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Secondary Immunodeficiency in Hematological Malignancies: Focus on Multiple Myeloma and Chronic Lymphocytic Leukemia.

Secondary immunodeficiency is reported in most patients with hematological malignancies such as chronic lymphocytic leukemia and multiple myeloma. The aim of our review was to evaluate the existing literature data on patients with hematological malignancies, with regard to the effect of immunodeficiency on the outcome, the clinical and therapeutic approach, and on the onset of noninfectious complications, including thrombosis, pleural effusion, and orofacial complications. Immunodeficiency in these patients has an intense impact on their risk of infection, in turn increasing morbidity and mort

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… Secondary Antifungal Prophylaxis With Voriconazole to Adhere to Scheduled Treatment in Leukemic Patients and Stem Cell Transplant Recipients . …

The 44th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians Poster Sessions

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Evolving Paradigms in Chronic Graft-Versus-Host Disease: From Global Immunosuppression to Precision Targeted and Cell-Based Therapies.

Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is a well-established treatment for a range of medical conditions. However, the procedure carries with it a significant risk of chronic graft-versus-host disease (cGVHD), which can have a considerable impact on patients’ quality of life and clinical outcomes. In recent years, there has been a marked shift in treatment strategies for this condition, with greater emphasis being placed on novel targeted therapies and cell therapies that target specific pathways. This shift in approach signifies a more profound comprehension of the pa

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… Particular caution is warranted in patients receiving concomitant azole antifungals such as voriconazole or fluconazole following transplantation. Furthermore, as a second-generation TKI targeted inhibitor, bosutinib has been demonstrated to suppress the expression of GZMK+ CD8 + T cells. …

Selected Abstracts from the 12th Annual Meeting of the Clinical Immunology Society: 2021 Virtual Annual Meeting: Immune Deficiency and Dysregulation North American Conference.

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P941 – P1197

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Abstracts - IANCON 2025

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Ход работы 34th Симпозиум ESVN-ECVN 23rd-24th сентябрь 2022.

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Oleocanthal as a Multifunctional Anti-Cancer Agent: Mechanistic Insights, Advanced Delivery Strategies, and Synergies for Precision Oncology.

Oleocanthal (OC), a secoiridoid phenolic compound exclusive to extra virgin olive oil (EVOO), has emerged as a promising nutraceutical with multifaceted anti-cancer properties. Despite its well-characterized anti-inflammatory and antioxidant effects, the mechanistic breadth and translational potential of OC in oncology remain underexplored and fragmented across the literature. This comprehensive review synthesizes and critically analyzes recent advances in the molecular, pharmacological, and translational landscape of OC's anti-cancer activities, providing an integrative framework to bridge pr

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… CML) | CYP3A4 | Inhibition | Reduces OC hydroxylation → ↑ OC plasma levels | Possible enhanced bioactivity/toxicity of OC Tamoxifen | Estrogen receptor modulator (breast cancer) | CYP3A4, CYP2C9 | Inhibition | Slows OC metabolism → ↑ OC systemic availability | May alter OC’s pharmacodynamic profile Voriconazole …

2020 CIS Annual Meeting: Immune Deficiency & Dysregulation North American Conference.

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Molecular Inhibitors of Growth Signals

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… Drug Interactions The concomitant use of strong CYP3A4 inhibitors (including anti-retroviral protease inhibitors, ketoconazole, clarithromycin, nefazodone, telithromycin, voriconazole) or inducers (including dexamethasone, phenytoin, carbamazepine, rifampin, rifabutin, rifampacin, phenobarbital) should …

Physiological functions and pharmacological targeting of transient receptor potential channels.

Transient receptor potential (TRP) channels represent an extensive and diverse protein family fulfilling salient roles as versatile cellular sensors and effectors. The pivotal role of TRP and related ion channels in sensory processes has been well documented. Over the last few years, a new concept has emerged that TRP proteins control an exceptionally broad spectrum of homeostatic physiological functions such as maintenance of body temperature, blood pressure, transmitter release from neurons, mineral and energy homeostasis, and reproduction. This notion is further supported by more than 20 he

Esid 2014 oral presentations.

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The 48th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians - Poster Session (P001 - P578).

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NAPCON 2025 – Best Original Research Abstracts

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Inflammation in cancer: therapeutic opportunities from new insights.

As one part of the innate immune response to external stimuli, chronic inflammation increases the risk of various cancers, and tumor-promoting inflammation is considered one of the enabling characteristics of cancer development. Recently, there has been growing evidence on the role of anti-inflammation therapy in cancer prevention and treatment. And researchers have already achieved several noteworthy outcomes. In the review, we explored the underlying mechanisms by which inflammation affects the occurrence and development of cancer. The pro- or anti-tumor effects of these inflammatory factors

Abstracts from the 37th Annual Meeting of the Society of General Internal Medicine, 2014, San Diego, CA, USA.

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Ход работы сессии 31st Европейский педиатрический конгресс по педиатрии: часть 2.

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The 46th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians Poster Session (P001-P706).

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Резюме докладов 38th - ежегодное собрание общества общей внутренней медицины.

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Selected Abstracts from the 13th Annual Meeting of the Clinical Immunology Society: 2022 Annual Meeting: Immune Deficiency and Dysregulation North American Conference

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