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Bone and joint quality remains impaired in long-term controlled acromegaly: an HR-pQCT study.

CONTEXT: Joint and bone disorders are frequent, disabling complications of acromegaly that progress despite biochemical remission. HR-pQCT provides a precise assessment of bone and joint quality. OBJECTIVE: To evaluate joint and bone quality in patients with long-term controlled acromegaly. DESIGN: Cross-sectional study. PARTICIPANTS: 17 acromegaly patients and 17 age- and sex-matched controls. MEASURES: HR-pQCT of hand joints, tibia, and radius; bone microindentation; vertebral fracture assessment; dual X-ray absorptiometry; circulating bone biomarkers; questionnaires. RESULTS: Patients

Towards a definition of an existential approach in cancer patients: a co-produced scoping review.

BackgroundAttention to existential needs has become part of daily treatment. Studies have described the concepts of existential experiences and existential interventions. However, a consensus or conceptual clarity regarding an existential approach in cancer patients is currently missing. This scoping review investigates the term existential approach and suggests a definition.MethodsWe searched PubMed, Embase, Web of Science, and PsycINFO databases until March 2024. We used the Joanna Briggs Institute guidance, and the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension

Oral Presentations

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Биология и болезни крыс

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HIV-1 matrix protein p17 misfolding forms toxic amyloidogenic assemblies that induce neurocognitive disorders.

Human immunodeficiency virus type-1 (HIV-1)-associated neurocognitive disorder (HAND) remains an important neurological manifestation that adversely affects a patient's quality of life. HIV-1 matrix protein p17 (p17) has been detected in autoptic brain tissue of HAND individuals who presented early with severe AIDS encephalopathy. We hypothesised that the ability of p17 to misfold may result in the generation of toxic assemblies in the brain and may be relevant for HAND pathogenesis. A multidisciplinary integrated approach has been applied to determine the ability of p17 to form soluble amyloi

The need for information among patients with hematological malignancies: Psychometric analyses of the 62-item Hematology Information Needs Questionnaire (HINQ-62).

The purpose of this study was to investigate the psychometric characteristics (content validity, internal consistency, and subscale structure) of the Hematology Information Needs Questionnaire-62 (HINQ-62), a patient reported outcome measure (PROM) for assessing the need for information among patients with hematological malignancies (HM-patients). Baseline data were used from a prospective study on the need for information which 336 newly diagnosed HM-patients had completed. In phase 1 (design phase), data from the first 135 patients were used and in phase 2 (validation phase), data from the r

ЭПОС/ПОНСА Резюме

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Wearable activity monitors in oncology trials: Current use of an emerging technology.

BackgroundPhysical activity is an important outcome in oncology trials. Physical activity is commonly assessed using self-reported questionnaires, which are limited by recall and response biases. Recent advancements in wearable technology have provided oncologists with new opportunities to obtain real-time, objective physical activity data. The purpose of this review was to describe current uses of wearable activity monitors in oncology trials.MethodsWe searched Pubmed, Embase, and the Cochrane Central Register of Controlled Trials for oncology trials involving wearable activity monitors publi

Differential Zoledronate Adsorption by Commercially Available Biphasic Calcium Phosphate Bone Substitutes.

Background/Objectives: Osteonecrosis of the jaw, a non-healing wound, is a side effect in patients treated with nitrogen-containing bisphosphonates (e.g., zoledronate) after some oral procedures. Considering zoledronate toxicity in surgical wounds and the capacity of calcium phosphate synthetic compounds to adsorb it, the aim of this work was to demonstrate and elucidate the mechanism underlying this adsorption. Methods: Four different calcium phosphate synthetic bone substitutes were used in this study: AdBone® BCP (0.5-1 mm), Guidor® easy-graft (0.5-1 mm), Maxresorb® (0.5-1 mm) and Maxresorb

На пути к изоляции восприятия и физиологических факторов, способствующих тепловой чувствительности при множественном склерозе: осмысления из новой экспериментальной модели.

ЦЕЛЬ: Определение того, смягчают ли снижение теплового ощущения всего кузова при локальном охлаждении кожи, вызванное теплотворным эффектом, визуальное обесценение у людей с множественным склерозом (MS), оптическим невритом и симптомами, чувствительными к воздействию тепла, независимо от повышения температуры ядра.МЕТОДЫ: Thirteen Участники7 :: повторное выделение эмиссий MS (MS) пациентами с односторонним (левым) оптическим невритом и симптомами, чувствительными к воздействию тепла; 6 Проведено визуальное испытание на эффективность каждого глаза на исходном уровне и при пассивном нагревании (

Совпадение в полном тексте источника
… Skin temperature was measured using wireless Thermochron iButtons (DS1922-F5#, Embedded Data System, Lawrenceberg, KY, USA) secured to the chest, shoulder, thigh, calf and lower back using hypoallergenic surgical tape (3 M Transpore 1527–1). …

Seasonal clustering of sinopulmonary mucormycosis in patients with hematologic malignancies at a large comprehensive cancer center.

BackgroundInvasive Mucorales infections (IMI) lead to significant morbidity and mortality in immunocompromised hosts. The role of season and climatic conditions in case clustering of IMI remain poorly understood.MethodsFollowing detection of a cluster of sinopulmonary IMIs in patients with hematologic malignancies, we reviewed center-based medical records of all patients with IMIs and other invasive fungal infections (IFIs) between January of 2012 and August of 2015 to assess for case clustering in relation to seasonality.ResultsA cluster of 7 patients were identified with sinopulmonary IMIs (

Micro- and Macrovascular Complications in Early-Onset Type 2 Diabetes in Indians: Prevalence and Predictors in a Prospective Cross-Sectional Study.

Introductionand Aims: The prevalence of T2DM is rising among young people, placing them at greater risk for complications. We studied the prevalence and predictors of micro- and macrovascular complications in early-onset diabetes subjects (EOD, MethodsA total of 800 subjects (400 EOD, 400 LOD), matched for gender and diabetes duration, were prospectively recruited and assessed for the prevalence of peripheral neuropathy, retinopathy, nephropathy, and ASCVD. Multivariate logistic regression analyzed predictors of diabetes complications.ResultsThe median age at diagnosis of diabetes was 35 years

Can electronic assessment tools improve the process of shared decision-making? A systematic review.

BackgroundPatient involvement in decision-making plays a prominent role in improving the quality of healthcare. Despite this, shared decision-making is not routinely implemented. However, electronic assessment tools that capture patients' history, symptoms, opinions and values prior to their medical appointment are used by healthcare professionals during patient consultations to facilitate shared decision-making.ObjectiveTo assess the effectiveness of electronic assessment tools to improve the shared decision-making process.MethodA systematic review was conducted following PRISMA guidelines. P

Oral chemotherapy agents in cats: clinical uses, administration and side effects.

PRACTICAL RELEVANCE: Cancer is a very common disease in cats, and many feline patients will require chemotherapy as part of their treatment plan, either as a sole agent or as part of multimodality therapy. Although some general practitioners might be reluctant to undertake injectable chemotherapy, oral chemotherapy may feel like a more acceptable treatment option to manage in practice. CLINICAL CHALLENGES: The small body size of many cats means that tablet sizes made for the human market are less appropriate, which creates dosing challenges. The administration of oral medication can also be a

Creative Arts Therapy for Anxiety, Depression, and Quality of Life in Cancer Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

BackgroundCancer is a significant psychological burden for patients. Previous evidence syntheses suggest creative arts therapies (CATs) may improve psychological outcomes, but are limited by heterogeneity in intervention types, study designs, and outcomes, and the lack of a certainty of evidence assessment.AimsWe conducted a robust systematic review and meta-analysis of current randomized trial literature to explore the efficacy of CATs in improving anxiety, depression, and quality of life in cancer patients.MethodsWe searched PubMed, Embase, and PsycInfo databases for peer-reviewed randomized

The impact of the gut microbiome on tumor immunotherapy: from mechanism to application strategies.

Immunotherapy is one of the fastest developing areas in the field of oncology. Many immunological treatment strategies for refractory tumors have been approved and marketed. Nevertheless, much clinical and preclinical experimental evidence has shown that the efficacy of immunotherapy in tumor treatment varies markedly among individuals. The commensal microbiome mainly colonizes the intestinal lumen in humans, is affected by a variety of factors and exhibits individual variation. Moreover, the gut is considered the largest immune organ of the body due to its influence on the immune system. In t

Clinical Posters From JADPRO Live 2022

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Biology and Diseases of Dogs

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Электронные постеры

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Rapid Fire Presentations

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