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The metabolites from traditional Chinese medicine targeting ferroptosis for cancer therapy.

Cancer is a major disease with ever-increasing morbidity and mortality. The metabolites derived from traditional Chinese medicine (TCM) have played a significant role in combating cancers with curative efficacy and unique advantages. Ferroptosis, an iron-dependent programmed death characterized by the accumulation of lipid peroxide, stands out from the conventional forms of cell death, such as apoptosis, pyroptosis, necrosis, and autophagy. Recent evidence has demonstrated the potential of TCM metabolites targeting ferroptosis for cancer therapy. We collected and screened related articles publ

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… decreased DDP-induced elevation of the binding of Nrf2 to the HO-1 promoter, thus decreasing HO-1 nuclear expression and reversing DDP-induced HO-1 nuclear translocation, ultimately enhancing the therapeutic effect of DDP ( Lou et al., 2021 ). 3.4 Saponin Ophiopogonin B (OP-B) is a saponin extracted from Ophiopogon … Ker Gawl. [ Asparagaceae ; Ophiopogon japonicus root tuber ]. …

A review of chemotherapeutic drugs-induced arrhythmia and potential intervention with traditional Chinese medicines.

Significant advances in chemotherapy drugs have reduced mortality in patients with malignant tumors. However, chemotherapy-related cardiotoxicity increases the morbidity and mortality of patients, and has become the second leading cause of death after tumor recurrence, which has received more and more attention in recent years. Arrhythmia is one of the common types of chemotherapy-induced cardiotoxicity, and has become a new risk related to chemotherapy treatment, which seriously affects the therapeutic outcome in patients. Traditional Chinese medicine has experienced thousands of years of cli

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… mainly composed of Huangqi (Astragalus), Taizishen (Pseudostellaria heterophylla), Chuanxiong (Ligusticum chuanxiong), Danggui (Angelica sinensis), Chishao (Paeonia lactiflora), Taoren (Persica), Honghua (Carthamus tinctorius), Niuxi (Achyranthes bidentata), Banxia (Pinellia ternata), and Maidong (Ophiopogon … and autophagy to reduce the cardiotoxicity of anthracyclines. ( Wang et al., 2021 ). 4.2.2 Tongmai Yangxin Pill Tongmai Yangxin Pill (TMYXP) is a traditional Chinese medicine (TCM) that primarily contains ingredients such as Dihuang (Rehmannia glutinosa), Jixueteng (Millettia speciosa), Maidong (Ophiopogon …

Research Progress on Chinese Herbal Medicine Components Targeting Ferroptosis for Cancer Therapy.

Recent studies indicate that ferroptosis shows unique advantages in oncotherapy, particularly in reversing multidrug resistance (MDR). Despite current therapeutic advancements, the treatment of high-incidence malignancies with dismal prognoses continues to face challenges, including limited clinical efficacy, significant side effects, and drug resistance. In recent years, Chinese herbal medicine (CHM) has gained increasing attention in anti-tumor therapy. CHM bioactive components are highly effective in inducing tumor cell ferroptosis, inhibiting tumor proliferation and migration, and reversin

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… Ophiopogonin B (OP-B), a saponin isolated from Ophiopogon japonicus , induces ferroptosis in NSCLC by suppressing the expression of the oncogene aurora kinase A (AURKA) [ 72 ]. …

CHAC1: a master regulator of oxidative stress and ferroptosis in human diseases and cancers.

CHAC1, an essential regulator of oxidative stress and ferroptosis, is increasingly recognized for its significant roles in these cellular processes and its impact on various human diseases and cancers. This review aims to provide a comprehensive overview of CHAC1's molecular functions, regulatory mechanisms, and effects in different pathological contexts. Specifically, the study objectives are to elucidate the biochemical pathways involving CHAC1, explore its regulatory network, and discuss its implications in disease progression and potential therapeutic strategies. As a γ-glutamyl cyclotrans

Targeting Autophagy with Natural Products as a Potential Therapeutic Approach for Cancer.

Macro-autophagy (autophagy) is a highly conserved eukaryotic intracellular process of self-digestion caused by lysosomes on demand, which is upregulated as a survival strategy upon exposure to various stressors, such as metabolic insults, cytotoxic drugs, and alcohol abuse. Paradoxically, autophagy dysfunction also contributes to cancer and aging. It is well known that regulating autophagy by targeting specific regulatory molecules in its machinery can modulate multiple disease processes. Therefore, autophagy represents a significant pharmacological target for drug development and therapeutic

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… cancers | [ 149 , 150 , 151 ] Nucleation | Polyphyllin D | | Steroidal saponin | Paris polyphylla | Increasing LC3-II and Beclin1 levels | Fevers, headaches, burns, and wounds, and treatment of snake venom | Human breast cancer cells | [ 152 ] Nucleation | Ophiopogonin B | | Saponin compound | Radix Ophiopogon …

Abstracts of the 12th European Cytogenomics Conference 2019 : Salzburg, Austria. 6-9 July 2019

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