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Building a comprehensive cancer survivorship program.

There is a significant increase in the number of people surviving cancer as a result of improved detection and better treatments. In the United States (US) alone, these numbers are estimated to reach 20 million by 2026 [Miller et al (2016) CA Cancer J Clin 66(4) 271-289)]; [Bluethmann et al (2016) Cancer Epidemiol Biomarkers Prev 25(7) 1029-1036]. Living through cancer treatment represents a life-changing event, often including residual and long-term emotional, physical, psychological and spiritual sequelae. Survivorship programming must encompass the clinical management of medical issues, loc

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… Mayo clinic survivorship program | https://www.mayoclinic.org/departments-centres/oncology/cancer-survivorship-clinics/overview | Mayo Clinic, based in Minnesota, US has a well-established survivorship program, which is presented on their easy to navigate website. …

Оценка и лечение мужской сексуальной дисфункции в болезни Паркинсона: клиническая дорожная карта.

Болезнь Паркинсона (PD) является прогрессивным нейродегенеративным заболеванием с множественными проявлениями, включая как моторные, так и немоторные симптомы. Одним из проявлений PD, который часто игнорируется, является сексуальная дисфункция (SD), которую могут испытывать пациенты. У лиц с ОВП могут быть дефекты сексуального желания, возбуждения или смазки, оргазма, эякуляции, боли и физических аспектов близости. Цель этой статьи состоит в том, чтобы дать общее представление о нынешней практике оценки и лечения сексуальной дисфункции у мужчин в контексте ПР. Следует отметить, что в этой стат

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… One study conducted on 3090 individuals with PD using the Minnesota Impulse Disorders Interview found that 3.5% of patients using a dopamine agonist have reported compulsive sexual behavior. 87 Please refer to the more recent study on EOPD ( https://pubmed.ncbi.nlm.nih.gov/38841693/ ). …

Bilateral Pathological Femoral Fractures Secondary to Long-Term Tenofovir Disoproxil Fumarate-Induced Osteomalacia in a Woman Living with HIV: A Case Report.

BACKGROUND: People living with HIV on long-term antiretroviral therapy (ART) face increased risks of bone loss and fragility fractures, partly due to tenofovir disoproxil fumarate (TDF), a commonly used nucleoside reverse transcriptase inhibitor. TDF is associated with proximal tubular dysfunction, renal phosphate wasting, osteomalacia, and pathological fractures. This case highlights severe, bilateral femoral fractures as a rare but debilitating manifestation of chronic TDF-induced osteomalacia in a postmenopausal woman. CASE PRESENTATION: A 43-year-old African woman with HIV (diagnosed >15

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… Data safety/advisory board participation for UK Meningitis Research Foundation, US National Institute for Allergy and Infectious Diseases; leadership or fiduciary roles for Advanced HIV Technical working group, Ministry of Health, Uganda, MARA Rural Health Consortium, Uganda, Meningitis Foundation, Minnesota …

An Observational Analysis of a Large Cohort of Pneumocystis jirovecii Pneumonia.

BACKGROUND: Pneumocystis jirovecii pneumonia (PCP) is increasingly seen in patients who are non-HIV immunocompromised hosts, yet modern risk factors and outcomes are poorly recognized and defined. METHODS: A retrospective review was conducted of adult patients who met criteria for proven or probable PCP from 2017 to 2024 across a large academic multicenter health system. The primary outcome was mortality among cohorts, defined by etiology of immunosuppression through univariate and age-adjusted logistic regression. Secondary analyses included trends in annual diagnoses and testing patterns.

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… Andrew H Limper, Division of Pulmonary and Critical Care, Mayo Clinic, Rochester, Minnesota, USA. Ayan Sen, Department of Critical Care, Mayo Clinic, Phoenix, Arizona, USA. Augustine S Lee, Department of Allergy and Pulmonary Medicine, Mayo Clinic, Jacksonville, Florida, USA. …

Outcomes of Patients with Newly Diagnosed Transplant-Ineligible Multiple Myeloma According to Clinical Trials Enrollment: Experience of a Single Institution.

The proportion of non-transplant-eligible (NTE) newly diagnosed multiple myeloma (NDMM) patients excluded from clinical trials (CTs) and their prognosis is unknown. CT results may not be generalizable to real-world practice due to strict recruitment criteria. We analyzed causes of NTE-NDMM patient exclusion form CTs and their outcomes. A total of 211 NTE-NDMM patients were included. They were divided into three periods: 2003-2007, 2008-2012, and 2013-2017. Overall, 50% received non-trial treatment (NCT), while 50% participated in a CT (20% control group (CG) and 30% experimental group (EG)). M

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… Incidence of multiple myeloma in Olmsted County, Minnesota: Trend over 6 decades Cancer 2004 101 2667 2674 10.1002/cncr.20652 15481060 3. Rodríguez-Lobato L.G. Pereira A. de Larrea C.F. Cibeira M.T. Tovar N. Jiménez-Segura R. Moreno D.F. Oliver-Caldés A. Rosiñol L. Bladé J. …

Rural and Urban Differences in Vegetable and Fruit Consumption Among Older Cancer Survivors in the Deep South: An Exploratory Cross-Sectional Study.

BackgroundCancer survivors, especially those who are older, experience increased comorbidity and risk for secondary cancers. A varied dietary pattern rich in vegetables and fruits (V&F) is recommended to improve health. However, V&F intake can differ by rural vs urban status.ObjectiveOur objective was to assess the differences in V&F consumption among older cancer survivors residing in urban- and rural-designated areas, and to explore whether differences exist according to sex, race, and cancer type.DesignThis was a cross-sectional secondary analysis.Participants/settingScreening data from the

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… Rural food deserts: Low-income perspectives on food access in Minnesota and Iowa . J Nutr Educ Behav . 2009 ; 41 ( 3 ): 176 – 187 . 19411051 10.1016/j.jneb.2008.06.008 47. Walker RE , Keane CR , Burke JG . …

Insights from Social Media on the Patient Experience of Living With Rare Eosinophil-Driven Diseases.

Eosinophilic granulomatosis with polyangiitis (EGPA) and hypereosinophilic syndrome (HES) are driven by persistently high eosinophil numbers, causing damage to tissues and organs. As rare diseases, they are often underappreciated by healthcare professionals. Using a social listening analysis, we collected patient and caregiver comments relating to EGPA and HES made on online social platforms between 1 January 2019 and 31 May 2020, in English, French, and German. Results were classified into key areas of interest. In total, 746 comments with consent to publish were collected mentioning EGPA, an

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… The epidemiology of antineutrophil cytoplasmic autoantibody-associated vasculitis in Olmsted County, Minnesota: a twenty-year US population-based study. Arthritis Rheumatol. 2017;69(12):2338-50. doi: 10.1002/art.40313 8. Ormerod AS, Cook MC. …

Epidemiology of osteoporotic fracture in Kazakhstan and development of a country specific FRAX model.

UNLABELLED: Retrospective and prospective population-based survey in a region of the Republic of Kazakhstan determined the incidence of fractures at the hip, proximal humerus and distal forearm. The hip fracture rates were used to create a FRAX® model to enhance fracture risk assessment in Kazakhstan. OBJECTIVE: This paper describes the epidemiology of osteoporotic fractures in the Republic of Kazakhstan that was used to develop a country specific FRAX® tool for fracture prediction. METHODS: We carried out a retrospective population-based survey in Taldykorgan in the Republic of Kazakhstan r

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… Fracture incidence in Olmsted County, Minnesota: comparison of urban and with rural rates and changes in urban rates over time. Osteoporos Int. 1999;9:29–37. doi: 10.1007/s001980050113. 33. Singer BR, McLauchlan CJ, Robinson CM, Christie J. Epidemiology of fracture in 15.000 adults. …

The burden of amyloid light chain amyloidosis on health-related quality of life.

BackgroundLight chain (AL) amyloidosis is a rare disease characterized by misfolded amyloid protein deposits in tissues and vital organs, and little is known about the burden of AL amyloidosis on health-related quality of life. This study aimed to quantify the burden of AL amyloidosis in terms of health-related quality of life in a diverse, community-based sample of AL amyloidosis patients.ResultsThe SF-36v2® Health Survey (SF-36v2), a widely used generic measure of health-related quality of life (using physical and mental summary scales and subscales assessing eight aspects of functioning and

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… Incidence and natural history of primary systemic amyloidosis in Olmsted County, Minnesota, 1950 through 1989. Blood. 1992;79:1817–22. 4. Pinney JH, Smith CJ, Taube JB, Lachmann HJ, Venner CP, Gibbs SD, et al. Systemic amyloidosis in England: an epidemiological study. …

Cardiac amyloidosis responding to bortezomib: case report and review of literature.

We report a case of a 53-year old patient with symptoms of congestive heart failure in whom a restrictive cardiomyopathy and a kappa-chain monoclonal gammopahty were diagnosed. Treatment with eight cycles of Bortezomib, a proteasome inhibitor, resulted in a significant regression of myocardial amyloid deposition and a notable clinical and hemodynamic improvement. Over the last few years, the management of cardiac amyloidosis has taken advantage of many of the advances of the chemotherapeutic regimens, as well as the wider availability of stem cell transplantation. The management of cardiac amy

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… Incidence and natural history of primary systemic amyloidosis in Olmsted County, Minnesota, 1950 through 1989. Blood. 1992;79:1817–22. 8. Gertz MA, Lacy MQ, Dispenzieri A. Amyloidosis. Hematol Oncol Clin North Am. 1999;13:1211–33. doi: 10.1016/s0889-8588(05)70122-2. 9. Shah KB, Inoue Y, Mehra MR. …

Vertebroplasty and kyphoplasty: a comparative review of efficacy and adverse events.

Vertebroplasty and kyphoplasty have become common surgical techniques for the treatment of vertebral compression fractures. Vertebroplasty involves the percutaneous injection of bone cement into the cancellous bone of a vertebral body with the goals of pain alleviation and preventing further loss of vertebral body height. Kyphoplasty utilizes an inflatable balloon to create a cavity for the cement with the additional potential goals of restoring height and reducing kyphosis. Vertebroplasty and kyphoplasty are effective treatment options for the reduction of pain associated with vertebral body

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… Incidence of clinically diagnosed vertebral fractures: a population-based study in Rochester, Minnesota, 1985–1989. J Bone Miner Res. 1992;7:221–7. doi: 10.1002/jbmr.5650070214. 11. Silverman SL. The clinical consequences of vertebral compression fracture. …

Recent clinical researches and technological development in TIL therapy.

Tumor-infiltrating lymphocyte (TIL) therapy represents a groundbreaking advancement in the solid cancer treatment, offering new hope to patients and their families with high response rates and long overall survival. TIL therapy involves extracting immune cells from a patient's tumor tissue, expanding them ex vivo, and infusing them back into the patient to target and eliminate cancer cells. This revolutionary approach harnesses the power of the immune system to combat cancers, ushering in a new era of T cell-based therapies along with CAR-T and TCR-therapies. In this comprehensive review, we a

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… |Masonic Cancer Center, University of Minnesota | USA | Phase 1|Phase 2 NCT03108495 | Cervical carcinoma | LN-145 | Iovance Biotherapeutics, Inc | USA | Phase 2 NCT03645928 | Metastatic melanoma, squamous cell carcinoma of the head and neck, non-small cell lung cancer | LN-144 (lifileucel)/LN-145 in … Intima Bioscience, Inc. ( https://www.intimabioscience.com ) is currently conducting a clinical trial initially at the University of Minnesota Masonic Cancer Center for patients with metastatic gastrointestinal epithelial cancer administering TIL which CISH has been inhibited using CRISPR ( NCT04426669 …

2026 Приложение к резюме Международного конгресса

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Beyond αβ T cells: NK, iNKT, and γδT cell biology in leukemic patients and potential for off-the-shelf adoptive cell therapies for AML.

Acute myeloid leukemia (AML) remains an elusive disease to treat, let alone cure, even after highly intensive therapies such as stem cell transplants. Adoptive cell therapeutic strategies based on conventional alpha beta (αβ)T cells are an active area of research in myeloid neoplasms given their remarkable success in other hematologic malignancies, particularly B-cell-derived acute lymphoid leukemia, myeloma, and lymphomas. Several limitations have hindered clinical application of adoptive cell therapies in AML including lack of leukemia-specific antigens, on-target-off-leukemic toxicity, immu

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… . | AML | Masonic Cancer Center, University of Minnesota | II | May-17 | December-19 | PMID: 34797911 NCT02763475 | NK Cells as Consolidation Therapy of Acute Myeloid Leukemia in Children/Adolescents | COMPLETED | Anti-relapse prophylactic activity of inoculating Natural Killer (NK) cells as consolidation … The primary objective is to study the potential efficacy of NK cells and IL-15 to achieve complete remission while maintaining safety. | AML | Masonic Cancer Center, University of Minnesota | II | October-15 | December-16 | PMID: 31266741 NCT01370213 | NK Cell Based Non-Myeloablative Transplantation …

Clinical characteristics and outcome of 318 families with familial monoclonal gammopathy: A multicenter Intergroupe Francophone du Myélome study.

Familial forms of monoclonal gammopathy, defined as multiple myeloma (MM) or Monoclonal Gammopathy of Undetermined Significance (MGUS), are relatively infrequent and most series reported in the literature describe a limited number of families. MM rarely occurs in a familial context. MGUS is observed much more commonly, which can in some cases evolve toward full-blown MM. Although recurrent cytogenetic abnormalities have been described in tumor cells of sporadic cases of MM, the pathogenesis of familial MM remains largely unexplained. In order to identify genetic factors predisposing to familia

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… Incidence of multiple myeloma in Olmsted County, Minnesota: trend over 6 decades. Cancer. 2004;101(11):2667‐2674. 2. Dumontet C, Couray‐Targe S, Teisseire M, Karlin L, Maucort‐Boulch D. Real life management of patients hospitalized with multiple myeloma in France. …

Расширенный полиглутамин в ATAXIN1 приводит к потере функции, которая усугубляет остроту множественного склероза в модели мыши EAE.

Ataxin-1 (ATXN1) — белок, в котором расширение его полиглутаминового тракта вызывает нервно-дегенеративное расстройство спинномозговой системы 1 (SCA1) в результате повышения функциональности. Недавно было продемонстрировано, что АТXN1 дикая порода играет защитную роль в регулировании жесткости экспериментального аутоиммунного энцефаломиелита (EAE) — хорошо зарекомендовавшей себя модели мыши для мультиклероза (MS). В этом исследовании дополнительно изучается роль ATXN1 с расширенным полиглутаминым трактом в контексте MS с использованием модели мыши EAE.МЕТОДЫ: Гемизигиозные мыши Atxn1 (Atxn12Q

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… The University of Minnesota Institutional Animal Care and Use Committee approved all animal use protocols. …

Оценка Саркопсии у пациентов с моноклональной гаммопатией неизвестного значения.

Предыстория: Мы стремились определить распространенность саркопии у пациентов с моноклонной гаммопатией неопределенного значения (MGUS) и оценить связи между MGS и саркопией. Методы: Eighty-two В исследование были зачислены пациенты с диагнозом MGUS. Прочность мышечника измерялась с помощью динамометра для рукоятки. Физическая эффективность оценивалась на основе оценки скорости похода по сравнению с 6-minute Прохождение теста. Масса мышц определяется с помощью анализатора биоэлектрического импульса. Результаты: Саркопания была подтверждена в 34.15% пациентов. Мужское превосходство было продемо

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… Body mass index associated with monoclonal gammopathy of undetermined significance (MGUS) progression in Olmsted County, Minnesota. Blood Cancer J. 2022;12:67. doi: 10.1038/s41408-022-00659-9. 26. Thompson M.A., Kyle R.A., Melton L.J., Plevak M.F., Rajkumar S.V. …

The core symptom in multiple myeloma patients undergoing chemotherapy: a network analysis.

BACKGROUND: During chemotherapy for multiple myeloma, symptoms include those related to the disease, as well as adverse effects of the treatment. Few studies have explored the relationships between these symptoms. Network analysis could identify the core symptom in the symptom network. OBJECTIVE: The aim of this study was to explore the core symptom in multiple myeloma patients undergoing chemotherapy. METHODS: This was a cross-sectional study in which sequential sampling was used to recruit 177 participants from Hunan, China. Demographic and clinical characteristics were surveyed using a se

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… Minnesota Cancer. 2005;104:442. doi: 10.1002/cncr.21177. 7. Sidhu G, Homsi Y. Severe lytic bone lesions in multiple myeloma. Am J Med Sci. 2019;357:e11–e12. doi: 10.1016/j.amjms.2018.12.006. 8. Mathew A, Farooqui HH, Kumar L. …

Association between Kidney Function, Proteinuria and the Risk of Multiple Myeloma: A Population-Based Retrospective Cohort Study in South Korea.

PURPOSE: While renal impairment is one of the first clinical manifestations of multiple myeloma (MM), declined renal function may conversely be a risk factor for cancers including MM. In this study, we investigated the relationship between chronic kidney disease and MM at a population level. MATERIALS AND METHODS: A total of 9,809,376 adults who participated in a nationwide health screening program and had no MM, cancer or end-stage renal disease at baseline were investigated for incidence of MM. The impact of estimated glomerular filtration rate (eGFR) and random urine dipstick proteinuria,

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… Kyle RA, Therneau TM, Rajkumar SV, Larson DR, Plevak MF, Melton LJ., 3rd Incidence of multiple myeloma in Olmsted County, Minnesota: trend over 6 decades. Cancer. 2004;101:2667–74. doi: 10.1002/cncr.20652. 21. Phekoo KJ, Schey SA, Richards MA, Bevan DH, Bell S, Gillett D, et al. …

Bidirectional Relationship Between Cancer and Heart Failure: Old and New Issues in Cardio-oncology.

The main focus of cardio-oncology has been the prevention and treatment of the cardiac toxicity of chemotherapy and radiotherapy. Furthermore, several targeted therapies have been associated with unexpected cardiotoxic side-effects. Recently, epidemiological studies reported a higher incidence of cancer in patients with heart failure (HF) compared with individuals without HF. On this basis, it has been proposed that HF might represent an oncogenic condition. This hypothesis is supported by preclinical studies demonstrating that hyperactivation of the sympathetic nervous system and renin-angiot

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… Incidence and natural history of primary systemic amyloidosis in Olmsted County, Minnesota, 1950 through 1989. Blood. 1992;79:1817–22. 55. Quarta CC, Solomon SD, Uraizee I et al. Left ventricular structure and function in transthyretin-related versus light-chain cardiac amyloidosis. …