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Revolutionising health care: Exploring the latest advances in medical sciences.

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… Wang Z, Xiang L, Lin F, Tang Y, Cui W.3D bioprinting of emulating homeostasis regulation for regenerative medicine applications. J Control Release. 2023;353:147-65. 10.1016/j.jconrel.2022.11.035 12. … Biomedical applications of three-dimensional bioprinted craniofacial tissue engineering. Bioeng Transl Med. 2022;8:e10333. 66. Ventola CL.Medical Applications for 3D Printing: Current and Projected Uses. P&T. 2014;39:704-11. 67. …

In Vivo Bone Tissue Engineering Strategies: Advances and Prospects.

Reconstruction of critical-sized bone defects remains a tremendous challenge for surgeons worldwide. Despite the variety of surgical techniques, current clinical strategies for bone defect repair demonstrate significant limitations and drawbacks, including donor-site morbidity, poor anatomical match, insufficient bone volume, bone graft resorption, and rejection. Bone tissue engineering (BTE) has emerged as a novel approach to guided bone tissue regeneration. BTE focuses on in vitro manipulations with seed cells, growth factors and bioactive scaffolds using bioreactors. The successful clinical

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… Currently, bioprinting-based vascularization strategy represents the most advanced technology of vascular network creation. 3D bioprinting of the vascular network is a promising approach, however, further preclinical studies are required [ 159 ]. … Progress in 3D bioprinting technology for tissue/organ regenerative engineering. Biomaterials. 2020;226:119536. doi: 10.1016/j.biomaterials.2019.119536. 66. Bahraminasab M. Challenges on optimization of 3D-printed bone scaffolds. Biomed. Eng. …

Advanced 3D Magnetic Scaffolds for Tumor-Related Bone Defects.

The need for bone substitutes is a major challenge as the incidence of serious bone disorders is massively increasing, mainly attributed to modern world problems, such as obesity, aging of the global population, and cancer incidence. Bone cancer represents one of the most significant causes of bone defects, with reserved prognosis regarding the effectiveness of treatments and survival rate. Modern therapies, such as hyperthermia, immunotherapy, targeted therapy, and magnetic therapy, seem to bring hope for cancer treatment in general, and bone cancer in particular. Mimicking the composition of

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… Currently, the most advanced method for obtaining scaffolds is 4D-printing, composed of 3D bioprinting and time integrated, as the fourth dimension. … Polymers and composites imprinting and 3D bioprinting are increasingly considered for bone tissue engineering in order to obtain feedback-regulated architecture. …

Biomimetic materials for medical applications.

AbstractRecent advances in biomedical research have facilitated the exploration of biomimetic materials and their potential for diagnosing and treating diseases. This review synthesizes reports of recent research into biomimetic materials and provides a focused analysis of their therapeutic and diagnostic efficacy across multiple physiological systems, including the locomotor, digestive, respiratory, urinary, endocrine, nervous, integumentary, hematopoietic, and circulatory systems. These findings highlight the transformative potential of these materials in the management of systemic diseases.

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… Kaith et al [ 125 ] explored the application of 3D bioprinting in tissue engineering and highlighted the effectiveness of manufacturing biofunctional scaffolds from polysaccharides in simulating the native tissue environment. …

Musculoskeletal Organs-on-Chips: An Emerging Platform for Studying the Nanotechnology-Biology Interface.

Nanotechnology-based approaches are promising for the treatment of musculoskeletal (MSK) disorders, which present significant clinical burdens and challenges, but their clinical translation requires a deep understanding of the complex interplay between nanotechnology and MSK biology. Organ-on-a-chip (OoC) systems have emerged as an innovative and versatile microphysiological platform to replicate the dynamics of tissue microenvironment for studying nanotechnology-biology interactions. This review first covers recent advances and applications of MSK OoCs and their ability to mimic the biophysic

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… For example, it necessitates additional steps for introducing and organizing the cells. [ 141 ] Besides, the need for multiple photolithographic processes and masks restricts the fabrication capabilities of soft lithography. [ 142 ] 3D Bioprinting Compared to soft lithography, 3D bioprinting in medical … can be categorized into nozzle‐based bioprinting, including inkjet and extrusion bioprinting, and photobioprinting, such as stereolithography (SLA) and laser‐assisted bioprinting (Figure 4B ). [ 145 , 146 ] These techniques can be employed to produce the tissues and/or microfluidic devices for MSK OoCs …

Rhabdomyosarcoma: Current Therapy, Challenges, and Future Approaches to Treatment Strategies.

Rhabdomyosarcoma is a rare cancer arising in skeletal muscle that typically impacts children and young adults. It is a worldwide challenge in child health as treatment outcomes for metastatic and recurrent disease still pose a major concern for both basic and clinical scientists. The treatment strategies for rhabdomyosarcoma include multi-agent chemotherapies after surgical resection with or without ionization radiotherapy. In this comprehensive review, we first provide a detailed clinical understanding of rhabdomyosarcoma including its classification and subtypes, diagnosis, and treatment str

Upcoming Revolutionary Paths in Preclinical Modeling of Pancreatic Adenocarcinoma.

To date, PDAC remains the cancer having the worst prognosis with mortality rates constantly on the rise. Efficient cures are still absent, despite all attempts to understand the aggressive physiopathology underlying this disease. A major stumbling block is the outdated preclinical modeling strategies applied in assessing effectiveness of novel anticancer therapeutics. Current in vitro preclinical models have a low fidelity to mimic the exact architectural and functional complexity of PDAC tumor found in human set, due to the lack of major components such as immune system and tumor microenviron

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… Bioprinting of 3D hydrogels. Lab Chip. (2015) 15:3111–5. 10.1039/C5LC90069G 76. Nakamura M, Iwanaga S, Henmi C, Arai K, Nishiyama Y. Biomatrices and biomaterials for future developments of bioprinting and biofabrication. Biofabrication. (2010) 2:014110. 10.1088/1758-5082/2/1/014110 77. … Bioprinting for cancer research. Trends Biotechnol. (2015) 33:504–13. 10.1016/j.tibtech.2015.06.007 84. Ma X, Liu J, Zhu W, Tang M, Lawrence N, Yu C, et al. 3D bioprinting of functional tissue models for personalized drug screening and in vitro disease modeling. …

Correlation analysis of serum CCL3, TRACP-5b, and sclerostin with the prognosis of multiple myeloma patients.

BACKGROUND: To investigate the clinical use of Sclerostin, tartrate-resistant acid phosphatase 5b (TRACP-5b), and serum C-C motif chemokine ligand 3 (CCL3) levels in assessing the health and prognosis of patients with multiple myeloma. METHODS: A total of 250 patients with multiple myeloma who visited the hospital between January 2023 and December 2024 were included as the observation group, while 150 healthy individuals evaluated during the same period served as the control group. Serum levels of CCL3, TRACP-5b, and Sclerostin were measured and compared in the observation group before and aft

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… Research progress of 3D-bioprinted functional pancreas and in vitro tumor models International Journal of Bioprinting. 2024;10(1):1256. doi: 10.36922/ijb.1256. 33. You H, Yao W, Yan L, Zhai Y, Yan Z, Shang J, Yan S, Shi X, Jin S, Ge X, Shen H, Pan J, Wu D, Fu C. …

Perspective Applications and Associated Challenges of Using Nanocellulose in Treating Bone-Related Diseases.

Bone serves to maintain the shape of the human body due to its hard and solid nature. A loss or weakening of bone tissues, such as in case of traumatic injury, diseases (e.g., osteosarcoma), or old age, adversely affects the individuals quality of life. Although bone has the innate ability to remodel and regenerate in case of small damage or a crack, a loss of a large volume of bone in case of a traumatic injury requires the restoration of bone function by adopting different biophysical approaches and chemotherapies as well as a surgical reconstruction. Compared to the biophysical and chemothe

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… Potential and limitations of nanocelluloses as components in biocomposite inks for three-dimensional bioprinting and for biomedical devices. Biomacromolecules 19 701–711.. 10.1021/acs.biomac.8b00053 oli M., Tomi S., Beki M. (2020). Immunological aspects of nanocellulose. Immunol. … The use of bacterial polysaccharides in bioprinting. Biotechnol. Adv. 37:107448. 10.1016/j.biotechadv.2019.107448 McCarthy R. R., Ullah M. W., Pei E., Yang G. (2019b). Antimicrobial inks: the anti-infective applications of bioprinted bacterial polysaccharides. …

Отчет о ДИД 1st Ежегодный Всемирный конгресс биомедицинской инженерии, проводимый в Сиане, Китай, 9-11 ноябрь 2017.

Мы рады представить на этом заседании резюме доклада "ДИД" 1st Всемирный конгресс биомедицинской инженерии 2017которая была проведена в Сиане в Китае [...].

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… Considering that the 3D bioprinting materials (Bioinks) are the key for 3D bioprinting, we start to develop and manufactureLAP (blue light initiator), and a variety of Bioinks, e.g., GelMA, HAMA, CSMA and ALMA. … StemEasy mainly focuses the development of stem cell-related products and their applications, meanwhile based on the company’s expertise, provide technical services on stem cell and 3D bioprinting. …

Review on Bortezomib Resistance in Multiple Myeloma and Potential Role of Emerging Technologies.

Multiple myeloma is a hematological cancer type. For its treatment, Bortezomib has been widely used. However, drug resistance to this effective chemotherapeutic has been developed for various reasons. 2D cell cultures and animal models have failed to understand the MM disease and Bortezomib resistance. It is therefore essential to utilize new technologies to reveal a complete molecular profile of the disease. In this review, we in-depth examined the possible molecular mechanisms that cause Bortezomib resistance and specifically addressed MM and Bortezomib resistance. Moreover, we also included

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… In a human bone marrow-like microenvironment produced by 3D bioprinting, MM cells were able to show better responses to Bortezomib [ 132 ]. Accordingly, scaffolds can be produced organically or synthetically from a basis where tumour cells can unite and mature. … A 3D-Bioprinted Multiple Myeloma Model. Adv. Healthc. Mater. 2022;11:2100884. doi: 10.1002/adhm.202100884. 133. Clara-Trujillo S., Tolosa L., Cordón L., Sempere A., Gallego Ferrer G., Gómez Ribelles J.L. …

Advances in the delivery of anticancer drugs by nanoparticles and chitosan-based nanoparticles.

Cancer is the leading cause of death globally, and conventional treatments have limited efficacy with severe side effects. The use of nanotechnology has the potential to reduce the side effects of drugs by creating efficient and controlled anticancer drug delivery systems. Nanoparticles (NPs) used as drug carriers offer several advantages, including enhanced drug protection, biodistribution, selectivity and, pharmacokinetics. Therefore, this review is devoted to various organic (lipid, polymeric) as well as inorganic nanoparticles based on different building units and providing a wide range of

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… Afra et al. ( Afra et al., 2024 ) authored a review article on crosslinkers CS compounds and their applications in 3D bioprinting for the development of CS-based bioinks. Furthermore, Shakil et al. ( Shakil et al., 2021 ) summarise the use of CS itself and its derivatives in treating cancer. … CS is attractive for tissue engineering and 3D bioprinting, but its high water content makes 3D printing challenging. Modifications are needed to improve printing accuracy. …

Artificial intelligence assisted preoperative planning and 3D-printing guiding frame for percutaneous screw reconstruction in periacetabular metastatic cancer patients.

BACKGROUND: The percutaneous screw reconstruction technique, known as the "Tripod Technique," has demonstrated favorable clinical outcomes in the management of metastatic periacetabular lesions, as evidenced by our prior investigations and corroborated by independent studies. Nevertheless, there is a steep learning curve in handling this technique, with possible complications such as intraarticular screw placement. METHODS: Preoperative pelvic CT scans were acquired before surgery and utilized for the guiding frame design. A convolutional neural network model was trained with annotated data t

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… Notable advancements include the integration of machine vision for multi-material 3D printing, improvements in 3D bioprinting processes, and robust quality control measures for 3D printed metal implants ( Ding et al., 2023 ). … Global hotspots and emerging trends in 3D bioprinting research. Front. Bioeng. Biotechnol. 11, 1169893. 10.3389/fbioe.2023.1169893 Du W., Wang J., Xu J., Zhao Z., Liu S., Yang L., et al. (2021). …

Engineering with Biomedical Sciences Changing the Horizon of Healthcare-A Review.

In the dynamic realm of healthcare, the convergence of engineering and biomedical sciences has emerged as a pivotal frontier. In this review we go into specific areas of innovation, including medical imaging and diagnosis, developments in biomedical sensors, and drug delivery systems. Wearable biosensors, non-wearable biosensors, and biochips, which include gene chips, protein chips, and cell chips, are all included in the scope of the topic that pertains to biomedical sensors. Extensive research is conducted on drug delivery systems, spanning topics such as the integration of computer modelin

Using Genomic Data in Personalized Oncology Medicine: An Exploratory Expert-Elicitation Study with Narrative Regulatory Mapping of Regulations, Implementations, and Challenges in Saudi Arabia.

BACKGROUND/OBJECTIVES: Personalized medicine represents a transformative approach to healthcare in Saudi Arabia. However, a significant research gap exists regarding the specific regulatory, implementation, and practical challenges of integrating genomic data into personalized oncology care in the Saudi context. We aimed to conduct an exploratory assessment of the current regulatory landscape, practices, and challenges related to genomic data use in personalized oncology in Saudi Arabia and to identify regulatory and practical gaps, propose actionable solutions, and outline future directions f

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… Experts have also highlighted the potential of 3D bioprinting in advancing cancer treatment. … Moreover, 3D bioprinting and personalized cancer vaccines offer promising new treatment modalities [ 48 , 49 ]. …

Patient-Derived Tumor Organoids for Drug Repositioning in Cancer Care: A Promising Approach in the Era of Tailored Treatment.

Malignancies heterogeneity represents a critical issue in cancer care, as it often causes therapy resistance and tumor relapse. Organoids are three-dimensional (3D) miniaturized representations of selected tissues within a dish. Lately, organoid technology has been applied to oncology with growing success and Patients Derived Tumor Organoids (PDTOs) constitute a novel available tool which fastens cancer research. PDTOs are in vitro models of cancer, and importantly, they can be used as a platform to validate the efficacy of anti-cancer drugs. For that reason, they are currently utilized in cli

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… Finally, a pivotal role is played by bioengineering, with the development of novel revolutionary 3D bioprinting and bio-fabrication materials. … Cellular extrusion bioprinting improves kidney organoid reproducibility and conformation Nat. Mater. 2020 10.1038/s41563-020-00853-9 33230326 PMC7855371 75. Huang L. Holtzinger A. Jagan I. BeGora M. Lohse I. Ngai N. Nostro C. Wang R. Muthuswamy L.B. Crawford H.C. …

Skeletal stem cells, a new direction for the treatment of bone and joint diseases.

Skeletal stem cells (SSCs) are tissue-specific stem cells characterized by their capacity for self-renewal and their position at the apex of the differentiation hierarchy. They can generate mature bone cell types essential for bone development, maintenance, and repair. Lineage tracing experiments have demonstrated that SSCs reside in the bone marrow, periosteum, and the resting zone of the growth plate. These findings not only enhance our understanding of bone growth and development mechanisms but also offer novel therapeutic strategies for conditions such as epiphyseal injuries, fractures, os

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… The HA/PLA composite scaffold fabricated via 3D bioprinting mimics the natural bone-cartilage interface through its gradient pore structure. … Review of alginate-based hydrogel bioprinting for application in tissue engineering. Biofabrication. 2019;11:042001. doi: 10.1088/1758-5090/ab331e. 128. de Souza JB, Rosa GDS, Rossi MC, Stievani FC, Pfeifer JPH, Krieck AMT, Bovolato ALC, Fonseca-Alves CE, Borrás VA, Alves ALG. …

The functional imperative in high-grade glioma.

Precision oncology has emerged as a promising strategy for treating high-grade gliomas, yet its clinical impact has been disappointing, with over 300 clinical trials on targeted therapies failing to yield substantial improvements in patient outcomes. Current approaches primarily focus on static, marker-driven tumor features, which capture only a small portion of the complex biology that governs therapeutic responses. Functional precision oncology (FPO) offers a complementary approach, enhancing treatment selection in a personalized manner by dynamically testing patient-derived tumor cells agai

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… years) | 100 | NCT04745975 | Shanghai, China | Interventional | Unknown status | 01 February 2021 | 01 January 2023 | Nil FPO for Metastatic Breast Cancer | HER2-negative breast cancer | Adults | 15 | NCT04450706 | UT, USA | Interventional | Completed | 16 February 2021 | 05 September 2024 | Nil 3D Bioprinted … Prediction of clinical precision chemotherapy by patient-derived 3D bioprinting models of colorectal cancer and its liver metastases. Adv. Sci. 11 , e2304460 (2024). 117. Varinelli, L. et al. …

Integrated Engineering of CAR-T Cells for Solid Tumours.

Chimeric antigen receptor (CAR) T-cell therapy has achieved durable efficacy in hematologic malignancies but encounters persistent obstacles in solid tumours, including antigen heterogeneity, a suppressive tumour microenvironment (TME), and intrinsic T-cell dysfunction. This review examines the transition from single-axis engineering to an integrated framework that addresses these hurdles in sequence. We delineate how next-generation CAR-T cells are designed for precise spatiotemporal activation through logic-gated and pharmacologically regulatable receptors, while being reinforced by metaboli

Priorities in Cardio-Oncology Basic and Translational Science: GCOS 2023 Symposium Proceedings: JACC: CardioOncology State-of-the-Art Review.

Despite improvements in cancer survival, cancer therapy-related cardiovascular toxicity has risen to become a prominent clinical challenge. This has led to the growth of the burgeoning field of cardio-oncology, which aims to advance the cardiovascular health of cancer patients and survivors, through actionable and translatable science. In these Global Cardio-Oncology Symposium 2023 scientific symposium proceedings, we present a focused review on the mechanisms that contribute to common cardiovascular toxicities discussed at this meeting, the ongoing international collaborative efforts to impro

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… seminal work has shown the predictive capacity of human cardiomyocytes derived from iPSCs, 127 , 128 organoids 129 can generate small replicas of the tissue of choice and have been used to model the enhanced sensitivity of the human ischemic heart to AIC. 130 Recent technical advances, 131 including 3D bioprinting … Lee A., Hudson A.R., Shiwarski D.J., et al. 3D bioprinting of collagen to rebuild components of the human heart. Science. 2019;365:482–487. doi: 10.1126/science.aav9051. 134. Weng K.C., Kurokawa Y.K., Hajek B.S., Paladin J.A., Shirure V.S., George S.C. …