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The Value of Torque Teno Virus (TTV) as a Marker for the Degree of Immunosuppression in Adult Patients after Hematopoietic Stem Cell Transplantation (HSCT).

Torque teno virus (TTV) is a nonenveloped, single-stranded, circular DNA virus of the family of Anelloviridae. The first contact with TTV usually occurs in early childhood, followed by persistent infection in bone marrow and lymphocytes. Increased levels of TTV-DNA are found in the serum in various states of immune deficiency. The objective of this study was to assess if monitoring of TTV viremia after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a predictive marker for immune-related clinical complications. In a retrospective study, 2054 whole-blood samples from 123 patie…

Metagenomic Next-Generation Sequencing Reveals Individual Composition and Dynamics of Anelloviruses during Autologous Stem Cell Transplant Recipient Management.

Over recent years, there has been increasing interest in the use of the anelloviruses, the major component of the human virome, for the prediction of post-transplant complications such as severe infections. Due to an important diversity, the comprehensive characterization of this viral family over time has been poorly studied. To overcome this challenge, we used a metagenomic next-generation sequencing (mNGS) approach with the aim of determining the individual anellovirus profile of autologous stem cell transplant (ASCT) patients. We conducted a prospective pilot study on a homogeneous patient

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… The blood viral load monitoring of the torque teno virus (TTV), a virus belonging to the Anelloviridae family, is increasingly proposed in this setting as illustrated by their use for the risk prediction of graft rejection and bacterial infections in solid organ transplant patients [ 2 , 3 , 4 ]. … Human Anelloviridae are also represented by torque teno mini virus (TTMV) and torque teno midi virus (TTMDV) belonging to Betatorquevirus and Gammatorquevirus genera, respectively [ 5 ]. …

Effect of Geographic Isolation on the Nasal Virome of Indigenous Children.

The influence of living in small remote villages on the diversity of viruses in the nasal mucosa was investigated in three Colombian villages with very different levels of geographic isolation. Metagenomic analysis was used to characterize viral nucleic acids in nasal swabs from 63 apparently healthy young children. Sequences from human virus members of the families Anelloviridae, Papillomaviridae, Picornaviridae, Herpesviridae, Polyomaviridae, Adenoviridae, and Paramyxoviridae were detected in decreasing proportions of children. The number of papillomavirus infections detected was greater amo…

Torque Teno Virus Loads as a Marker of Immunosuppression in Pediatric Kidney Transplant Recipients.

BACKGROUND: Long-term renal function and survival after kidney transplantation rely on appropriate immunosuppressive treatment to prevent the risk of rejection. New biomarkers are needed to accurately assess the degree of immunosuppression in renal transplant recipients in order to avoid organ rejection and the development of opportunistic infections. Highly prevalent in humans, torque teno virus (TTV), which belongs to the family Anelloviridae, is a small, nonenveloped, single-stranded DNA virus which has not been linked with any specific human illness, but which constitutes a major component…

Anellovirus loads are associated with outcomes in pediatric lung transplantation.

Anelloviruses are DNA viruses ubiquitously present in human blood. Due to their elevated levels in immunosuppressed patients, anellovirus levels have been proposed as a marker of immune status. We hypothesized that low anellovirus levels, reflecting relative immunocompetence, would be associated with adverse outcomes in pediatric lung transplantation. We assayed blood samples from 57 patients in a multicenter study for alpha- and betatorquevirus, two anellovirus genera. The primary short-term outcome of interest was acute rejection, and longer-term outcomes were analyzed individually and as "c

Cervicovaginal DNA Virome Alterations Are Associated with Genital Inflammation and Microbiota Composition.

While the link between the cervicovaginal bacterial microbiome, human papillomavirus (HPV) infection, and cervical cancer is recognized (P. … ion was associated with decreased virome richness and alpha diversity and an increased abundance of Anelloviridae species from the genus Alphatorquevirus. Lactobacillus bacteriophages were closely associated with increased Lactobacillus abundance, consistent with phage-host relationships. Interestingly, bacteria-bacteriophage transkingdom interactions were link …

Ancient dental pulp: Masterpiece tissue for paleomicrobiology.

INTRODUCTION: Dental pulp with special structure has become a good reference sample in paleomicrobiology-related blood-borne diseases, many … kettsia prowazeki, Staphylococcus aureus, Borrelia recurrentis, Bartonella henselae) and one virus (Anelloviridae) were identified. Y. pestis had the most published in quantity and all methods were investigated for this pathogen, S. aureus and B. recurrentis were identified by three different methods and others only by one. The combining methods interestingly i …

Dysbiosis of fecal virome in pediatric Crohn's disease and its dynamic changes during infliximab therapy.

UNLABELLED: The gut virome is an emerging but underexplored component of the human microbiota, especially in pediatric Crohn's disease (CD). … ut virome, with remission associated with higher abundances of Microviridae and Siphoviridae, while Anelloviridae, Myoviridae, and Podoviridae were enriched in IFX-NR at baseline. These findings suggest the virome as a potential biomarker for predicting clinical outcome in pediatric CD, offering a novel avenue for disease diagnosis and personalized treatment st …

Establishment and Application of a Duplex TaqMan Real-Time PCR Assay for Simultaneous Detection of Chicken Anemia Virus (CAV) and Gyrovirus Galga 1 (GyVg1).

Both Chicken anemia virus (CAV) and Gyrovirus galga 1 (GyVg1) belong to the family Anelloviridae and genus Gyrovirus. They are non-enveloped, single-stranded circular DNA viruses that can infect chicken populations, leading to similar clinical symptoms such as growth retardation and immunosuppression, making clinical differentiation challenging. This study established a duplex TaqMan real-time PCR assay to simultaneously detect CAV and GyVg1. Specific primers and probes were developed to target the VP3 gene of CAV (labeled with VIC) and the VP1 gene of GyVg1 (labeled with FAM). The optimizatio…

Comparative viral load analysis of torque Teno virus and Torque teno mini virus in COVID-19 infected and non-infected individuals in the United Arab Emirates.

BACKGROUND: Torque teno virus (TTV) and Torque teno mini virus (TTMV) are highly prevalent, non-pathogenic viruses from the Anelloviridae family that commonly circulate in healthy individuals. Their replication dynamics are closely linked to the host immune status, with viral loads typically increasing during immune suppression or dysregulation associated with viral infections, transplantation, or chronic inflammation. Emerging evidence suggests that TTV may serve as a biomarker of immune competence, with increasing interest in its role during SARS-CoV-2 infection. This study investigated the …

Women suffering from overactive bladder syndrome exhibit a higher urethral viral abundance compared to healthy controls: a pilot study.

The interactions between the human bacterial microbiome and essential bodily functions are well established for organ systems such as the oral cavity, gut, and female reproductive tract. However, the urinary microbiome, particularly its viral component, remains largely unexplored. Emerging evidence suggests that the urinary microbiome may play a significant role in the development of overactive bladder syndrome (OAB). This study aims to fill this knowledge gap by investigating the potential link between the urethral virome and female overactive bladder syndrome, and by aligning these findings

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… NCBI_tax Family Species Host Positive OAB Negative 1 ( n = 5) 2 ( n = 5) 3 ( n = 5) 4 ( n = 5) 120,381 Papillomaviridae Human papillomavirus type 87 HUMAN 3 0 0 0 10,596 Papillomaviridae Human papillomavirus type 56 HUMAN 1 0 0 0 687,358 Anelloviridae Torque Teno Virus 19 HUMAN 1 0 0 0 687,368 Anelloviridae … NCBI_tax | Family | Species | Host | Positive OAB | Negative 1 ( n = 5) | 2 ( n = 5) | 3 ( n = 5) | 4 ( n = 5) 120,381 | Papillomaviridae | Human papillomavirus type 87 | HUMAN | 3 | 0 | 0 | 0 10,596 | Papillomaviridae | Human papillomavirus type 56 | HUMAN | 1 | 0 | 0 | 0 687,358 | Anelloviridae | Torque …

The Impact of Human Microbiotas in Hematopoietic Stem Cell and Organ Transplantation.

The human microbiota heavily influences most vital aspects of human physiology including organ transplantation outcomes and transplant rejection risk. A variety of organ transplantation scenarios such as lung and heart transplantation as well as hematopoietic stem cell transplantation is heavily influenced by the human microbiotas. The human microbiota refers to a rich, diverse, and complex ecosystem of bacteria, fungi, archaea, helminths, protozoans, parasites, and viruses. Research accumulating over the past decade has established the existence of complex cross-species, cross-kingdom interac

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… A notable number of studies report the notable predominance of Anelloviridae (such as the TTV) in lung transplant recipient–sourced bronchoalveolar lavage and oropharyngeal wash samples ( 223 , 232 – 234 ). … A recent study analyzing the plasma virome of liver transplant recipients both pre- and post-liver transplant reported an Anelloviridae bloom dominating the immunosuppressed post-transplant plasma virome that was accompanied by several complications. …

Регулирование на основе Virobiome микробиота-гут-мозговой оси сигнализирует и нейроиммунный гомеостаз.

Ось человеческого кишечника все чаще признается как сложная двунаправленная коммуникационная система, объединяющая микробные, нейронные, эндокринные и иммунные сети, формирующие неврологическое здоровье. Хотя бактериальный вклад в этот диалог получил широкую окраску, вирусный компонент кишечной экосистемы, виром, стал важным компонентом, связанным с физиологическим регулированием принимающей стороны. В этом обзоре обобщены данные, свидетельствующие о том, что бактериофаги и эукариотические вирусы могут способствовать микробному и иммунальному гомеостазу и оказывать влияние на сигнализацию вдол

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… The Anelloviridae family of viruses is widespread in human populations, particularly in immunocompromised individuals [ 46 ]. … Anelloviruses , specifically members of the Anelloviridae family such as Torque teno virus (TTV) , are small, circular, single-stranded DNA viruses that are highly prevalent in human populations, especially in immunocompromised individuals [ 244 ]. …

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