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The leptomeninges as a critical organ for normal CNS development and function: First patient and public involved systematic review of arachnoiditis (chronic meningitis).

BACKGROUND & IMPORTANCE: This patient and public-involved systematic review originally focused on arachnoiditis, a supposedly rare "iatrogenic chronic meningitis" causing permanent neurologic damage and intractable pain. We sought to prove disease existence, causation, symptoms, and inform future directions. After 63 terms for the same pathology were found, the study was renamed Diseases of the Leptomeninges (DLMs). We present results that nullify traditional clinical thinking about DLMs, answer study questions, and create a unified path forward. METHODS: The prospective PRISMA protocol is pu

Disability Weights Measurement for 289 Causes of Disease Considering Disease Severity in Korea.

BackgroundFor the Korean Burden of Disease (KBD) 2015 study, we have amended disability weights for causes of disease adapting the methodology of the KBD disability weight 2012 study.MethodsWe conducted a self-administered web-based survey in Korea using ranking five causes of disease. A total of 605 physicians and medical college students who were attending in third or fourth grade of a regular course performed the survey. We converted the ranked data into paired comparison data and ran a probit regression. The predicted probabilities for each cause of disease were calculated from the coeffic

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… | Measles | 0.254 | 0.203 | 0.312 29 | Varicella | 0.241 | 0.193 | 0.293 30 | Malaria | 0.438 | 0.381 | 0.497 31 | Chagas disease | 0.547 | 0.489 | 0.604 32 | Leishmaniasis | 0.408 | 0.350 | 0.467 33 | African trypanosomiasis | 0.432 | 0.376 | 0.490 34 | Schistosomiasis | 0.381 | 0.323 | 0.442 35 | Cysticercosis …

Disease burden of ageing, sex and regional disparities and health resources allocation: a longitudinal analysis of 31 provinces in Mainland China.

ObjectivesTo measure the disease burden of ageing based on age-related diseases (ARDs), the sex and regional disparities and the impact of health resources allocation on the burden in China.DesignA national comparative study based on Global Burden of Diseases Study estimates and China's routine official statistics.Setting and participantsThirty-one provinces of Mainland China were included for analysis in the study. No individuals were involved.MethodsWe first identified the ARDs and calculated the disability-adjusted life years (DALYs) of ARDs in 2016. We assessed the ARD burden disparities b

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… causes at Level 2 | GBD causes at Level 3 Infectious diseases | Respiratory infections and tuberculosis | Tuberculosis, diarrheal diseases, lower respiratory diseases Other infectious diseases | Meningitis, encephalitis, tetanus, varicella and herpes zoster Neglected tropical diseases and malaria | Cysticercosis …

Rare Diseases of the Orbit.

This article provides an overview of rare orbital diseases. Congenital malformations, inflammatory diseases, benign and malignant neoplasias are described. Although it represents a relatively small area of the body the orbit contains multiple different tissues. Therefore, a great variety of diseases can be found within the orbital space. That is the reason, why both the completeness and the level of detail in the description of particular diseases must be somewhat limited. Nevertheless, clinical manifestations, important aspects of diagnosis, treatment strategies, and, when specific data are a

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… additionally systemic corticosteroids combination of albendazole, praziquantel, and surgical excision in cases of unclear diagnosis or compression-induced loss of vision, surgical excision required 61 , fine needle aspiration may be applied for diagnostics and therapy (albendazole injection) 59 5.1.4.2 Cysticercosis …

Disability Weights Measurement for 228 Causes of Disease in the Korean Burden of Disease Study 2012.

Disability weight for each disease plays a key role in combining years lived with disability and years of life lost in disability adjusted life year. For the Korean Burden of Disease 2012 study, we have conducted a re-estimation of disability weights for causes of disease by adapting the methodology of a recent Global Burden of Disease study. Our study was conducted through a self-administered web-based survey using a paired comparison (PC) as the main valuation method. A total of 496 physicians and medical college students who were attending in third or fourth grade of a regular course conduc

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… 0.256 | 0.176-0.351 Tetanus | 0.524 | 0.425-0.623 Measles | 0.279 | 0.192-0.383 Varicella | 0.223 | 0.147-0.316 Malaria | 0.471 | 0.373-0.573 Chagas disease | 0.647 | 0.550-0.739 Leishmaniasis | 0.411 | 0.317-0.512 African trypanosomiasis | 0.515 | 0.416-0.616 Schistosomiasis | 0.340 | 0.253-0.435 Cysticercosis …

Relevance Index Regional Variation by Each Disease and Its Essential Medical Field: A Retrospective Data Analysis From 2016-2020 in Korea.

BackgroundTo precisely build a healthcare delivery system at regional levels, local patients' healthcare service utilization patterns must be examined. Hence, this study utilized trend analysis of the relevance index of each disease of each essential medical service field at the municipal and provincial levels.MethodsThis study analyzed customized databases released by the National Health Insurance Service from 2016-2020. Diseases defined in the Korean National Burden of Disease (KNBD) study were categorized into the following essential medical service fields: trauma care, cardiocerebrovascula

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… 87.7 | 89.4 | 87.5 | 87.5 | 88.5 33 | Malaria | 50.0 | 50.0 | 82.9 | 50.0 | 85.1 34 | Chagas disease | 50.0 | 0.0 | 50.0 | 0.0 | 0.0 35 | Leishmaniasis | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 36 | African trypanosomiasis | 50.0 | 50.0 | 0.0 | 0.0 | 0.0 37 | Schistosomiasis | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 38 | Cysticercosis …

Rapid health transition in China, 1990-2010: findings from the Global Burden of Disease Study 2010.

BACKGROUND: China has undergone rapid demographic and epidemiological changes in the past few decades, including striking declines in fertility and child mortality and increases in life expectancy at birth. Popular discontent with the health system has led to major reforms. To help inform these reforms, we did a comprehensive assessment of disease burden in China, how it changed between 1990 and 2010, and how China's health burden compares with other nations. METHODS: We used results of the Global Burden of Diseases, Injuries, and Risk Factors Study 2010 (GBD 2010) for 1990 and 2010 for China

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… ·5 | Malaria | 0·2 (0·1–0·3) | 0·1 (0·0–0·1) | −63·2 | <0·05 (0·0–0·05) | <0·05 (0·0–0·05) | −72·1 | Leishmaniasis | 6·5 (2·8–14·7) | 1·8 (0·8–3·6) | −71·2 | 0·6 (0·2–1·2) | 0·1 (0·1–0·3) | −73·5 | Schistosomiasis | 8·5 (0·0–50·4) | 8·5 (0·0–50·2) | 0·2 | 0·9 (0·0–5·6) | 0·6 (0·0–3·5) | −37·9 | Cysticercosis … Comparing 1990 (data not shown) with 2010, eight causes switched from significantly better than average to indistinguishable from average: falls, congenital anomalies, neonatal encephalopathy, poisonings, rheumatic heart disease, hookworm, ascariasis, and cysticercosis. …

Updating Disability Weights for Measurement of Healthy Life Expectancy and Disability-adjusted Life Year in Korea.

BackgroundThe present study aimed to update the methodology to estimate cause-specific disability weight (DW) for the calculation of disability adjusted life year (DALY) and health-adjusted life expectancy (HALE) based on the opinion of medical professional experts. Furthermore, the study also aimed to compare and assess the size of DW according to two analytical methods and estimate the most valid DW from the perspective of years lost due to disability and HALE estimation.MethodsA self-administered web-based survey was conducted ranking five causes of disease. A total of 901 participants star

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… Chagas disease | 0.575 | 0.394 | 0.604 | 0.487 28 | Visceral leishmaniasis | 0.424 | 0.332 | 0.520 | 0.443 29 | Cutaneous and mucocutaneous leishmaniasis | 0.373 | 0.315 | 0.466 | 0.418 30 | African trypanosomiasis | 0.490 | 0.357 | 0.511 | 0.438 31 | Schistosomiasis | 0.383 | 0.318 | 0.421 | 0.399 32 | Cysticercosis …

The burden of disease in Spain: results from the global burden of disease study 2010.

BackgroundWe herein evaluate the Spanish population's trends in health burden by comparing results of two Global Burden of Diseases, Injuries, and Risk Factors Studies (the GBD studies) performed 20 years apart.MethodsData is part of the GBD study for 1990 and 2010. We present results for mortality, years of life lost (YLLs), years lived with disability, and disability-adjusted life years (DALYs) for the Spanish population. Uncertainty intervals for all measures have been estimated.ResultsNon-communicable diseases accounted for 3,703,400 (95% CI 3,648,270-3,766,720) (91.3%) of 4,057,400 total

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… Neglected tropical diseases and malaria | 8.5 (2.3–21.8) | 15.6 (2.5–51.2) | 83% | 69.6 (39.7–120.3) | 64.9 (35.1–120.1) | −7% Malaria | 0.5 (0–3.9) | 0.1 (0–0.8) | −75% | 0.5 (0–3.9) | 0.1 (0–0.8) | −75% Leishmaniasis | 1.3 (0.6–2.7) | 1.4 (0.6–2.9) | 6% | 10.6 (7.4–14.7) | 8.4 (5.8–11.5) | −21% *Cysticercosis …

How does academia respond to the burden of infectious and parasitic disease?

BackgroundAcademic research is one of the main avenues through which humans can fight the threat of infectious diseases. However, there have been concerns regarding whether the academic system has provided sufficient efforts to fight infectious diseases we potentially face. Answering these questions could contribute to evidence-based recommendations for setting research priorities and third-mission policies.MethodsWith a focus on one of the most common categories of communicable diseases, infectious and parasitic diseases (IPDs), we searched Web of Science for articles and reviews relevant to

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… OR "Leishmania" OR "phlebotomine" OR "psychodidae" OR "kalaazar" OR "kala-azar" OR "kala azar" OR "sand fly" OR "sandflies" OR "sand flies" OR "filariasis" OR "elephantiasis" OR "wuchereria" OR "brugia malayi" OR "Onchocerciasis" OR "Onchoceriasis" OR "river blindness" OR "onchocerca volvulus" OR "Cysticercosis …

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Parasites revive hope for cancer therapy.

Parasites have attained a life-long stigma of being detrimental organisms with deleterious outcomes. Yet, recently, a creditable twist was verified that can dramatically change our perception of those parasites from being a source of misery to millions of people to a useful anti-cancerous tool. Various parasites have shown promise to combat cancer in different experimental models, including colorectal, lung, and breast cancers, among others. Helminths and protozoan parasites, as well as their derivatives such as Echinococcus granulosus protein KI-1, Toxoplasma gondii GRA15II, and Trypanosoma c

Availability of secondary healthcare data for conducting pharmacoepidemiology studies in Colombia: A systematic review.

Real-world evidence (RWE) is emerging as a fundamental component of the post-marketing evaluation of medicinal products. Even though the focus on RWE studies has increased in Colombia, the availability of secondary data sources to perform this type of research is not well documented. Thus, we aimed at identifying and characterizing secondary data sources available in Colombia. We performed a systematic literature review on PubMed, EMBASE, and VHL using a combination of controlled vocabulary and keywords for the concepts of electronic health records, epidemiologic studies and Colombia. A total

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… Mapping the residual incidence of taeniasis and cysticercosis in Colombia, 2009–2013, using geographical information systems: implications for public health and travel medicine. Travel Med Infect Dis. 2018;22:51‐57. 220. Rodríguez‐Vargas AL. …

Abstracts - IANCON 2024

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Global burden of 292 causes of death in 204 countries and territories and 660 subnational locations, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023.

BACKGROUND: Timely and comprehensive analyses of causes of death stratified by age, sex, and location are essential for shaping effective health policies aimed at reducing global mortality. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2023 provides cause-specific mortality estimates measured in counts, rates, and years of life lost (YLLs). GBD 2023 aimed to enhance our understanding of the relationship between age and cause of death by quantifying the probability of dying before age 70 years (70q0) and the mean age at death by cause and sex. This study enables comparis

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… 8% (−96·2 to −95·4) * Schistosomiasis 21·6 (19·8 to 23·9) 13·5 (12·3 to 14·8) −37·7% (−42·8 to −31·9) * 0·4 (0·4 to 0·4) 0·2 (0·1 to 0·2) −59·4% (−62·7 to −56·0) * 987·8 (898·1 to 1115·3) 564·3 (508·2 to 623·0) −42·9% (−47·7 to −37·9) * 16·5 (15·0 to 18·5) 6·8 (6·2 to 7·5) −58·5% (−61·9 to −55·1) * Cysticercosis …

C-Reactive Protein: Pathophysiology, Diagnosis, False Test Results and a Novel Diagnostic Algorithm for Clinicians.

The current literature provides a body of evidence on C-Reactive Protein (CRP) and its potential role in inflammation. However, most pieces of evidence are sparse and controversial. This critical state-of-the-art monography provides all the crucial data on the potential biochemical properties of the protein, along with further evidence on its potential pathobiology, both for its pentameric and monomeric forms, including information for its ligands as well as the possible function of autoantibodies against the protein. Furthermore, the current evidence on its potential utility as a biomarker of

Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017.

BACKGROUND: How long one lives, how many years of life are spent in good and poor health, and how the population's state of health and leading causes of disability change over time all have implications for policy, planning, and provision of services. We comparatively assessed the patterns and trends of healthy life expectancy (HALE), which quantifies the number of years of life expected to be lived in good health, and the complementary measure of disability-adjusted life-years (DALYs), a composite measure of disease burden capturing both premature mortality and prevalence and severity of ill

Global, regional, and national disability-adjusted life-years (DALYs) for 333 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016.

BACKGROUND: Measurement of changes in health across locations is useful to compare and contrast changing epidemiological patterns against health system performance and identify specific needs for resource allocation in research, policy development, and programme decision making. Using the Global Burden of Diseases, Injuries, and Risk Factors Study 2016, we drew from two widely used summary measures to monitor such changes in population health: disability-adjusted life-years (DALYs) and healthy life expectancy (HALE). We used these measures to track trends and benchmark progress compared with e

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… | –78·2 (–84·6 to –68·8) * Schistosomiasis | 2096·8 (1340·2 to 3410·1) | 2464·8 (1447·7 to 4194·7) | 1863·6 (1122·0 to 3175·2) | –11·1 (–17·5 to –6·7) * | –24·4 (–26·2 to –21·9) * | 42·8 (27·5 to 69·2) | 37·5 (22·2 to 63·5) | 24·9 (15·0 to 42·3) | –41·9 (–46·3 to –38·9) * | –33·7 (–35·4 to –31·6) * Cysticercosis …

Резюме докладов 38th - ежегодное собрание общества общей внутренней медицины.

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Резюме ЭСП 2013.

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