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The antioxidant effect of green tea catechin ameliorates experimental liver injury.

PURPOSE: Several studies have reported green tea catechin to have both antifibrotic and anti-oxidative effects. The goal of this study was to evaluate the effect of green tea cathechin therapy in hepatic tissue injury using cholestatic rats with bile duct ligation. MATERIALS AND METHODS: We performed bile duct ligation on cholestatic seven-week-old male Wistar rats and classified them into three groups according to the method of treatment. The groups comprised the SHAM group, the NT-group (no-treatment-group), and the T-group (treatment-group). The rats were orally administered green tea cate

HIV type-1 entry inhibitors with a new mode of action.

BACKGROUND: The development of antiviral drugs has provided crucial new means to mitigate or relieve the debilitating effects of many viral pathogens. Regular use of these drugs has led to generation of resistant strains, making the control of many viral infections very difficult, particularly in HIV-seropositive and AIDS patients. A rich source for the discovery of new HIV infection inhibitors has been, and continues to be, the 'mining' of the large diversity of compounds already available in nature, and specifically those from botanical extracts. METHODS: Using a newly developed direct bind

Formulation and evaluation of herbal anti-acne moisturizer.

The moisture content present in human skin makes it look young and the use of moisturizer results in fastening the moisture with a surface film of oil. Acne vulgaris is one of the most commonly seen diseases among the youth. The present study is focused on the use of herbs as moisturizer for acne treatment. The anti-acne moisturizer was formulated from herbal crude extracts and investigated the physico-chemical parameters as well as antibacterial activity of the formulation. The study revealed that ethanol extract of Andrographis paniculata, Glycyrrhiza glabra, Ocimum sanctum, Azadiracta indic

Concomitant inhibition of HSP90, its mitochondrial localized homologue TRAP1 and HSP27 by green tea in pancreatic cancer HPAF-II cells.

Pancreatic cancer is a deadly disease characterized by poor prognosis and patient survival. Green tea polyphenols have been shown to exhibit multiple antitumor activities in various cancers, but studies on the pancreatic cancer are very limited. To identify the cellular targets of green tea action, we exposed a green tea extract (GTE) to human pancreatic ductal adenocarcinoma HPAF-II cells and performed two-dimensional gel electrophoresis of the cell lysates. We identified 32 proteins with significantly altered expression levels. These proteins are involved in drug resistance, gene regulation,

Matcha, a powdered green tea, ameliorates the progression of renal and hepatic damage in type 2 diabetic OLETF rats.

Matcha, a powdered green tea produced by grinding with a stone mill, has been popularly used in the traditional tea ceremony and foods in Japan. Matcha is well known to be richer in some nutritional elements and epigallocatechin 3-O-gallate than other green teas. In our previous study, epigallocatechin 3-O-gallate exhibited protective effects against renal damage in a rat model of diabetic nephropathy. In the present study, we investigated the preventive effects of Matcha (50, 100, or 200 mg/kg/day) on the progression of hepatic and renal damage in type 2 diabetic Otsuka Long-Evans Tokushima F

Green tea and vitamin E enhance exercise-induced benefits in body composition, glucose homeostasis, and antioxidant status in elderly men and women.

OBJECTIVE: To investigate the effects of green tea plus vitamin E in addition to exercise on body composition and metabolic and antioxidant parameters in healthy elderly individuals. DESIGN: Interventional randomized controlled prospective trial. METHODS: For 12 weeks, 22 elderly men and women (age: 71.1 ± 1.2 years; body mass index: 28.3 ± 0.5 kg/m(2) [mean ± SE]) undertook 30 minutes of moderately intense walking 6 d/wk. They were randomly assigned to ingest either green tea plus vitamin E (GTVE; 3 cups and 400 IU, respectively; n = 11) or placebo (n = 11). Data on anthropometrics, fasting

Lactobacillus casei YRL577 combined with plant extracts reduce markers of non-alcoholic fatty liver disease in mice.

Probiotics and plant extracts are considered to prevent the development of non-alcoholic fatty liver disease (NAFLD). The present study explores the effects of using both probiotics and plant extracts on NAFLD. The present study evaluated the effects of plant extracts on lipid droplet accumulation and the growth of probiotics in vitro. A C57BL/6 mouse model was used to examine the effects of probiotics and plant extracts on NAFLD. Body weight and food intake were measured. The levels of serum lipids, oxidative stress and the liver injury index were determined using commercial kits. Haematoxyli

The effect of Chinese Jinzhida recipe on the hippocampus in a rat model of diabetes-associated cognitive decline.

BACKGROUND: To investigate the effects of treatment with Multi component Chinese Medicine Jinzhida (JZD) on behavioral deficits in diabetes-associated cognitive decline (DACD) rats and verify our hypothesis that JZD treatment improves cognitive function by suppressing the endoplasmic reticulum stress (ERS) and improving insulin signaling transduction in the rats' hippocampus. METHODS: A rat model of type 2 diabetes mellitus (T2DM) was established using high fat diet and streptozotocin (30 mg/kg, ip). Insulin sensitivity was evaluated by the oral glucose tolerance test and the insulin toleranc

EGCG inhibits proliferation of cardiac fibroblasts in rats with cardiac hypertrophy.

This study was carried out in order to investigate the effects of epigallocatechin gallate (EGCG) on myocardial fibrosis and cell proliferation in cardiac hypertrophy. Cardiac hypertrophy was established in rats by abdominal aortic constriction, and EGCG at doses of 25, 50 and 100 mg/kg was administered intragastrically for 6 weeks. The results showed that in the rats with cardiac hypertrophy, EGCG at 25 - 100 mg/kg dose-dependently reduced heart weight indices, decreased atrial natriuretic polypeptide and endothelin levels in plasma, but increased nitrite (the oxidative product of NO) levels

Green tea (-)-epigallocatechin-gallate modulates early events in huntingtin misfolding and reduces toxicity in Huntington's disease models.

Huntington's disease (HD) is a progressive neurodegenerative disorder for which only symptomatic treatments of limited effectiveness are available. Preventing early misfolding steps and thereby aggregation of the polyglutamine (polyQ)-containing protein huntingtin (htt) in neurons of patients may represent an attractive therapeutic strategy to postpone the onset and progression of HD. Here, we demonstrate that the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG) potently inhibits the aggregation of mutant htt exon 1 protein in a dose-dependent manner. Dot-blot assays and atomic force

Role of phytoconstituents in the management of COVID-19.

BackgroundCOVID-19, a severe global pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has emerged as one of the most threatening transmissible disease. As a great threat to global public health, the development of treatment options has become vital, and a rush to find a cure has mobilized researchers globally from all areas.Scope and approachThis review focuses on deciphering the potential of different secondary metabolites from medicinal plants as therapeutic options either as inhibitors of therapeutic targets of SARS-CoV-2 or as blockers of viral particles entry

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… ( Calophyllum blancoi ) Image 23 HCoV 229E Against Protease [ 101 ] Anthraquinones Emodin ( Rheum officinale ) Image 24 SARS-CoV Inhibit binding of S-protein to ACE2 [ 102 ] Coumarins Psoralidin ( Cullen corylifolium ) Image 25 SARS CoV Against PL Pro [ 94 ] Tannins Tannic acid ( Camellia sinensis ) … sinensis 3CL Pro inhibition [ 173 ] Licoleafol Image 66 Glycyrrhiza uralensis 3CL Pro inhibition [ 173 ] Taiwan-homoflavone A Image 67 Cephalotaxus wilsoniana Binds with 3CL pro and ACE2 [ 55 ] Afzelin Image 68 3CL Pro inhibition and ACE2 [ 174 ] Isoquercitrin Image 69 3CL Pro inhibition and ACE2 [ …

Therapeutic potential of green tea catechin, (-)-epigallocatechin-3-O-gallate (EGCG) in SARS-CoV-2 infection: Major interactions with host/virus proteases.

BACKGROUND: The current COVID-19 pandemic from the human pathogenic virus SARS-CoV-2 has resulted in a major health hazard globally. The mor … V-2 efficacy of (-)-epigallocatechin-3-O-gallate (EGCG), a major catechin constituent of green tea (Camellia sinensis (L.) Kuntze) beverage to highlight the scope of EGCG in clinical medicine as both prophylaxis and treatment of present COVID-19 infection. In addition, the factors related to poor oral bioavailabilty of EGCG was also analysed for a suggestion for fu …

Bone-Targeted Agents in Breast Cancer: Do We Now Have All the Answers?

The bone-targeted agents (BTAs), bisphosphonates and denosumab, have an established role in the treatment of metastatic breast cancer bone disease and the prevention of cancer-treatment-induced bone loss. Evidence in support of their ability to improve survival in early breast cancer now indicates that the bisphosphonates are effective in postmenopausal women (naturally or chemically induced), but denosumab does not have similar benefits when added to standard adjuvant therapy. In postmenopausal women with early breast cancer, the choice of BTA may differ depending on the indication for treatm

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… sinensis and metromic zoledronic acid reduces bone metastases from breast cancer cells disseminated in bone | Luo et al 37 Triple negative mouse mammary 4T1 cells | Immune competent | Combining Camellia sinensis and metromic zoledronic acid reduces primary tumour growth and metastasis to other organs … Clin Cancer Res . 2014 ; 20 : 2922 – 2932 . 24687923 10.1158/1078-0432.CCR-13-1246 PMC4040234 37 Luo KW Ko CH Yue GG , et al The combined use of Camellia sinensis and metronomic zoledronic acid in a breast cancer-induced osteolysis mouse model . …

Research prioritization of men's health and urologic diseases.

OBJECTIVES: We sought to determine whether disease representation in the Cochrane Database of Systematic Reviews (CDSR) reflects disease burden, measured by the Global Burden of Disease (GBD) Study as disability-adjusted life-years (DALYs). MATERIALS AND METHODS: Two investigators performed independent assessment of ten men's health and urologic diseases (MHUDs) in CDSR for systematic review and protocol representation, which were compared with percentage of total 2010 DALYs for the ten conditions. Data were analyzed for correlation using Spearman rank analysis. RESULTS: Nine of ten MHUDs we

The Most Competent Plant-Derived Natural Products for Targeting Apoptosis in Cancer Therapy.

Cancer is a challenging problem for the global health community, and its increasing burden necessitates seeking novel and alternative therapies. Most cancers share six basic characteristics known as "cancer hallmarks", including uncontrolled proliferation, refractoriness to proliferation blockers, escaping apoptosis, unlimited proliferation, enhanced angiogenesis, and metastatic spread. Apoptosis, as one of the best-known programmed cell death processes, is generally promoted through two signaling pathways, including the intrinsic and extrinsic cascades. These pathways comprise several compone

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… sinensis | Water | Leaf | IC 50 = 86.68 ± 0.73 μg/mL | HT-29 | Increased: activation of caspase-3, -9, and -8 Decreased: NR Camellia sinensis | Water | Leaf | 15 × 10 5 μg/day | Clinical trial, patients with colorectal cancer | Increased: NR Decreased: incidence of metachronous adenomas; size of relapsed … Antiproliferative effects of Camellia sinensis (known as tea plant) on the colorectal cancer cell line, HT-29, was affirmed to be attributed to its apoptosis-triggering capability, which is evidenced by activating caspase-3, -8, and -9 in these cancer cells. …

Theranostic Potentials of Gold Nanomaterials in Hematological Malignancies.

Hematological malignancies (HMs) are a heterogeneous group of blood neoplasia generally characterized by abnormal blood-cell production. Detection of HMs-specific molecular biomarkers (e.g., surface antigens, nucleic acid, and proteomic biomarkers) is crucial in determining clinical states and monitoring disease progression. Early diagnosis of HMs, followed by an effective treatment, can remarkably extend overall survival of patients. However, traditional and advanced HMs' diagnostic strategies still lack selectivity and sensitivity. More importantly, commercially available chemotherapeutic dr

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… Ahmeda et al. (2020) [ 159 ], Zangeneh et al. (2020) [ 160 ], and Hemmati (2020) [ 161 ] also got similar in vitro and in vivo results from b-AuNPs synthesized from Camellia sinensis , Hibiscus sabdariffa flower, and Hymus vulgaris leaf, respectively. … Shahriari et al. (2016) [ 180 ] prepared hydroxyl-capped b-AuNPs using Camellia sinensis leaf extract and conjugated b-AuNPs with asparagine (Asn). MTT-assay results showed that Asn-b-AuNPs displayed concentration-dependent (3–300 μg/mL) antiproliferative activity toward CCRF-CEM cells at 39 °C. …

Phytochemical-Based Nanomedicine for Advanced Cancer Theranostics: Perspectives on Clinical Trials to Clinical Use.

In the current chapter, a new strategic compilation of phytochemicals with potent antitumor properties has been addressed, most importantly focusing on cell cycle arrest and apoptotic signaling mechanism. A promising approach in tumor prevention is to eliminate cancer cells preferably via cell cycle arrest and programmed cell death with lesser harm to neighboring normal cells. Cancer cells have a survival advantage to escape apoptosis and relentlessly divide to proliferate, gearing up the cell cycle process. Recently, the use of phytochemical-derived conjugated chemotherapeutic agents has incr

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… For example, phytobioactive compounds such as; epigallocatechin gallate (EGCG), a polyphenol isolated from Camellia sinensis (Tea); genistein, a soy isoflavonoid derived from Glycin max Linn.; sulforaphane, an organosulfur compound from isothiocyanate class; curcumin, another polyphenol extracted from … Epigallocatechin Gallate [EGCG] Epigallocatechin gallate is a polyphenol, flavan and gallate ester, catechin, isolated from the tea plant Camellia sinensis (Theaceae). …

Фитохимические вещества, направляемые на сигнализацию BDNF для лечения неврологических расстройств.

Неврологические расстройства определяются ухудшением или нарушением структуры и функции нервной системы. Эти заболевания, включая множественный склероз, болезнь Альцгеймера, болезнь Паркинсона, болезнь Хантингтона и шизофрению, вызваны сложными патологическими процессами, в том числе эксцитотоксичностью, нейроинфламмацией, окислительным стрессом, генетическими мутациями и скомпрометированным нейротрофическим сигналом. Несмотря на то, что в настоящее время лекарственные препараты устраняют симптомы, их долгосрочная эффективность ограничена из-за неблагоприятных побочных эффектов и слабых нейроз

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… Similarly, Epigallocatechin-3-gallate (EGCG) extracted from Camellia sinensis mitigates NDs in APP/PS1 mice by enhancing CREB and NGF activity by TrkA phosphorylation via c-Raf/ERK1/2-mediated neurological protection [ 166 ]. …

Нацеливание на природные полифенолы антиоксидантов в целях защиты от нейроинфламмации и нейродегенеративных заболеваний: всеобъемлющий обзор.

Полифенолы, природные фитонутриенты, встречающиеся в растительных продуктах питания, привлекли значительное внимание к их потенциальному терапевтическому воздействию в неврологических заболеваниях и нейроинфламмации. Эти соединения обладают различными возможностями нейрозащиты, включая антиоксидантные, антивоспалительные и антиамильоидные свойства, которые способствуют смягчению развития таких нейродегенеративных заболеваний, как болезнь Альцгеймера (AD), болезнь Паркинсона (PD), деменция, множественный склероз (MS), Строк и болезнь Хантингтона (HD). Полифенолы были тщательно изучены на предме

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… sinensis) Animal models of Huntington’s disease Inhibits apoptosis, reduces oxidative stress, and inflammation Li et al. (2024c) Quercetin Apples, onions, berries Animal models of ischemic stroke Reduces inflammation, inhibits excitotoxicity, and oxidative stress Shi et al. (2024) Luteolin Celery … Epigallocatechin gallate (EGCG), from green tea ( Camellia sinensis ), inhibits apoptosis while also reducing oxidative stress and inflammation ( Tao et al., 2024 ). …

Существенный потенциал борьбы с миломой вливания зеленого чая и его компонента дигидромиритина.

Множественная миелома (ММ) — фатальная гематологическая порча, характеризующаяся перерастанием моноклонных плазменных клеток. Хотя зеленый чай имеет хорошо задокументированные антивизорные свойства, его специфические последствия для MM по-прежнему плохо характеризуются. Цель этого исследования состояла в изучении антимиеломной активности вливаний четырех репрезентативных зеленых чая и выявлении их эффективных компонентов. Мы обнаружили, что апоптоз клеток MM был вызван зелеными чайными вливаниями в зависимости от концентрации, при этом вливание чая в Билуочун продемонстрировало самую мощную эф

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… Green tea, derived from the fresh leaves of the tea plant ( Camellia sinensis L. ), represents one of the most widely consumed traditional beverages worldwide, particularly popular in Southeast Asian countries. …