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Clinical course of cow's milk protein allergy/intolerance and atopic diseases in childhood.

A cohort of 1,749 newborns from the municipality of Odense, born during 1995 at the Odense University Hospital, were followed up prospective … panel of inhalant allergens (birch, grass, mugwort, dog, cat, horse, Dermatophagoidespteronyssinus, Dermatophagoides farinae, alternaria and cladosporium herbarum). Furthermore, lung function measurements were performed in children when 10 and 15 years of age. Based on controlled milk elimination and challenge procedures, the diagnosis of CMPA/I was confirmed in 39 out of …

LncRNA OIP5‑AS1 aggravates house dust mite‑induced inflammatory responses in human bronchial epithelial cells via the miR‑143‑3p/HMGB1 axis.

Bronchial asthma poses a serious threat to human health. Previous studies have documented the role of long non‑coding RNAs (lncRNAs) in asthma. However, the molecular mechanism underlying bronchial asthma remains unclear. The aim of the present study was to evaluate the role of the lncRNA Opa‑interacting protein 5 antisense RNA1 (OIP5‑AS1) in the house dust mite‑induced inflammatory response in human bronchial epithelial cells. BEAS‑2B cells were treated with Dermatophagoides pteronyssinus peptidase 1 (Der p1) to establish an in vitro model of asthma. OIP5‑AS1 expression levels increased in BE

Trifuhalol A Suppresses Allergic Inflammation through Dual Inhibition of TAK1 and MK2 Mediated by IgE and IL-33.

The activation and degranulation of immune cells play a pivotal role in allergic inflammation, a pathological condition that includes anaphylaxis, pruritus, and allergic march-related diseases. In this study, trifuhalol A, a phlorotannin isolated from Agarum cribrosum, inhibited the degranulation of immune cells and the biosynthesis of IL-33 and IgE in differentiated B cells and keratinocytes, respectively. Additionally, trifuhalol A suppressed the IL-33 and IgE-mediated activation of RBL-2H3 cells through the regulation of the TAK1 and MK2 pathways. Hence, the effect of trifuhalol A on allerg

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… HDM ( Dermatophagoides farina ) extract ointment (Biostir AD) was obtained from Biostir Inc., (Osaka, Japan). ELISA kits for IL-4 and IgE were purchased from Invitrogen (Frederick, MD, USA). Power SYBR ® Green Master Mix was purchased from Applied Biosystems (Foster, CA, USA). … A novel atopic dermatitis model induced by topical application with dermatophagoides farinae extract in NC/Nga mice Allergol. Int. 2007 56 139 148 17460441 10.2332/allergolint.O-06-458 37. Hashimoto Y. Arai I. Takano N. Tanaka M. Nakaike S. …

Clinical characteristics of Mycoplasma pneumoniae pneumonia in children with atopic constitution and risk factors for disease severity: a retrospective comparative study.

OBJECTIVE: To compare the clinical characteristics and immune-inflammatory markers between Mycoplasma pneumoniae pneumonia children with and without atopic constitution, and to identify independent risk factors for severe MPP within the atopic group. METHODS: We retrospectively analyzed the medical records of 377 children diagnosed with MPP at Wuhan Children's Hospital between January 1, 2019, and December 31, 2024, who underwent allergen-specific immunoglobulin E (sIgE) testing for both inhalant and food allergens. The children were divided into two groups based on their atopic constitution:

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… Inhalant allergen panel (10 items) Short Ragweed (Ambrosia artemisiifolia), Mugwort (Artemisia vulgaris), House Dust Mite (Dermatophagoides pteronyssinus), Dust Mite (Dermatophagoides farinae), Cat dander, Dog dander, House Dust, Cockroach, Alternaria alternata, and Willow (Salix). …

Role of Ceramide from Glycosphingolipids and Its Metabolites in Immunological and Inflammatory Responses in Humans.

Glycosphingolipids (GSLs) are composed of hydrophobic ceramide and hydrophilic sugar chains. GSLs cluster to form membrane microdomains (lipid rafts) on plasma membranes, along with several kinds of transducer molecules, including Src family kinases and small G proteins. However, GSL-mediated biological functions remain unclear. Lactosylceramide (LacCer, CDw17) is highly expressed on the plasma membranes of human phagocytes and mediates several immunological and inflammatory reactions, including phagocytosis, chemotaxis, and superoxide generation. LacCer forms membrane microdomains with the Sr

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… Treatment of 3D keratinocytes with PaCDase and water-soluble stimulants of keratinocytes, including trypsin, Dermatophagoides pteronyssinus class 1 allergen (Der p1), and Dermatophagoides farinae allergen (Der f1) had no effect on the expression of any of the genes in our DNA microarray analysis [ 55 …

Proceedings of the Canadian Society of Allergy and Clinical Immunology Annual Scientific Meeting 2018

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… Methods: 79 children aged 5 to 18 years with respiratory allergy (atopic bronchial asthma and/or allergic rhinitis) were included in the study. 68 out of 79 (86%) were found to have sensitization to house dust mites Dermatophagoides Pteronyssinus and/or Dermatophagoides Farinae. … These patients were divided into two groups: study group: 36 children with sensitivity to major allergens received sublingual therapy with a mixture of house dust mites (Dermatophagoides Pteronyssinus and/or Dermatophagoides Farinae), and control group: 20 children with sensitivity to minor allergens …

Erratum.

In the article "House Dust Mite Sublingual Immunotherapy for Allergic Rhinoconjunctivitis: Comprehensive Review and Meta-Analytical Evidence … ma Test), CPT (Conjunctival Provocation Test), CSMS (Combined Symptom and Medication Score), Der f (Dermatophagoides farinae), Der p (Dermatophagoides pteronyssinus), DU (Developmental Unit), EEC (Environmental Exposure Chamber), HDM (House Dust Mite), ICS (Inhaled Corticosteroid), IgE (Immunoglobulin E), IgG4 (Immunoglobulin G4), INSS (Individual Nasal Symptom Score), IR …

NAPCON 2025 – Best Original Research Abstracts

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… The most frequent sensitizers were house dust mites – Dermatophagoides pteronyssinus (51%) and Dermatophagoides farinae (43%)—followed by cockroach (40%), housefly (40%), mosquito (39%), and ant (37%). …

Post-Translational Modifications in Atopic Dermatitis: Current Research and Clinical Relevance.

Atopic dermatitis (AD) is a chronic and relapsing cutaneous disorder characterized by compromised immune system, excessive inflammation, and skin barrier disruption. Post-translational modifications (PTMs) are covalent and enzymatic modifications of proteins after their translation, which have been reported to play roles in inflammatory and allergic diseases. However, less attention has been paid to the effect of PTMs on AD. This review summarized the knowledge of six major classes (including phosphorylation, acetylation, ubiquitination, SUMOylation, glycosylation, o-glycosylation, and glycati

2018 Ежегодное совещание СНГ: Североамериканская конференция по вопросам неадекватности и регулирования.

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In vitro расширила человека CD4+CD25+ регуляционные T клетки, подавляющие распространение Т клеток.

Регулирующие Т клетки (Tregs) оказались критически важными в балансе между автоиммунизацией и терпимостью и были связаны с несколькими аутоиммунными заболеваниями человека. Однако небольшое число трегов в периферии крови ограничивает их терапевтический потенциал. Поэтому мы разработали протокол, который позволит расширить "Трегз" при сохранении их подавляющей активности. Мы изолировали клетки CD4+CD25 hi от человеческой периферической крови и расширили их in vitro в присутствии anti-CD3 и anti-CD28 Магнитные кситы и высокие концентрации внешнего интерлейкина (IL) -2. Траги были эффективно расш

Abstracts for NAPCON 2025

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Integumentary System

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