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The multiple roles of interferon regulatory factor family in health and disease.

Interferon Regulatory Factors (IRFs), a family of transcription factors, profoundly influence the immune system, impacting both physiological and pathological processes. This review explores the diverse functions of nine mammalian IRF members, each featuring conserved domains essential for interactions with other transcription factors and cofactors. These interactions allow IRFs to modulate a broad spectrum of physiological processes, encompassing host defense, immune response, and cell development. Conversely, their pivotal role in immune regulation implicates them in the pathophysiology of v

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… Here, IRF8 expression diminishes while IRF4 expression escalates. 222 , 223 In the dark zone germinal center response, IRF8 critically regulates genes such as activation-induced cytidine deaminase (AICDA or AID) and B cell leukemia/lymphoma 6 (BCL6). 224 The AICDA gene encodes AID protein, a crucial …

Novel drug targets for personalized precision medicine in relapsed/refractory diffuse large B-cell lymphoma: a comprehensive review.

Diffuse large B-cell lymphoma (DLBCL) is a clinically heterogeneous lymphoid malignancy and the most common subtype of non-Hodgkin's lymphoma in adults, with one of the highest mortality rates in most developed areas of the world. More than half of DLBLC patients can be cured with standard R-CHOP regimens, however approximately 30 to 40 % of patients will develop relapsed/refractory disease that remains a major cause of morbidity and mortality due to the limited therapeutic options.Recent advances in gene expression profiling have led to the identification of at least three distinct molecular

Резюме книги для 27th Конгресс Европейской ассоциации гематологии

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UEG Week 2017 Oral Presentations

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UEG Week 2015 Poster Presentations

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