiotic therapy and surgical intervention. …

Safety and Tolerability of Letetresgene Autoleucel (GSK3377794): Pilot Studies in Patients with Advanced Non-Small Cell Lung Cancer.

PurposeThe study aims to evaluate the safety, tolerability, and antitumor response of letetresgene autoleucel (lete-cel), genetically modified autologous T cells expressing a T-cell receptor specific for New York esophageal squamous cell carcinoma 1 (NY-ESO-1)/LAGE-1a shared epitope, alone or in combination with pembrolizumab, in HLA-A*02-positive (HLA-A*02:01, HLA-A*02:05, and/or HLA-A*02:06) patients with NY-ESO-1- and/or LAGE-1a-positive non-small cell lung cancer.Patients and methodsStudy 208749 was a single-arm study of lete-cel alone. Study 208471 was a multiarm study of lete-cel alone o

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… blood cell count decreased | 1 (14) | 2 (29) | 2 (33) | 4 (67) Hemoglobin decreased | 1 (14) | 1 (14) | 0 | 0 Pancytopenia | 1 (14) | 2 (29) | 0 | 0 ICANS | 1 (14) | 2 (29) | 0 | 0 Treatment-emergent SAEs, n (%) | Grade ≥3 | Total b Arm A ( n = 7) | | Any event | 5 (71) | 5 (71) CRS | 0 | 1 (14) Empyema …

Clinical outcomes of antimicrobial resistance in cancer patients: a systematic review of multivariable models.

BackgroundInfections are major causes of disease in cancer patients and pose a major obstacle to the success of cancer care. The global rise of antimicrobial resistance threatens to make these obstacles even greater and hinder continuing progress in cancer care. To prevent and handle such infections, better models of clinical outcomes building on current knowledge are needed. This internally funded systematic review (PROSPERO registration: CRD42021282769) aimed to review multivariable models of resistant infections/colonisations and corresponding mortality, what risk factors have been investig

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… Matsutani N Yoshiya K Chida M Sakaguchi H Kikkawa T Fukuda H Postoperative empyema following lung cancer surgery Oncotarget 2018 9 29810 9 10.18632/oncotarget.25629 30038722 PMC6049863 32. …

Резюме ESPR 2013Европейское общество педиатрической радиологии 50th Ежегодное совещание и 36th Курсы для аспирантов. Июнь 3–7 2013. Будапешт, Венгрия.

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… (UK) Computed tomography compared with ultrasound and chest radiography in children with pleural empyema 2009 Senocak E. (Turkey) MRI and DWI findings in children with hemophagocytic lymphohistiocytosis: tendency for symmetricity 2010 Franchi-Abella S. …

Acute and Chronic Respiratory Failure in Cancer Patients

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… These effusions represent sequela of a number of conditions common to the cancer patient including primary malignant effusion, infectious parapneumonic effusion and empyema, pulmonary embolism, heart failure, and more. …

45th International Symposium on Intensive Care & Emergency Medicine.

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63rd Annual Conference of the Indian Society of Gastroenterology, ISGCON 2022-January 5th - 8th, 2023 in Jaipur.

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Резюме МКАРЕ 2023 77th Национальный конгресс " СИААРТИ "

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Infectious Diseases

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… Other than fever, may involve any organ system, particularly joints (sacroiliitis), GU (epididymo-orchitis), CNS (meningitis), eyes (uveitis), cardiac (endocarditis), pulmonary (pneumonitis, pleural effusion, empyema), and can cause abscesses (hepatic, splenic, thyroid, epidural). …

Disorders of the Gastrointestinal System

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Abstracts - IANCON 2025

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Proceedings of the RAMI Intern Section Meeting.

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