Результаты поиска

Essential oils and their constituents as anticancer agents: a mechanistic view.

Exploring natural plant products as an option to find new chemical entities as anticancer agents is one of the fastest growing areas of research. Recently, in the last decade, essential oils (EOs) have been under study for their use in cancer therapy and the present review is an attempt to collect and document the available studies indicating EOs and their constituents as anticancer agents. This review enlists nearly 130 studies of EOs from various plant species and their constituents that have been studied so far for their anticancer potential and these studies have been classified as in vitr

Совпадение в полном тексте источника
… Ocimum sanctum EO affects enzymes, namely SOD, CAT, and GST, and increases the levels of reduced glutathione, a nonenzymatic antioxidant which is responsible for decrease in the size of tumour and its incidence in the mice with the induced toxicity [ 82 ]. … sanctum seed oil Journal of Ethnopharmacology 2000 72 1-2 29 34 2-s2.0-0034284901 10967450 10.1016/s0378-8741(00)00194-x 83 Gali-Muhtasib HU Affara NI Chemopreventive effects of sage oil on skin papillomas in mice Phytomedicine 2000 7 2 129 136 2-s2.0-0034069142 10839216 10.1016/S0944-7113(00)80085 …

Rosmarinic Acid and Related Dietary Supplements: Potential Applications in the Prevention and Treatment of Cancer.

Cancer constitutes a severe threat to human health and quality of life and is one of the most significant causes of morbidity and mortality worldwide. Natural dietary products have drawn substantial attention in cancer treatment and prevention due to their availability and absence of toxicity. Rosmarinic acid (RA) is known for its excellent antioxidant properties and is safe and effective in preventing and inhibiting tumors. This review summarizes recent publications on culture techniques, extraction processes, and anti-tumor applications of RA-enriched dietary supplements. We discuss techniqu

Совпадение в полном тексте источника
… Ethanolic Extract of Ocimum sanctum Leaves Reduced Invasion and Matrix Metalloproteinase Activity of Head and Neck Cancer Cell Lines Asian Pac. J. Cancer Prev. APJCP 2020 21 363 370 10.31557/APJCP.2020.21.2.363 32102512 PMC7332114 28. Nazir S. Jan H. Tungmunnithum D. Drouet S. Zia M. Hano C. …

Theranostic Potentials of Gold Nanomaterials in Hematological Malignancies.

Hematological malignancies (HMs) are a heterogeneous group of blood neoplasia generally characterized by abnormal blood-cell production. Detection of HMs-specific molecular biomarkers (e.g., surface antigens, nucleic acid, and proteomic biomarkers) is crucial in determining clinical states and monitoring disease progression. Early diagnosis of HMs, followed by an effective treatment, can remarkably extend overall survival of patients. However, traditional and advanced HMs' diagnostic strategies still lack selectivity and sensitivity. More importantly, commercially available chemotherapeutic dr

Совпадение в полном тексте источника
… Using an MTT assay, Gautam et al. (2017) reported that b-AuNPs prepared from Ocimum sanctum leaf extract displayed cytotoxicity toward Dalton’s lymphoma (DL) cells. b-AuNPs decreased mitochondrial-membrane potential (ΔΨm) and, thereby, induced apoptosis through the mitochondrial pathway. …

Targeted phytotherapy: essential oils, multi-target cancer action & nanodelivery.

Biochemical components of essential oils (EOs) are an innovative but largely underexplored type of precision phytotherapy (PT) in oncology owing to their anticancer activity against many types of tumors. This article discusses the important multitargeted molecular mechanisms of EOs (apoptosis, cell cycle arrest, angiogenesis, metastasis, tumor microenvironment) and their role as antitumor agents. In particular, an effort has been made to emphasize on the most notable volatile EOs such as thymol, eugenol, limonene, β-caryophyllene, and their interaction with oncogenic signaling pathways (NF-κB,

Совпадение в полном тексте источника
… , β-carotene (2.81 mg/100g), phenolic compounds (632 mg/100g) | Size: 105 nm; PdI: 0.12; Zeta: -17.2 mV; EE: 80.51%; STable 6 months | Cytotoxicity against MDA-MB-231 (55% reduction at 386 μg/mL, 72h); No toxicity on L929; 97% colony reduction at 386 μg/mL; 40% migration inhibition at 48h | ( 117 ) Ocimum … sanctum (Tulsi) | Green synthesis (essential oil-mediated reduction of HAuCl 4 ) | Os-AuNPs (Ocimum sanctum essential oil-gold nanoparticles) | Gold nanoparticles (AuNPs) | Methyl isoeugenol, caryophyllene, eugenol | Size: 57.81 nm (DLS), 24–28 nm (TEM); PDI: 0.42; Zeta: -27.6 mV; Spherical/triangular …

Животные модели периферической нейропатии, вызванной химиотерапией, для гематологических заболеваний: обзор.

Химиотерапия это one основные виды лечения гематологовых магнестов. Однако периферическая нейропатия, вызванная химиотерапией (CIPN) one Наиболее часто встречающиеся долгосрочные токсичные реакции в химиотерапии, а также случаи CIPN влияют на качество жизни пациентов и могут приводить к прерыванию химиотерапии в тяжелых случаях, снижая тем самым эффективность химиотерапии. В настоящее время мы резюмируем существующие зверские модели CIPN, включая характеристики нескольких общих животных моделей, таких, как периферическая нейропатия, вызванная бортезомибами, периферическая нейропатия, вызванная

Совпадение в полном тексте источника
… Exploring the potential effect of Ocimum sanctum in vincristine‐induced neuropathic pain in rats. J Brachial Plex Peripher Nerve Inj. 2014;05:e3‐e11. 10.1186/1749-7221-5-3 39. Muthuraman A, Singh N, Jaggi AS. …

Radioprotectors & mitigators in radiation therapy: Harnessing diverse pathways for optimizing clinical outcomes.

Radioprotectors are agents that protect normal tissues from the harmful effects of radiation during cancer treatment. Combining these protective agents with advanced radiotherapy techniques such as stereotactic body radiotherapy (SBRT) and proton therapy offers a promising strategy to enhance therapeutic efficacy while minimizing normal tissue toxicity. However, despite extensive research and the identification of numerous potential radioprotectors, only a few have made it into clinical practice. It is primarily because the transition from laboratory research to clinical application faces sign

Совпадение в полном тексте источника
… Osmium compounds, including those derived from tulsi (Ocimum sanctum) , are known for their ability to counteract radiation-induced damage. Additionally, glutathione and cysteine derivatives, as thiol-based compounds, protect DNA by donating electrons to neutralize ROS 13 . …

Therapeutic Uses and Pharmacological Properties of Shallot (Allium ascalonicum): A Systematic Review.

BackgroundShallot (Allium ascalonicum L.) is a traditional plant species used throughout the world both for culinary purposes and as a folk remedy. To date (i.e., April 2022), there is no report on the main pharmacological activities exerted by shallot preparations and/or extracts.Scope and approachThe aim of this study was to comprehensively review the pharmacological activities exerted by shallot, with rigorous inclusion and exclusion criteria based on the scientific rigor of studies. Prisma guidelines were followed to perform the literature search.Key findings and conclusionsThe literature

Совпадение в полном тексте источника
… . # Coriandrum sativum; Zingiber offcinale; Alpinia galanga; Cymbopogon citratus; Citrus hystrix; Citrus aurantiifolia; Capsicum frutescens; Curcuma longa; Ocimum basilicum; Ocimum sanctum; Momordica charantia; Solanum torvum; Morinda citrifolia . ## Mentha longifolia; Cuminum cyminum; Zataria multiflora …

Pathobiology of cancer chemotherapy-induced peripheral neuropathy (CIPN).

Chemotherapy induced peripheral neuropathy (CIPN) is a type of neuropathic pain that is a major dose-limiting side-effect of potentially curative cancer chemotherapy treatment regimens that develops in a "stocking and glove" distribution. When pain is severe, a change to less effective chemotherapy agents may be required, or patients may choose to discontinue treatment. Medications used to alleviate CIPN often lack efficacy and/or have unacceptable side-effects. Hence the unmet medical need for novel analgesics for relief of this painful condition has driven establishment of rodent models of C

Совпадение в полном тексте источника
… Exploring the potential effect of Ocimum sanctum in vincristine-induced neuropathic pain in rats . J. Brachial. Plex. Peripher. Nerve Inj . 5 : 3 10.1186/1749-7221-5-3 20181005 PMC2832770 Kidd J. F. Pilkington M. F. Schell M. J. Fogarty K. E. Skepper J. N. Taylor C. W. ( 2002 ). …

The influence of neuro-tumor interactions on tumorigenesis and therapeutic response.

The intricate crosstalk between the nervous system and tumors has emerged as a pivotal determinant of tumorigenesis, progression, and therapeutic response. This review synthesizes current insights into neuro-tumor interactions, highlighting how neuronal networks within the tumor microenvironment (TME) modulate cancer cell proliferation, invasion, and angiogenesis by releasing neurotransmitters, growth factors, etc. The neuro-immune axis, a critical interface linking neural signaling to immune regulation, is explored in depth, elucidating how neuronal-derived molecules influence the phenotype a

Совпадение в полном тексте источника
… The role of ursolic acid, a pharmacologically active compound from ocimum sanctum L. as a potential chemotherapeutic agent. Curr Pharm Anal. 2025;21:77–87. 128. Kuol N, Stojanovska L, Apostolopoulos V, Nurgali K. Role of the nervous system in tumor angiogenesis. …

A Comprehensive Review on the Therapeutic Potential of Curcuma longa Linn. in Relation to its Major Active Constituent Curcumin.

Curcuma longa Linn. (C. longa), popularly known as turmeric, belongs to the Zingiberaceae family and has a long historical background of having healing properties against many diseases. In Unani and Ayurveda medicine, C. longa has been used for liver obstruction and jaundice, and has been applied externally for ulcers and inflammation. Additionally, it is employed in several other ailments such as cough, cold, dental issues, indigestion, skin infections, blood purification, asthma, piles, bronchitis, tumor, wounds, and hepatic disorders, and is used as an antiseptic. Curcumin, a major constitu

Proceedings of International Conference on Cell Death in Cancer and Toxicology. February 20-22, 2018. Guest Editors: Kausar M. Ansari, CSIR-IITR, India and Dhyan Chandra, Roswell Park, USA.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.