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Infectious Complications of Cancer Therapy

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… Cutaneous mucormycosis due to Absidia corymbifera occurring after bone marrow transplantation. Bone Marrow Transplant. 1997;19:513–515. doi: 10.1038/sj.bmt.1700667. 196. Fleming R.V., Walsh T.J., Anaissie E.J. Emerging and less common fungal pathogens. …

63rd Annual Conference of the Indian Society of Gastroenterology, ISGCON 2022-January 5th - 8th, 2023 in Jaipur.

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Pulmonary aspergillosis: diagnosis and treatment.

Aspergillus species are the most frequent cause of fungal infections of the lungs with a broad spectrum of clinical presentations including invasive pulmonary aspergillosis (IPA) and chronic pulmonary aspergillosis (CPA). IPA affects immunocompromised populations, which are increasing in number and diversity with the advent of novel anti-cancer therapies. Moreover, IPA has emerged as a complication of severe influenza and coronavirus disease 2019 in apparently immunocompetent hosts. CPA mainly affects patients with pre-existing lung lesions and is recognised increasingly frequently among patie

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… Guidance on imaging for invasive pulmonary aspergillosis and mucormycosis: from the imaging working group for the revision and update of the consensus definitions of fungal disease from the EORTC/MSGERC. Clin Infect Dis 2021; 72: S79–S88. doi: 10.1093/cid/ciaa1855 11. Lamoth F, Alexander BD. …

Post-Transplant Cyclophosphamide and Tacrolimus-Mycophenolate Mofetil Combination Governs GVHD and Immunosuppression Need, Reducing Late Toxicities in Allogeneic Peripheral Blood Hematopoietic Cell Transplantation from HLA-Matched Donors.

Combined direct antineoplastic activity and the long-lasting immunological effects of allogeneic hematopoietic cell transplant (HCT) can cure many hematological malignancies, but broad adoption requires non-relapse mortality (NRM) rates and graft-versus-host disease (GVHD) control. Recently, posttransplant cyclophosphamide (PTCy) given after a bone marrow transplant significantly reduced GVHD-incidence, while PTCy given with tacrolimus/mofetil mycophenolate (T/MMF) showed activity following allogeneic peripheral blood stem cell transplantation (alloPBSCT). Here, we report the experience of a l

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… While no patients died from such infections, two experienced aspergillus pneumonia and one suffered mucormycosis ( Table 2 ). 3.3. …

Respiratory Tract Infections: Sinusitis, Bronchitis, and Pneumonia

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… The increased incidence of pulmonary mucormycosis may be related to changes in antifungal utilization with a shift away from amphotericin B compounds in favor of mold-active triazole drugs like voriconazole [ 102 ]. …

Ocular Manifestations Associated with Hematologic Malignancies: Mechanisms, Diagnosis, and Management.

Background: Hematologic malignancies (HMs), including leukemia and lymphoma, are systemic diseases that may cause a wide range of ocular manifestations. Methods: We searched PubMed/MEDLINE (2015-2026) and identified articles with an emphasis on clinically relevant studies and recent developments. Results: Clinically, ocular involvement presents with diverse manifestations, including retinal hemorrhage, vitreoretinal lymphoma, choroidal infiltration, orbital masses, treatment-related ocular toxicities, graft-versus-host disease, and secondary infectious complications. These findings may mimic o

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… Mucormycosis in a Child with Acute Lymphoblastic Leukemia: Case Report. Arch. Argent. Pediatr. 2025;123:e202410544. doi: 10.5546/aap.2024-10544.eng. 136. Liu C., Li G.H., Guo H.P., Zhou N.C., Liu L. Mixed Phenotype Acute Leukemia with Fungal Endophthalmitis: A Case Report. …

Skin manifestations associated with systemic diseases - Part II.

The skin, by reflecting internal processes, externalizes what happens inside the body in many diseases. Thus, the skin, as an organ, extrapolates its functions of protection, barrier and signals the existence of systemic diseases, expanding the importance of the dermatologist beyond the skin surface. Thus, the dermatologist investigates diagnostic hypotheses for conditions related to all systems and refers patients to the appropriate specialty. Combined with examination by a trained eye, the skin, due to its easy access, is still the ideal place for performing biopsies, which often clarify the

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… Rhinocerebral mucormycosis is a serious disease, with high mortality, and is associated with diabetic ketoacidosis. It is mainly caused by species of the genus Rhizopus , Rhizomucor , and Lichtheimia (formerly called Absidia ), opportunistic and angioinvasive fungi. …

Abstracts

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NAPCON 2025 – Best Original Research Abstracts

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… Methods: We retrospectively reviewed the records of 15 patients with histopathologically confirmed pulmonary mucormycosis at Yashoda Hospitals, Hyderabad from January 2024 to January 2025. … Conclusion: Pulmonary mucormycosis predominantly affects middle-aged diabetic men and often masquerades as other pulmonary diseases. …

Beyond BCMA: newer immune targets in myeloma.

AbstractThe identification and targeting of B-cell maturation antigen (BCMA) through immunotherapeutic strategies such as antibody-drug conjugates, chimeric antigen receptor T cells, and T-cell engagers have revolutionized the care of patients with multiple myeloma (MM). These treatment modalities have improved the survival outcomes of patients with relapsed and/or refractory MM compared with previously established strategies and are moving into earlier lines of therapy. Despite their efficacy, the majority of patients eventually relapse, necessitating additional therapeutic targets for salvag

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… The toxicities observed included grade 2 to 4 CRS and 2 grade 5 events: hemorrhagic pancreatitis in the context of CRS, CAR-related hemophagocytic lymphohistiocytosis, disseminated mucormycosis, and pseudomonal pneumonia in 1 patient and organizing pneumonia during prolonged severe lymphopenia in the …

Are we there yet? CAR-T therapy in multiple myeloma.

The last few years have seen a revolution in cellular immunotherapies for multiple myeloma (MM) with novel antigen targets. The principle new target is B-cell maturation antigen (BCMA). Autologous chimeric antigen receptor T-cell (CAR-T) therapy directed against BCMA was first approved by the US Food and Drug Administration (FDA) and European Medicines Agency (EMA) in 2021, although approval by the National Institute for Health and Care Excellent (NICE) is awaited. Initial response rates in patients with heavily pretreated MM have been impressive, but patients are still relapsing. Furthermore,

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… preclinical models. 112 In preliminary results for MELANI‐01 ( NCT04142619 ), a first‐in‐human phase I dose escalation trial, 2/5 patients responded; however, both subsequently died (one from organising pneumonia and the second from haemorrhagic pancreatitis in the context of grade 4 CRS, HLH, disseminated mucormycosis …

61st Annual Conference of Indian Society of Gastroenterology, Virtual Diamond Jubilee ISGCON 2020, 19-20th December 2020.

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Unlocking Novel Therapeutic Potential of Angiotensin II Receptor Blockers.

Pharmaceutical companies keep producing novel drugs and drug treatments for improving the life of every sick individual, most often following a pattern; a specific drug for a specific condition. Evidence suggests that different medications can have a positive effect on different pathological conditions. The full potential of existing therapies can be revealed through drug repurposing-also referred to as drug repositioning, reprofiling, or re-tasking-which involves identifying new therapeutic uses for approved or investigational drugs beyond their original indications. One significant target in

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… (HER2)-positive breast cancer [ 86 ] | Metastatic breast cancer, gastric cancer, and early breast cancer [ 87 , 88 , 89 ] | Approved | Temsirolimus | Renal cell carcinoma [ 90 ] | Lung Adenocarcinoma [ 91 ] | Investigational Infectious | Apmphotericin B | Antifungal [ 92 ] | Leishmaniasis [ 93 ], Mucormycosis …

Use of short interfering RNA delivered by cationic liposomes to enable efficient down-regulation of PTPN22 gene in human T lymphocytes.

Type 1 diabetes and thyroid disease are T cell-dependent autoimmune endocrinopathies. The standard substitutive administration of the deficient hormones does not halt the autoimmune process; therefore, development of immunotherapies aiming to preserve the residual hormonal cells, is of crucial importance. PTPN22 C1858T mutation encoding for the R620W lymphoid tyrosine phosphatase variant, plays a potential pathophysiological role in autoimmunity. The PTPN22 encoded protein Lyp is a negative regulator of T cell antigen receptor signaling; R620W variant, leading to a gain of function with parado

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… Successful treatment of rhino-orbital mucormycosis by a new combination therapy with liposomal amphotericin B and micafungin. Auris Nasus Larynx 2012; 39: 224–228. doi: 10.1016/j.anl.2011.03.006 36. Joly F, Ray-Coquard I, Fabbro M, Donoghoe M, Boman K, Sugimoto A, et al. …

Chest and Mediastinum

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Всемирный конгресс молекулярного воображения 2022.

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Established and Emerging Concepts to Treat Imbalances of Iron Homeostasis in Inflammatory Diseases.

Inflammation, being a hallmark of many chronic diseases, including cancer, inflammatory bowel disease, rheumatoid arthritis, and chronic kidney disease, negatively affects iron homeostasis, leading to iron retention in macrophages of the mononuclear phagocyte system. Functional iron deficiency is the consequence, leading to anemia of inflammation (AI). Iron deficiency, regardless of anemia, has a detrimental impact on quality of life so that treatment is warranted. Therapeutic strategies include (1) resolution of the underlying disease, (2) iron supplementation, and (3) iron redistribution str

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… The iron chelator deferasirox protects mice from mucormycosis through iron starvation. J. Clin. Investig. 2007;117:2649–2657. doi: 10.1172/JCI32338. 203. …

Oral complications in hematopoietic stem cell recipients: the role of inflammation.

Hematopoietic stem cell transplantation (HSCT) is widely used as a potentially curative treatment for patients with various hematological malignancies, bone marrow failure syndromes, and congenital immune deficiencies. The prevalence of oral complications in both autologous and allogeneic HSCT recipients remains high, despite advances in transplant medicine and in supportive care. Frequently encountered oral complications include mucositis, infections, oral dryness, taste changes, and graft versus host disease in allogeneic HSCT. Oral complications are associated with substantial morbidity and

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… Noncandidal fungal organisms may be also associated with oral infection in immunocompromised cancer patients, including infection by species of Aspergillus , mucormycosis, and Rhizopus [ 165 ]. …

Моноклональные антитела: от волшебной пули до точного оружия.

Моноклональные антитела (mAbs) используются для профилактики, обнаружения и лечения широкого спектра неинфекционных и инфекционных заболеваний. За последние несколько лет рынок МП рос экспоненциально, при этом ожидаемый совокупный годовой прирост (CAGR) составил 11.07% от 2024 (В тыс.237.64 млрд. долл. США на конец 2023) к 2033 (В тыс.679.03 млрд. долл. США к концу 2033). С момента появления технологии гибридомы 1975, терапия на базе антител была реализована с использованием муринных антител, которые стали еще более гуманизированными и полностью человеческими антителами, что уменьшило риск имм

The Potential and Prospects of Marine Drugs in Intervening Nerve-Tumor Crosstalk.

The bidirectional crosstalk between the nervous system and tumors has emerged as a transformative new frontier in both precision oncotherapy and mechanism-driven cancer pain management. Marine natural products with inherent neuroactive properties exhibit unparalleled intervention advantages for targeting this complex pathophysiological axis. Herein, we systematically and prospectively dissect the multi-layered bidirectional communication between the nervous system and malignancies, comprehensively summarize the pivotal contributions of marine-derived bioactive molecules to advances in neurosci

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… In silico prediction and structure-based multitargeted molecular docking analysis of selected bioactive compounds against mucormycosis. Bull. Natl. Res. Cent. 2022;46:24. doi: 10.1186/s42269-022-00704-4. 72. Adam O.M., Nugraha J., Machfoed M.H., Turchan A. …