Результаты поиска

[Effects and safety of gonadotrophin-releasing hormone agonist combined with estradiol patch and oral medroxyprogesterone acetate on endometriosis].

OBJECTIVE: To evaluate effects and safety of gonadotrophin-releasing hormone agonist (GnRH-a) combined with transdermal estradiol and medrox … %; P < 0.01. (3) Before the treatment, patients'VAS scores of total, pelvic pain, dysmenorrheal and dyspareunia were 7.43 +/- 3.20, 2.35 +/- 1.82, 4.93 +/- 1.98 and 0.14 +/- 0.53 in group A and were 7.71 +/- 2.02, 2.57 +/- 1.60, 4.86 +/- 1.56 and 0.29 +/- 1.07 in group B; after treatment, the scores above were changed to 0. 14 +/- 0.36, 0.07 +/- 0.27, 0.07 +/ …

Burden of somatic morbidity associated with a surgically verified diagnosis of endometriosis at a young age: a register-based follow-up cohort study in Finland.

STUDY QUESTION: How does the burden of somatic disorders compare between women with surgically verified endometriosis diagnosed in adolescen … (2.01 [1.83-2.22]), respectively. In women with endometriosis, a higher incidence was seen also for dyspareunia, uterine myomas, celiac disease, asthma, anaemia, high blood pressure, hypercholesterolemia or cardiovascular diseases; autoimmune diseases, and disorders of the thyroid gland. For women with ovarian endometriosis only, we observed a lower HR of hig …

Polydatin: Pharmacological Mechanisms, Therapeutic Targets, Biological Activities, and Health Benefits.

Polydatin is a natural potent stilbenoid polyphenol and a resveratrol derivative with improved bioavailability. Polydatin possesses potential biological activities predominantly through the modulation of pivotal signaling pathways involved in inflammation, oxidative stress, and apoptosis. Various imperative biological activities have been suggested for polydatin towards promising therapeutic effects, including anticancer, cardioprotective, anti-diabetic, gastroprotective, hepatoprotective, neuroprotective, anti-microbial, as well as health-promoting roles on the renal system, the respiratory s

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… In addition, clinical studies showed that PEA/polydatin combination improved chronic pelvic pain, dysmenorrhea, deep dyspareunia, and dyschezia [ 215 , 216 , 218 ]. It also improved life quality and psychological condition [ 218 ]. … In addition, results of a review study showed that administration of PEA/polydatin 400 mg/40 mg twice a day exerted positive effects against endometriotic chronic pelvic pain, including improving chronic pelvic pain, dysmenorrhea, and deep dyspareunia [ 215 ]. …

Multidisciplinary Resection of Deeply Infiltrative Endometriosis.

STUDY OBJECTIVE: To describe a multidisciplinary approach for the resection of deeply infiltrative endometriosis using the robotic platform. … ultiple organs. PATIENT: A 47-year-old woman with a 4-year history of severe pelvic pain, dysuria, dyspareunia, dyschezia, and dysmenorrhea failing multiple medical therapies presented to our clinic to discuss surgical options. After thorough counseling, the decision was made to proceed with definitive surgical management. Postoperatively, the patient was ad …

Relationship Between Inflammation-Nutrition Composite Indices and Ovarian Endometrioma: A Retrospective Observational Study.

ObjectiveEndometriosis is a chronic inflammatory disease with impacts on reproduction, health and quality of life, yet its diagnosis is often delayed. Ovarian endometrioma (OMA) is the most common subtype of endometriosis. The establishment of simple predictive indicators could screen women at high risk of OMA, thereby potentially facilitating the early diagnosis and management of endometriosis. This study aimed to comprehensively evaluate the predictive performance of inflammation and inflammation-nutrition composite indices for ovarian endometrioma (OMA) among women of reproductive age in Ch

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… disease defined by the presence of endometrial-like tissues outside the uterus, which is thought to arise by retrograde menstruation typically, affecting 6–10% of women at reproductive age and up to 50% of women with infertility. 1–3 Its common clinical symptoms include chronic pelvic pain, dysmenorrhea, dyspareunia …

Single-incision mini-slings versus standard synthetic mid-urethral slings for surgical treatment of stress urinary incontinence in women: The SIMS RCT.

BACKGROUND: Stress urinary incontinence is the most common type of urinary incontinence in premenopausal women. Until recently, synthetic mi … interval -0.1, 0.1; p = 0.92). However, more women in the single-incision mini-sling group reported dyspareunia [12% (17/145), compared with 4.8% (7/145) in the standard mid-urethral sling group, risk difference 7.0%, 95% confidence interval 1.9% to 12.1%]. The base-case economics results showed no difference in costs (-£6, 95% confidence interval -£228 to £2 …

Проверка полиномического (нелинейного) воздействия неврологической и физической инвалидности на сексуальное благополучие при множественном склерозе.

Множественный склероз (MS) относится к числу наиболее распространенных хронических аутоиммунных расстройств, затрагивающих центральную нервную систему. В Польше коэффициент заболеваемости НР составляет 6.3 Процент 100,000 Пациенты. Результаты исследований свидетельствуют о том, что люди, страдающие от НР, в меньшей степени вовлечены в сексуальную жизнь как в физическом, так и в эмоциональном плане, они считают, что секс для них менее важен, чем для здоровых людей, и их половая мотивация ограничена, особенно его физическое измерение. МЕТОДЫ: Всего 121 В исследовании приняли участие люди. Он исп

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… and sexual dysfunctions (lack or loss of sexual desire, lack of sexual pleasure, lack or delay of orgasm, erectile dysfunction, vaginal dryness, premature orgasm, vaginismus, dyspareunia, vulvodynia, pain during intercourse, pain in intimate areas, other and the question “Do you believe that MS affects …

How does academia respond to the burden of infectious and parasitic disease?

BackgroundAcademic research is one of the main avenues through which humans can fight the threat of infectious diseases. However, there have been concerns regarding whether the academic system has provided sufficient efforts to fight infectious diseases we potentially face. Answering these questions could contribute to evidence-based recommendations for setting research priorities and third-mission policies.MethodsWith a focus on one of the most common categories of communicable diseases, infectious and parasitic diseases (IPDs), we searched Web of Science for articles and reviews relevant to

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… " OR "Attention deficit" OR "hyperactivity" OR "Bipolar disorder" OR "Borderline personality disorder" OR "Bruxism" OR "Bulimia nervosa" OR "Conduct disorder" OR "Conversion disorder" OR "Delirium tremens" OR "Dementia" OR "Depression disorder" OR "Depressive disorder" OR "Depressive psychosis" OR "Dyspareunia … Menopausa*" OR "Metrorrhagia" OR "Mittelschmerz" OR "Premenstrual tension syndrome" OR "postmenopausal atrophic" OR "vulvo atrophy" OR "vaginal atrophy" OR "Bartholin abscess" OR "Bartholin cyst" OR "Cervical polyp" OR "Cervicitis" OR "Corpus luteum cyst" OR "Cyst of ovary" OR "Cystocele" AND "midline" OR "Dyspareunia …

Identification of iron metabolism-related predictive markers of endometriosis and endometriosis-relevant ovarian cancer.

Endometriosis is associated with ovarian cancers, mainly endometrioid and clear-cell carcinomas. Iron metabolism has been shown to play a role in endometriosis. Therefore, it is vital to explore the relationship between iron metabolism and ovarian cancer and to identify novel markers for diagnostics and therapeutics. The endometriosis dataset GSE51981 and the ovarian cancer dataset GSE26712 were obtained from the gene expression omnibus database, and differentially expressed genes were identified. Iron metabolism genes were obtained from molecular signatures database, and hub genes from the 3

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… Ectopic endometrium development involves the interaction of endocrine, immune, microbial, proinflammatory, and proangiogenic processes as well as environmental factors. [ 3 ] These factors in turn cause patients to develop clinical symptoms such as lower abdominal pain and dysmenorrhea, infertility, dyspareunia …

Hormone therapy for sexual function in perimenopausal and postmenopausal women.

BACKGROUND: The perimenopausal and postmenopausal periods are associated with many symptoms, including sexual complaints. This review is an … ausal symptoms (symptoms such as hot flushes, night sweats, sleep disturbance, vaginal atrophy, and dyspareunia) or early postmenopausal women (within five years after menopause). The 'unselected postmenopausal women' subgroup included 26 studies, which included women regardless of menopausal symptoms and women whose last menstrual period was more than five y …

The Impact of Histone Modifications in Endometriosis Highlights New Therapeutic Opportunities.

Endometriosis is a chronic disorder of the female reproductive system which afflicts a great number of women worldwide. Histone deacetylases (HDACs) prevent the relaxation of chromatin, thereby positively or negatively modulating gene transcription. The current review aims at studying the impact of histone modifications and their therapeutic targeting in endometriosis. In order to identify relevant studies, a literature review was conducted using the MEDLINE and LIVIVO databases. The current manuscript represents the most comprehensive, up-to-date review of the literature focusing on the parti

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… More accurately, even though affected individuals may remain asymptomatic, patients suffering from endometriosis usually claim chronic pelvic pain, which deteriorates before the onset of menstruation, infertility, vaginal bleeding or dyspareunia [ 3 ]. …

Mesh, graft, or standard repair for women having primary transvaginal anterior or posterior compartment prolapse surgery: two parallel-group, multicentre, randomised, controlled trials (PROSPECT).

BACKGROUND: The use of transvaginal mesh and biological graft material in prolapse surgery is controversial and has led to a number of enqui … erence 0·10, -0·33 to 0·52; p=0·66. Serious adverse events such as infection, urinary retention, or dyspareunia or other pain, excluding mesh complications, occurred with similar frequency in the groups over 1 year (mesh trial: 31/430 [7%] with standard repair vs 34/435 [8%] with mesh, risk ratio [RR] 1·08, 95% CI 0·68 to 1·72; p=0·73; graft trial: 23/367 [6% …

Mutation profile and chromosomal abnormality in adenomyosis.

In briefBy tissue-selective next-generation sequencing, we showed that adenomyotic epithelium harbored genomic alterations thought to be relevant to the development and progression of adenomyosis, including somatic mutations in several cancer-associated genes with high mutant allele frequencies and the gain of chromosome 1q. Clonal relationships among multiple adenomyotic lesions and the normal uterine endometrium delineate the oligoclonal origin of adenomyosis and the spatial expansion of mutant clones.AbstractTo identify the distinctive features of mutation profiles in adenomyosis compared t

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… This disease severely diminishes the quality of life by causing heavy menstrual bleeding, dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility ( Razavi et al. 2019 , Kho et al. 2021 ). …

Surgical interventions for the management of chronic pelvic pain in women.

BACKGROUND: Chronic pelvic pain (CPP) is a common gynaecological condition accounting for 20% of all gynaecological referrals. There are wid … dy of 56 participants found no difference in the effect of LUNA on non-cyclical pain (P = 0.854) or dyspareunia (P = 0.41); however, there was a difference favouring LUNA on dysmenorrhea (P = 0.045) and dyschezia (P = 0.05). We are also uncertain of the effect of LUNA compared to vaginal uterosacral ligament resection on pelvic pain at 12 months (MD 2.00, 95% …

Symptom Clusters and Symptom Burden in Cancer Survivors.

ContextLimited information is available on the symptom burden and symptom clusters in cancer survivors.ObjectivesDescribe the occurrence, severity, and distress of 44 symptoms; determine risk factors associated with a higher symptom burden; and evaluate for symptom clusters using symptom occurrence rates.MethodsSurvivors (n = 1147) were recruited using an online survey. Symptom burden and symptom clusters were assessed using the Memorial Symptom Assessment Scale that included 44 symptoms and evaluated occurrence, severity, and distress. Simultaneous multivariable linear regression analysis was

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… The most common sexual problems in female cancer survivors include vaginal dryness, vaginal stenosis, dyspareunia, decreased libido, and difficulty reaching orgasm [ 57 , 58 ]. …

Use of endoanal ultrasound for reducing the risk of complications related to anal sphincter injury after vaginal birth.

BACKGROUND: During childbirth, many women sustain trauma to the perineum, which is the area between the vaginal opening and the anus. These … ife. The study did not report any data on the need for secondary repair of external anal sphincter, dyspareunia, women's satisfaction with care or the planned or actual mode of birth in any subsequent pregnancy. We were unable to assess the detection rates of OASIS with EAUS from the included study because women with clinically-detected OASIS were excluded fr …

Sexual health in patients with malignant hematological disease: a Danish cross-sectional study.

BackgroundPatients who undergo treatment for hematologic malignancies may experience a decline in sexual health, alterations in sexual functioning, and reproductive capacity during survivorship.AimThis study investigated the prevalence of sexual dysfunction and factors influencing sexual activity and functioning in patients with hematologic malignancies, to identify potential targets for interventions in clinical practice.MethodsThis nationwide cross-sectional study included adult patients diagnosed with a hematologic malignant disease in Denmark in the period from January 20, 2013, to August

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… such as body image, identity, sexual quality of life (QOL), and distress, all of which pose a threat to overall sexual well-being. 5 , 6 Sexual dysfunction is prevalent in cancer patients and can result in diminished sexual desire and arousal, and difficulty achieving orgasm. 7 In women, it comprises dyspareunia …

Surgical management of pelvic organ prolapse in women.

BACKGROUND: Pelvic organ prolapse may occur in up to 50% of parous women. A variety of urinary, bowel and sexual symptoms may be associated … after the anterior polypropylene mesh repair and no differences in quality of life data or de novo dyspareunia were identified. Blood loss (MD 64 ml, 95% CI 48 to 81), operating time (MD 19 min, 95% CI 16 to 21), recurrences in apical or posterior compartment (RR 1.9, 95% CI 1.0 to 3.4) and de novo stress urinary incontinence (RR 1.8, 95% CI 1.0 to 3.1) were …

Linzagolix therapy versus a placebo in patients with endometriosis-associated pain: a prospective, randomized, double-blind, Phase 3 study (EDELWEISS 3).

STUDY QUESTION: Does linzagolix administered orally once daily for up to 3 months at a dose of 75 mg alone or 200 mg in combination with add … pelvic pain were observed in both linzagolix groups when compared to placebo. Small improvements in dyspareunia scores were observed in both linzagolix groups but they were not significant. In both groups, hypoestrogenic effects were mild, with low rates of hot flushes and bone density loss of <1%. A daily dose of 200 mg linzagolix with ABT or 75 mg linzagoli …

Pre- and postsurgical medical therapy for endometriosis surgery.

BACKGROUND: Endometriosis is a common gynaecological condition affecting 10% to 15% of reproductive-age women and may cause dyspareunia, dysmenorrhoea, and infertility. One treatment strategy is combining surgery and medical therapy to reduce the recurrence of endometriosis. Though the combination of surgery and medical therapy appears to be beneficial, there is a lack of clarity about the appropriate timing of when medical therapy should be used in relation with surgery, that is, before, after, or both before and after surgery, to maximize treatment response. OBJECTIVES: To determine the eff…