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Late Breaking Orals.

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… University, Salzburg, Salzburg, Austria; 2 Cell Therapy Institute, Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI ‐ TReCS), Paracelsus Medical University (PMU), Salzburg, Austria, Salzburg, Austria; 3 Exosomics, Siena, Italy; 4 HansaBioMed Life Sciences Ltd, Mäealuse 2/1, 12618 Tallinn, Estonia … , Tallinn, Estonia; 5 Institute for Infection Prevention and Hospital Epidemiology, Faculty of Medicine, University Medical Center Freiburg, Freiburg, Germany, Freiburg, Germany Introduction : Isolation of purified EV populations from plasma remains a conceptual and methodological topic of discussion …

Strategies to improve recruitment to randomised trials.

BACKGROUND: Recruiting participants to randomised controlled trials (RCTs) is challenging. Identifying effective recruitment strategies woul … tely 10 additional participants per 100 approached. The studies involved mostly women in the UK and Estonia. No cost or retention data were reported. Telephone reminder versus no telephone reminder. Telephone reminders to people who did not respond to an initial postal invitation boosted recruitment by 6% (95% CI 3% to 9%; 2 studies, 1450 participants), i …

Европейский статус карты CAR-T и будущие направления улучшения доступа к клеточной терапии CAR для гематологовых маньяков.

Несмотря на свои большие надежды, осуществление терапии CAR-T является индивидуализированным, технически сложным и дорогостоящим лечением, которое по-прежнему сопряжено с трудностями, что затрудняет доступ пациентов в различных странах и внутри стран. С тех пор 2018, six в Европе (т.е. Европейская экономическая зона; утвержден ЕС) 15 Гематологические признаки злоумышленничества. Чтобы лучше понять доступ пациентов к коммерческой терапии CAR-T, одобренной ЕС, мы провели оценку нынешнего положения дел в целом. 30 Страны, в которых одобрение ЕС действительно, плюс Соединенное Королевство, рассмат

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… In 26% of the countries ( n = 8), including Bulgaria, Cyprus, Estonia, Iceland, Latvia, Liechtenstein, Lithuania, and Malta, no EU‐approved CAR‐T products were reimbursed. … As no CAR‐T products were commercially available in Bulgaria, Cyprus, Estonia, Iceland, Latvia, Liechtenstein, Lithuania, and Malta, time to access could not be calculated for these countries. …

FSHB -211 G>T is a major genetic modulator of reproductive physiology and health in childbearing age women.

STUDY QUESTION: Are the genetic variants FSHB -211 G>T (rs10835638), FSHR c.2039 A>G (Asn680Ser, rs6166) and FSHR -29 G>A (rs1394205) associ … ited during the HAPPY PREGNANCY study (2013-2015) at the Women's Clinic, Tartu University Hospital, Estonia. Serum FSH, LH and AMH were measured in the follicular phase (Days 2-6) of the menstrual cycle. All three single nucleotide polymorphisms (SNPs) were genotyped by PCR and Taqman allelic discrimination assay. The effect of the analysed variants on ho …

Measuring the global, regional, and national burden of multiple myeloma from 1990 to 2019.

BackgroundMultiple myeloma (MM) is a major health concern. Understanding the different burden and tendency of MM in different regions is crucial for formulating specific local strategies. Therefore, we evaluated the epidemiologic patterns and explored the risk factors for MM death.MethodsData on MM were collected from the 2019 Global Burden of Disease study. We used incidence, mortality, and disability adjusted life-years to estimate the global, regional, and national burden of MM.ResultsIn 2019, there were 155,688 (95% UI, 136,585 - 172,577) MM cases worldwide, of which 84,516 (54.3%, 70,924

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… ) | Dominica (5.89) | Kyrgyzstan (0.55) | Palau (0.59) | Mongolia (0.60) Age Standardized DALY Rate | Monaco (199.23) | Barbados (139.63) | Dominica (132.87) | Kyrgyzstan (13.33) | Thailand (14.67) | Palau (14.71) Percentage change in rates from 1990 to 2019 ASIR | Belarus (1.45) | Jamaica (1.24) | Estonia … (1.11) | Bahrain(−0.24) | Northern Mariana Islands(− 0.23) | Guam (− 0.22) ASDR | Jamaica (1.12) | Belarus (1.07) | Estonia(0.79) | Bahrain(−0.32) | Jordan(−0.28) | Northern Mariana Islands (− 0.52) Age Standardized DALY Rate | Jamaica (1.18) | Belarus (1.09) | Turkmenistan (0.96) | Bahrain(−0.35) | …

Evolution of clinical benefit in cancer trials: comparing pivotal approval data with updated efficacy.

BACKGROUND: Many oncology drugs are approved by the Food and Drug Administration (FDA) based on interim analyses from randomized controlled trials (RCTs) using immature efficacy data. Although expedited approvals expedite access, they create uncertainty about the durability of benefit and long-term efficacy. We aimed to systematically compare initial and updated results from RCTs supporting FDA oncology approvals, evaluating longitudinal changes in relative efficacy. METHODS: All phase II-III RCTs supporting FDA oncology drug approvals from 2006-2025 that reported both initial and updated res

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… Footnotes Edited by: Carlos Laranjeira , Polytechnic Institute of Leiria, Portugal Reviewed by: Vahur Valvere , North Estonia Medical Centre, Estonia Simeone D'Ambrosio , University of Naples Federico II, Italy Data availability statement The original contributions presented in the study are included …

Объем хориоидного плефуса при нарушениях мозга: систематический обзор.

БАКGROUND: Чороидный плефус — это сильно сосудистая структура, расположенная в боковом, третьем и четвертом желудочках мозга. Недавние исследования показывают, что изменения объема чороидного плефуса связаны с прогрессированием различных заболеваний мозга. Алгоритмы сегментации значительно улучшили нашу способность изучать объем чороидного плефуса в связи с различными патологиями. Таким образом, конкретная цель данного обзора заключалась в описании насколько оценка объема чороидного плефуса предоставляет клинически значимую информацию в заболеваниях мозга. МЕТОДЫ: Была проведена обширная поис

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… Age matched controls Huang et al. 2022, China, USA, Estonia [ 35 ] CS 3 T, 3D T1w Automated (FS) LV 53 TRS 46 Non-TRS 66HC 1.26 (SEM 0.06) 1.26 (SEM 0.07) 0.94 (SEM 0.05) – Enlarged CPV in TRS and non-TRS significantly vs. … Age matched controls Huang et al. 2022, China, USA, Estonia [ 35 ] | CS | 3 T, 3D T1w | Automated (FS) | LV | 53 TRS 46 Non-TRS 66HC | 1.26 (SEM 0.06) 1.26 (SEM 0.07) 0.94 (SEM 0.05) | – | Enlarged CPV in TRS and non-TRS significantly vs. …

ESCP 36th European Symposium on Clinical Pharmacy ‘Implementing Clinical Pharmacy in Community and Hospital Settings: Sharing the Experience’, Istanbul, Turkey 25–27 October 2007; Abstracts

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… observation of converting cyclosporin to tacrolimus in renal transplant patients at middlemore hospital PT-151 The role of the clinical pharmacist on oncology service: pain management PT-191 A comparative study of prescribing errors requiring contact with the prescriber before dispensing in Norway, Estonia … 180 Pediatric use of infliximab: retrospective study PT-187 An assessment of professional practices about antifungal agents prescriptions in the department of conventional hematology at Nantes University Hospital PT-188 Pharmacotherapy of first-episode psychosis in the psychiatry clinics of the north estonia …

Глобальные, региональные и национальные тенденции и бремя множественного склероза среди подростков и молодежи: анализ данных 1990 в адрес 2021 и прогнозы в отношении 2040.

СПРАВОЧНАЯ ИНФОРМАЦИЯ И ЦЕЛИ: Множественный склероз (МС) оказывает значительное воздействие на подростков и молодежь (возраст) 15-39 годы), вызывая серьезные неврологические расстройства. Несмотря на прогресс в области лечения, глобальное бремя сохраняется из-за различий в доступе к медицинскому обслуживанию и факторах образа жизни. В настоящем исследовании анализируются глобальные, региональные и национальные тенденции и бремя НР с использованием глобального бремени болезней (ГБЗ) 2021 данные с уделением особого внимания влиянию социально-демографического индекса (ИПД). МЕТОДЫ: Использование

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… The most significant reductions in death rates were recorded in Estonia (−63·4%), Slovenia (−53·1%), and Latvia (−50·3%) ( Supplementary Table S3 ). … In contrast, the most considerable reductions during this period occurred in Estonia (−59·3%), Latvia (−47·2%), and Slovenia (−43·6%) ( Supplementary Table S4 ). Age and sex patterns In 2021, the global point prevalence of MS in AYAs continued to increase. …

Estimating complete cancer prevalence in Europe: validity of alternative vs standard completeness indexes.

IntroductionComparable indicators on complete cancer prevalence are increasingly needed in Europe to support survivorship care planning. Direct measures can be biased by limited registration time and estimates are needed to recover long term survivors. The completeness index method, based on incidence and survival modelling, is the standard most validated approach.MethodsWithin this framework, we consider two alternative approaches that do not require any direct modelling activity: i) empirical indices derived from long established European registries; ii) pre-calculated indices derived from U

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… Dataset | Type of analysis | Registration length (years) | Number of registries | Registries | Population (% study coverage) a) | Empirical index | 35 | 8 | Denmark, Estonia, Finland, Iceland, Norway, Scotland, Geneva (Switzerland) , Parma (Italy) | 23,592,911 (5%) b) | Model-based index | >=30 | 11 … Storm (National CR) ; Estonia: M. Mägi; K. Innos* (National CR) ; Finland: N. Malila; J. Pitkäniemi (National CR) ; France: M. Velten (Bas Rhin CR) ; X. Troussard (Basse Normandie, Haematological Malignancies CR) ; A.M. Bouvier; V. Jooste* (Burgundy, Digestive CR) ; A.V. …

Nanotherapeutics in the EU: an overview on current state and future directions.

The application of nanotechnology in areas of drug delivery and therapy (ie, nanotherapeutics) is envisioned to have a great impact on public health. The ability of nanotherapeutics to provide targeted drug delivery, improve drug solubility, extend drug half-life, improve a drug's therapeutic index, and reduce a drug's immunogenicity has resulted in the potential to revolutionize the treatment of many diseases. In this paper, we review the liposome-, nanocrystal-, virosome-, polymer therapeutic-, nanoemulsion-, and nanoparticle-based approaches to nanotherapeutics, which represent the most suc

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… Abbreviations: AT, Austria; BE, Belgium; BG, Bulgaria; CH, Switzerland; -CMS, concerned member state; CP, centralized procedure; CY, Cyprus; CZ, Czech Republic; DE, Germany; DK, Denmark; EE, Estonia; EL, Greece; EMA, European Medicines Agency; ES, Spain; FI, Finland; FR, France; HMA, Heads of Medicines … Abbreviations: Ala, alanine; AT, Austria; BE, Belgium; BG, Bulgaria; -CMS, concerned member state; CP, centralized procedure; CY, Cyprus; CZ, Czech Republic; DE, Germany; DK, Denmark; EE, Estonia; EL, Greece; EMA, European Medicines Agency; ES, Spain; Fab, fragment antigen binding; Fl, Finland; FR, France …

Inflammation markers in cutaneous melanoma - edgy biomarkers for prognosis.

BACKGROUND: Parasitic infections of the gastrointestinal tract is one of the highest causes of morbidity and mortality among HIV infected individuals. This is due to the colonization of the intestinal tract by parasites influenced by induced enteropathy caused by HIV infection. CD+4 t-lymphocytes count is a marker of the immune status of HIV infected individuals. OBJECTIVE: This study investigated the prevalence of gastrointestinal parasitic infections among HIV coinfected individuals in relation to their immunological status. METHODS: CD+4 t-lymphocytes count was determined using fluorescen

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… The European countries we are using in our analysis are the following: Austria, Belgium, Bulgaria, Croatia, Cyprus, Czechia, Denmark, Estonia, Finland, France, Germany, Greece, Hungary, Iceland, Ireland, Italy, Latvia, Lithuania, Luxembourg, Malta, Netherlands, Norway, Poland, Portugal, Romania, Slovakia …

Резюме докладов 51st Конференция Европейского общества генетики человека: плакаты

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… Laan 1 1 Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia, 2 Andrology Centre, Tartu University Hospital, Tartu, Estonia Introduction: Infertility affects 5-7% of men. …

Cancer burden in Europe: a systematic analysis of the GLOBOCAN database (2022).

BackgroundCancer remains a significant public health challenge in Europe, with substantial regional disparities in incidence, mortality, and access to healthcare. This study analyses cancer patterns across Eastern, Northern, Southern, and Western Europe in 2022, highlighting key public health implications and gaps in prevention and treatment.MethodsUsing data from GLOBOCAN 2022, this study assessed total new cancer cases, age-standardized incidence and mortality rates (ASRs) per 100,000, and cumulative cancer risk at age 75. The top three cancers by sex and region were also analysed to identif

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… Population(s) included: Denmark, Estonia, Finland, Iceland, Ireland, Latvia, Lithuania, Norway, Sweden, United Kingdom, Faroe Islands, Aland Islands, Sark, Svalbard and Jan Mayen Islands, Guernsey, Jersey, Isle of Man Fig. 7 Top 5 most frequent cancers in Northern Europe 2022, all sexes, all ages. … Population(s) included: Denmark, Estonia, Finland, Iceland, Ireland, Latvia, Lithuania, Norway, Sweden, United Kingdom, Faroe Islands, Aland Islands, Sark, Svalbard and Jan Mayen Islands, Guernsey, Jersey, Isle of Man Southern Europe recorded 972,199 new cancer cases (531,344 in males, 440,855 in females …

Incidence and risk factors for suicide and attempted suicide following a diagnosis of hematological malignancy.

Solid tumors are associated with an increased risk of suicide, however, there is limited detailed information on the risk of suicide in patients with hematological malignancies. Therefore, we conducted a population-based study including 47,220 patients with hematological malignancies (diagnosed 1992-2006) and their 235,868 matched controls to define the incidence and risk factors for suicide and suicide attempt. Information on suicides, suicide attempts, and preexisting psychiatric disorders was obtained from Swedish registers and individual medical records. There was a twofold increased (haza

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… Oncol 2004 22 4209 4216 15483032 10.1200/JCO.2004.02.052 Innos K Rahu K Rahu M Baburin A Suicides among cancer patients in Estonia: a population-based study Eur. J. Cancer 2003 39 2223 2228 14522382 10.1016/s0959-8049(03)00598-7 Sverige. …

Физическая активность, упражнения и реабилитация в Миастении Гравис: систематический обзор и сводный анализ.

Миастения гравис вызывает колебания, оживляемую слабость, создавая неопределенность в отношении физической активности и физических упражнений. В ходе этого систематического обзора были изучены обычная физическая активность и оседлое поведение, препятствия и факторы, препятствующие занятиям спортом, структурированные упражнения, мышечная подготовка дыхательных путей и физическая реабилитация в аутоиммунной миастении. С самого начала был проведен поиск в PubMed, Scopus и Web of Science Core Collection. 30 июль 2026, без даты базы данных или лингвистических фильтров; поиск в обратном направлении

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… Earlier reports from Sweden and Estonia compared participants with MG with matched controls or compared national cohorts. … Design/context: linked cross-sectional comparisons between countries and between MG and control groups, Sweden and Estonia | Sweden: 70 invited, 40 surveyed, 34 examined; controls 188/400. Estonia: 36/92 in Sabre. …

Suicide after a Diagnosis of Cancer: Follow-Up of 1.4 Million Individuals, 2009-2019.

Background: The study explores whether Polish cancer patients face elevated suicide risk, emphasizing the vital need to comprehend and mitigate their unique mental health struggles. Methods: We conducted a cohort study based on Polish National Cancer Registry data (diagnosis in 2009-2019). Age-, sex-, and year-standardized mortality ratios (SMR) are presented with 95% confidence intervals (CIs) overall and by sex. Results: The study included 1.43 million individuals diagnosed with cancer. There were 830 suicide cases in this group. The overall SMR for suicide was 1.34 (95% CI 1.25-1.43). The h

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… Suicides among cancer patients in Estonia: A population-based study Eur. J. Cancer 2003 39 2223 2228 10.1016/S0959-8049(03)00598-7 14522382 22. Beghi M. Butera E. Cerri C.G. Cornaggia C.M. Febbo F. Mollica A. Berardino G. Piscitelli D. Resta E. Logroscino G. …

Risk of Suicide After Cancer Diagnosis in England.

ImportanceA diagnosis of cancer carries a substantial risk of psychological distress. There has not yet been a national population-based study in England of the risk of suicide after cancer diagnosis.ObjectivesTo quantify suicide risk in patients with cancers in England and identify risk factors that may assist in needs-based psychological assessment.Design, setting, and participantsPopulation-based study using data from the National Cancer Registration and Analysis Service in England linked to death certification data of 4 722 099 individuals (22 million person-years at risk). Patients (aged

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… consistent association, and the divergent findings are likely to be explained by the size of the area of aggregation. 14 Findings in the Context of Other Studies A number of studies have found an elevated risk of suicide in patients with cancer, in settings such as England, Finland, Sweden, Italy, Estonia …

Characteristics of clinical trials in rare vs. common diseases: A register-based Latvian study.

BackgroundConducting clinical studies in small populations may be very challenging; therefore quality of clinical evidence may differ between rare and non-rare disease therapies.ObjectiveThis register-based study aims to evaluate the characteristics of clinical trials in rare diseases conducted in Latvia and compare them with clinical trials in more common conditions.MethodsThe EU Clinical Trials Register (clinicaltrialsregister.eu) was used to identify interventional clinical trials related to rare diseases (n = 51) and to compose a control group of clinical trials in non-rare diseases (n = 1

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… Between May 2004 and June 2007, four clinical trials on orphan medicinal products were approved in Lithuania, one trial in Estonia, and no trials in Latvia. …

Investigation and management of osteoporosis in aged trauma patients: a treatment algorithm adapted to the German guidelines for osteoporosis.

BACKGROUND: Osteoporosis-associated fractures are of increasing importance in trauma surgery. Systematic diagnostics and treatment of osteoporosis during a hospital stay, however, remain inadequate. Therefore, a specific algorithm for diagnosing and treating osteoporosis in trauma surgery patients was developed based on the DVO (German Osteology Society) guideline for osteoporosis from 2014. METHODS: In a first step, the individuals' age and risk profile for osteoporosis is identified considering specific fractures indicating osteoporosis and risk factors assessed by a specific questionnaire.

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… Quality of life, resource use, and costs related to hip fracture in Estonia. Osteoporos Int. 2016;27(8):2555–66. doi: 10.1007/s00198-016-3544-4. 18. Lyles KW, Colon-Emeric CS, Magaziner JS, Adachi JD, Pieper CF, Mautalen C, Hyldstrup L, Recknor C, Nordsletten L, Moore KA, et al. …