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Venous thromboembolism in cancer patients: an underestimated major health problem.

Venous thromboembolism (VTE) is a major health problem among patients with cancer, its incidence in this particular population is widely increasing. Although VTE is associated with high rates of mortality and morbidity in cancer patients, its severity is still underestimated by many oncologists. Thromboprophylaxis of VTE now considered as a standard of care is still not prescribed in many institutions; the appropriate treatment of an established VTE is not yet well known by many physicians and nurses in the cancer field. Patients are also not well informed about VTE and its consequences. Many

Регулирование Kynurenin Pathway в Relapping Rising Multial Sclerosis и его корреляции с прогрессивным нейродегенерацией.

Несмотря на отсутствие острых повреждений при многократном склерозе (MS), хроническое нейродегенерация продолжает развиваться, и потенциальным основополагающим механизмом может быть кинурайнский путь (КП). Как известно, продолжительная активация КП от хронического воспаления усугубляет прогресс нервно-дегенеративных заболеваний за счет производства нейротоксичных метаболитов. В числе 8 КП метаболиты, six из них, а именно: кинурень (КИН), 3- Гидроксилкилинин (3ГК), антраиличная кислота (АА), кинуриновая кислота (КИНА) и квинолинская кислота (QUIN) были связаны с нейродегенерацией.Чтобы получить

Nanoimmunotherapy: the smart trooper for cancer therapy.

Immunotherapy has gathered significant attention and is now a widely used cancer treatment that uses the body's immune system to fight cancer. Despite initial successes, its broader clinical application is hindered by limitations such as heterogeneity in patient response and challenges associated with the tumor immune microenvironment. Recent advancements in nanotechnology have offered innovative solutions to these barriers, providing significant enhancements to cancer immunotherapy. Nanotechnology-based approaches exhibit multifaceted mechanisms, including effective anti-tumor immune response

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… Fluorine-assembled NPs have been created to combat immunosuppression caused by Tregs [ 214 ]. By efficiently reducing hypoxia in the TME, the O 2 included in perfluorocarbon-based fluorine-assembled NPs can prevent Treg invasion and proliferation. … Conversely, when fluorine-assembled NPs are exposed to laser radiation, they lower GSH levels, which in turn lowers Foxp3 expression in Tregs and achieves the goal of reversing tumor immune suppression. Hybrid NPs functionalized with tLyp1 peptide for the delivery of imatinib. …

Trends in Kampo Medicine Usage as Supportive Care During Anticancer Drug Treatment in Japanese Patients: A Nationwide Cohort Analysis from Fiscal Years 2015 to 2021.

The adverse effects of anticancer drugs significantly impact the quality of life of patients undergoing chemotherapy, necessitating evidence-based supportive therapies. In Japan, Kampo medicines, traditional Japanese herbal therapies used for relief of various symptoms, have been widely used as complementary and alternative treatments for cancer, despite limited evidence regarding their efficacy and safety. Thus, we investigated the actual use of Kampo medicines as supportive care in patients undergoing anticancer drug treatment and evaluated the trends in prescription according to year. We an

Overdiagnosis of a typical carcinoid tumor as an adenocarcinoma of the lung: a case report and review of the literature.

BackgroundOverdiagnosis of bronchopulmonary carcinoid tumors together with overtreatment can cause serious postoperative consequences for the patient. We report of a patient with a typical bronchopulmonary carcinoid tumor, which was initially misdiagnosed and treated as an adenocarcinoma of the lung. GnrH receptors and the associated Raf-1/MEK/ERK-1/2-pathway are potential targets for analogs in cancer treatment. We suspected a correlation between the lack of tumor growth, application of leuprolide and the Raf-1/MEK/ERK-1/2-pathway. Therefore, we examined GnrH receptor status in the examined s

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… PET/CT Eur J Nucl Med Mol Imaging 2010 37 67 77 10.1007/s00259-009-1205-y 19618183 Chong S Lee KS Chung MJ Han J Kwon OJ Kim TS Neuroendocrine tumors of the lung: clinical, pathologic, and imaging findings Radiographics 2006 26 41 58 10.1148/rg.261055057 16418242 Jadvar H Segall GM False-negative fluorine …

Radiomics-based classification of medication-related osteonecrosis of the jaw using panoramic radiographs.

OBJECTIVES: Medication-related osteonecrosis of the jaw (MRONJ) caused by bone resorption inhibitors is difficult to treat and reduces the patient's quality of life. We aimed to classify the likelihood of MRONJ development using panoramic radiographs taken prior to bone resorption inhibitor administration. METHODS: We included patients who underwent panoramic radiographic evaluation at Hiroshima University Hospital prior to bone resorption inhibitor administration. Thirty-two patients with MRON of the mandible (16 men and 16 women) and 57 without MRONJ (23 men and 34 women) were selected. The

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… oral surgery, studies have focused on evaluating various applications of radiomics, including the diagnosis of cervical lymph nodes [ 10 , 11 ], prediction of cervical lymph node metastasis in tongue cancer [ 12 ], and evaluation of the histopathological grade of oral squamous cell carcinoma using18-fluorine-fluorodeoxyglucose …

Head-to-Head Comparison between FDG and 11C-Methionine in Multiple Myeloma: A Systematic Review.

The aim of this systematic review is to provide a comprehensive overview of the existing literature, comparing 18F-fluorodeoxyglucose (FDG) and 11C-methionine (MET) for the imaging of multiple myeloma (MM) with positron emission computed tomography (PET/CT). Relevant studies published from 2013 up to March 2023 were selected by searching Scopus, PubMed, and Web of Science. Selected imaging studies were analyzed using a modified version of the critical Appraisal Skills Programme (CASP). Ten studies encompassing 335 patients were selected. On a patient-based analysis, MET sensitivity ranged betw

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… In this regard, a synthetic amino-acid labeled with 18 F-fluorine, namely 18 F-fluciclovine or 18 F-FACBC [ 25 ], recently implemented in clinical practice for the imaging of prostate cancer recurrence, provided promising results in a preliminary study carried out in patients with newly diagnosed MM …

Thalidomide upper limb embryopathy - pathogenesis, past and present management and future considerations.

This review article provides a comprehensive overview of thalidomide upper limb embryopathy including updates about its pathogenesis, a historical account of the management of the paediatric thalidomide patient, experience with management of the adult patient, as well as creating awareness about early onset age-related changes associated with limb differences. Despite its withdrawal from the market in November 1961, novel discoveries have meant thalidomide is licensed again and currently still in use to treat a variety of conditions, including inflammatory disorders and some cancers. Yet, if n

Predicting tumour response.

Response prediction is an important emerging concept in oncologic imaging, with tailored, individualized treatment regimens increasingly becoming the standard of care. This review aims to define tumour response and illustrate the ways in which imaging techniques can demonstrate tumour biological characteristics that provide information on the likely benefit to be received by treatment. Two imaging approaches are described: identification of therapeutic targets and depiction of the treatment-resistant phenotype. The former approach is exemplified by the use of radionuclide imaging to confirm ta

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… Response assessment of aggressive non-Hodgkin's lymphoma by integrated International Workshop Criteria and fluorine-18-fluorodeoxyglucose positron emission tomography. J Clin Oncol. 2005;23:4652–4661. doi: 10.1200/JCO.2005.01.891. doi:10.1200/jco.2005.01.891. PMid:15837965. 11. …

The research progress on radionuclides in osteoporosis diagnosis and drug efficacy monitoring.

Osteoporosis is a common metabolic bone disease that seriously affects the quality of life and health of patients. Traditional diagnostic methods, such as dual energy X-ray absorptiometry (DXA), have limitations in early detection and dynamic monitoring, making it difficult to meet clinical needs. This paper focuses on the potential of radionuclide imaging techniques, such as Single Photon Emission Computed Tomography (SPECT) and Positron Emission Tomography (PET), in the early diagnosis of osteoporosis. The paper further elaborates on the importance of radionuclides in evaluating the therapeu

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… Positron emitting isotopes, such as Fluorine-18, are commonly used to bind to cells with active glucose metabolism, indicating the presence of tumors or other lesions. …

Ядерное изображение костных метастазов в раке простаты: появление современных методов с использованием новых радиотрацеров

Точная установка рака простаты (ПХА) при начальной диагностике и при биохимических рецидивах имеет важное значение для определения прогноза и оптимальной стратегии лечения. На сегодняшний день обработка метастатической ПХА основана главным образом на результатах обычной съемки с использованием абдоминопелвича, рассчитываемого по томографии (КТ) и синтиграфии костей. Однако эти исследования имеют ограниченную чувствительность и специфичность, что ограничивает их способность точно выявлять и количественно оценивать реальные масштабы активных заболеваний. Для обнаружения ПХА были разработаны совр

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… Abbreviations 68 Ga | 68 Gallium 18 F | 18 Fluorine 18 F-FCH | 18 F-fluorocholine 18 F-FDHT | 18 F-fluordihydrotestosterone 18 F-NaF | 18 F-sodium fluoride ADT | androgen-deprivation therapy AR | androgen receptor BCR | biochemical recurrence BS | bone scintigraphy CRPC | castration-resistant prostate …

The Role of Natural Killer Cells as a Platform for Immunotherapy in Pediatric Cancers.

Purpose of reviewWe aim to review the most recent findings in the use of NK cells in childhood cancers.Recent findingsNatural killer cells are cytotoxic to tumor cells. In pediatric leukemias, adoptive transfer of NK cells can bridge children not in remission to transplant. Interleukins (IL2, IL15) can enhance NK cell function. NK cell-CAR therapy has advantages of shorter life span that lessens chronic toxicities, lower risk of graft versus host disease when using allogeneic cells, ability of NK cells to recognize tumor cells that have downregulated MHC to escape T cells, and possibly less li

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… Kennis BA Michel KA Brugmann WB Laureano A Tao RH Somanchi SS Einstein SA Bravo-Alegria JB Maegawa S Wabha A Kiany S Gordon N Silla L Schellingerhout D Khatua S Zaky W Sandberg D Cooper L Lee DA Bankson JA Gopalakrishnan V Monitoring of intracerebellarly-administered natural killer cells with fluorine …

Bone metastases in pheochromocytomas and paragangliomas: a narrative review of presentation, diagnosis and management.

BACKGROUND: Bone metastases (BM) are a frequent and clinically relevant manifestation in patients with metastatic pheochromocytomas and paragangliomas (mPPGL). OBJECTIVE: This narrative review aims to summarize the current understanding of the pathophysiology, epidemiology, clinical presentation, complications, quality of life impact, and management of BM in mPPGL. SUMMARY: Bone and lymph nodes are among the most common metastatic sites in malignant PPGL. Skeletal involvement-particularly in paragangliomas-is associated with a high incidence of skeletal-related events (SREs), including patho

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… Positron emission tomography/computed tomography with fluorine-18-labeled fluorodeoxyglucose 18 F-FDG PET/CT plays an important role in detecting and monitoring BM in PPGL, especially in metastatic disease and tumors with SDHB mutations. … Positron emission tomography/computed tomography with fluorine-18-labeled fluorodopa ( 18 F-L-3,4-Dihydroxyphenylalanine) The performance of 18 F-FDOPA PET/CT depends on tumor subtype and genetic background. …

Theranostics - a sure cure for cancer after 100 years?

Cancer has remained a formidable challenge in medicine and has claimed an enormous number of lives worldwide. Theranostics, combining diagnostic methods with personalized therapeutic approaches, shows huge potential to advance the battle against cancer. This review aims to provide an overview of theranostics in oncology: exploring its history, current advances, challenges, and prospects. We present the fundamental evolution of theranostics from radiotherapeutics, cellular therapeutics, and nanotherapeutics, showcasing critical milestones in the last decade. From the early concept of targeted d

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… Such rhPSMA ligands can be labeled with 18 F, whereas the chelator is used for the complexation of a cold metal (like nat Ga or nat Lu) or can be labeled with a radiometal (like gallium-68, lutetium-177, or actinium-225), keeping the fluorine side nonradioactive with 19 F. …

Резюме АОКНМБ и СНМИКС 2025

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… ABAOCNMB059: Retrospective Analysis and Optimization of Automated Fluorine-18 Radiopharmaceutical Production Across Two Synthesis Platforms Raviteja Nanabala 1 , Arun PK 1 , Junais Pokkat 1 , Anees Muhammed K 1 , Dilshad Kottuparamban 1 , Shinooj Maniyoth Kuni 1 , Vishnunath Pazhakkal 1 , Thomas George … Conclusion This is a first comprehensive assessment of radiation exposure received during the transport of fluorine-18 radiopharmaceuticals. …

Prophylactic fluoroquinolones in hematopoietic stem cell transplant recipients: A meta-analytic comparison of ciprofloxacin and levofloxacin.

BACKGROUND: Hematopoietic stem cell transplantation (HSCT) is a critical therapeutic intervention for hematological malignancies. However, infections remain a leading complication. Fluoroquinolones, particularly ciprofloxacin and levofloxacin, are commonly employed as prophylactic agents. This study compares their efficacy in preventing post-HSCT infections. METHODS: A systematic review and meta-analysis were conducted using the Cochrane and Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. Relevant studies comparing ciprofloxacin and levofloxacin in HSCT recipien

Can 18F-NaF PET/CT before Autologous Stem Cell Transplantation Predict Survival in Multiple Myeloma?

There is an unmet need for positron emission tomography (PET) radiotracers that can image bone disease in multiple myeloma (MM) in a more sensitive and specific way than the widely used 18F-fluorodeoxyglucose (18F-FDG). Sodium fluoride (18F-NaF) is a highly sensitive tracer of bone reconstruction, evolving as an important imaging agent for the assessment of malignant bone diseases. We attempted to investigate for the first time the prognostic significance of 18F-NaF PET/CT in newly diagnosed, symptomatic MM patients planned for autologous stem cell transplantation (ASCT). Forty-seven patients

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… Evaluation of the skeletal kinetics of fluorine-18-fluoride ion with PET J. Nucl. Med. 1992 33 633 642 1569473 11. Grant F.D. Fahey F.H. Packard A.B. Davis R.T. Alavi A. Treves S.T. Skeletal PET with 18 F-fluoride: Applying new technology to an old tracer J. Nucl. …

Всемирный конгресс молекулярного воображения 2022.

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… Indeed, although 19 F-MRI provides high image contrast due to the almost complete lack of fluorine background in living organisms, fluorine probes with high content of highly mobile and chemically equivalent fluorine atoms are needed. … We demonstrated the novel employment of innovative fluorinated and biocompatible MRI-traceable fibers. …

Emerging Insights into Granulomatous and Amyloidogenic Cardiomyopathies.

Background: Granulomatous and amyloidogenic cardiomyopathies are infiltrative conditions that can be fatal if left untreated. Among these, cardiac amyloidosis and cardiac sarcoidosis are significant but often underdiagnosed causes of heart failure, each serving as cardiac manifestations of broader systemic diseases. Advancements in imaging techniques and the emergence of novel therapies-particularly for cardiac amyloidosis-have brought these conditions into sharper focus for both clinicians and researchers. Methods: We conducted a comprehensive review of the literature by searching databases i

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… Positron Emission Tomography Fluorine-18 fluorodeoxyglucose (FDG) PET has become an essential imaging technique for diagnosing and evaluating CS, especially in situations where standard methods like echocardiography or MRI may not provide clear results. …

Mapping the research trends and hotspots on solid pulmonary nodules from 2000-2024: insights from bibliometric analysis.

BackgroundDue to extensive low-dose computed tomography (CT) screening, the detection rate of solid pulmonary nodules (PNs) is constantly rising. However, existing studies lack a comprehensive understanding of its emerging research trends and interdisciplinary progress, especially in terms of artificial intelligence (AI) integration and molecular characteristics. In this study, we conduct a comprehensive bibliometric analysis to clarify the current research trends and predict future research hotspots in this field, in order to improve diagnostic accuracy, reduce overtreatment, and promote inno

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… Several studies have indicated that a nomogram based on fluorine-18 fluorodeoxyglucose positron emission tomography/CT ( 18 F-FDG PET/CT), integrating radiomics features and age, has higher sensitivity for predicting mediastinal LNM compared to prediction models based solely on PET/CT parameters and …