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Updating Disability Weights for Measurement of Healthy Life Expectancy and Disability-adjusted Life Year in Korea.

BackgroundThe present study aimed to update the methodology to estimate cause-specific disability weight (DW) for the calculation of disability adjusted life year (DALY) and health-adjusted life expectancy (HALE) based on the opinion of medical professional experts. Furthermore, the study also aimed to compare and assess the size of DW according to two analytical methods and estimate the most valid DW from the perspective of years lost due to disability and HALE estimation.MethodsA self-administered web-based survey was conducted ranking five causes of disease. A total of 901 participants star

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… diseases | 0.562 | 0.388 | 0.511 | 0.438 151 | Chronic obstructive pulmonary disease (mild) | 0.474 | 0.351 | 0.617 | 0.494 152 | Chronic obstructive pulmonary disease (moderate) | 0.658 | 0.438 | 0.577 | 0.472 153 | Chronic obstructive pulmonary disease (severe) | 0.753 | 0.503 | 0.812 | 0.646 154 | Silicosis …

Analgesic Alkaloids Derived From Traditional Chinese Medicine in Pain Management.

Chronic pain is one of the most prevalent health problems. The establishment of chronic pain is complex. Current medication for chronic pain mainly dependent on anticonvulsants, tricyclic antidepressants and opioidergic drugs. However, they have limited therapeutic efficacy, and some even with severe side effects. We turned our interest into alkaloids separated from traditional Chinese medicine (TCM), that usually act on multiple drug targets. In this article, we introduced the best-studied analgesic alkaloids derived from TCM, including tetrahydropalmatine, aloperine, oxysophocarpine, matrine

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… tetrandrae radix] | Hot-plate test ( Zhao et al., 2014 ) Acetic acid-induced abdominal constriction (writhing) test ( Zhao et al., 2014 ) | Treatment of arthritis ( Kong X, et al., 2020 ) Treatment of arrhythmia ( Kong X. et al., 2020 ) Treatment of hypertension ( Kong X. et al., 2020 ) Treatment of silicosis … Clinically, tetrandrine has been applied to treat arthritis, arrhythmia, hypertension, silicosis, pneumoconiosis, hepatic fibrosis, and portal hypertensive gastropathy ( Kong X. et al., 2020 ). …

Association Between Common Variable Immunodeficiency and Pulmonary Amyloidosis: Review.

Background: Common variable immunodeficiency (CVID) is the most frequent symptomatic primary antibody deficiency, associated with recurrent infections, immune dysregulation, and non-infectious complications. Amyloidosis is a rare but severe complication with pulmonary involvement being exceptional. Objective: The aim of this study was to review reported cases of amyloidosis complicating CVID and present a unique case of pulmonary involvement. Methods: A literature research identified observational studies and case reports linking amyloidosis with CVID. Additionally, we describe a patient with

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… The differential diagnosis of pulmonary amyloidosis includes metastatic disease, congestive heart failure, miliary tuberculosis, sarcoidosis, silicosis, hypersensitivity pneumonitis, and other interstitial lung diseases [ 58 ]. …

The pathological anatomical collection of the Natural History Museum Vienna.

The pathological anatomical collection Vienna (Pathologisch-Anatomische Sammlung Wien; PASW) is a living and still growing research collection. It was established as early as 1796 as part of the Medical University of Vienna, acquired the status of an independent federal museum in 1971, and was assigned to the Natural History Museum Vienna in 2012. It houses a wide range of human wet and dry specimens and further objects, such as moulages, medical devices, microbiological and histological specimens, and a photo archive (approximately 50,000 objects), which, as a meaningful source, may contribut

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… Other examples of diseases manifested in the respiratory system and reported by Sedivy [ 24 ] include cases of tracheitis (originating in diphtheria), fibrosis, carcinoma, chondroma, or are caused by external impacts such as respirable dust ( Staublungen , silicosis, asbestosis, etc.). …

Epidemiological science and cancer control.

Epidemiological methods are essential for the discovery of cancer risks and prognostic factors as well as for the evaluation of cancer prevention measures. In this review, we discuss epidemiological surveillance procedures for data collection and processing to guide and evaluate the consequences of anticancer efforts for populations, assess the identification of cancer risk factors, examine barriers to cancer screening and recommended rules for early diagnosis programs. Epidemiological studies have shown that hindrances to cancer information assessment are currently encountered in developing c

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… sobre a questão Rev Saude Publica 2001 17 (1) 7 29 10.1590/S0102-311X2001000100002 11241924 72 Gloyne SR Two cases of squamous carcinoma of the lug occurring in asbestosis Tubercle 1935 17 5 10 10.1016/S0041-3879(35)80795-2 73 Lynch K Smith W Pulmonary asbestosis III: carcinoma of lung in asbestos-silicosis …

Beyond regulations at DNA levels: A review of epigenetic therapeutics targeting cancer stem cells.

In the past few years, the paramount role of cancer stem cells (CSCs), in terms of cancer initiation, proliferation, metastasis, invasion and chemoresistance, has been revealed by accumulating studies. However, this level of cellular plasticity cannot be entirely explained by genetic mutations. Research on epigenetic modifications as a complementary explanation for the properties of CSCs has been increasing over the past several years. Notably, therapeutic strategies are currently being developed in an effort to reverse aberrant epigenetic alterations using specific chemical inhibitors. In thi

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… CircRNAs CircRNAs are a single‐stranded closed circular RNAs that lack 5’‐3’ ends and poly (A) tails. 73 In recent years, there have been an increasing number of reports that circRNAs might be related to the pathogenesis of silicosis, 74 diabetes, 75 osteoarthritis, 76 Alzheimer's disease, 77 cardiovascular …

Modern radiopharmaceuticals for lung cancer imaging with positron emission tomography/computed tomography scan: A systematic review.

IntroductionIn this study, we evaluated the use and the contribution of radiopharmaceuticals to the field of lung neoplasms imaging using positron emission tomography/computed tomography.MethodsWe conducted review of the current literature at PubMed/MEDLINE until February 2020. The search language was English.ResultsThe most widely used radiopharmaceuticals are the following:Experimental/pre-clinical approaches: (18)F-Misonidazole (18F-MISO) under clinical development, D(18)F-Fluoro-Methyl-Tyrosine (18F-FMT), 18F-FAMT (L-[3-18F] (18)F-Fluorothymidine (18F-FLT)), (18)F-Fluoro-Azomycin-Arabinosi

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… Other pathologic entities such as emphysema, silicosis, previous tuberculosis, and interstitial pneumonitis can be linked with false-positive lymph nodes. …

Interstitial Lung Disease and Pulmonary Fibrosis: A Practical Approach for General Medicine Physicians with Focus on the Medical History.

Interstitial lung disease (ILD) and pulmonary fibrosis comprise a wide array of inflammatory and fibrotic lung diseases which are often confusing to general medicine and pulmonary physicians alike. In addition to the myriad of clinical and radiologic nomenclature used in ILD, histopathologic descriptors may be particularly confusing, and are often extrapolated to radiologic imaging patterns which may further add to the confusion. We propose that rather than focusing on precise histologic findings, focus should be on identifying an accurate etiology of ILD through a comprehensive and detailed m

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… Standard imaging in silicosis and coal worker’s pneumoconiosis. Radiol. Clin. N. Am. 1992;30:1147–1154. 143. Friedman A.C., Fiel S.B., Fisher M.S., Radecki P.D., Lev-Toaff A.S., Caroline D.F. Asbestos-related pleural disease and asbestosis: A comparison of CT and chest radiography. AJR Am. J. …

Abstracts for NAPCON 2025

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Inflammatory stromal and T cells mediate human bone marrow niche remodeling in clonal hematopoiesis and myelodysplasia.

Somatic mutations in hematopoietic stem/progenitor cells (HSPCs) can lead to clonal hematopoiesis of indeterminate potential (CHIP) and progression to myelodysplastic syndromes (MDS). Using single-cell and anatomical profiling of a large cohort of human bone marrow (BM), we show that the HSPC BM niche in CHIP and MDS is undergoing inflammatory remodeling. This includes loss of CXCL12⁺ adipogenic stromal cells and the emergence of a distinct population of inflammatory mesenchymal stromal cells (iMSCs), which arise in CHIP and become more prevalent in MDS. Functional studies in primary BM HSPC-M

Advances in α-Lipoic Acid for Disease Prevention: Mechanisms and Therapeutic Insights.

α-Lipoic acid (ALA) is a naturally occurring compound with diverse biological functions, widely distributed in animal and plant tissues. It has attracted considerable attention due to its versatile therapeutic potential. However, despite these promising prospects, the clinical application of ALA remains limited by its low bioavailability and chemical instability and an incomplete understanding of its multifaceted mechanisms across various diseases. This review provides a comprehensive overview of the biochemical properties of ALA, including its direct free-radical-scavenging activity, regenera

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… Yan et al. [ 41 ] reported that the low expression of lipoic acid synthase (LIAS) aggravated pulmonary fibrosis caused by SiO 2 , while ALA supplementation promoted an immune balance between Th17 and Treg responses, reducing the accumulation of ECM and inflammatory cells in lung tissues, alleviating silicosis …

Extraglandular Manifestations of Sjögren’s Syndrome (SS): Dermatologic, Arthritic, Endocrine, Pulmonary, Cardiovascular, Gastroenterology, Renal, Urology, and Gynecologic Manifestations

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… Other factors to be excluded in the differential diagnosis of ILD in SS patients include Inhaled substances Inorganic Silicosis Asbestosis Berylliosis Organic Hypersensitivity pneumonitis including molds Drug-induced Antibiotics Anti-arrhythmic agents Infection Atypical pneumonia, including mycobacterial …

Malignant mesothelioma tumours: molecular pathogenesis, diagnosis, and therapies accompanying clinical studies.

The pathetic malignant mesothelioma (MM) is a extremely uncommon and confrontational tumor that evolves in the mesothelium layer of the pleural cavities (inner lining- visceral pleura and outer lining- parietal pleura), peritoneum, pericardium, and tunica vaginalis and is highly resistant to standard treatments. In mesothelioma, the predominant pattern of lesions is a loss of genes that limit tumour growth. Despite the worldwide ban on the manufacture and supply of asbestos, the prevalence of mesothelioma continues to increase. Mesothelioma presents and behaves in a variety of ways, making dia

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… Silicosis, asbestos-related diseases, war-site exposures and a variety of topics in chronic obstructive pulmonary disease. Curr Opin Pulmonary Med (2023) 29:61–2. doi: 10.1097/MCP.0000000000000936 6. Germine M, Puffer JH. …

Reactive Oxygen Species Bridge the Gap between Chronic Inflammation and Tumor Development.

According to numerous animal studies, adverse environmental stimuli, including physical, chemical, and biological factors, can cause low-grade chronic inflammation and subsequent tumor development. Human epidemiological evidence has confirmed the close relationship between chronic inflammation and tumorigenesis. However, the mechanisms driving the development of persistent inflammation toward tumorigenesis remain unclear. In this study, we assess the potential role of reactive oxygen species (ROS) and associated mechanisms in modulating inflammation-induced tumorigenesis. Recent reports have e

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… For instance, alcohol abuse is implicated in chronic hepatitis and hepatocarcinoma [ 12 ], H. pylori infection can cause chronic gastritis and gastric cancer [ 13 ], asbestos-dependent silicosis contributes to lung cancer, patients with gingivitis and periodontitis have a higher risk of oral cancer [ …

Targeting fibrosis, mechanisms and cilinical trials.

Fibrosis is characterized by the excessive extracellular matrix deposition due to dysregulated wound and connective tissue repair response. Multiple organs can develop fibrosis, including the liver, kidney, heart, and lung. Fibrosis such as liver cirrhosis, idiopathic pulmonary fibrosis, and cystic fibrosis caused substantial disease burden. Persistent abnormal activation of myofibroblasts mediated by various signals, such as transforming growth factor, platelet-derived growth factor, and fibroblast growh factor, has been recongized as a major event in the occurrence and progression of fibrosi

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… Mossman BT Churg A Mechanisms in the pathogenesis of asbestosis and silicosis Am. J. Respir. Crit. Care Med 1998 157 1666 1680 10.1164/ajrccm.157.5.9707141 9603153 37. …

The Minderoo-Monaco Commission on Plastics and Human Health.

BACKGROUND: Plastics have conveyed great benefits to humanity and made possible some of the most significant advances of modern civilization … plastic production suffer increased mortality from traumatic injury, coal workers' pneumoconiosis, silicosis, cardiovascular disease, chronic obstructive pulmonary disease, and lung cancer. Plastic production workers are at increased risk of leukemia, lymphoma, hepatic angiosarcoma, brain cancer, breast cancer, mesothelioma, neurotoxic injury, and decrease …

SUBJECT INDEX Volume 125 (JANUARY–JUNE, 2004)

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Purinergic Signalling: Therapeutic Developments.

Purinergic signalling, i.e., the role of nucleotides as extracellular signalling molecules, was proposed in 1972. However, this concept was not well accepted until the early 1990's when receptor subtypes for purines and pyrimidines were cloned and characterised, which includes four subtypes of the P1 (adenosine) receptor, seven subtypes of P2X ion channel receptors and 8 subtypes of the P2Y G protein-coupled receptor. Early studies were largely concerned with the physiology, pharmacology and biochemistry of purinergic signalling. More recently, the focus has been on the pathophysiology and the

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… P2X7R modulate lung inflammatory, fibrotic and functional changes in silicosis, an occupational lung disease ( Monção-Ribeiro et al., 2014 ). P2X4R mediate acute airway inflammation by regulating dendritic cell function ( Wiesler et al., 2016 ). … Alveolar macrophages contribute substantially to chronic lung inflammation development, including silicosis, idiopathic pulmonary fibrosis, hypersensitivity pneumonitis, sarcoidosis, and asbestosis. …

Targeting Oxidative Stress as a Therapeutic Approach for Idiopathic Pulmonary Fibrosis.

Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease characterized by an abnormal reepithelialisation, an excessive tissue remodelling and a progressive fibrosis within the alveolar wall that are not due to infection or cancer. Oxidative stress has been proposed as a key molecular process in pulmonary fibrosis development and different components of the redox system are altered in the cellular actors participating in lung fibrosis. To this respect, several activators of the antioxidant machinery and inhibitors of the oxidant species and pathways have been assayed in precl

The Fifth International Meeting of ISEV, ISEV2016, Rotterdam, The Netherlands, 4 - 7 May, 2016.

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