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Acupuncture for Chemotherapy-Induced Peripheral Neuropathy: A Systematic Review and Meta-Analysis with Trial Sequential Analysis.

BACKGROUND: Effective options for managing chemotherapy-induced peripheral neuropathy (CIPN) remain limited. Evidence supporting acupuncture for CIPN continues to accumulate, warranting a comprehensive synthesis to clarify its effects. METHODS: We searched eight databases and extracted study characteristics from the included studies. We assessed risk of bias using the Cochrane RoB 2 tool and graded the certainty of evidence using the GRADE framework. Meta-analyses evaluated CIPN symptoms, clinical effectiveness rate (ER), nerve conduction study (NCS) parameters, and quantitative sensory testi

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… limiting its clinical benefit. 2 Among these toxicities, chemotherapy-induced peripheral neuropathy (CIPN) is one of the most common and challenging, affecting approximately 68% of patients within 1 month of treatment. 3 , 4 CIPN primarily manifests as hypoesthesia, such as numbness in the extremities, or hyperesthesia …

Синдром PEEMS: 2026 Обновленная информация по диагностике, статистике рисков и управлению.

Синдром PEMS — это угрожающий жизни синдром, вызванный плазменной неоплазмой. Основными критериями для этого синдрома являются полиномропатическое расстройство клональных клеток (ПХД), склеротические повреждения костей, повышенный сосудистый эндотелиальный фактор роста и наличие болезни Каслмана. Незначительные особенности включают в себя органомегалию, эндокринопатию, характерные изменения кожи, папилледему, вневаскулярную перегрузку объема и тромбоцитоз. Диагноз синдрома POEMS three основных критериев, two в том числе полиномропаты и клональные плазменные клетки, и по крайней мере one незнач

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… The quality and extent of the neuropathy, which is peripheral, ascending, symmetrical, and affecting both sensation and motor function should be elicited [ 57 ]; in our experience, pain may be a dominant feature in about 10%–15% of patients, though in one report as many as 76% of patients had hyperesthesia …

Feline infectious peritonitis.

The article discusses feline infectious peritonitis (FIP), an important disease frequently seen in veterinary practice. FIP causes many problems to the veterinarian as it can be difficult to definitively diagnose the disease, as there is no effective treatment, and as prophylactic interventions are not very successful. Although intense research has created a lot of new knowledge about this disease in the last years, there are still many unanswered questions. The objective of this article is to review recent knowledge and to increase understanding of the complex pathogenesis of FIP.

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… In addition, incoordination, intention tremors, hyperesthesia, behavioral changes, and cranial nerve defects can be seen [98] , [99] . If cranial nerves are involved, neurologic signs like visual deficits and loss of menace reflex may be present, depending on which cranial nerve is damaged. …

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Chemotherapy-induced peripheral neuropathy in children and adolescent cancer patients.

Brain cancer and leukemia are the most common cancers diagnosed in the pediatric population and are often treated with lifesaving chemotherapy. However, chemotherapy causes severe adverse effects and chemotherapy-induced peripheral neuropathy (CIPN) is a major dose-limiting and debilitating side effect. CIPN can greatly impair quality of life and increases morbidity of pediatric patients with cancer, with the accompanying symptoms frequently remaining underdiagnosed. Little is known about the incidence of CIPN, its impact on the pediatric population, and the underlying pathophysiological mecha

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… orthostatic hypotension | Arzanian et al. (2009) , Anghelescu et al. (2011) , Purser et al. (2014) , Courtemanche et al. (2015b) , Lavoie Smith et al. (2015) , Kerckhove et al. (2017) , Bjornard et al. (2018) Oxaliplatin | Paresthesia and dysesthesia of the hands, feet and perioral region, acute cold hyperesthesia …

Hematopoietic Tumors

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… Dogs with intravascular lymphoma usually have signs related to CNS, peripheral nervous system (PNS), or ocular involvement, 93 , 94 , 95 , 96 , 97 , 98 including paraparesis, ataxia, hyperesthesia, seizures, blindness, lethargy, anorexia, weight loss, diarrhea, polyuria, polydipsia, and intermittent …

Proceedings 27th Symposium ESVN‐ECVN

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Emergency Care

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Integumentary System

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The leptomeninges as a critical organ for normal CNS development and function: First patient and public involved systematic review of arachnoiditis (chronic meningitis).

BACKGROUND & IMPORTANCE: This patient and public-involved systematic review originally focused on arachnoiditis, a supposedly rare "iatrogenic chronic meningitis" causing permanent neurologic damage and intractable pain. We sought to prove disease existence, causation, symptoms, and inform future directions. After 63 terms for the same pathology were found, the study was renamed Diseases of the Leptomeninges (DLMs). We present results that nullify traditional clinical thinking about DLMs, answer study questions, and create a unified path forward. METHODS: The prospective PRISMA protocol is pu

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… papilledema) Bowel and bladder incontinence is an early sign in most patients with lower spine involvement | CN palsy, (facial nerve involved first with NB) | meningismus Approximately 1/3 of patients complain of ambulation difficulty due to weakness or balance dysfunction | HA | Fogginess Sensory numbness, hyperesthesia …

Hematopoietic Tumors

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… Dogs with intravascular lymphoma usually present with signs relative to CNS, PNS, or ocular involvement. 66 , 67 , 68 , 69 , 70 , 71 These include paraparesis, ataxia, hyperesthesia, seizures, blindness, lethargy, anorexia, weight loss, diarrhea, polyuria, polydipsia, and intermittent fever. …

Резюме книги: Тема: 13th Международный симпозиум на тему " Ходжкин лимфома " ; октябрь 2024

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Colorectal Cancer at the Crossroads: The Good, the Bad, and the Future of Platinum-Based Drugs.

Colorectal cancer (CRC) remains a significant global health challenge, ranking third in incidence and second in mortality among cancers worldwide. This review addresses the complex landscape of CRC, focusing on incidence, mortality trends, preventive strategies, and the evolving therapeutic approaches, particularly highlighting the role of platinum-based drugs like oxaliplatin (OXP). It also underscores the increasing burden of CRC, with factors such as westernized diets, aging populations, and genetic predispositions contributing to its prevalence. Therapeutically, early detection greatly enh

Hematopoietic Tumors

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… Dogs with intravascular lymphoma usually present with signs related to CNS, PNS, or ocular involvement, 84 , 85 , 86 , 87 , 88 including paraparesis, ataxia, hyperesthesia, seizures, blindness, lethargy, anorexia, weight loss, diarrhea, polyuria, polydipsia, and intermittent fever. …

The proteasome as a druggable target with multiple therapeutic potentialities: Cutting and non-cutting edges.

Ubiquitin Proteasome System (UPS) is an adaptable and finely tuned system that sustains proteostasis network under a large variety of physiopathological conditions. Its dysregulation is often associated with the onset and progression of human diseases; hence, UPS modulation has emerged as a promising new avenue for the development of treatments of several relevant pathologies, such as cancer and neurodegeneration. The clinical interest in proteasome inhibition has considerably increased after the FDA approval in 2003 of bortezomib for relapsed/refractory multiple myeloma, which is now used in

The International Headache Congress - IHS and EHF joint congress 2021 : Virtual. 8-12 September 2021.

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C

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Ход работы сессии 31st Европейский педиатрический конгресс по педиатрии: часть 2.

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Электронные постеры

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Резюме докладов 38th - ежегодное собрание общества общей внутренней медицины.

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