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Neovascular Age-Related Macular Degeneration: Therapeutic Management and New-Upcoming Approaches.

Age-related macular degeneration (AMD) constitutes a prevalent, chronic, and progressive retinal degenerative disease of the macula that affects elderly people and cause central vision impairment. Despite therapeutic advances in the management of neovascular AMD, none of the currently used treatments cures the disease or reverses its course. Medical treatment of neovascular AMD experienced a significant advance due to the introduction of vascular endothelial growth factor inhibitors (anti-VEGF), which dramatically changed the prognosis of the disease. However, although anti-VEGF therapy has be

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… Adverse events of interest included uveitis and iritis (2.2% for each) with brolucizumab 6 mg vs. 0.3% and 0%, respectively, with aflibercept in HAWK; corresponding rates in HARRIER were <1% in both arms [ 122 ]. … The incidence of severe IOI was 1.6 percent with one reported case of iritis and one reported case of uveitis. There were no reported cases of endophthalmitis or retinal vasculitis in this study. …

Treatment of sarcoid granulomatous interstitial nephritis with adalimumab.

Sarcoidosis is a systemic disease with multiorgan involvement which can cause renal failure through several different mechanisms. Granulomatous interstitial nephritis is an important albeit less frequent cause of clinically significant renal disease. Herein, we present the case of a 46 year old woman with a history of sarcoidosis whom we evaluated for rapidly worsening kidney function and proteinuria. Renal biopsy revealed granulomatous interstitial nephritis. After therapy with adalimumab, her renal function improved with a significant reduction in proteinuria. Repeat kidney biopsy showed res

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… In 1987, the patient presented with an episode of iritis and was found to have hilar adenopathy. A bronchial biopsy was consistent with sarcoidosis. …

Use of bisphosphonates in prostate cancer: Current status.

Bisphosphonates are a relatively newer class of drugs which have been used for the prevention of skeletal related complications of age related osteoporosis or metastatic disease from carcinoma breast or multiple myeloma. Their role in the management of prostate cancer is still under evolution. We hereby review the ongoing and some published randomized trials to define the role of bisphosphonates in various stages of prostate cancer.

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… Acute phase reaction in the form of arthralgia, fever, transient leucopenia, bone pain, iritis etc. is commonly seen with intravenous administration but is usually self-limited. Nephrotic syndrome and jaw osteonecrosis have also been reported. …

Role of zoledronic acid in the prevention and treatment of osteoporosis.

Taken once a year, intravenous zoledronic acid (Zol) (Reclast® or Aclasta®) is a third-generation nitrogen-containing bisphosphonate that is effective compared with placebo in reducing the risk of fractures in patients with postmenopausal osteoporosis and recent low-trauma hip fracture. In glucocorticoid-induced osteoporosis, there is no significant difference between Zol and risedronate for new fractures. Improvements in bone mineral density and early reduction of bone remodeling markers are observed in postmenopausal osteoporosis, recent low-trauma hip fracture, and glucocorticoid-induced os

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… Ocular adverse events Patients who were treated with Zol had an absolute increase of 0.69% (3.34% vs 2.65%) in inflammatory ocular adverse events (mainly conjunctivitis) in the first 15 days after the infusion. 25 In HORIZON-RFT, only one case of iritis was reported in the Zol group. 35 In the male … osteoporosis trial, two cases of conjunctivitis and one case of eye pain were reported in the Zol group and one case of iritis in the alendronate group. 23 , 60 In the GIO trial, one case of conjunctivitis was reported in the Zol group. 37 Tolerability Zol 5 mg administered via a 15-minute IV infusion …

Характеристики увейта и множественный склероз фенотип пациентов с множественным склерозом, связанным с увеитом: систематический обзор и метаанализ.

Подведение итогов и мета-анализирование характеристик увеита и многократного склероза (MS) фенотипа пациентов с множественным склерозом, связанным с увеитом (MSAU), в рамках систематического обзора и метаанализа. 25, 2023, с использованием баз данных PubMed, Embase и Virtual Health Bibrary (VHL). Мы проводили исследования с участием пациентов в ССАУ, например, сериалы, 10 - пациенты, перекрестные исследования, анализ конкретных случаев и когортные исследования. Качество и риск отклонения оценивались с использованием инструментов CLARITY и проверенных параметров, таких, как инструменты Hoy et a

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… search algorithm included a combination of terms reflecting the diseases of interest (uveitis) and (multiple sclerosis) using the following search strategy: “multiple sclerosis”[MeSH Terms] OR “multiple sclerosis”[Title/Abstract]) AND (“Iridocyclitis”[MeSH Terms] OR “Iridocyclitis”[Title/Abstract] OR “Iritis … ”[MeSH Terms] OR “Iritis”[Title/Abstract] OR “Uveitis”[MeSH Terms] OR “Uveitis”[Title/Abstract] OR “retinal vasculitis”[MeSH Terms] OR “retinal vasculitis”[Title/Abstract]). …

Cyclodestructive procedures for non-refractory glaucoma.

BACKGROUND: Glaucoma is a leading cause of blindness worldwide. It results in a progressive loss of peripheral vision and, in late stages, l … n after the procedure, and many had transient conjunctival burns (percentages not reported). Severe iritis occurred in two eyes and hyphema occurred in three eyes. No instances of hypotony or phthisis bulbi were reported. The only adverse outcome that was reported by the treatment group was atonic pupil (RR 0.89 in the low-energy group, 95% CI 0.47 to 1. …

Ocular complications with the use of radium-223: a case series.

BackgroundRadium-223 is used for the treatment of osseous metastases in castrate-resistant prostate cancer, and has been shown to increase time to the first skeletal-related event, reduce the rate of hospitalization, and improve quality of life. It is well tolerated, with hematologic toxicity as the main adverse event. Thus far, no ocular complication has been reported in the literature after initial administration of radium-223 with a single case reported of ocular complications after a patient's second course of radium-223.Case presentationsWe present three cases of ocular complications afte

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… In this phase I/II study assessing retreatment with Ra-223 for mCRPC, ocular AEs including cataract formation, cataract worsening, iritis, uveitis, glaucoma, and photopsia occurred in 11% (5/44) of patients. …

Case report: Immune-mediated meibomian gland dysfunction following pembrolizumab therapy for advanced urothelial carcinoma.

Ocular immune-related adverse events are a relatively rare complication of immune checkpoint inhibitors. Common ocular toxicities range from dry eyes to inflammatory uveitis and ocular myasthenia gravis. Here, we present the case of a 55-year-old woman with recurrent urothelial carcinoma of the ureter after initially being managed with neoadjuvant cisplatin-based chemotherapy and surgical resection. She was treated with pembrolizumab which was complicated by immune-mediated pneumonitis after the eighth cycle, which was managed with a prolonged steroid course. The patient also developed red eye

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… Other reported ocular irAEs include blepharitis, episcleritis, and iritis (all reported in < 1% of patients receiving anti-CTLA-4 antibody therapy) as well as keratitis (n = 3 cases documented) ( 1 , 4 – 6 ). …

Fucoidan Exerts Anticancer Effects Against Head and Neck Squamous Cell Carcinoma In Vitro.

Fucoidans have been reported to exert anticancer effects with simultaneous low toxicity against healthy tissue. That correlation was observed in several cancer models, however, it has never been investigated in head and neck cancer before. To magnify the efficacy of conventional therapy, the administration of agents like fucoidan could be beneficial. The aim of this study was to evaluate the anticancer effect of Fucus vesiculosus (FV) extract alone and with co-administration of cisplatin in head and neck squamous cell carcinoma (HNSCC) in vitro. MTT assay results revealed an FV-induced inhibit

A Continuous Registry of Medical Record, Patient Input, and Epidemiological Data of Patients With Ulcerative Colitis: a Multicentre, Prospective, Observational Clinical Registry Study in Japan.

BackgroundThis registry aims to allow for a prospective non-interventional observational study of ulcerative colitis. This will facilitate monitoring of the current state of ulcerative colitis in Japan and improving the long-term disease course and adverse events associated with current treatment options.MethodsInclusion of patients from five centres in Japan is planned. The study is expected to take place from July 15, 2020, to November 30, 2024. Background, demographics, and medical history/information will be collected from electronic medical records at enrolment. Medical information includ

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… mercaptopurine, leukocyte apheresis (including granulocyte and monocyte adsorption apheresis). c Includes peripheral joint involvement, spondyloarthritis (including ankylosing spondylitis and sacroiliitis), involvement of the skin (erythema nodosum, pyoderma grangrinosum, other), involvement of the eyes (iritis …

Diagnosis and Management of Oncologic Emergencies.

Oncologic emergencies may be seen in any emergency department and will become more frequent as our population ages and more patients receive chemotherapy. Life-saving interventions are available for certain oncologic emergencies if the diagnosis is made in a timely fashion. In this article we will cover neutropenic fever, tumor lysis syndrome, hypercalcemia of malignancy, and hyperviscosity syndrome. After reading this article the reader should be much more confident in the diagnosis, evaluation, and management of these oncologic emergencies.

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… compared to normal cells; therefore, lysis of malignant cells releases large quantities of phosphate into the circulation, which ultimately binds with calcium to form calcium phosphate crystals. 39 The crystals deposit into soft tissue and can contribute to complications such as urinary obstruction, iritis …

The Use of Imaging in Management of Patients with Low Back Pain.

Lower back pain (LBP) is one of the most common chief complaints encountered in primary care. Advanced imaging studies, including computerized tomography (CT) and magnetic resonance imaging (MRI), are frequently ordered in the setting of LBP. Structural abnormalities are commonly identified by CT and MRI in patients complaining of low back pain, however, these findings are also found in asymptomatic patients. In the past decade, multiple guidelines have been published to help providers identify patients in whom the use of advanced imaging is appropriate. In this article, we review common condi

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… Systemic disease manifestations such as uveitis and iritis may also be present. …

Evaluating the Immunogenicity, Efficacy, and Effectiveness of Recombinant Zoster Vaccine for Global Public Health Policy.

Background: Herpes zoster (HZ) is a painful neurocutaneous disease caused by the varicella-zoster virus. The recombinant zoster vaccine (RZV) is becoming increasingly incorporated into national vaccination schedules. We aimed to evaluate RZV from a global public health policy perspective. Methods: We performed a rapid review of studies evaluating the immunogenicity, efficacy, and effectiveness of RZV for protection against HZ and associated complications. We searched PubMed for English-language studies published between 7 August 2012 and 30 September 2023. Included studies reported vaccine eff

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… If VZV reactivates in certain cranial nerves, it can also cause herpes zoster ophthalmicus (HZO) and this may lead to conjunctivitis, keratitis, iritis, uveitis, and vision loss [ 6 ]. …

Ophthalmic Manifestations in Patients with Blood Malignancies.

Ocular complications can occur in up to 90% of patients with blood malignancies. Such complications range from direct infiltration to local hemostatic imbalance and treatment-related toxicity. This narrative review is based on a systematic computerized search of the literature conducted until January 2024 and examines the common ocular complications associated with blood cancers. Ocular complications from primary disease include mass effects from ocular adnexal lymphomas and intraocular lymphomas, with B-cell lymphomas accounting for 95% of primary ocular presentations. Secondary disease invol

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… Leukemic iritis with hypopyon. Cancer. 1979;44:1511–1513. doi: 10.1002/1097-0142(197910)44:4<1511::AID-CNCR2820440449>3.0.CO;2-O. 58. Ploysangam P., Reynolds A.L. Iris Infiltration as a Sign of Relapse in a Child with Chronic Myeloid Leukemia. …

Multisystemic sarcoidosis-important lessons learnt from one of the great imitators.

We report a case of a woman who was admitted with a suspicion of metastatic malignancy of unknown primary origin. A few months prior to her admission, she presented to a rheumatologist with acute anterior uveitis, psoriasiform rashes and polyarthritis. A diagnosis of psoriatic arthropathy was made and she was treated accordingly. Soon after she presented with persistent back and right upper quadrant abdominal pain for which she had a CT scan done with evidence of hilar lymphadenopathy, liver hypodensities and lytic-sclerotic bone lesions. She was referred to our hospital for further investigat

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… Clinicians may hone in on the diagnosis of sarcoidosis in the setting of ‘classical' clinical syndromes, such as Löfgren’s syndrome—an acute variant of sarcoidosis classically presenting with erythema nodosum, hilar adenopathy, ankle oligoarthritis and possibly iritis; lupus pernio with acral papulonodules …

Seventeen-year reassessment of diagnostic transitions, biologic therapy initiation and mortality in spondyloarthritis: results from the REGISPON-3 study.

OBJECTIVES: To evaluate disease evolution, diagnostic transitions, time to biologic treatment initiation and mortality in patients with spondyloarthritis (SpA) after 17 years from the original Spanish Registry of Spondyloarthritis (REGISPONSER). METHODS: Spondyloarthritis Registry 3 (REGISPON-3) is a two-timepoint longitudinal study with patients fulfilling the European Spondyloarthropathy Study Group criteria participating in the REGISPONSER study and re-evaluated after 17 years. Clinical, laboratory, radiological and treatment data were collected and compared with baseline. Diagnostic chang

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… . | Anterior iritis/uveitis | 0.79 (0.45 to 1.39) | 0.42 | 409 | | Urethritis, cervicitis, acute diarrhoea in the month before arthritis | 2.59 (0.85 to 7.89) | 0.09 | 410 | n.s. | Sacroiliitis | 0.49 (0.29 to 0.83 ) | <0.01 | 410 | n.s. | Pain improvement with previous NSAIDs | 0.31 (0.10 to 0.97 …

VEXAS Syndrome-Review.

VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome is a newly defined refractory adult-onset autoinflammatory syndrome caused by somatic mutations in the ubiquitin-like modifier-activating enzyme 1 (UBA1) gene in hematopoietic stem and progenitor cells, resulting in a shift in UBA1 isoform expression. Thus, patients develop a spectrum of systemic inflammatory manifestations and hematologic symptoms. To date, patients respond poorly to immune suppressive drugs, except high-dose glucocorticoids, and no treatment guidelines have been established. Given the high mortality ra

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… | 5 (50) | | Cochlea/vestibular dysfunction | | 1 (7) | | | | | | 1 (7) | Ocular involvement | 7 (28) | 5 (46) | | 6 (43) | 5 (42) | 47 (40) | 20 (24) | 4 (32) | 4 (36) | Scleritis | 1 (4) | | | | | 10 (9) | | | | Episcleritis | 3 (12) | 1 (9) | 2 (13) | | | 14 (12) | | | | Iritis …

The Anti-Cancer Effect of Cinnamon Aqueous Extract: A Focus on Hematological Malignancies.

Cinnamon is an evergreen and tropical plant of the family Lauraceae, growing particularly in Sri Lanka, whose aqueous extract has been tested in different studies to evaluate its possible use as an anti-cancer compound. Both in vitro and in vivo experiments seem to confirm that it acts on various cellular pathways, contributing to down-regulating the activity of molecules that stimulate the proliferation and survival of cells such as the transcription factors NF-KB and AP-1, COX-2, dihydrofolate reductase and pro-angiogenic substances such as VEGF, while up-regulating the function of immune ce

Parthenolide: pioneering new frontiers in hematological malignancies.

Hematological malignancies are the fifth most prevalent cancer category in developed countries, presenting significant treatment challenges. The side effects of chemotherapy and its non-selective nature have led researchers to explore combination therapies to enhance efficacy and improve patient outcomes. Parthenolide (PTL) emerges as a promising candidate, being the first small molecule identified for its selective action against leukemic stem cells. This article provides an overview of PTL's effects and its potential as a complementary treatment for hematological malignancies. A systematic s

Ocular effects caused by viral infections and corresponding vaccines: An overview of varicella zoster virus, measles virus, influenza viruses, hepatitis B virus, and SARS-CoV-2.

Many viral infections can affect vision and the visual system. Vaccination to prevent diseases is commonplace today, acting by stimulating an immune response without developing the pathology. It involves the production of persisting antibodies against the pathogen and the activation of T cells. Certain diseases have already been eradicated by rigorous vaccination campaigns, while others are hoped to be eliminated soon. Vaccines currently available on the market are largely safe, even if they can rarely cause some adverse effects, such as ocular complications. Analyzing existing literature, we

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… Almost every ocular structure can be involved, with blepharitis, conjunctivitis, epithelial or stromal keratitis, endotheliitis, iritis, trabeculitis, and retinitis. …