Результаты поиска

Обнаружение сфингосин-1-Фосфатных модуляторов-рецепторов в качестве потенциальных CHI3L1 Inhibitors с помощью лигандского виртуального скрининга и моделирования молекулярной динамики.

Множественный склероз характеризуется воспалением центральной нервной системы, обезвоживанием и нейронным дегенерацией. Нынешние методы диагностики и прогнозирования не являются точными, что требует использования биомаркеров для индивидуализированных методов лечения. Читинас 3-подобный 1 (CHI3L1) стал потенциальным прогнозным маркером с повышенными уровнями, связанными с серьезностью заболеваний и риском рецидива. Несмотря на его терапевтический потенциал, было выявлено несколько ингибиторов CHI3L1. На основе виртуального скрининга на основе лиганда и моделирования молекулярной динамики разреш

Совпадение в полном тексте источника
… This list encompasses various drug families, including kinase inhibitors like cabozantinib, alpha-1 adrenergic antagonists such as terazosin and dixazosin, and anti-inflammatory medications such as nabumetone and phenylbutazone. …

Medicine manipulation: An alternative to mitigate therapeutic gaps in the Brazilian Unified Health System?

Despite the various initiatives carried out in Brazil and in the world, the challenge of offering essential medicines in adequate presentations remains, especially to the public affected by diseases considered neglected and the pediatric population, for whom the therapeutic options remain limited. The main objective of this study was to evaluate the production of manipulated medicines as a strategy to mitigate therapeutic and access gaps to essential medicines within the Brazilian public health system, called the Unified Health System (SUS). The evaluation, carried out between 2020 and 2021, i

Совпадение в полном тексте источника
… camphor, acetaminophen, carbamazepine, paraquat, chlordiazepoxide, parathion, chlorpheniramine, penicillin, chloroquine, silver, cocaine, primaquine, colchicine, probenecid, propoxyphene, propantheline, diazepam, mepacrine, digitalis, quinidine, strychnine, quinine, ethchlorvynol, methyl salicylate, phenylbutazone …

The Dynamic Role of Curcumin in Mitigating Human Illnesses: Recent Advances in Therapeutic Applications.

Herbal medicine, particularly in developing regions, remains highly popular due to its cost-effectiveness, accessibility, and minimal risk of adverse effects. Curcuma longa L., commonly known as turmeric, exemplifies such herbal remedies with its extensive history of culinary and medicinal applications across Asia for thousands of years. Traditionally utilized as a dye, flavoring, and in cultural rituals, turmeric has also been employed to treat a spectrum of medical conditions, including inflammatory, bacterial, and fungal infections, jaundice, tumors, and ulcers. Building on this longstandin

Совпадение в полном тексте источника
… . | [ 236 ] In vivo | Curcumin is less ulcerogenic than phenylbutazone and exerts anti-inflammatory activity that is comparable to that of phenylbutazone. …

Some Aspects and Convergence of Human and Veterinary Drug Repositioning.

Drug innovation traditionally follows a de novo approach with new molecules through a complex preclinical and clinical pathway. In addition to this strategy, drug repositioning has also become an important complementary approach, which can be shorter, cheaper, and less risky. This review provides an overview of drug innovation in both human and veterinary medicine, with a focus on drug repositioning. The evolution of drug repositioning and the effectiveness of this approach are presented, including the growing role of data science and computational modeling methods in identifying drugs with po

Совпадение в полном тексте источника
… . | IM Phenylbutazone H | Phen-Pred | 2284/1/07 MgSzH ÁTI | 8 November 1999 | National authorization | Dog | For the treatment of inflammatory diseases of the musculoskeletal system (arthritis, tendinitis, rheumatism), hyperthermia, heat stroke, and inflammatory processes of traumatic or bacterial origin … Active Ingredient INN | Species | IC 50 − COX-1 (µM) | IC 50 − COX-2 (µM) | COX-1:COX-2 | Reference Metamizole sodium | Dog | 350 | >1000 | <1 | [ 191 , 192 ] Phenylbutazone | Dog | 17 | 28 | 0.6–9.7 | [ 193 , 194 , 195 ] Tolfenamic acid | Dog | - | 3.53 | 0.06–15 | [ 196 , 197 , 198 , 199 ] Cat | - …

Multisystemic sarcoidosis-important lessons learnt from one of the great imitators.

We report a case of a woman who was admitted with a suspicion of metastatic malignancy of unknown primary origin. A few months prior to her admission, she presented to a rheumatologist with acute anterior uveitis, psoriasiform rashes and polyarthritis. A diagnosis of psoriatic arthropathy was made and she was treated accordingly. Soon after she presented with persistent back and right upper quadrant abdominal pain for which she had a CT scan done with evidence of hilar lymphadenopathy, liver hypodensities and lytic-sclerotic bone lesions. She was referred to our hospital for further investigat

Совпадение в полном тексте источника
… Polyarteritis nodosa Giant cell arteritis Systemic lupus erythematosus Primary biliary cirrhosis Crohn’s disease Rheumatoid arthritis Idiopathic Sarcoidosis Neoplastic Haematologic malignancy Lymphoma—in particular Hodgkin’s lymphoma Intra-abdominal neoplasms Others Drugs Allopurinol Carbamazepine Isoniazid Phenylbutazone …

Сердечно-сосудистые заболевания

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… Tetracycline, phenylbutazone (not to be used in dairy cattle over 20 months of age), and IV sodium iodide also are capable of causing a severe thrombophlebitis when inadvertent perivascular leaking occurs. … Tissue necrosis associated with extremely irritating drugs (e.g., 50% dextrose, 20% sodium iodide, and phenylbutazone) placed perivascularly or resulting in thrombophlebitis eventually will cause sloughing, cellulitis, or sterile abscess formation. …

Сердечно-сосудистые заболевания

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Googling the Guggul (Commiphora and Boswellia) for Prevention of Chronic Diseases.

Extensive research during last 2 decades has revealed that most drugs discovered today, although costs billions of dollars for discovery, and yet they are highly ineffective in their clinical response. For instance, the European Medicines Agency has approved 68 anti-cancer drugs, and out of which 39 has reached the market level with no indication of increased survival nor betterment of quality of life. Even when drugs did improve survival rate compared to available treatment strategies, most of these were found to be clinically insignificant. This is a fundamental problem with modern drug disc

Совпадение в полном тексте источника
… Comparison of the anti-inflammatory activity of C. mukul (an indigenous drug) with those of phenylbutazone and ibuprofen in experimental arthritis induced by mycobacterial adjuvant. Arzneimittelforschung 27, 1455–1457. Sharma M. L., Bani S., Singh G. B. (1989). …

Acute myeloid leukemia: from NGS, through scRNA-seq, to CAR-T. dissect cancer heterogeneity and tailor the treatment.

Acute myeloid leukemia (AML) is a malignant blood cancer with marked cellular heterogeneity due to altered maturation and differentiation of myeloid blasts, the possible causes of which are transcriptional or epigenetic alterations, impaired apoptosis, and excessive cell proliferation. This neoplasm has a high rate of resistance to anticancer therapies and thus a high risk of relapse and mortality because of both the biological diversity of the patient and intratumoral heterogeneity due to the acquisition of new somatic changes. For more than 40 years, the old gold standard "one size fits all"

Совпадение в полном тексте источника
… Syndrome - Wiskott-Aldrich Syndrome - Ataxia-teleangiectasia - Down Syndrome - Klinefelter Syndrome - Patau Syndrome - Germline mutations Chemotherapy drugs | - Alkylating agents: cyclophosphamide, melphalan, nitrogen mustard - Topoisomerase II inhibitors: etoposide, teniposide - Chloramphenicol - Phenylbutazone …

Lost in Translation (LiT): IUPHAR Review 6.

Translational medicine is a roller coaster with occasional brilliant successes and a large majority of failures. Lost in Translation 1 ('LiT1'), beginning in the 1950s, was a golden era built upon earlier advances in experimental physiology, biochemistry and pharmacology, with a dash of serendipity, that led to the discovery of many new drugs for serious illnesses. LiT2 saw the large-scale industrialization of drug discovery using high-throughput screens and assays based on affinity for the target molecule. The links between drug development and university sciences and medicine weakened, but t

Совпадение в полном тексте источника
… Aplastic anaemia with chloramphenicol, phenylbutazone and oxyphenbutazone led to their withdrawal or severe limitations on their use in the mid‐1970s. …

A Comprehensive Review on the Therapeutic Potential of Curcuma longa Linn. in Relation to its Major Active Constituent Curcumin.

Curcuma longa Linn. (C. longa), popularly known as turmeric, belongs to the Zingiberaceae family and has a long historical background of having healing properties against many diseases. In Unani and Ayurveda medicine, C. longa has been used for liver obstruction and jaundice, and has been applied externally for ulcers and inflammation. Additionally, it is employed in several other ailments such as cough, cold, dental issues, indigestion, skin infections, blood purification, asthma, piles, bronchitis, tumor, wounds, and hepatic disorders, and is used as an antiseptic. Curcumin, a major constitu

Совпадение в полном тексте источника
… Curcumin is equally efficacious as cortisone or phenylbutazone when given orally in acute inflammation . C. longa given orally to reduce inflammatory edema considerably. …

DNA Damaging Drugs

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Biology and Diseases of Dogs

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Р

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Emergency Care

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Hematopoietic Tumors

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… However, a retrovirus with morphology typical of lentiviruses has been isolated from mononuclear cells obtained from the peripheral blood of a dog with ALL. 270 In humans, acute leukemia has been associated with exposure to radiation, benzene, phenylbutazone, and antineoplastic agents. 271 , 272 , 273 …

Hematopoietic Tumors

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Diseases of the Nervous System

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Резюме книги для 27th Конгресс Европейской ассоциации гематологии

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.