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The interplay of exercise and green tea: a new road in cancer therapy.

Exercise is one of the most important activities for every individual due to its proven health beneficials. Several investigations have highlighted the advantageous impacts of aerobic exercise, largely attributed to its capacity to enhance the body's capability to defend against threats against oxidative stress. The information currently accessible suggests that adding regular aerobic exercise to a daily routine greatly decreases the chances of developing serious cancer and passing away. An unevenness in the levels of free radicals and the body's antioxidant defenses, made up of enzyme and non

Minimally effective concentration of zoledronic acid to suppress osteoclasts in vitro.

Zoledronic acid is regarded as the most potent bisphosphonate and is widely used in patients with osteoporosis; however, its side effects, including acute-phase reactions, gastrointestinal complaints, renal dysfunction and bisphosphonate-associated osteonecrosis impair the safety and quality of life of patients. The present study was designed to determine the minimal effective concentration of zoledronic acid through testing the dose-dependent effects of zoledronic acid on osteoclast suppression. A primary culture of bone marrow mononuclear cells obtained from C57 mice (age, 6 weeks) was estab

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… The combined use of Camellia sinensis and metronomic zoledronic acid in a breast cancer-induced osteolysis mouse model. J Cancer Res Clin Oncol. 2015;141:1025–1036. doi: 10.1007/s00432-014-1882-1. 29. …

Nature-Inspired Strategies in Cancer Management: The Potential of Plant Extracts in Modulating Tumour Biology.

Cancer is a serious group of diseases that is a huge problem on a global scale and is the second most common cause of death. Commonly used therapies do not always lead to the complete elimination of diseased cells or tissues and are also burdened with side effects that reduce the quality of life of patients. Due to these difficulties, new therapeutic approaches are still being sought. In recent years, there has been a return to interest in natural methods of treating various diseases, among which phytochemicals are particularly interesting. This article reviews plant extracts with anticancer p

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… Another well-known compound, epigallocatechin gallate (EGCG) from green tea ( Camellia sinensis ), has been shown to arrest the cell cycle in lung cancer cells by blocking the transition from G1 to S phase. … angiogenesis inhibition—affecting the level of angiogenic/angiostatic mediators: PDGF, HGF, IL-8, IL-6, TIMP-1, and MMP-9 | [ 90 ] Boerhaavia diffusa | Punarnava/Spreading Hogweed | Immunomodulatory effect | [ 103 ] Callisetmon viminalis | Weeping Bottlebrush | Antiangiogenic: angiogenesis inhibition | [ 99 ] Camellia …

Exploring the top 30 drugs associated with drug-induced constipation based on the FDA adverse event reporting system.

ObjectiveThis project aims to identify the top 30 drugs most commonly associated with constipation and their signal values within the FDA Adverse Event Reporting System database.MethodsWe extracted adverse drug events (ADEs) related to constipation from the FAERS database spanning from January 1, 2004, to September 30, 2023. We compiled the 30 most frequently reported drugs based on the frequency of constipation events. We employed signal detection methodologies to ascertain whether these drugs elicited significant signals, including reporting odds ratio, proportional reporting ratio, multi-it

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… Cancer risk associated with lorcaserin - the FDA’s review of the CAMELLIA-TIMI 61 trial. N. Engl. J. Med. 383, 1000–1002. 10.1056/NEJMp2003873 Shirai K., Fujita T., Tanaka M., Fujii Y., Shimomasuda M., Sakai S., et al. (2019). …

Etodolac improves collagen induced rheumatoid arthritis in rats by inhibiting synovial inflammation, fibrosis and hyperplasia.

Synovial hyperplasia is the main cause of chronic rheumatoid arthritis (RA), but the mechanism of synovial hyperplasia is still unclear. Etodolac (ETD) is a selective COX-2 inhibitor for relieving pain and stiffness in RA, but the disease modifying effect is still lack of evidence. Proteomics method was used to study the differential proteome of synovial tissue in collagen induced arthritis (CIA) in rats. With the help of STRING analysis, the upregulated proteins enriched in the cluster of complement and coagulation cascades and platelet degranulation were highlighted, these proteins with fibr

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… Computational aided mechanistic understanding of Camellia sinensis bioactive compounds against co-chaperone p23 as potential anticancer agent. J Cell Biochem. 2019;120(11):19064–19075. doi: 10.1002/jcb.29229. 73. Zhu J, Yan F, Tao J, Zhu X, Liu J, Deng S, Zhang X. …

An evaluation based on the analytic hierarchy process and GGEbiplot on French fry potato genotypes in Yunnan, China.

A total of 33 potato (Solanum tuberosum L.) cultivars and breeding clones imported from the United States and two local cultivars (Yunshu 401 and Cooperation 88, CK) were planted and evaluated. To determine their suitability for processing into French fries at five locations (e1-e5) in Yunnan Province, China, we developed a comprehensive evaluation system using the analytical hierarchy process (AHP). Eleven evaluation indicators for French fry quality, yield, and agronomic characteristics with a relative importance (weight coefficients) of 0.483, 0.301 and 0.216, respectively, were used to ana

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… Comprehensive evaluation of 47 tea [Camellia sinensis (L.) O. Kuntze] germplasm based on entropy weight method and grey relational degree. Genet. Resour. Crop Evol 68 (8), 3257–3270. doi: 10.1007/s10722-021-01184-7 Waxman A., Stark J., Thornton M. K., Olsen N., Guenthner J., Novy R. G. (2018). …

Clinically proven natural products against breast cancer, with mechanistic insights.

BackgroundBreast cancer still stands to be the foremost contributor to cancer-related incidence and mortality in women globally accounting for about 14% of all female cancer-related deaths worldwide. This research seeks to illustrate the mechanisms and clinical findings of natural products against breast cancer treatment.MethodologyRequired data for this review article was retrieved employing several readily obtainable search databases, including Web of Science® (Thomson Reuters, USA), PubMed® (U.S. National Library of Medicine, USA), and SciVerse Scopus® (Elsevier Properties S.A., USA), takin

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… Green tea Green tea, from Camellia sinensis leaves, is an ancient beverage [ 93 ]. The countless positive health impact of green tea is the reason for its prominence in nutraceuticals and functional foods. …

Mechanistic Insights into the Metabolic Pathways and Neuroprotective Potential of Pentacyclic Triterpenoids: In-Depth Analysis of Betulin, Betulinic, and Ursolic Acids.

Due to their complexity, both genotypic and phenotypic, neurodegenerative diseases are one of the main causes of death globally nowadays. Among phytochemicals of high scientific interest, based on experimental studies, pentacyclic triterpenoids (TTs), including mainly betulin, betulinic, and ursolic acid, became targets of scientific research in recent years, especially in terms of their biological activity and pharmacological potential. Due to their anti-inflammatory and antioxidant properties, as well as their involvement in cellular signal transductions, they have been observed to act as an

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… Many medicinal plants and their secondary metabolites (e.g., ginseng, Gingko biloba , Curcuma longa , Bacopa monnieri , Withania somnifera , Camellia sinensis ), have been known for their neuroprotective properties, terpenoids being one of the most noteworthy and extensively researched categories. …

Вытяжка из листа EGb 761* в качестве образца продукта по концепции процесса.

Часто недооценивается тот факт, что экстракты, получаемые с одного и того же растения, могут существенно различаться по их фитохимическому составу, а также по их фармакокинетическим и фармакодинамическим свойствам, которые лежат в основе их клинической эффективности и безопасности. Специальная экстрактная EGb 761- Это... one из наиболее изученных выдержек растений в мире. В настоящем обзоре, используя этот экстракт в качестве парадигмы, мы рассказываем о том, как климат, район сбора урожая, обработка растительного материала, процесс сушки, экстракционные растворители и детали последующих этапо

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… This is intuitive with one of the most straightforward extractions known: infusions of tea [ Camellia sinensis (L.) Kuntze ( Theaceae )] leaves. …

Regulation of microRNAs by natural agents: new strategies in cancer therapies.

MicroRNAs (miRNAs) are short noncoding RNA which regulate gene expression by messenger RNA (mRNA) degradation or translation repression. The plethora of published reports in recent years demonstrated that they play fundamental roles in many biological processes, such as carcinogenesis, angiogenesis, programmed cell death, cell proliferation, invasion, migration, and differentiation by acting as tumour suppressor or oncogene, and aberrations in their expressions have been linked to onset and progression of various cancers. Furthermore, each miRNA is capable of regulating the expression of many

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… Epigallocatechin-3-Gallate (EGCG) The epigallocatechin-3-gallate (EGCG) is the major polyphenol found in green tea ( Camellia sinensis ) with anticancer effects. …

Anti-Cancer Natural Products and Their Bioactive Compounds Inducing ER Stress-Mediated Apoptosis: A Review.

Cancer is the second biggest cause of death worldwide. Despite a number of studies being conducted, the effective mechanism for treating cancer has not yet been fully understood. The tumor-microenvironment such as hypoxia, low nutrients could disturb function of endoplasmic reticulum (ER) to maintain cellular homeostasis, ultimately leading to the accumulation of unfolded proteins in ER, so-called ER stress. The ER stress has a close relation with cancer. ER stress initiates unfolded protein response (UPR) to re-establish ER homeostasis as an adaptive pathway in cancer. However, persistent ER

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… Induction of apoptosis in PNT1a and PC3 cells through CHOP expression, triggering BH3-only proteins, AIF and cleavage of caspase-3,-9 was demonstrated by the treatment of Polyphenol E (derived from Camellia sinensis ) [ 144 ]. …

Cancer Stem Cells: The Potential Targets of Chinese Medicines and Their Active Compounds.

The pivotal role of cancer stem cells (CSCs) in the initiation and progression of malignancies has been rigorously validated, and the specific methods for identifying and isolating the CSCs from the parental cancer population have also been rapidly developed in recent years. This review aims to provide an overview of recent research progress of Chinese medicines (CMs) and their active compounds in inhibiting tumor progression by targeting CSCs. A great deal of CMs and their active compounds, such as Antrodia camphorate, berberine, resveratrol, and curcumin have been shown to regress CSCs, in t

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… . | [ 28 , 88 ] Green tea catechins | The leaf of Camellia sinensis (L.) O. …

Plant-Derived Natural Products in Cancer Research: Extraction, Mechanism of Action, and Drug Formulation.

Cancer is one of the main causes of death globally and considered as a major challenge for the public health system. The high toxicity and the lack of selectivity of conventional anticancer therapies make the search for alternative treatments a priority. In this review, we describe the main plant-derived natural products used as anticancer agents. Natural sources, extraction methods, anticancer mechanisms, clinical studies, and pharmaceutical formulation are discussed in this review. Studies covered by this review should provide a solid foundation for researchers and physicians to enhance basi

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… The main dietary sources of EGCG is green tea ( Camellia sinensis , Theaceae) [ 67 ] and cocoa-based products [ 68 ]. …

Acquired platelet disorders.

Platelets are essential to primary hemostasis, and defects in their number or function can lead to clinically significant bleeding or thrombosis. Acquired platelet disorders are far more common than the inherited forms and arise in a wide range of settings, including drug exposure, autoimmune, systemic, and critical illnesses. This review examines current understanding of the mechanisms driving acquired platelet dysfunction and outlines the diagnostic and therapeutic approaches that are shaping contemporary standards of care. Drug-related and immune-mediated platelet defects remain the most re

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… . ¶ Matcha, a powdered green tea gaining global popularity, is derived from the same plant as regular green tea ( Camellia sinensis ) but contains higher concentrations of catechins, particularly epigallocatechin gallate (EGCG, the main compound responsible for green tea’s antiplatelet effects). …

Prevention of Anthracycline-Induced Cardiotoxicity: The Good and Bad of Current and Alternative Therapies.

Doxorubicin (Dox)-induced cardiotoxicity (DIC) remains a serious health burden, especially in developing countries. Unfortunately, the high cost of current preventative strategies has marginalized numerous cancer patients because of socio-economic factors. In addition, the efficacy of these strategies, without reducing the chemotherapeutic properties of Dox, is frequently questioned. These limitations have widened the gap and necessity for alternative medicines, like flavonoids, to be investigated. However, new therapeutics may also present their own shortcomings, ruling out the idea of "natur

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… Cardioprotective Potential of Quercetin Against DIC Quercetin is an important bioflavonoid, belonging to the class of flavanols, found in numerous plants and plant products such as, Camellia sinensis , grapes and Nasturtium officinale ( Figure 6 ) ( 82 ). …

Osteoprotective Roles of Green Tea Catechins.

Osteoporosis is the second most common disease only secondary to cardiovascular disease, with the risk of fracture increasing with age. Osteoporosis is caused by an imbalance between osteoblastogenesis and osteoclastogenesis processes. Osteoclastogenesis may be enhanced, osteoblastogenesis may be reduced, or both may be evident. Inflammation and high reactive oxygen enhance osteoclastogenesis while reducing osteoblastogenesis by inducing osteoblast apoptosis and suppressing osteoblastic proliferation and differentiation. Catechins, the main polyphenols found in green tea with potent anti-oxida

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… Catechins Tea, brewed from the dried leaves of Camellia sinensis, is a common drink. In 2010, global consumption of tea was 4.52 million tons. Most of the teas are black tea and green tea [ 37 ]. …

Current Perspectives of the Applications of Polyphenols and Flavonoids in Cancer Therapy.

The development of anticancer therapies that involve natural drugs has undergone exponential growth in recent years. Among the natural compounds that produce beneficial effects on human health, polyphenols have shown potential therapeutic applications in cancer due to their protective functions in plants, their use as food additives, and their excellent antioxidant properties. The possibility of combining conventional drugs-which are usually more aggressive than natural compounds-with polyphenols offers very valuable advantages such as the building of more efficient anticancer therapies with l

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… Natural sources of flavan-3-ols are mainly the “tea plant” ( Camellia sinensis ), and some cocoas. Therefore, they are highly present in the human diet in both beverages (tea) and solid foods (chocolates) [ 82 , 98 ]. …

The Role of Plant-Derived Natural Products as a Regulator of the Tyrosine Kinase Pathway in the Management of Lung Cancer.

One of the most common malignant tumors worldwide is lung cancer, and it is associated with the highest death rate among all cancers. Traditional treatment options for lung cancer include radiation, chemotherapy, targeted therapy, and surgical resection. However, the survival rate is low, and the outlook is still dreadfully dire. The pursuit of a paradigm change in treatment approaches is, therefore, imperative. Tyrosine kinases (TKs), a subclass of protein kinases, regulate vital cellular function by phosphorylating tyrosine residues in proteins. Mutations, overexpression, and autocrine parac

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… . | [ 104 ] (-)-Epigallocatechin-3-gallate (EGCG) | Phenolics | Camellia sinensis | Hepatocellular carcinoma and colorectal cancer | Prevented the EGFR-TKs from activating. | [ 105 ] Breast cancer cell invasion | In MCF-7, MCF-7TAM, and MDA-MB-231 cells, EGCG and IIF treatments decreased the migratory …

Targeting Autophagy with Natural Products as a Potential Therapeutic Approach for Cancer.

Macro-autophagy (autophagy) is a highly conserved eukaryotic intracellular process of self-digestion caused by lysosomes on demand, which is upregulated as a survival strategy upon exposure to various stressors, such as metabolic insults, cytotoxic drugs, and alcohol abuse. Paradoxically, autophagy dysfunction also contributes to cancer and aging. It is well known that regulating autophagy by targeting specific regulatory molecules in its machinery can modulate multiple disease processes. Therefore, autophagy represents a significant pharmacological target for drug development and therapeutic

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… Inhibition of the PI3K/AKT/mTOR pathway in HCC | Dietary supplement; several pharmacological actions | A wide range of human cancers | Inhibition of autophagy flux in in the HEKs and CSCC [ 112 , 113 ] Initiation | EGCG, catechin and epicatechin | EGCG | Polyphenols | Coffee plant seeds, Tea leaves of Camellia … Tea made from the leaves of the plant Camellia sinensis is a popular beverage [ 220 ]. …

The nutrigenomic-epigenetic axis in cancer: from dietary bioactives to precision oncology.

Cancer development and progression are increasingly understood to arise from dynamic interactions between genetic alterations and environmentally driven epigenetic regulation, with dietary exposures representing one of the most biologically influential and modifiable factors. Given the expanding evidence linking nutrition to epigenomic remodeling, a comprehensive synthesis of how specific dietary components influence cancer-relevant epigenetic mechanisms is needed to clarify their preventive and therapeutic relevance. This review brings together mechanistic, epidemiologic, and translational fi