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Свет в диагностике, терапии и хирургии.

Легкие и оптические методы оказывают глубокое воздействие на современную медицину, и в настоящее время в клинической практике используются многочисленные лазеры и оптические устройства для оценки состояния здоровья и лечения заболеваний. Последние достижения в области биомедицинской оптики позволили использовать все более сложные технологии, в частности технологии, которые объединяют фотонику с нанотехнологией, биоматериалами и генной инженерией. В настоящем Обзоре мы вновь обращаемся к основам взаимодействия легкой материи, описываем применение света в визуализации, диагностике, терапии и хир

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… Endovenous laser treatment is effective for treating lower-extremity venous insufficiency such as great saphenous vein reflux 29 . … vein reflux: long-term results J Vasc Interv Radiol 14 991 996 2003 12902556 10.1097/01.rvi.0000082864.05622.e4 30 Proebstle TM Moehler T Herdemann S Reduced recanalization rates of the great saphenous vein after endovenous laser treatment with increased energy dosing: Definition of a threshold for …

СРП 2013

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Re-Cellularised Kidney Scaffold for Chikungunya Virus Propagation: A Novel Approach.

BACKGROUND: Re-emerging viral attacks are catastrophic for health and economy. It is crucial to grasp the viral life cycle, replication and mutation policies and attack strategies. It is also absolute to fathom the cost-efficient antiviral remedies earliest possible. METHODS: We propose to use a lab-grown organ (re-cellularized scaffold of sheep kidney) for viral culture and understand its interaction with extra-cellular matrices of the host tissue. RESULTS: Our findings showed that the chikungunya virus (CHIKV) could be better replicated in tissue-engineered bio models than cell culture. A

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… Walawalkar S Verma MK Almelkar S Re-endothelization of human saphenous vein scaffold surfaces for bioprosthesis fabrication J Biomater Appl 2020 34 1081 1091 10.1177/0885328219898349 31910724 23. …

Vascular Access Devices for Stem Cell Transplantation: A Review of Catheter Types-A Crucial Step Towards the Enhancement of Patient Care.

Central venous access devices (CVADs) play a pivotal role in managing stem cell recipients, providing reliable access for the administration of chemotherapy, blood products, progenitor infusion, parenteral nutrition, and other crucial treatments. This review critically evaluates the various types of CVADs commonly employed in transplant settings, examining their indications, complications, and best practices to enhance patient outcomes. Moreover, it emphasizes the significance of broadening the selection algorithm for vascular devices and incorporating patient expectations and comfort into rou

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… FICCs (Femorally inserted central catheters)—inserted into veins of the lower limb (common femoral vein, superficial femoral vein, saphenous vein). TIVAD Totally implantable venous access device (or port). Chest ports, also known as CICC ports. Femoral ports, also known as FICC port. …

Hematology

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… Extension to deep vein system rarely occurs through perforating veins and is most likely when the proximal greater saphenous vein or saphenous–femoral junction is involved Notes Approach to Anticoagulation Therapies Class/Drugs Mechanism Indications Usual dose Complications/ monitoring Warfarin Inhibition …

Профилактика и лечение венозного тромбоэмболия у пациентов с множественной миеломой: руководящие принципы клинической практики от имени Европейской сети миеломы.

Венозный тромбоэмболизм (VTE) является частым осложнением у пациентов с множественной миеломой (MM), что приводит к повышению заболеваемости, смертности, прерыванию лечения и снижению качества жизни. Основные рекомендации включают следующее: Информирование пациентов о риске ВТЕ и признаках/симптомах тромбоза глубокой вены и легочной эмболии. Специализированная помощь. - создание специализированного диагностического и лечебного механизма для профилактики и лечения ВТЕ в амбулаторных условиях. Оценка рисков. Регулярная оценка риска VTE с использованием подтвержденных оценок. Первичная тромбопроф

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… Superficial vein thrombosis (SVT) of the long saphenous vein within 3 cm of the saphenofemoral junction (SFJ) is considered equivalent to a DVT. …

MSC-EV therapy for bone/cartilage diseases.

Mesenchymal stromal cells (MSCs) have been utilized in cell therapy for various diseases. Recent studies have demonstrated that extracellular vesicles (EVs) released by MSCs play an important role in their therapeutic activities. EVs contain a variety of bioactive molecules such as proteins, messenger RNAs (mRNAs), and micro RNAs (miRNAs) and modify the function of the recipient cells by transferring these molecules. Despite the promising potential of EV therapy as a substitute for MSC therapy, there are challenges that need to be addressed for the clinical success of EV therapy. EV quality ha

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… Sadat-Ali et al., 2021 Autologous BMSCs Autologous BMSCs derived osteoblasts Autologous BMSCs derived osteoblasts-EVs N/A N/A Rabbits Ovariectomy Injected in the saphenous vein HR-pQCT: Osteoblast treatment showed the highest bone mass Yang et al., 2020 Human UC-MSC a-MEM + 10 % exosome-free-FBS + 100 … Sadat-Ali et al., 2021 | Autologous BMSCs Autologous BMSCs derived osteoblasts Autologous BMSCs derived osteoblasts-EVs | N/A | N/A | Rabbits Ovariectomy | Injected in the saphenous vein | HR-pQCT: Osteoblast treatment showed the highest bone mass Yang et al., 2020 | Human UC-MSC | a-MEM + 10 % exosome-free-FBS …

Current approach to the diagnosis and treatment of femoral-popliteal arterial disease. A systematic review.

Peripheral arterial disease (PAD) is a common manifestation of atherosclerosis affecting 5 million adults in the United States, with an age-adjusted prevalence of 4% to 15% and increasing up to 30% with age and the presence of cardiovascular risk factors. In this article we focus on lower extremity PAD and specifically on the superficial femoral and proximal popliteal artery (SFPA), which are the most common anatomic locations of lower extremity atherosclerosis. We summarize current evidence and perform a systematic review on the diagnostic evaluation as well as the medical, endovascular and s

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… A comparative evaluation of polytetrafluoroethylene, umbilical vein, and saphenous vein bypass grafts for femoral-popliteal above-knee revascularization: a prospective randomized Department of Veterans Affairs cooperative study. J Vasc Surg. 2000;32:268–77. doi: 10.1067/mva.2000.106944. 130. …

Emergency Care

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… In cats and small dogs, however, a long catheter placed in the lateral or medial saphenous vein can be used for trends in CVP monitoring. …

Health Risks from Microplastics in Intravenous Infusions: Evidence from Italy, Spain, and Ecuador.

The rising incidence of microplastics (MPs) is a possible health risk to humans. The present study aims to analyze the presence of MPs in intravenous (IV) infusions and compare MP concentrations from multiple brands. The IV solutions of 29 medical devices (IV-MDs) from seven brands commercialized in Ecuador, Spain, and Italy have been selected under specific consideration to carry out the study. The detection of MPs has been quite obvious in almost all of the samples from brands in the mentioned countries. MP concentrations ranged from 9 to 20 MPs/L in glass containers to 166-299 MPs/L in plas

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… Detection of microplastics in human saphenous vein tissue using μFTIR: A pilot study. PLoS ONE. 2023;18:e0280594. doi: 10.1371/journal.pone.0280594. 13. Yang Y., Xie E., Du Z., Peng Z., Han Z., Li L., Yang X. Detection of various microplastics in patients undergoing cardiac surgery. Environ. Sci. …

Acupuncture in the treatment of chemotherapy-induced peripheral neuropathy: a meta-analysis and data mining.

BackgroundThe efficacy and acupoint selection of acupuncture in treating chemotherapy-induced peripheral neuropathy (CIPN) remain controversial. This study aims to explore the specific efficacy and acupoint selection of acupuncture in treating CIPN through a meta-analysis and data mining.MethodsSearching for clinical trials on acupuncture treatment for CIPN in 8 databases, evaluating its efficacy and safety through a meta-analysis, and exploring its acupoint selection through data mining.ResultsThe meta-analysis included 21 studies and 2,121 patients, showing that compared with the control gro

Резюме ESPR 2013Европейское общество педиатрической радиологии 50th Ежегодное совещание и 36th Курсы для аспирантов. Июнь 3–7 2013. Будапешт, Венгрия.

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Coronary atherosclerosis and chemotherapy: From bench to bedside.

Cardiovascular disease, particularly coronary artery disease, is the leading cause of death in humans worldwide. Coronary heart disease caused by chemotherapy affects the prognosis and survival of patients with tumors. The most effective chemotherapeutic drugs for cancer include proteasome inhibitors, tyrosine kinase inhibitors, immune checkpoint inhibitors, 5-fluorouracil, and anthracyclines. Animal models and clinical trials have consistently shown that chemotherapy is closely associated with coronary events and can cause serious adverse cardiovascular events. Adverse cardiovascular events a

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… In vivo human lower extremity saphenous vein bypass grafts manifest flow mediated vasodilation. J Vasc Surg. (2009) 50:1063–70. 10.1016/j.jvs.2009.06.022 17. Minhas A, Goerlich E, Corretti M, Arbab-Zadeh A, Kelle S, Leucker T, et al. …

Миграционный арест и трансэндотелиальная торговля патогенными клетками, подобными ТH17, осуществляются с помощью дифференцированных хемокинов.

Человеческие TH17/тип 17 клетки выражают хемокиновый рецептор CCR6, но функции CCR6 и других химокиновых рецепторов в экстравазации клеток типа 17 Т не были полностью определены. Здесь мы показываем, что периферийные клетки крови человека CD4+CCR6+T, которые одновременно выражают CCR2, имеют патогенную сигнатуру TH17, могут производить подстрекательские цитокины без активации Т клеточного рецептора, и демонстрируют более широкое выражение генов, связанных с патогенностью и активацией, в цереброспинной жидкости пациентов с множественным склерозом по сравнению с контролем. В газовых камерах с ак

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… Nonetheless, other investigators have also described poor/undetectable binding of CCL2 to ECs 36 , 67 – 69 , including to HUVECs, HDMECs, or human ECs from saphenous vein, lung, or brain 69 . …

Вирусная инфекция Эпштейна-Барра поощряет диагностику Т клеток в гуманизированной модели мыши множественного склероза.

Скрытая инфекция вируса Эпштейн-Барр (ЭБВ) является серьезным фактором риска для развития множественных склерозов (МС), хотя основополагающие механизмы остаются неясными. Для изучения этой связи мы спровоцировали экспериментальный аутоиммунный энцефаломиелит (EAE) в мышах с иммунодефицитными мышами, восстановленных с периферийными моноядерными клетками крови (PBMC) у лиц, которые имели или не имели историю заражения EBV и/или повторного образования MS (RMS). Мыши HuPBMC EAE, генерируемые EBV-серонегативными здоровыми донорами, были менее восприимчивы к возникновению серьезных неврологических с

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… Following a 3-week reconstitution period, circulating human CD45 + cell repopulation was confirmed by saphenous vein blood sampling and flow cytometric analysis. …

A novel approach to enhance glioblastoma multiforme treatment efficacy: non-coding RNA targeted therapy and adjuvant approaches.

BackgroundGlioblastoma multiforme (GBM) is a lethal brain tumor. With the current gold standard chemotherapy treatment, temozolomide (TMZ), many patients do not survive beyond one year. While the urgency of researching novel treatments is understandable, the prohibitively high costs and the prolonged duration of research and clinical trials significantly delay the availability of medical advancements to the general public. This highlights the urgent need for adjuvant therapies to enhance treatment effectiveness.Main bodyRecent research has suggested the potential of repurposing FDA-approved dr

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… Initially calculating from Alzheimer's Disease Dataset (Salomon ( GSE5281 ) [ 57 ], Cotman ( GSE48350 ) [ 58 ], GTEx [ 59 ] and ICGC GBM-US [ 60 ]), GBM stem cell models, G7 and G26, the lncRNA TP73-AS1(Bgee database: expressed most in ovary, uterus and saphenous vein) is responsible to TMZ resistance …

Resveratrol and Cardiovascular Diseases.

The increased incidence of cardiovascular diseases (CVDs) has stimulated research for substances that could improve cardiovascular health. Among them, resveratrol (RES), a polyphenolic compound notably present in grapes and red wine, has been involved in the "French paradox". RES is known for its antioxidant and anti-inflammatory properties and for its ability to upregulate endothelial NO synthase (eNOS). RES was able to scavenge (•)OH/O₂(•-) and peroxyl radicals, which can limit the lipid peroxidation processes. Moreover, in bovine aortic endothelial cells (BAEC) under glucose-induced oxidati

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… Effects of resveratrol on vascular tone and endothelial function of human saphenous vein and internal mammary artery Int. J. Cardiol. 2005 105 209 215 10.1016/j.ijcard.2005.01.013 16243115 129. Amadio P. Baldassarre D. Tarantino E. Zacchi E. Gianellini S. Squellerio I. Amato M. Weksler B.B. …

Lymph node metastasis in cancer progression: molecular mechanisms, clinical significance and therapeutic interventions.

Lymph nodes (LNs) are important hubs for metastatic cell arrest and growth, immune modulation, and secondary dissemination to distant sites through a series of mechanisms, and it has been proved that lymph node metastasis (LNM) is an essential prognostic indicator in many different types of cancer. Therefore, it is important for oncologists to understand the mechanisms of tumor cells to metastasize to LNs, as well as how LNM affects the prognosis and therapy of patients with cancer in order to provide patients with accurate disease assessment and effective treatment strategies. In recent years

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… The superficial inguinal LNs are classified into a central group and four quadrants separated by the great saphenous vein and a horizontal line at the saphenofemoral junction. Deep inguinal nodes are situated proximal to the femoral artery and vein. …

SUBJECT INDEX Volume 125 (JANUARY–JUNE, 2004)

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Current and future applications of ultrasound imaging in peripheral nerve disorders.

Neuromuscular ultrasound (NMUS) is a rapidly evolving technique used in neuromuscular medicine to provide complimentary information to standard electrodiagnostic studies. NMUS provides a dynamic, real time assessment of anatomy which can alter both diagnostic and management pathways in peripheral nerve disorders. This review describes the current and future techniques used in NMUS and details the applications and developments in the diagnosis and monitoring of compressive, hereditary, immune-mediated and axonal peripheral nerve disorders, and motor neuron diseases. Technological advances have

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… In addition, pre-operative identification of nerve position and anatomical variants with NMUS can prevent iatrogenic transection, as can occur in the sural nerve, for example, during small saphenous vein stripping, and can guide further management including transposition and neurolysis[ 261 ]. …