Результаты поиска

PNEUMONIA | Community Acquired Pneumonia, Bacterial and Other Common Pathogens

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… Therapy with an antipneumococcal quinolone (gatifloxacin, gemifloxacin, levofloxacin, moxifloxacin) is not necessary in these outpatients, because they are not at risk for organisms such as DRSP and enteric Gram-negatives. … There are differences among the available agents in their intrinsic activity against pneumococcus, and, based on MIC data, these agents can be ranked from most to least active as: gemifloxacin (available only in oral form), moxifloxacin, gatifloxacin, and levofloxacin. …

[Prospects for development of new antituberculous drugs].

Tuberculosis (TB) is a growing international health concern, since it is the leading infectious cause of death in the world today. Moreover, … ifapentine, and rifalazil), fluoroquinolones (ciprofloxacin, ofloxacin, sparfloxacin, levofloxacin, gatifloxacin, sitafloxacin, moxifloxacin, and others), and new macrolides (clarithromycin, azithromycin, and roxithromycin). Second, I described other types of agents which are being developed as antimycobacterial drugs. Some of the agents discussed are already …

The role of topical moxifloxacin, a new antibacterial in Europe, in the treatment of bacterial conjunctivitis.

This article discusses current practice in the treatment of conjunctivitis and how the use of topical moxifloxacin can increase therapeutic … nd instead are reserved for use as a last resort. In other parts of the world topical lomefloxacin, gatifloxacin and/or besifloxacin are also available. The strategy of using novel topical fluoroquinolones as a last resort reflects a belief that the use of topical fluoroquinolones may enhance the development of resistance, jeopardizing future availability of a …

Bisphosphonate conjugation for bone specific drug targeting.

Bones provide essential functions and are sites of unique biochemistry and specialized cells, but can also be sites of disease. The treatment of bone disorders and neoplasia has presented difficulties in the past, and improved delivery of drugs to bone remains an important goal for achieving effective treatments. Drug targeting strategies have improved drug localization to bone by taking advantage of the high mineral concentration unique to the bone hydroxyapatite matrix, as well as tissue-specific cell types. The bisphosphonate molecule class binds specifically to hydroxyapatite and inhibits

Совпадение в полном тексте источника
… Table 2 Structure References 1 Image 15 ( Herczegh et al., 2002 ) ( Houghton et al., 2008 ) Norfloxacin: X = C, R = C 2 H 5 Enoxacin: X = N, R = C 2 H 5 Ciprofloxacin: X = C, R = cyclopropyl 2 Image 16 ( Houghton et al., 2008 ) Gatifloxacin 3 Image 17 Gatifloxacin 4 Image 18 Moxifloxacin 5 Image 19 Moxifloxacin … | Structure | References 1 | Image 15 | ( Herczegh et al., 2002 ) ( Houghton et al., 2008 ) Norfloxacin: X = C, R = C 2 H 5 Enoxacin: X = N, R = C 2 H 5 Ciprofloxacin: X = C, R = cyclopropyl | 2 | Image 16 | ( Houghton et al., 2008 ) Gatifloxacin | 3 | Image 17 Gatifloxacin | 4 | Image 18 Moxifloxacin …

Distribution patterns of drug resistance Mycobacterium tuberculosis among HIV negative and positive tuberculosis patients in Western Kenya.

INTRODUCTION: Globally anti-tuberculosis drug resistance is one of the major challenges affecting control and prevention of tuberculosis. Ke … ond-line drug resistant strains identified among HIV negative patients included Ethionamide (0.3%), Gatifloxacin (0.3%), Amikacin (0.3%) and Capreomycin (0.3%). There was no second line drug monoresistance among HIV positive TB patients. Multi/poly drug resistance were noted among HIV-negative patients in, INH + AMK (0.7%), INH + PZA (1%), INH + GFX (0.7%, INH …

Unraveling the Anti-Cancer Mechanisms of Antibiotics: Current Insights, Controversies, and Future Perspectives.

Cancer persists as a significant global health challenge, claiming millions of lives annually despite remarkable strides in therapeutic innovation. Challenges such as drug resistance, toxicity, and suboptimal efficacy underscore the need for novel treatment paradigms. In this context, the repurposing of antibiotics as anti-cancer agents has emerged as an attractive prospect for investigation. Diverse classes of antibiotics have exhibited promising anti-cancer properties in both in vitro and in vivo studies. These mechanisms include the induction of apoptosis and cell cycle arrest, generation o

Совпадение в полном тексте источника
… Gatifloxacin, a third-generation quinolone, successfully inhibited the growth of two pancreatic cancer cell lines in vitro. … Gatifloxacin Induces S and G2-Phase Cell Cycle Arrest in Pancreatic Cancer Cells via P21/P27/P53. PLoS ONE. 2012;7:e47796. doi: 10.1371/journal.pone.0047796. 110. Foster J.L., Conroy P.J., Searle A.J., Willson R.L. …

Treatment of enteric fever (typhoid and paratyphoid fever) with cephalosporins.

BACKGROUND: Typhoid and paratyphoid (enteric fever) are febrile bacterial illnesses common in many low- and middle-income countries. The Wor … unclear whether ceftriaxone decreases convalescent faecal carriage compared to the fluoroquinolone gatifloxacin (RR 0.18, 95% CI 0.01 to 3.72; 1 trial, 73 participants; very low-certainty evidence) and length of hospital stay may be longer in participants treated with ceftriaxone compared to participants treated with the fluoroquinolone ofloxacin (mean of 12 …

[The history of the development and changes of quinolone antibacterial agents].

The quinolones, especially the new quinolones (the 6-fluoroquinolones), are the synthetic antibacterial agents to rival the Beta-lactam and … efloxacin (LFLX), fleroxacin (FRLX), tosufloxacin (TFLX), levofloxacin (LVFX), sparfloxacin (SPFX), gatifloxacin (GFLX), prulifloxacin (PULX) and also pazufloxacin (PZFX). The advantages of these compounds, e.g., LVFX, SPFX and GFLX, are that their spectrum includes Gram-positive bacteria species as well as Gram-negative bacteria and they improve bioavailabili …

Prevalence, Attributes, and Risk Factors of QT-Interval-Prolonging Drugs and Potential Drug-Drug Interactions in Cancer Patients: A Prospective Study in a Tertiary Care Hospital.

Introduction Cancer chemotherapy regimens include multiple classes of adjuvant drugs as supportive therapy. Because of the concurrent intake of other drugs (like antiemetics, antidepressants, analgesics, and antimicrobials), there is a heightened risk for possible QT interval prolongation. There is a dearth of evidence in the literature regarding the usage of QT-prolonging anticancer drugs and associated risk factors that have the propensity to prolong QT interval. The purpose was to explore the extent of the use of QT-interval-prolonging drugs and potential QT-prolonging drug-drug interaction

Совпадение в полном тексте источника
… Rates of torsades de pointes associated with ciprofloxacin, ofloxacin, levofloxacin, gatifloxacin, and moxifloxacin. Frothingham R. Pharmacotherapy. 2001;21:1468–1472. doi: 10.1592/phco.21.20.1468.34482. 61. …

Antimicrobial treatment guidelines for acute bacterial rhinosinusitis.

UNLABELLED: Treatment guidelines developed by the Sinus and Allergy Health Partnership for acute bacterial rhinosinusitis (ABRS) were origin … ve rank order of predicted clinical efficacy for adults: 90% to 92% = respiratory fluoroquinolones (gatifloxacin, levofloxacin, moxifloxacin), ceftriaxone, high-dose amoxicillin/clavulanate (4 g/250 mg/day), and amoxicillin/clavulanate (1.75 g/250 mg/day); 83% to 88% = high-dose amoxicillin (4 g/day), amoxicillin (1.5 g/day), cefpodoxime proxetil, cefixime (ba …

Клиническое представление лептоспироза: ретроспективное исследование 34 Пациенты поступили в одно учебное заведение во Франции.

Лептоспироз имеет весьма изменчивое клиническое представление, которое может быть связано с различными заражающими сероварами, факторами хост-компьютеров или их комбинацией. Это исследование проводилось ретроспективно 34 Число пациентов с серологическим подтвержденным лептоспирозом, принятых в течение отчетного периода 1992-2002. Наиболее частыми симптомами при поступлении в школу были лихорадка (см.100%), головная боль75%), миальгии55%), артхальгии45%) и рвотой (т.е.39%). Применяемые лабораторные исследования включали в себя лимфопенцию (см.85%), тромбоцитопенсия75%), повышенные ферменты пече

Совпадение в полном тексте источника
… Four isolates showed high resistance to fluoroquinolones (>128 mg/L), including norfloxacin, levofloxacin, sparfloxacin, gatifloxacin and pazufloxacin. The MIC range for sitafloxacin was between <0.25 and 8 mg/L. …

Распространяется жизнь, угрожая вирусом Нокардии отитидискавиарум у молодой женщины с недавно диагностированным системным волшебством эритематос, отчетом по делу и анализом литературы.

По сообщениям, инфекция, вызванная нокардией, наблюдается главным образом у иммунокомпромиссированных пациентов. Обычно он представляет собой легочную или распространенную болезнь с предрасположенностью к мозгу. Инфекции - это редкая этиология внутричерепной сосудистой аневризмы. В этой связи мы сообщаем о случае распространения Nocardia otitidiscaviarum (N. otitidiscaviarum) у молодой женщины, у которой недавно был диагностирован системный волчан (SLE), осложняемый развитием инфекционной внутричерепной аневризмы. Насколько нам известно, это четвертый случай внутричерепной аневризмы, связанной

Совпадение в полном тексте источника
… et al . , 2005 | 70/M | Rheumatoid arthritis, Infliximab | Skin | CT head and Lung Normal | Ofloxacin + Clindamycin | + | Recovered | [41] Sharma et al . , 2007 | 36/F | Sickle Cell, End Stage Renal Disease | Lung Blood | multiple pulmonary nodules scattered throughout both lung fields | Amikacin + Gatifloxacin …

Non-diabetic hypoglycemia: bridging gaps in diagnosis and treatment: a position statement report by the Arabic Association for the Study of Diabetes and Metabolism (AASD).

BACKGROUND: Non-diabetic hypoglycemia presents a substantial diagnostic challenge due to its diverse and often nonspecific symptomatology. The resultant delay in diagnosis can lead to a myriad of misdiagnoses. This misidentification not only prolongs patient suffering but also elevates the risk of severe complications, such as permanent neurologic damage and mortality. Recognizing the clinical nuances of non-diabetic hypoglycemia is paramount for timely and accurate diagnosis, which ultimately enhances patient outcomes and safety. MAIN BODY: A position statement has been formulated by the Ara

Совпадение в полном тексте источника
… antidepressants (TCAs): (e.g., doxepin, imipramine, nortriptyline) Antidepressant of selective serotonin re-uptake inhibitors (SSRIs) family: (e.g., fluoxetine, sertraline) Mono-Amin Oxidase Inhibitors (MAOIs): (e.g., selegiline, rasagiline) Antipsychotics, lithium and valproate Certain antibiotics (e.g., gatifloxacin …

Abstracts cont.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… In 25 patients the antibiotics (ceftriaxone, gatifloxacin and imipinem) administrated arterially. These patients compiled the first group and the rest patients - the control group. Results : The Balthazar, Ranson (more than 3) score was not different in both groups at admission. … Applying gatifloxacin in the complex management of SAP has a benefit in prevention of purulent complications. R1993: Drug-resistance and drug-sensitiveness of bacterias causing urinary tract infections in women under general practice care in Silesian Province I. Szymczyk, W. Lukas, J. Józwiak, M. …

Drug Repurposing of Selected Antibiotics: An Emerging Approach in Cancer Drug Discovery.

Drug repurposing is a method of investigating new therapeutic applications for previously approved medications. This repurposing approach to "old" medications is now highly efficient, simple to arrange, and cost-effective and poses little risk of failure in treating a variety of disorders, including cancer. Drug repurposing for cancer therapy is currently a key topic of study. It is a way of exploring recent therapeutic applications for already-existing drugs. Theoretically, the repurposing strategy has various advantages over the recognized challenges of creating new molecular entities, inclu

Совпадение в полном тексте источника
… . | ( 27 ) (b) Enoxacin (c) Norfloxacin (d) Ciprofloxacin (e) Ofloxacin (f) Lomefloxacin (g) Sparfloxacin (h) Grepafloxacin (i) Clinafloxacin (j) Gatifloxacin (k) Moxifloxacin (l) Gemifloxacin (m) Trovafloxacin (n) Garenoxacin 6. | Macrolide | (a) Erythromycin | Macrolides revolve around their ability …

P941 – P1197

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.