Результаты поиска

[Sedation and analgesia in intensive therapy].

INTRODUCTION: In the operating room, anaesthetist must provide unconsciousness, analgesia and muscular relaxation. In intensive therapy (IT) … a continuous i.v. infusion (10-20 mg/h). Other opioid agents used in IT are: fentanil, alfentanil, sufentanil. Non-steroidal anti-inflammatory drugs (NSAID-s) are: aspirin, ibuprofen, ketoprofen, diclofenac, ketorolac. NSAID-s may have an opioid sparing effect and be of particular benefit for the relief of pain from bones and joints. They interfere with the …

Pleiotropic opioid regulation of spinal endomorphin 2 release and its adaptations to opioid withdrawal are sexually dimorphic.

We studied adaptations to acute precipitated opioid withdrawal of spinal μ-opioid receptor (MOR)-coupled regulation of the release of endomorphin 2 (EM2). The release of this highly MOR-selective endogenous opioid from opioid-naive spinal tissue of male rats is subjected to MOR-coupled positive as well as negative modulation via cholera toxin-sensitive G(s) and pertussis toxin-sensitive G(i)/G(o), respectively. The net effect of this concomitant bidirectional modulation is inhibitory. MOR-coupled pleiotropic regulation of EM2 release is retained in opioid-withdrawn spinal tissue of male rats,

[Esketamine Alleviates Postoperative Depressive Symptoms in Frail Elderly Patients Undergoing Thoracoscopic Radical Resection of Lung Cancer: A Randomized Double-Blind Controlled Trial].

OBJECTIVE: To investigate the effect of esketamine on postoperative depression in frail elderly patients undergoing thoracoscopic radical re … levels of serum NSE were significantly lower at T1 and T2 (P < 0.01); the consumption of propofol, sufentanil, remifentanil, and sevoflurane during surgery in the Esk group was significantly reduced (P < 0.05 or 0.01); the incidence of postoperative nausea/vomiting and hyperalgesia was significantly lower (P < 0.01); the duration of postoperative mechanical …

[Requisite muscle relaxation using vecuronium for tracheobronchial suction in neurosurgical intensive care patients].

Coordination of respiratory care with protection of the brain is critical in neurosurgical intensive care. Therefore, in addition to hyperve … ous subarachnoid hemorrhage were investigated. All patients were on-line sedated with midazolam and sufentanil and controlled ventilation was adjusted to maintain a paCO2 of 30 +/- 2 mmHg. Respiratory and hemodynamic parameters and ICP (epidural probe) were continuously monitored and recorded on an integrated data bank. After a bolus dose of propofol, routin …

Surgical techniques for patients with cancer-related neuropathic pain.

In this manuscript, we discuss the use of neuromodulatory techniques such as intrathecal therapy (IT) and spinal cord stimulation (SCS) for cancer pain in neuro-oncology patients. Currently, cancer pain management relies on oral opioids, which have a number of systemic side effects particularly in a chronic setting. An escalation of pain therapy for pain relief, such as neuromodulation, is necessary to improve neuro-oncology patients' quality of life. The paper highlights the need for more comprehensive pain management for patients during and after receiving cancer therapies. IT allows analges

Совпадение в полном тексте источника
… opioids 2 , 6 , 17 Pump malfunctions leading to overdose or withdrawal Fentanyl | Mu-opioid agonist 3 | No documented granuloma formation in preclinical models 16 | Systemic side effects associated with opioids 2 , 6 , 18 Not extensively studied for IT Pump malfunctions leading to overdose or withdrawal Sufentanil … registry analysis of 1403 patients with cancer pain demonstrated that the 283 patients with baseline scores available had VASPI scores improved at 6 months ( P = .0007) and at 12 months ( P = .0026). 29 IT hydromorphone may prevent breakthrough pain more successfully than morphine. 25 Fentanyl and sufentanil …

Brainstem responses can predict death and delirium in sedated patients in intensive care unit.

OBJECTIVES: In critically ill patients, the assessment of neurologic function can be difficult because of the use of sedative agents. It is not known whether neurologic signs observed under sedation can predict short-term outcomes. The objective of this study was to assess whether abnormal brainstem responses within the first 24 hrs of sedation are associated with mortality and altered mental status postsedation. DESIGN: Observational prospective study including an initial single-center and a subsequent multicenter study to develop and then validate the prognostic models. SETTING: Three mixe

Efficacy of repetitive transcranial magnetic stimulation on postoperative pain in patients undergoing video-assisted thoracoscopic surgery: study protocol for a prospective, single-center, randomized controlled trial.

BACKGROUND: Video-assisted thoracoscopic surgery (VATS) is a key treatment for many cardiothoracic issues, but intraoperative factors can lead to acute postoperative pain (APSP), impacting recovery and quality of life. While multimodal analgesic methods are used, they have notable side effects. Repetitive transcranial magnetic stimulation (rTMS) offers a non-invasive pain relief option by stimulating the primary motor cortex (M1), effective in chronic pain management. However, its role in preventing and treating APSP after VATS needs confirmation through high-quality clinical trials. METHODS/

Совпадение в полном тексте источника
… Anesthesia induction will be achieved via intravenous administration of propofol (1.5–2 mg/kg), sufentanil (0.1–0.5 μg/kg), and cisatracurium (0.15 mg/kg). A properly sized double-lumen endotracheal tube or bronchial blocker will be inserted via rapid sequence intubation. … Postoperative patient-controlled intravenous analgesia (PCIA) will be administered: Sufentanil 2 μg/kg + Ondansetron 0.2 mg/kg + Normal Saline to a total volume of 100 ml; baseline infusion rate 2 ml/h, PCA bolus dose 0.5 ml, with a 15-min lockout interval. …

Esketamine improves postoperative sleep quality in thoracic surgery patients with preoperative sleep disturbance: a randomized controlled trial.

OBJECTIVE: To investigate the effect of multiple intraoperative subanesthetic doses of esketamine on postoperative sleep quality in non-card … ating attenuated hypotension at induction and blunted stress response at extubation. Intraoperative sufentanil consumption was significantly lower in the esketamine group. Compared with preoperative levels, serum IL-6 concentrations increased in both groups on POD 1, 3, and 5; however, the esketamine group exhibited lower IL-6 levels than the control group o …

[Effect of respiratory mechanics-guided sedation strategy on diaphragm function in mechanical ventilated patients with chronic obstructive pulmonary disease].

OBJECTIVE: To investigate the effects of respiratory mechanics-guided sedation strategy on diaphragm function in chronic obstructive pulmona … ia and sedation. The sedatives were dexmedetomidine combined with propofol, and the analgesics were sufentanil in both groups. Respiratory mechanics monitoring was performed every 6 hours in the observational group, and the depth of sedation was adjusted according to the parameters of respiratory mechanics: when airway resistance (Raw) > 20 cmH2O×L-1×s-1, de …

Ice-cream used as cryotherapy during high-dose melphalan conditioning reduces oral mucositis after autologous hematopoietic stem cell transplantation.

Oral mucositis (OM) is one of the most frequent adverse events of high-dose conditioning chemotherapy with melphalan prior to autologous hematopoietic stem cell transplantation (AHSCT). It significantly reduces the patients' quality of life. One of the preventive strategies for OM is cryotherapy. We retrospectively analyzed whether commercially available ice-cream could prevent OM during the melphalan infusion. We retrospectively analyzed 74 patients after AHSCT to see whether there is any correlation between OM and cryotherapy (ice-cream), melphalan dose (140 mg/m2 or 200 mg/m2). The incidenc

Совпадение в полном тексте источника
… Comparative efficacy of patient-controlled administration of morphine, hydromorphone, or sufentanil for the treatment of oral mucositis pain following bone marrow transplantation. Pain. 1997;72(3):333–346. doi: 10.1016/s0304-3959(97)00059-6. 7. …

[The effects of long-term sedation on intestinal function].

Gastrointestinal integrity with intact function are of main importance in critically ill patients, and not only as a route of nutritional su … ure, in contrast to the patients in groups 8, 9, and 10. The last group received the combination of sufentanil, midazolam and methohexitone to achieve a deep sedation. The rate of normal enteric tube feeding in these patients with severe head trauma was 30%. CONCLUSIONS. In patients with severe head trauma who need deep sedation to prevent dangerous high int …

Консолидация, систематическая оценка и сопоставление руководящих рекомендаций в отношении лечения хронической боли: Протокол для составления карты рекомендаций в отношении цифрового хронического заболевания.

ВВЕДЕНИЕ: Хроническая боль 1 В 5 :: взрослые и дети во всем мире; однако управление попрежнему носит весьма различный характер, и, как правило, обеспечивается низкий уровень медицинского обслуживания. Несогласованность рекомендаций, содержащихся в руководящих принципах клинической практики в отношении лечения хронической боли, способствует неоптимальному лечению пациентов. Мы будем разрабатывать и распространять живую цифровую карту рекомендаций в отношении хронической боли (e-Chronic Bain RecMap) для выявления заслуживающих доверия рекомендаций в three высокоприоритетные области1) опиоиды,2)

Совпадение в полном тексте источника
… hydrocodone or hydromorphone or ketobemidone or levorphanol or lofentanil or meperidine or meptazinol or methadone or methadyl acetate or morphine or nalbuphine or opium or oxycodone or oxymorphone or pentazocine or phenazocine or phenoperidine or pirinitramide or promedol or propoxyphene or remifentanil or sufentanil … hydrocodone or hydromorphone or ketobemidone or levorphanol or lofentanil or meperidine or meptazinol or methadone or methadyl acetate or morphine or nalbuphine or opium or oxycodone or oxymorphone or pentazocine or phenazocine or phenoperidine or pirinitramide or promedol or propoxyphene or remifentanil or sufentanil …

Analgesic efficacy of an opioid-free postoperative pain management strategy versus a conventional opioid-based strategy following open major hepatectomy: an open-label, randomised, controlled, non-inferiority trial.

BACKGROUND: Convincing clinical evidence regarding completely opioid-free postoperative pain management using erector spinae plane block (ES … p did not receive ESPB and was treated with a conventional intravenous opioid-based pump (2.5-μg/kg sufentanil and 10-mg tropisetron diluted to 100 mL with 0.9% NS). Patients in the VC-ESPB group underwent magnetic resonance imaging (MRI) to identify local anaesthetic diffusion after ESPB was performed under ultrasound guidance. The primary outcome was posto …

Акушерская анестезия/анагезия не влияет на курс болезни при множественном склерозе: 10- Ретроспективное когортное исследование.

ЦЕЛИ: Множественный склероз (МС) часто встречается у молодых женщин, а воздействие акушерской анестезии/анагезии на болезнь плохо изучено. Ни одно из предыдущих исследований не было посвящено изучению состояния заболевания женщин, работающих в Чешской Республике. Цель этого исследования заключалась в оценке случаев или отсутствия рецидивов 6-month Послеродовый период в MS parturients с акушерской анестезией и без нее. МАТЕРИАЛЫ И МЕТОДЫ: Мы ретроспективно изучили все поставки (n = 58,455) в университетской больнице Брно 2004 в адрес 2013 и выявила женщин, имеющих ICD-10 код G35 (MS), зарегистр

Совпадение в полном тексте источника
… Comparison of parturient ‐ controlled remifentanil with epidural bupivacain and sufentanil for labour analgesia: Randomised controlled trial . Biomedical papers , 158 ( 2 ), 227 – 232 . 10.5507/bp.2012.073 23128818 Vachova , M. ( 2012 ). A global epidemic of multiple sclerosis? …

Which Analgesic Should We Use to Relieve Pain After Knee or Hip Arthroplasty? A Systematic Review and Network Meta-analysis of RCTs.

BACKGROUND: Effective postoperative pain management after knee and hip arthroplasties offers substantial clinical benefits; however, clinici … ced the risk of nausea (OR 0.1 [95% CrI 0.0 to 0.7]), whereas nerve-block bupivacaine combined with sufentanil increased the risk (OR 6 [95% CrI 1 to 31]). No other differences were observed across interventions for the remaining adverse events. CONCLUSION: For knee arthroplasty, local levobupivacaine appeared to be the most effective option. For hip arthro …

Antiseptic Functions of CGK012 against HMGB1-Mediated Septic Responses.

High mobility group box 1 (HMGB1), a protein with important functions, has been recognized as a potential therapeutic target for the treatment of sepsis. One possible mechanism for this is that inhibiting HMGB1 secretion can exert antiseptic effects, which can restore the integrity of the vascular barrier. (7S)-(+)-cyclopentyl carbamic acid 8,8-dimethyl-2-oxo-6,7-dihydro-2H,8H-pyrano[3,2-g]chromen-7-yl-ester (CGK012) is a newly synthesized pyranocoumarin compound that could function as a novel small-molecule inhibitor of the Wnt/β-catenin signaling pathway. However, no studies have yet determi

Совпадение в полном тексте источника
… Sufentanil inhibits migration of human leukocytes through human endothelial cell monolayers. Anesth. Analg. 1998;87:1181–1185. doi: 10.1213/00000539-199811000-00038. 32. Bae J.S., Rezaie A.R. …

Investigating the Analgesic Mechanisms of Acupuncture for Cancer Pain: Insights From Multimodal Bioelectrical Signal Analysis.

PurposeCancer pain management remains a significant clinical challenge. While acupuncture has shown potential in alleviating cancer pain, its underlying mechanisms are not yet fully understood. This study investigates the neurophysiological mechanisms underlying acupuncture's analgesic effects using multimodal bioelectrical signal analysis.Patients and methodsFifteen cancer pain patients underwent acupuncture while wearing portable, multi-sensor devices to capture bioelectrical signals. Pain levels were assessed using the Numerical Rating Scale (NRS) before and during needle retention. Neuroph

Совпадение в полном тексте источника
… For example, when the acupuncture - drug combined anesthesia technique was used in conjunction with tracheal intubation, the intraoperative usage of sufentanil was reduced by approximately 20%. …

Anaesthesia as an influence in tumour progression.

PURPOSE: Tumour growth and the formation of metastases are essential elements in the progression of cancer. The centre of treatment is the surgical resection of primary solid tumours. But even if the tumour can be removed without microscopic residual cells, local recurrences and distant metastases occur and determine the patient's fate. During the operation, tumour cells are shed from the primary tumour and released into the circulation. These circulating tumour cells might play an important role in the formation of new tumour sites. Therefore, a functional innate and adaptive immune system is

Совпадение в полном тексте источника
… A third prospective study compared a TIVA in combination with a paravertebral nerve block with sevoflurane both in addition to remifentanil intraoperatively and a sufentanil pump postoperatively in radical lung resection for non-small cell lung cancer (NSCLC). …

[Effects of continuous goal-directed analgesia on fluid resuscitation of massive burn patients during shock].

Objective: To investigate the effects of continuous goal-directed analgesia on fluid resuscitation during shock stage in patients with massi … intermittent analgesia (IA) group (68 cases,with average age of 45 years old) according to whether sufentanil injection was continuously used for intravenous analgesia during the shock stage. The patients in the 2 groups were predominantly male. Before and at 72 h of treatment, the severity of disease and trauma pain of patients in the 2 groups were scored …

The Missing Link: Integrating Interventional Pain Management in the Era of Multimodal Oncology.

Cancer-related pain (CrP) is one of the most frequent and debilitating issues that affect the quality of life of patients with cancer. Systemic analgesics, particularly opioids, have been the cornerstone of pain management. However, the following shortcomings of the mentioned therapies, such as side effects, tolerance, and inadequate relief in refractory cases, make implementing a more complete, multimodal treatment plan necessary. Interventional pain management (IPM) uses specific invasive procedures, with different degree of invasiveness, such as nerve blocks, neurolysis, neuromodulation, an

Совпадение в полном тексте источника
… The Polyanalgesic Consensus Conference does, however, support the intrathecal injection of various opioid drugs, including hydromorphone, fentanyl, and sufentanil, as well as the nonopioids bupivacaine and clonidine, either alone or in combination [ 106 , 111 ]. …