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Pharmacological treatments in panic disorder in adults: a network meta-analysis.

BACKGROUND: A panic attack is a discrete period of fear or anxiety that has a rapid onset and reaches a peak within 10 minutes. The main sym … goraphobia. The strongest reductions in agoraphobia symptoms were found for citalopram, reboxetine, escitalopram, clomipramine and diazepam, compared to placebo. For the pooled intervention classes, we examined the two primary outcomes (response and dropout). The classes of medication were: SSRIs, SNRIs, TCAs, MAOIs and BDZs. For the response outcome, all clas …

Home Treatment of Older People with Symptomatic SARS-CoV-2 Infection (COVID-19): A structured Summary of a Study Protocol for a Multi-Arm Multi-Stage (MAMS) Randomized Trial to Evaluate the Efficacy and Tolerability of Several Experimental Treatments to Reduce the Risk of Hospitalisation or Death in outpatients aged 65 years or older (COVERAGE trial).

OBJECTIVES: To assess the efficacy of several repurposed drugs to prevent hospitalisation or death in patients aged 65 or more with recent s … eatment with piperaquine, halofantrine, dasatinib, nilotinib, hydroxyzine, domperidone, citalopram, escitalopram, potent inhibitors or inducers of cytochrome P450 CYP3A4 isoenzyme, repaglinide, azathioprine, 6-mercaptopurine, theophylline, pyrazinamide, warfarin; Known hypersensitivity to any of the trial drugs or to chloroquine and other 4-aminoquinolines, am …

Эффективность транскраниального прямого тока (tDCS) на нейропсихиатрических Симптомах в множестве склерозов (MS) - обзор и понимание возможных механизмов действий.

Введение: Нейропсихиатрические симптомы, такие, как депрессия и беспокойство, являются значительным бременем для пациентов с множественным склерозом (МС). Их патофизиология сложна и еще не до конца понятна. Существует срочная потребность в неинвазивных методах лечения, которые непосредственно нацелены на мозг и помогают пациентам с склерозом. Одним из таких возможных способов лечения является транскраниальная стимуляция прямого тока (TDCS) - популярный и эффективный метод неинвазивной стимуляции мозга. Методы: В рамках этого механистического обзора изучается эффективность ТДСС в лечении депрес

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… Plasma biomarkers in a placebo-controlled trial comparing tDCS and escitalopram efficacy in major depression. Prog. Neuropsychopharmacol. Biol. Psychiatry. 2018;86:211–217. doi: 10.1016/j.pnpbp.2018.06.003. 84. Pereira G.M., Soares N.M., Souza A.R., Becker J., Finkelsztejn A., Almeida R.M.M. …

Выявляется высокий уровень использования медицинских услуг после операции на шейном позвоночнике с использованием комплексных методов прогнозирования.

Расходы на медицинское обслуживание пациентов с хроническими заболеваниями позвоночника и пациентов, проходящих хирургическую операцию, продолжают расти заметными темпами. Таким образом, выявление пациентов, подверженных риску в плане более широкого использования послеоперационного медицинского обслуживания, имеет решающее значение для оптимизации результатов медицинского обслуживания и распределения ресурсов. Цель нашего исследования заключается в использовании целого ряда предоперабельных характеристик пациентов, включая всеобъемлющую медицинскую, хирургическую и социальную историю, для разр

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… preoperative windoww | “captopril”, “lisinopril”, “enalapril”, “ramipril”, “benazepril”, “fosinopril”, “moexipril”, “perindopril”, “quinapril”, “trandolapril” ARB | “losartan”, “valsartan”, “azilsartan”, “candesartan”, “eprosartan”, “irbesartan”, “olmesartan”, “telmisartan” | Antidepressants | “citalopram”, “escitalopram …

Abstracts from the 11th International Conference for Healthcare and Medical Students (ICHAMS) : Virtual. 10-12 February 2022.

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… Methods Patients with MDD (n=211) recruited from 6 outpatient centres in Canada were treated with escitalopram for 8 weeks and evaluated at 8 and 16 weeks for clinical and functional response/remission (Montgomery-Asberg Depression Rating Scale [MADRS]). … Responders continued escitalopram, while non-responders received adjunctive aripiprazole for a further 8 weeks. Insomnia and suicidal ideation were evaluated at weeks 0, 8, and 16, while suicidal risk was evaluated at baseline. …

Prevention of depression in adults with long-term physical conditions.

BACKGROUND: Major depression is one of the world's leading causes of disability in adults with long-term physical conditions compared to tho … alyses on pharmacological interventions included 837 participants comparing citalopram (one trial), escitalopram (three trials), a mixed sample of fluoxetine/nortriptyline (one trial), melatonin (one trial), milnacipran (one trial), and sertraline (three trials), each to placebo. Included types of long-term physical conditions were acute coronary syndrome (one …

Использование биомаркеров для прогнозирования ответа на транскраниальную прямую токовую стимуляцию (tDCS): систематический обзор скопинга.

ВВЕДЕНИЕ: Транскраниальная прямая токовая стимуляция (tDCS) — это неперерывная нейромодуляция с увеличивающимся количеством доказательств эффективности при лечении нейропсихиатрических состояний. Нужны биомаркеры для прогнозирования и мониторинга эффективности tDCS. Наша цель — провести систематический обзор для оценки доказательств о способности биомаркеров прогнозировать реакцию на tDCS и выявить перспективные кандидатные биомаркеры в популяции пациентов с нейропсихиатрическими заболеваниями. МЕТОДЫ: Комплексные поиски были проведены в базах данных MEDLINE и EMBASE 24/09/2023. Статьи были о

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… Plasma biomarkers in a placebo-controlled trial comparing tDCS and escitalopram efficacy in major depression. Prog Neuropsychopharmacol Biol Psychiatry. (2018) 86:211–7. doi: 10.1016/j.pnpbp.2018.06.003, PMID: 96. Al-Kaysi AM, Al-Ani A, Loo CK, Powell TY, Martin DM, Breakspear M, et al. …

Отчет о ДИД 1st Ежегодный Всемирный конгресс биомедицинской инженерии, проводимый в Сиане, Китай, 9-11 ноябрь 2017.

Мы рады представить на этом заседании резюме доклада "ДИД" 1st Всемирный конгресс биомедицинской инженерии 2017которая была проведена в Сиане в Китае [...].

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… Major Depressive Disorder, Prediction of Clinical Outcome after 4 and 8 Weeks of Citalopram/Escitalopram Therapy: A Data-Driven Machine Learning Approach Weinshilboum, R.M. … In this study, we have used a data-driven machine learning approach to join validated measures of depression severity and metabolomic data at baseline to predict clinical response in depressed patients treated with citalopram/escitalopram with re-evaluation at 4 and 8 weeks. …

Analysis of Factors Associated with Hiccups Using the FAERS Database.

In this study, we used the large number of cases in the FDA adverse-event reporting system (FAERS) database to investigate risk factors for drug-induced hiccups and to explore the relationship between hiccups and gender. From 11,810,863 adverse drug reactions reported between the first quarter of 2004 and the first quarter of 2020, we extracted only those in which side effects occurred between the beginning and end of drug administration. Our sample included 1454 adverse reactions for hiccups, with 1159 involving males and 257 involving females (the gender in 38 reports was unknown). We perfor

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… Second-generation SSRIs: Human monoamine transporter binding profile of escitalopram and R-fluoxetine Biol. Psychiatry 2001 50 345 350 10.1016/S0006-3223(01)01145-3 11543737 33. Vardy J. Chiew K. Galica J. Pond G.R. Tannock I.F. …

Trazodone in the Management of Major Depression Among Elderly Patients with Dementia: A Narrative Review and Clinical Insights.

ObjectiveMajor depressive disorder (MDD) often co-occurs with dementia and other neurological disorders, and treatment with antidepressants can improve symptoms, quality of life, and survival in these patients. This narrative review provides an expert opinion about the role and effectiveness of trazodone in the treatment of older adults with MDD and cognitive impairment due to physical illnesses, such as dementia.ResultsBecause of its mechanism of action, trazodone can treat several depression symptoms often seen in people with dementia, including insomnia, agitation, anxiety, cognitive impair

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… For non-emergent situations, the proposed medication sequence encompasses trazodone, donepezil, and memantine, followed by antidepressants like escitalopram and sertraline, second-generation antipsychotics, prazosin, and carbamazepine. 59 According to a systematic review about the Effectiveness of Pharmacological …

Antidepressant Drug Sertraline against Human Cancer Cells.

The use of FDA-approved drugs for new indications represents a faster and more economical way to find novel therapeutic agents for cancer therapy, compared to the development of new drugs. Repurposing drugs is advantageous in a pharmacological context since these drugs already have extensive data related to their pharmacokinetics, facilitating their approval process for different diseases. Several studies have reported the promising anticancer effects of sertraline, both alone and combined, in different types of cancer cell lines. Here, we performed a literature review on the anticancer potent

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… Effects of Acute and Long-Term Administration of Escitalopram and Citalopram on Serotonin Neurotransmission: An in Vivo Electrophysiological Study in Rat Brain Neuropsychopharmacology 2005 30 1269 1277 10.1038/sj.npp.1300686 15702136 78. Hervás I. Vilaró M.T. Romero L. Scorza M.C. Mengod G. …

АКНП 60th Ежегодное совещание: выдержки из плакатов P276 - P550.

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Dermatologic conditions in women receiving systemic cancer therapy.

As advances in cancer therapies have improved cancer-related survival, novel therapeutics have also introduced a variety of dermatologic toxicities, and an increased number of patients are living with these sequalae. Women with cancer in particular experience a spectrum of dermatologic conditions that affect their skin, hair, nail, and mucosal surfaces. Studies have shown that these toxic effects can significantly affect quality of life and alter a woman's self-image, cultural identity, femininity, sexuality, and mental health. In severe instances, dermatologic toxicities may even disrupt canc

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… The selective serotonin reuptake inhibitors that are safe to use with tamoxifen include citalopram, sertraline, and escitalopram ( Barton et al., 2010 , Freeman et al., 2011 , Loprinzi et al., 2009 ); paroxetine and fluoxetine should be avoided because they inhibit the cytochrome P450 2D6 pathway ( Carris …

Глубокая стимуляция мозга в гипоталамической области: систематический обзор.

КОЛИЧЕСТВО: Глубокая стимуляция мозга (БРС) успешно используется для лечения циклопатии, включая движение, беспокойство и поведенческие расстройства. Гипоталамус является важнейшим интеграционным центром для многих периферийных и центральных путей, связанных с сердечно - сосудистыми, метаболическими и поведенческими функциями, и представляет собой потенциальную цель нейромодуляции в лечебных условиях. Проведение систематического обзора, изучение гипоталамических целей в ДБС, их признаков и основных клинических результатов.МЕТОДЫ: База данных PubMed, Scopus и Web of Science была подвергнута обы

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… intermittent explosive disorder (4, 100%) NS Self-injurious behavior (4, 100%), hetero-aggressive behavior (3, 75%), hyperphagia (1, 25%), anxiety (1, 25%), hypersexuality (1, 25%), onychophagia (1, 25%) Valproate sodium (3, 75.0%), olanzapine (1, 25.0%), levomepromazine (2, 50.0%), sertraline (2, 50.0%), escitalopram … intermittent explosive disorder (4, 100%) NS Self-injurious behavior (4, 100%), hetero-aggressive behavior (3, 75%), hyperphagia (1, 25%), anxiety (1, 25%), hypersexuality (1, 25%), onychophagia (1, 25%) Valproate sodium (3, 75.0%), olanzapine (1, 25.0%), levomepromazine (2, 50.0%), sertraline (2, 50.0%), escitalopram …

Окисляющий стресс и воспаление в патогенезе неврологических расстройств: механизмы и последствия.

Нейрозащита — это активный подход к защите нервной системы, включая мозг, спинной мозг и периферийные нервы, путем предотвращения или ограничения повреждения нервных клеток и других компонентов. Она защищает центральную нервную систему от повреждений от острых и прогрессивных нейродегенеративных расстройств. Окисляющий стресс, дисбаланс между естественными механизмами защиты тела и образованием реактивных видов кислорода, имеет решающее значение для развития неврологических расстройств. Из-за высокой скорости метаболизма и потребления кислорода мозг особенно уязвим к окисляющему стрессу. Чрезм

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… Selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine, sertraline, and escitalopram, although not specific to neurological disorders, are used in depression and anxiety, conditions often associated with neurological manifestations. …

Essential Medicinal Chemistry of Essential Medicines.

Since 1977, the World Health Organization publishes a list of essential medicines, i.e., those that satisfy the priority health care needs of the population and are selected with regard to disease prevalence and public health relevance, evidence of clinical efficacy, and safety, as well as comparative costs and cost-effectiveness. The Essential Medicines List (EML) is an invaluable tool for all countries to select those medicines that have an excellent risk/benefit ratio and that are reputed to be of pivotal importance to health. In the present perspective, we describe the chemical composition

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… Yet, this most likely means that the EML Expert Panel did not consider chiral switches of a significant clinical added benefit, in a dissimilar fashion compared with the market recognition that some of these molecules received in the 1990s (esomeprazole, escitalopram). …

Prevalence, Attributes, and Risk Factors of QT-Interval-Prolonging Drugs and Potential Drug-Drug Interactions in Cancer Patients: A Prospective Study in a Tertiary Care Hospital.

Introduction Cancer chemotherapy regimens include multiple classes of adjuvant drugs as supportive therapy. Because of the concurrent intake of other drugs (like antiemetics, antidepressants, analgesics, and antimicrobials), there is a heightened risk for possible QT interval prolongation. There is a dearth of evidence in the literature regarding the usage of QT-prolonging anticancer drugs and associated risk factors that have the propensity to prolong QT interval. The purpose was to explore the extent of the use of QT-interval-prolonging drugs and potential QT-prolonging drug-drug interaction

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… Fluorouracil (L01BC02) | 21 (1.5) Nilotinib (L01XE08) | 10 (0.7) Dasatinib (L01XE06) | 7 (0.5) Tamoxifen (L02BA01) | 6 (0.4) Epirubicin (L01DB03) | 2 (0.1) Lapatinib (L01EH01) | 2 (0.1) Eribulin Mesylate (L01XX41) | 1 (0.1) Leuprolide (L02AE02) | 1 (0.1) Antidepressant (n=3) | Known risk of TdP (n=1) | Escitalopram …

Small molecule metabolites: discovery of biomarkers and therapeutic targets.

Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite signatures that have close proximity to subject's phenotypic informative dimension, are useful for predicting diagnosis and prognosis of diseases as well as monitoring treatments. The lack of early biomarkers could lead to poor diagnosis and serious outcomes. Therefore, noninvasive diagnosis and monitoring methods with high specificity and selectivity are desperately needed. Small molecule metabolites-based metabolomics has b

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… The decrease of plasma kynurenine level may indicate the therapeutic response of escitalopram, suggesting that it may participate in the pathophysiological response of severe depression caused by escitalopram treatment. 705 Metabolic signatures of cholangiocarcinoma patients showed that the TCA cycle …

Rediscovering trazodone for the treatment of major depressive disorder.

Trazodone is a triazolopyridine derivative that belongs to the class of serotonin receptor antagonists and reuptake inhibitors (SARIs). The drug is approved and marketed in several countries worldwide for the treatment of major depressive disorder (MDD) in adult patients. In clinical studies, trazodone has demonstrated comparable antidepressant activity to other drug classes, including tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs) and serotonin-noradrenaline (norepinephrine) reuptake inhibitors (SNRIs). Moreover, the SARI action of trazodone may overcome the

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… Efficacy and Tolerability of Trazodone in MDD Several head-to-head studies have demonstrated the comparable antidepressant efficacy between trazodone and other drug classes, including TCAs (amitriptyline and imipramine), SSRIs (fluoxetine, paroxetine, sertraline, citalopram and escitalopram), SNRIs …

Drugs and Epigenetic Molecular Functions. A Pharmacological Data Scientometric Analysis.

Interactions of drugs with the classical epigenetic mechanism of DNA methylation or histone modification are increasingly being elucidated mechanistically and used to develop novel classes of epigenetic therapeutics. A data science approach is used to synthesize current knowledge on the pharmacological implications of epigenetic regulation of gene expression. Computer-aided knowledge discovery for epigenetic implications of current approved or investigational drugs was performed by querying information from multiple publicly available gold-standard sources to (i) identify enzymes involved in c

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… methyltransferase (DNMT) inhibitor | Prostate cancer | [ 64 ] Eflornithine (α-difluoromethylornithine) | Ornithine decarboxylase | Reversal of the global DNA hypomethylation and the specific hypermethylation of the ER-α gene in rats with induced colon tumors | Facial hirsutism, sleeping sickness | [ 21 ] Escitaloprame …