Результаты поиска

Repetitive Transcranial Magnetic Stimulation: Is it an Effective Treatment for Cancer Pain?

Cancer is a major public health issue, with an estimated 20 million new cases and 9.7 million cancer-related deaths worldwide in 2022. Approximately 44.5% of patients experience cancer pain, significantly impacting their quality of life and causing physical and psychological burdens. Repetitive transcranial magnetic stimulation (rTMS), a non-invasive neuromodulation technique, shows potential in managing cancer pain. This review summarizes current research on rTMS for cancer pain, focusing on pain directly caused by tumors, pain from cancer treatments, postoperative pain, and cancer-related sy

Совпадение в полном тексте источника
… The fact that naloxone significantly reduces the analgesic effects of M1 stimulation [ 85 ] further supports the involvement of endogenous opioids in rTMS-induced pain relief. …

Poly(ethylene glycol)-Prodrug Conjugates: Concept, Design, and Applications.

Poly(ethylene glycol) (PEG) is the most widely used polymer in delivering anticancer drugs clinically. PEGylation (i.e., the covalent attachment of PEG) of peptides proteins, drugs, and bioactives is known to enhance the aqueous solubility of hydrophobic drugs, prolong circulation time, minimize nonspecific uptake, and achieve specific tumor targetability through the enhanced permeability and retention effect. Numerous PEG-based therapeutics have been developed, and several have received market approval. A vast amount of clinical experience has been gained which has helped to design PEG prodru

Совпадение в полном тексте источника
… PEG-uricase | Gout | iv | Market Macugen | PEG-aptamer | Age-related macular degeneration | Intraviteal | Market PEG-drug conjugates NKTR-102 | PEG-irinotecan | Cancer-metastatic breast | iv | Phase II PEG-SN38 | Multiarm PEG-camptothecan derivative | Cancer-various | iv | Phase II NKTR-118 | PEG-naloxone …

Evaluating the Link between BAFF System Gene Expression and Acute Rejection Development in Kidney Transplantation.

B-cell activating factor (BAFF) system signaling is critical for B-cell homeostasis, effector functions, and tolerance maintenance in transplants, but it has not been studied in kidney transplant recipients (KTRs). The aim was to analyze the changes in BAFF system expression in KTRs with/without acute rejection (AR/NAR). The BAFF system expression was analyzed by qPCR in 40 KTRs. A meta-analysis of BAFF system expression and histological renal damage was identified by the Chronic Allograft Damage Index (CADI) and performed from the GEO database. Proliferation-inducing ligand (APRIL) expression

Совпадение в полном тексте источника
… The extent of and factors associated with self-reported overdose and self-reported receipt of naloxone among people who inject drugs (PWID) in England, Wales and Northern Ireland. Int. J. Drug Policy. 2017;46:34–40. doi: 10.1016/j.drugpo.2017.05.017. 17. …

Localized secretion of ATP and opioids revealed through single Ca2+ channel modulation in bovine chromaffin cells.

In bovine chromaffin cells, the Ca2+ channels involved in exocytosis are effectively inhibited by ATP and opioids that are coreleased with catecholamines during cell activity. This autocrine loop causes a delay in Ca2+ channel activation that is quickly removed by preceding depolarizations. Changes in Ca2+ channel gating by secreted products thus make it possible to correlate Ca2+ channel activity to secretory events. Here, using cell-attached patch recordings, we found a remarkable correlation between delayed Ca2+ channel openings and neurotransmitter secretion induced by either local or whol

Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015.

BACKGROUND: Non-fatal outcomes of disease and injury increasingly detract from the ability of the world's population to live in full health, a trend largely attributable to an epidemiological transition in many countries from causes affecting children, to non-communicable diseases (NCDs) more common in adults. For the Global Burden of Diseases, Injuries, and Risk Factors Study 2015 (GBD 2015), we estimated the incidence, prevalence, and years lived with disability for diseases and injuries at the global, regional, and national scale over the period of 1990 to 2015. METHODS: We estimated incid

Совпадение в полном тексте источника
… Within the USA, prescription opioids have been estimated to account for 37% of drug overdose deaths in 2013. 42 , 43 The availability of overdose response treatments in the form of naloxone kits to laypersons has also accelerated. 44 An alternative approach is opioid substitution treatment to reduce … 2000–2013 (accessed June 24, 2016). 43 Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report (MMWR) https://www.cdc.gov/mmwr/preview/mmwrhtml/mm6401a10.htm (accessed June 24, 2016). 44 Centers for Disease Control and Prevention Opioid overdose prevention programs providing naloxone …

Management of Itch in the Elderly: A Review.

Chronic itch is common in the elderly patient and may be caused by a variety of known dermatologic and non-dermatologic conditions and can have a significant effect on quality of life. Age-related changes in barrier function, immunosenescence, and neuronal changes and neuropathies are common predisposing factors to chronic itch in this age group. Certain primary dermatologic conditions are more common in the elderly and can cause chronic itch. Also, co-morbid diseases particularly of the renal, hepatobiliary, or hematologic systems, psychologic conditions, or medications may contribute to chro

Совпадение в полном тексте источника
… Medications that antagonize the mu-opioid receptor, such as naloxone, naltrexone, or nalmefene, have been demonstrated to be effective in reducing itch in chronic urticaria, AD, PN as well as cholestatic and uremic itch [ 104 ]. …

Role of the Bone Microenvironment in the Development of Painful Complications of Skeletal Metastases.

Cancer-induced bone pain (CIBP) is the most common and painful complication in patients with bone metastases. It causes a significant reduction in patient quality of life. Available analgesic treatments for CIBP, such as opioids that target the central nervous system, come with severe side effects as well as the risk of abuse and addiction. Therefore, alternative treatments for CIBP are desperately needed. Although the exact mechanisms of CIBP have not been fully elucidated, recent studies using preclinical models have demonstrated the role of the bone marrow microenvironment (e.g., osteoclast

Совпадение в полном тексте источника
… For instance, in C3H/HeJ mice receiving intratibial inoculations of osteolytic fibrosarcoma, increased expression of P2X3 receptor in the peripheral nociceptive fibers is observed, and peri-tumoral injections of receptor antagonist naloxone-methiodide (A-317491) inhibited cancer-mediated thermal hyperalgesia …

A scoping review of breakthrough cancer pain: Multidimensional patient needs and influencing factors.

ObjectivesBreakthrough cancer pain (BTcP), a common complication among cancer patients, has been confirmed to have extensive impacts on patients' lives. However, existing research remains fragmented, lacking a systematic theoretical framework to integrate these findings. This scoping review aimed to systematically examine the multidimensional needs and influencing factors of BTcP patients based on Kolcaba's Comfort Theory, construct a conceptual mapping of BTcP needs and influences, and explore the theoretical foundations and practical pathways of related interventions.MethodsUsing a scoping r

Совпадение в полном тексте источника
… minutes - 65.5% patients reach maximum pain intensity within ≤ 10 minutes - Post-meal BTcP Characteristics: Lower intensity (6.9/10) ,Faster onset (77.8% reach maximum intensity within ≤ 10 minutes),Shorter duration (45.8 minutes) - More common in pancreatic cancer patients Associated with oseltamivir/naloxone … minutes - 65.5% patients reach maximum pain intensity within ≤ 10 minutes - Post-meal BTcP Characteristics: Lower intensity (6.9/10) ,Faster onset (77.8% reach maximum intensity within ≤ 10 minutes),Shorter duration (45.8 minutes) - More common in pancreatic cancer patients Associated with oseltamivir/naloxone …

Глобальное состояние исследований и тенденции навязчивого сексуального поведения: всеобъемлющий библиометрический анализ.

СТРОИТЕЛЬНОЕ ПОЛОЖЕНИЕ В СВЯЗИ С СТРАТЕГИЧЕСКИМ ПОЛОЖЕНИЕМ В СВЯЗИ С СТРАТЕГИЧЕСКИМ ПОЛОЖЕНИЕМ (CSBD) - это состояние психического здоровья, которое привлекло к себе значительное внимание в ходе научных исследований, особенно после его включения в одиннадцатый пересмотренный вариант Международной классификации болезней (International Classification of Beasons) (International Classification of Bisons (CSBDD).ICD-11) Всемирной организацией здравоохранения. Несмотря на это признание, эта область по-прежнему является фрагментарной в связи с продолжающимся обсуждением вопроса о ее классификации и о

Совпадение в полном тексте источника
… These theoretical models suggest that CSBD may be subdivided into two subgroups: one driven primarily by cue reactivity associated with increased ventral striatum activity (more likely to respond to naloxone) and another using sexual behavior as a coping mechanism for negative emotions (more likely to …

Forecasting drug utilization and expenditure in a metropolitan health region.

BackgroundNew pharmacological therapies are challenging the healthcare systems, and there is an increasing need to assess their therapeutic value in relation to existing alternatives as well as their potential budget impact. Consequently, new models to introduce drugs in healthcare are urgently needed. In the metropolitan health region of Stockholm, Sweden, a model has been developed including early warning (horizon scanning), forecasting of drug utilization and expenditure, critical drug evaluation as well as structured programs for the introduction and follow-up of new drugs. The aim of this

Совпадение в полном тексте источника
… New formulations of fentanyl may also contribute to increased expenditures as well as the new fixed combination of naloxone and oxycodon. Some savings will be achieved through patent expiry and the introduction of generics to sumatriptan. …

Emergency Care

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Curcumin as a promising therapeutic agent for diabetic neuropathy: from molecular mechanisms to functional recovery.

Diabetes mellitus is an endocrine disorder characterized by prolonged hyperglycemia. It results from either insulin deficiency (type 1 diabetes mellitus, T1DM) or insulin resistance (type 2 diabetes mellitus, T2DM). This condition has emerged as a significant health concern in recent years. Hyperglycemia induces the overproduction of reactive oxygen species (ROS), which can modulate multiple pathways, including AGEs-RAGE, PKC stimulation, NF-κB and PI3K/AKT. These pathways contribute to diabetes-related complications such as inflammation, oxidative stress, insulin resistance, and reduced gluco

Совпадение в полном тексте источника
… The partial reversal of curcumin’s anti-allodynic effects by naloxone pretreatment implicates endogenous opioid signaling in its analgesic action. … For example, its effects are partially reversed by naloxone, which suggests that it should be used with caution when combined with opioid medications. …

Opioid Use at End-Of-Life Among Nova Scotia Patients With Cancer.

Purpose: To determine the factors associated with opioid analgesic prescriptions as measured by community pharmacy dispensations to all Nova Scotia (NS) patients with cancer at end-of-life from 2005 to 2009. Methods: The NS Cancer Registry and the NS Prescription Monitoring Program (NSPMP) were used to link Nova Scotians who had a cancer diagnosis and received a prescription for opioids in their last year of life (n = 6,186) from 2005 to 2009. The association of factors with opioid dispensations at end-of-life were determined (e.g., patient demographics, type of prescriber, type of cancer, and

Совпадение в полном тексте источника
… N02AA05); fentanyl (ATC: N02AB03); codeine (ATC: R05DA04); hydromorphone (ATC: N02AA03); acetylsalicylic acid/opioid combinations (ATC: N02BA51); acetaminophen/opioid combinations (ATC: N02BE51, N02AA59); methadone (ATC: N07BC02); buprenorphine (ATC: N02AE01) (excludes buprenorphine combination with naloxone …

Clinical Posters From JADPRO Live 2023.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… Harm reduction strategies not mentioned in the survey or responses but important to mention are naloxone and buprenorphine. …

Последствия злоупотребления наркотиками для путей ферроптоза: потенциальные терапевтические цели для расстройств, связанных с потреблением психоактивных веществ.

Серьезными проблемами в области здравоохранения во всем мире, особенно в развитых странах, по-прежнему являются расстройства, связанные с потреблением психоактивных веществ. Для ОСВ характерна устойчивая нейроинфламмация и синаптическая дисфункция мозга. Несмотря на десятилетия интенсивного расследования, детальные механизмы, лежащие в основе ВСГ, по-прежнему остаются иллюзорными. Ферроптоз — это высокорегулируемый процесс смерти клеток, на который сильно влияют метаболизм железа, пероксидация липидов, производство реактивных видов кислорода (РОС) и антиоксидантные системы. Он был связан с мно

Совпадение в полном тексте источника
… Ferrostatin-1 (Fer-1)( Xu et al., 2022 ; Yu et al., 2026 ) | RTA | •Attenuated neuronal injury, •Restored GPX4 •Preserved synaptic proteins •Reduced lipid peroxidation Opioids (Morphine) | Liproxstatin-1 (Lip-1)( Chen et al., 2019 ) Deferoxamine (DFO)( Huang et al., 2024 ) Cordycepin ( Li et al., 2025 ) Naloxone …

Chemotherapy-Induced Peripheral Neuropathy: Epidemiology, Pathomechanisms and Treatment.

PurposeThis review provides an update on the current clinical, epidemiological and pathophysiological evidence alongside the diagnostic, prevention and treatment approach to chemotherapy-induced peripheral neuropathy (CIPN).FindingsThe incidence of cancer and long-term survival after treatment is increasing. CIPN affects sensory, motor and autonomic nerves and is one of the most common adverse events caused by chemotherapeutic agents, which in severe cases leads to dose reduction or treatment cessation, with increased mortality. The primary classes of chemotherapeutic agents associated with CI

Совпадение в полном тексте источника
… Oxycodone In a multicentre, phase IV study, oxycodone and naloxone taken together with gabapentin (≥ 900 mg/day) was found to decrease mean numeric rating scale pain scores from 6.0 ± 1.3 to 4.7 ± 2.1, after 4 weeks ( p = < 0.0001) [ 276 ]. …

Использование биомаркеров для прогнозирования ответа на транскраниальную прямую токовую стимуляцию (tDCS): систематический обзор скопинга.

ВВЕДЕНИЕ: Транскраниальная прямая токовая стимуляция (tDCS) — это неперерывная нейромодуляция с увеличивающимся количеством доказательств эффективности при лечении нейропсихиатрических состояний. Нужны биомаркеры для прогнозирования и мониторинга эффективности tDCS. Наша цель — провести систематический обзор для оценки доказательств о способности биомаркеров прогнозировать реакцию на tDCS и выявить перспективные кандидатные биомаркеры в популяции пациентов с нейропсихиатрическими заболеваниями. МЕТОДЫ: Комплексные поиски были проведены в базах данных MEDLINE и EMBASE 24/09/2023. Статьи были о

Cancer Pain Is Not One-Size-Fits-All: Evolving from Tradition to Precision.

Cancer pain remains a significant challenge in oncology, profoundly affecting patients' quality of life, function, and prognosis. Historically under-recognized and managed with a uniform, opioid-centric approach, cancer pain was often inadequately treated. Advances in pain assessment, multimodal analgesia, and supportive care have improved outcomes, yet traditional algorithms frequently fail to address the complex, heterogeneous nature of cancer pain. Contemporary management is shifting toward precision and personalized medicine, integrating genetic, molecular, and biomarker data with individu

Совпадение в полном тексте источника
… The guidelines stress risk mitigation, including opioid agreements, prescription drug monitoring program checks, urine drug testing in selected patients, constipation prophylaxis, and co-prescribing naloxone for high-risk individuals. …

Abstracts of the 36th Annual Meeting of the Society of General Internal Medicine. April 24-27, 2013. Denver, Colorado, USA.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Public health and international drug policy.

UNLABELLED: In September 2015, the member states of the United Nations endorsed sustainable development goals (SDG) for 2030 that aspire to … e in reducing overdose deaths. Restrictive drug policies also contribute to unnecessary controls on naloxone, a medicine that can reverse overdose very effectively. Though a small percentage of PWUD will ever need treatment for drug dependence, that minority faces enormous barriers to humane and affordable treatment in many countries. There are often no na …