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β-Glucan as Trained Immunity-Based Adjuvants for Rabies Vaccines in Dogs.

The mechanisms of trained immunity have been extensively described in vitro and the beneficial effects are starting to be deciphered in in v … he adaptive immune response of an inactivated rabies vaccine (Rabisin®). Injection of β-glucan from Euglena gracilis was performed 1 month before vaccination with Rabisin® supplemented or not with the same β-glucan used as adjuvant. Trained innate immunity parameters were assessed during the first month of the trial. The second phase of the study was focused on th …

Serum pyridoxal in active peptic ulceration.

Fasting serum pyridoxal was assayed by an automated microbiological system in 50 patients with endoscopically confirmed active peptic ulceration. Thirty patients had gastric ulceration, 14 had duodenal, four had pyloric canal ulceration, and two had both a gastric and a duodenal ulcer. Serum pyridoxal was below normal in 28 of the gastric ulcer group and in one of the duodenal ulcer group. No difference in the age, sex, drug, alcohol intake, or diet could be distinguished between those two groups.

Intelligent image-activated sorting of large cells enabled by elasto-inertial focusing.

Image-activated cell sorting (IACS) enables high-speed sorting of cells based on real-time analysis of their images, providing a powerful me … nt rate of 172 events per second (eps). Finally, we realized elasto-inertial focusing-based IACS of Euglena gracilis, a large microalgal cell species, based on intracellular lipid droplet formation, demonstrating 4.5-fold enrichment of target cells from 11.9% to 53.8% at 128 eps. Our work highlights that IACS based on elasto-inertial focusing enables the sorting o …

Effect of 10 freshwater microalgae on in vitro methane mitigation and rumen fermentation.

Agriculture is at the pivot point between anthroposphere, biosphere, and atmosphere. Innovative solutions are needed to reduce agricultural emissions and improve sustainability. Microalgae animal feed could be such a solution. This study aimed to evaluate the effects of 10 freshwater microalgae: Auxenochlorella protothecoides, Chlamydomonas pulvinate, Chlorella luteoviridis, Chlorella variabilis, Euglena mutabilis, Parachlorella kessleri, Stichococcus bacillaris, Tetradesmus acuminatus, Tetradesmus obliquus, and Tetraselmis gracilis, on ruminal methane (CH4) production, nutrient digestibility,

Comparison in Structure and Immunomodulatory Activities of β-Glucans Derived From Yeast and Euglena.

The molecular architecture and physicochemical traits of β-glucans vary among their sources, potentially influencing their biological activity. In this study, we analyzed the molecular configurations of four β-glucans sourced from yeast and euglena, and assessed their impact on immune regulation using RAW264.7 macrophages activated by lipopolysaccharide (LPS). The findings revealed that yeast-derived β-glucans have a smaller particle size than those from euglena, yet the yeast β-glucans possess a higher molecular weight. The ratio of glycoside bonds indicated that yeast β-glucans possess side

Suppressive action of docosahexaenoic acid enriched-Euglena on reduction of endothelium-dependent relaxation in stroke-prone spontaneously hypertensive rats (SHRSP).

Stroke-prone spontaneously hypertensive rats (SHRSP) were fed a diet containing docosahexaenoic acid (DHA)-enriched Euglena glacilis (DHA-Euglena) as the protein source from 5 weeks of age. The effects on endothelial functions were investigated by perfusion experimentation using mesenteric vasculature, and compared with the effects of antihypertensive drugs. (1) At 13 weeks of age, SHRSP fed the DHA-Euglena diet showed an average blood pressure of 220 mmHg, which was 20 mmHg lower (p < 0.05) than that in the control group, while SHRSP of the captopril-treated group (angiotensin I converting en

An evaluation of simultaneously administered free and intrinsic factor bound radioactive cyanocobalamin in the diagnosis of pernicious anaemia in the elderly.

The definitive diagnosis of pernicious anaemia (PA) in the elderly is by no means always straightforward, particularly when inappropriate medication has been introduced before the institution of specific investigatory procedures. A detailed haematological study was carried out on 301 patients aged 60-95 with a serum B(12) concentration at the laboratory's lower level of normal of 150 ng per litre (Euglena gracilis assay). The diagnosis of PA was based on strict predetermined haematological criteria. All patients were subsequently studied by the simultaneous oral administration of the dual isot…

The Gut-Bone Marrow Axis: Deciphering the Mechanistic Impact of Microbial Metabolites on Hematopoietic Homeostasis and Disorders.

The gut microbiota is increasingly recognized as a dynamic endocrine-like microbial network that exerts systemic effects far beyond the gastrointestinal tract. Emerging evidence supports the existence of a "gut-bone marrow axis" through which gut-derived signals orchestrate hematopoietic homeostasis. However, shifting from correlative observations to causal mechanisms remains a major challenge in defining precise microbial impacts on hematopoietic outcomes. In this review, we systematically synthesize current knowledge on the molecular mechanisms by which microbial products-specifically short-

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… Improvement of intestinal iron absorption in patients with anemia | FOS, GOS, Inulin, Resistant Starch, Euglena gracilis paramylon, Glutamine-Fiber-Oligosaccharide(GFO) | [ 95 ] [ 96 ] [ 97 ] Synbiotics | Synergistically promote the proliferation of beneficial bacteria, enhance immune modulation, and …

Unlocking the Therapeutic Potential of Algae-Derived Compounds in Hematological Malignancies.

Algae are a rich source of bioactive compounds that have a wide range of beneficial effects on human health and can show significant potential in the treatment of hematological malignancies such as leukemia, lymphoma, and multiple myeloma. These diseases often pose a therapeutic challenge despite recent advances in treatment (e.g., the use of immunomodulatory drugs, proteasome inhibitors, CD38 monoclonal antibodies, stem cell transplant, and targeted therapy). A considerable number of patients experience relapses or resistance to the applied therapies. Algal compounds, alone or in combination

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… However, some studies reported that paramylon (β-1,3-glucan) isolated from microalga Euglena gracilis may have antitumor properties [ 19 , 25 , 96 ]. Exopolysaccharides (EPSs) were extracted from the marine microalga Tetraselmis suecica grown in autotrophic or heterotrophic conditions [ 97 ]. … Metabolomic Analysis and Pathway Profiling of Paramylon Production in Euglena Gracilis Grown on Different Carbon Sources Int. J. Biol. Macromol. 2023 246 125661 10.1016/j.ijbiomac.2023.125661 37399871 97. Parra-Riofrío G. García-Márquez J. Casas-Arrojo V. Uribe-Tapia E. Abdala-Díaz R.T. …