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Advances in α-Lipoic Acid for Disease Prevention: Mechanisms and Therapeutic Insights.

α-Lipoic acid (ALA) is a naturally occurring compound with diverse biological functions, widely distributed in animal and plant tissues. It has attracted considerable attention due to its versatile therapeutic potential. However, despite these promising prospects, the clinical application of ALA remains limited by its low bioavailability and chemical instability and an incomplete understanding of its multifaceted mechanisms across various diseases. This review provides a comprehensive overview of the biochemical properties of ALA, including its direct free-radical-scavenging activity, regenera

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… , MDA, ROS | [ 41 ] Male Wistar rats (125–130 g) | 100 mg/kg/day, orally, 21 days | ↑GSH, TAC; ↓TGF-β1, IFN-γ, ALT, AST, MTC, α-SMA | [ 42 ] C57BLKS/J mice (8 weeks) | Overexpressed LIAS gene | ↑NRF2, P65, IKK-β, I-κB; ↓TNF-α, TGF-β1, Vimentin, α-SMA, PAI-1, COL1-α1, COL3-α1 | [ 43 ] Male albino rats … cell lung cancer | | | A549 cells; Nude mice (6 weeks) | 5 mM, 24 h; 50 mg/kg/day, orally, 18 days | ↑LDH, BAX/BCL-2, p62, p-p70S6K/p70S6K, p-mTOR/mTOR; ↓LC3-II, VPS34, Beclin-1, ATG13 | [ 46 ] H460, H292, H23 cells | 0–5 μM, 48 h | ↓CD133, ALDH1A1, CD44, Oct-4, β-catenin, p-Akt, EMT (E-cadherin, Vimentin …

Circulating Tumour Cells (CTCs) in NSCLC: From Prognosis to Therapy Design.

Designing optimal (neo)adjuvant therapy is a crucial aspect of the treatment of non-small-cell lung carcinoma (NSCLC). Standard methods of chemotherapy, radiotherapy, and immunotherapy represent effective strategies for treatment. However, in some cases with high metastatic activity and high levels of circulating tumour cells (CTCs), the efficacy of standard treatment methods is insufficient and results in treatment failure and reduced patient survival. CTCs are seen not only as an isolated phenomenon but also a key inherent part of the formation of metastasis and a key factor in cancer death.

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… Lindsay et al. also observed that NSCLC patients with NG_007726.3 EGFR mutation had higher CTC counts, including a vimentin + CTC (a marker of EMT) phenotype [ 70 ]. … This process was associated with increased expression of epithelial markers (E-cadherin) and decreased expression of mesenchymal markers (vimentin and N-cadherin). …

The role of exosomes in lung cancer metastasis and clinical applications: an updated review.

Lung cancer is the leading cause of cancer-associated deaths accounting for 24% of all cancer deaths. As a crucial phase of tumor progression, lung cancer metastasis is linked to over 70% of these mortalities. In recent years, exosomes have received increasing research attention in their role in the induction of carcinogenesis and metastasis in the lung. In this review, recent studies on the contribution of exosomes to lung cancer metastasis are discussed, particularly highlighting the role of lung tumor-derived exosomes in immune system evasion, epithelial-mesenchymal transition, and angiogen

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… Exosomes derived from highly metastatic lung cancer cells, PC14HM, express a higher levels of vimentin than those from non-metastatic lung cancer cells, PC14. … Treatment of human bronchial epithelial cells with PC14HM-derived exosomes, resulted in a significantly increased level of vimentin, triggering EMT in recipient HBECs [ 38 ]. …

Сравнительный анализ нервно-воспалительных путей болезни Альцгеймера, болезни Паркинсона и множественного склероза: понимание сходства и различий.

Растет интерес к нейродегенеративным болезням, усугубляющим значительное социально-экономическое бремя, вызванное старением общества. Несмотря на то, что каждая болезнь имеет различные этиологии, нейроинфламмация, как считается, играет решающую роль в болезни Альцгеймера (AD), болезни Паркинсона (PD) и множественном склерозе (MS). Помимо патогенной функции воспаления мозга, растет число свидетельств того, что иммунная реакция необходима для нейрорегенерации. Этот обзор сравнивает и контрастирует с нейроинфламационными путями, которые характерны для различных нейродегенеративных заболеваний. В

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… Prominent indicators like vimentin, which causes cell enlargement, and glial fibrillary acidic protein (GFAP) are expressed more often in reactive astrocytes. … In the APP/PS1 animal model of AD, the reduction of GFAP and vimentin raises the Aβ plaque load and decreases the astrocytic reactivity ( Kraft et al., 2013 ). Additionally, there also might occur a neuroprotective mechanism for reactive astrocytes. …

Evaluation of epidemiological and pathological features of symptomatic spinal metastases in Romania - what could we learn from a retrospective study?

Metastases are the most common tumors of the spine. As an important increase in the annual incidence of spinal metastases (SMs) has been observed in the last decade, the aim of this study was to describe the epidemiology and histopathological types of SMs surgically treated in the Neurosurgery Clinics of a Regional Hospital in North-Eastern Romania over a period of five years, in order to define a certain tumor profile that would benefit from an early screening. We retrospectively evaluated 115 adult patients, searching for demographic data (gender and age of the patients), primary tumor chara

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… An IHC-positive reaction was considered in the presence of a brown membrane staining of tumoral cell for human epidermal growth factor receptor 2 (HER2), cytoplasm staining in tumoral cells for pan-cytokeratin (CK) AE1/AE3, CK7, CK20, CK8/18, CK19, vimentin, Melan A, and human melanoma black 45 (HMB45 … BioSystems | 1/100 | Citrate, pH 6 CK19 | Mouse monoclonal | DAKO | 1/100 | Citrate, pH 6 ER | Rabbit monoclonal | DAKO | RTU | Citrate, pH 6 PR | Mouse monoclonal | DAKO | RTU | Citrate, pH 6 HER2 | Polyclonal rabbit | DAKO | 1/400 | Citrate, pH 6 PSA | Polyclonal rabbit | DAKO | 1/50 | Citrate, pH 6 Vimentin …

The role of EMT-related lncRNA in the process of triple-negative breast cancer metastasis.

Triple-negative breast cancer (TNBC) is the most malignant and fatal subtype of breast cancer, which has characterized by negativity expression of ER, PR, and HER2. Metastasis is the main factor affecting the prognosis of TNBC, and the process of metastasis is related to abnormal activation of epithelial-mesenchymal transition (EMT). Recent studies have shown that long non-coding RNA (LncRNA) plays an important role in regulating the metastasis and invasion of TNBC. Therefore, based on the metastasis-related EMT signaling pathway, great efforts have confirmed that LncRNA is involved in the mol

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… From the perspective of molecular markers, the dynamic process of EMT involves the loss of Claudin-1, E-cadherin, and cytokeratin expression, which are replaced by over-expressed vimentin and N-cadherin characterized by the mesenchymal cell phenotype [ 17 ]. … Changes in other EMT-related molecules were observed simultaneously when AFAP1-AS1 was silenced; for example, N-cadherin and vimentin expression were down-regulated, while E-cadherin expression was elevated. …

Investigating the functions and molecular mechanisms of DTX3L in cancer progression.

In the field of tumor research, the process by which E3 ubiquitin ligases specifically ubiquitinate substrate proteins and promote their degradation has garnered significant attention. DTX3L, an emerging E3 ubiquitin ligase of the Deltex family, is closely associated with the development and progression of various malignant tumors. Through multiple mechanisms such as epigenetic modifications, signal pathway activation, and protein interaction networks, DTX3L precisely regulates key biological processes, including cell proliferation, cycle progression, migration, invasion, and apoptosis. This r

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… In SiHa and HeLa cells, DTX3L knockdown significantly reduces Snail, Vimentin, and N-cadherin expression and increases E-cadherin expression, indicating that DTX3L may promote tumor migration and invasion. … Additionally, DTX3L depletion reduces multiple epithelial-mesenchymal transition (EMT) associated gene expressions (KRT14, Vimentin, FOXC2, TWIST, ZEB1, SLUG, N-cadherin, Fibronectin) while upregulating E-cadherin. …

Резюме: 32 Второй Конгресс ЭСП и Международный конгресс XXXIII МПД.

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ATGL sensitizes hepatocellular carcinoma cells to genotoxic drugs by modulating p53 acetylation/phosphorylation status.

Hepatocellular carcinoma (HCC) accounts for approximately 90% of liver cancer cases. Few therapeutic options are available for HCC patients due to intrinsic drug resistance or the low efficacy of conventional chemotherapeutic drugs, including genotoxic agents. We previously demonstrated that adipose triglyceride lipase (ATGL) is downregulated in HCC and shows anti-neoplastic activity by affecting sensitivity to different therapeutic approaches. On the basis of this evidence, we assessed the contribution of ATGL activity to the modulation of the DNA damage response induced by genotoxic drugs. W

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… Wang F Rong M Zhang L Solomon AD Gui W Li J Vimentin intermediate filaments orchestrate DNA nonhomologous end joining repair and lipolysis after DNA damage Oncogene 2025 44 3025 36 10.1038/s41388-025-03465-2 40550847 Wang F, Rong M, Zhang L, Solomon AD, Gui W, Li J, et al. … Vimentin intermediate filaments orchestrate DNA nonhomologous end joining repair and lipolysis after DNA damage. Oncogene. 2025;44:3025–36. 40550847 10.1038/s41388-025-03465-2 16. …

Cancer Stem Cells: The Potential Targets of Chinese Medicines and Their Active Compounds.

The pivotal role of cancer stem cells (CSCs) in the initiation and progression of malignancies has been rigorously validated, and the specific methods for identifying and isolating the CSCs from the parental cancer population have also been rapidly developed in recent years. This review aims to provide an overview of recent research progress of Chinese medicines (CMs) and their active compounds in inhibiting tumor progression by targeting CSCs. A great deal of CMs and their active compounds, such as Antrodia camphorate, berberine, resveratrol, and curcumin have been shown to regress CSCs, in t

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… It could also induce CSCs differentiation through up-regulating several differentiation markers, such as peripherin , vimentin and neurofilament [ 127 ]. Combination of curcumin with epigallocatechin gallate (EGCG) could synergize against breast cancer by inducing CSCs differentiation. … Furthermore, they could inhibit epithelial-mesenchymal transition by inhibiting the expression of snail, nuclear beta-catenin, vimentin and slug. They also further reduced activity of LEF-1/TCF responsive reporter and thereby suppressed migration and invasion of prostate CSC. …

CD70 as a target in cancer immunotherapy: advances, challenges, and future directions.

Cancer immunotherapy represents a paradigm shift in oncology by leveraging the immune system to target tumors. The therapeutic efficacy of these approaches depends critically on identifying molecular targets that enhance treatment responses while limiting toxicity. CD70, a TNF family member, has emerged as a promising target due to its overexpression in hematologic malignancies and solid tumors contrasted with restricted expression in healthy tissues. This differential expression profile implies that CD70-directed therapies could achieve tumor-specific cytotoxicity with reduced off-target effe

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… In solid tumors, CD70 signaling associates with cancer stemness and epithelial-mesenchymal transition (EMT) by upregulating EMT-related genes (SOX2, CD44, vimentin, Snail, Slug, β-catenin) while activating MAPK and overexpressing RhoE ( 2 ). … Within solid tumors, CD70 signaling fosters cancer stem cell characteristics and epithelial-mesenchymal transition by upregulating EMT-associated transcriptional regulators such as SOX2, CD44, Vimentin, Snail, Slug, and β-catenin while concurrently activating MAPK signaling and inducing RhoE overexpression …

Drug prioritization identifies panobinostat as a tailored treatment element for patients with metastatic hepatoblastoma.

BACKGROUND: Patients with metastatic hepatoblastoma are treated with severely toxic first-line chemotherapies in combination with surgery. Yet, inadequate response of lung metastases to neo-adjuvant chemotherapy still compromises patient outcomes making new treatment strategies, tailored to more efficient lung clearance, mandatory. METHODS: We harnessed a comprehensive patient-derived xenograft platform and a variety of in vitro and in vivo assays to establish the preclinical and biological rationale for a new drug for patients with metastatic hepatoblastoma. RESULTS: The testing of a librar

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… Spheroids were then incubated with antibodies against surfactant protein C (SP-C) as pulmonary marker, vimentin (VIM) as mesenchymal marker, and alpha-feto protein (AFP) as HB marker overnight at 4°C (detailed information in Suppl. Table 3). … A Immunofluorescence images of individual spheroids of lung epithelial cells (BEAS-2B), neonatal skin fibroblasts (HDFn) and hepatoblastoma models stained for the airway epithelial cell marker surfactant C (SP-C), the mesenchymal marker vimentin (VIM) and the hepatoblastoma marker alpha fetoprotein ( …

A Perspective on Withania somnifera Modulating Antitumor Immunity in Targeting Prostate Cancer.

Medicinal plants serve as a lead source of bioactive compounds and have been an integral part of day-to-day life in treating various disease conditions since ancient times. Withaferin A (WFA), a bioactive ingredient of Withania somnifera, has been used for health and medicinal purposes for its adaptogenic, anti-inflammatory, and anticancer properties long before the published literature came into existence. Nearly 25% of pharmaceutical drugs are derived from medicinal plants, classified as dietary supplements. The bioactive compounds in these supplements may serve as chemotherapeutic substance

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… Similarly, WFA deters VEGF-mediated tube formation by HUVECs and binds to vimentin and intermediate filament protein to inhibit tumor angiogenesis [ 42 , 43 ]. 2.4. … The tumor inhibitor and antiangiogenic agent withaferin A targets the intermediate filament protein vimentin Chemistry & Biology 2007 14 6 623 634 10.1016/j.chembiol.2007.04.010 2-s2.0-34250346795 17584610 PMC3228641 43 Prasanna Kumar S. Shilpa P. Salimath B. P. …

The crosstalk between non-coding RNAs and oxidative stress in cancer progression.

As living standards elevate, cancers are appearing in growing numbers among younger individuals globally and these risks escalate with advancing years. One of the reasons is that instability in the cancer genome reduces the effectiveness of conventional drug treatments and chemotherapy, compared with more targeted therapies. Previous research has discovered non-coding RNAs' crucial role in shaping genetic networks involved in cancer cell growth and invasion through their influence on messenger RNA production or protein binding. Additionally, the interaction between non-coding RNAs and oxidativ

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… The transformation process is accompanied by alterations in stage markers (epithelial markers: E-cadherin, cytokeratin, tight junction proteins; mesenchymal markers: N-cadherin, MMP, vimentin, fibronectin, α-SMA, LLGL1/2). 25 , 26 This process is orchestrated by both intra- and extracellular signaling … For instance, exposure to ropivacaine in glioma cells induces oxidative stress and apoptosis, leading to the up-regulation of E-calmodulin expression and inhibition of vimentin protein expression through the circSCAF11/miR-145-5p axis. 65 Similarly, up-regulation of circRBPMS in breast cancer affects …

Indian Ayurvedic medicine: Overview and application to brain cancer.

Ayurveda is the traditional medicine system of India, and has been in practice for millennia. It is a traditional approach that uses 1000's of different plant preparations in various combinations for treatment of human ailments, including cancer. Ethnopharmacological and phytochemical analyses are now elucidating the bioactive constituents of the different plant species and herbal formulations, including ashwagandha, curcumin, guduchi, triphala, and others. To provide an overview of: 1) the ethnopharmacology of Ayurveda and several of its most important plant species and formulations, includin

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… This disruption of the cytoskeleton is also linked to disassembly of vimentin, vimentin depolymerization, and filament aggregation [ [12] , [13] , [14] , [15] , [16] ]. … Withaferin A also targets many pathways that are known to be dysregulated in high-grade gliomas, including the p53 signaling pathway, MAPK/ERK signaling pathway, PI3K/Akt/mTOR signaling pathway, NF-κB signaling pathway, and the angiogenesis pathways (i.e., reducing VEGF and vimentin, endothelial cell …

Patient-Derived Organoids as a Promising Tool for Multimodal Management of Sarcomas.

The management of sarcomas, a diverse group of cancers arising from connective tissues, presents significant challenges due to their heterogeneity and limited treatment options. Patient-derived sarcoma organoids (PDSOs) have emerged as a promising tool in the multimodal management of sarcomas, offering unprecedented opportunities for personalized medicine and improved treatment strategies. This review aims to explore the potential of PDSOs as a promising tool for multimodal management of sarcomas. We discuss the establishment and characterization of PDSOs, which realistically recapitulate the

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… sarcoma (PAS), epithelioid sarcoma (ES), rhabdomyosarcoma (RMS), malignant giant-cell tumor (MGT), chondrosarcoma (CS), chordoma (CD), giant osteosarcoma (GOS), synovial sarcoma (SS), malignant schwannoma (MS), hemangiopericytoma (HP), metalloproteinases (MMP9), Poly [ADP-ribose] polymerase 1 (PARP1), vimentin … PDSOs showed positive immunoreactivity for pan-keratin, vimentin, CD34, and PCNA, indicating similarities to the original tumor. Cell doubling 2.3 to 3.3-fold in 72 h | The organoids showed sensitivity to doxorubicin within the range of 1.5–15 mM for both patients. …

Therapeutic Targeting of Cancer Stem Cells in Human Glioblastoma by Manipulating the Renin-Angiotensin System.

Patients with glioblastoma (GB), a highly aggressive brain tumor, have a median survival of 14.6 months following neurosurgical resection and adjuvant chemoradiotherapy. Quiescent GB cancer stem cells (CSCs) invariably cause local recurrence. These GB CSCs can be identified by embryonic stem cell markers, express components of the renin-angiotensin system (RAS) and are associated with circulating CSCs. Despite the presence of circulating CSCs, GB patients rarely develop distant metastasis outside the central nervous system. This paper reviews the current literature on GB growth inhibition in r

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… On the other hand, TGF-β1 was shown to induce EMT in GB cells by decreasing the expression of E-cadherin, inducing up-regulation of mesenchymal markers (e.g., N-cadherin, vimentin), crucial regulators (e.g., Twist1, β-catenin), EMT-activating transcription factors (e.g., Snail, Slug, Zeb1); and activating … Effects mediated by ATIIR1 are associated with changes typical of EMT, namely increased expression of E-cadherin, reduced ZEB1 and vimentin levels. A comprehensive review of the many current studies on GB CSCs and EMT-MET in glioma is beyond the scope of this review. …

Molecular interactions of miR-338 during tumor progression and metastasis.

BackgroundCancer, as one of the main causes of human deaths, is currently a significant global health challenge. Since the majority of cancer-related deaths are associated with late diagnosis, it is necessary to develop minimally invasive early detection markers to manage and reduce mortality rates. MicroRNAs (miRNAs), as highly conserved non-coding RNAs, target the specific mRNAs which are involved in regulation of various fundamental cellular processes such as cell proliferation, death, and signaling pathways. MiRNAs can also be regulated by long non-coding RNAs (lncRNAs) and circular RNAs (

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… MiR-338-3p reduced MM cell proliferation and migration through MACC1 targeting, resulting in E-cadherin upregulation and vimentin downregulation [ 158 ]. … Moreover, NFATc1 silencing upregulated CDH1 and downregulated CDH2 and vimentin. MiR-338 reduced cell proliferation and EMT via NFATc1 targeting in NSCLC cells [ 170 ]. …

Keyword Index for Volume 95

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… inhibitor 1483 UFT 159, 817 uranium miners 1280 uterine-sparing 1314 V600E BRAF 581 vaccination 896 validation 42 vascular endothelial growth factor (VEGF) 1013, 1611 vascular endothelial growth factor receptor-3 75 vascular endothelial growth factor-C 75 venous infiltration 1050 vessel 1 vimentin …

WT1: The Hinge Between Anemia Correction and Cancer Development in Chronic Kidney Disease.

Hypoxia-inducible factor-prolyl hydroxylase inhibitors (HIF-PHIs) emerge as promising agents to treat anemia in chronic kidney disease (CKD) but the major concern is their correlated risk of cancer development and progression. The Wilms' tumor gene, WT1, is transcriptionally regulated by HIF and is known to play a crucial role in tumorigenesis and invasiveness of certain types of cancers. From the mechanism of action of HIF-PHIs, to cancer hypoxia and the biological significance of WT1, this review will discuss the link between HIF, WT1, anemia correction, and cancer. We aimed to reveal the re

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… Exposure of breast cancer cells to a low-oxygen microenvironment facilitates cell migration by inducing the upregulation of vimentin and downregulation of epithelial marker proteins (Lester et al., 2007). … Co-expression of Cytokeratin and Vimentin in Colorectal Cancer Highlights a Subset of Tumor Buds and an Atypical Cancer-Associated Stroma . Hum. Pathol. 87 , 18 – 27 . 10.1016/j.humpath.2019.02.002 30794893 Moore A. W. McInnes L. Kreidberg J. Hastie N. D. Schedl A. ( 1999 ). …