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Sulforaphane protects against sodium valproate-induced acute liver injury.

Drug-induced hepatotoxicity is one of the most commonly encountered obstacles in the field of medical practice. Sodium valproate (VPA) is among many drugs with reported hepatotoxic effects. Sulforaphane (SFN) is a thiol compound found in wide abundance in cruciferous plants that has numerous reported therapeutic efficacies. The current investigation sheds light on the potential hepatoprotective effect of SFN against VPA-induced liver injury in rats. Twice daily VPA (700 mg/kg, i.p.) for 7 days induced significant biochemical alterations and hepatic histopathological damage. SFN (0.5 mg/kg, ora

Albugo-imposed changes to tryptophan-derived antimicrobial metabolite biosynthesis may contribute to suppression of non-host resistance to Phytophthora infestans in Arabidopsis thaliana.

BACKGROUND: Plants are exposed to diverse pathogens and pests, yet most plants are resistant to most plant pathogens. Non-host resistance describes the ability of all members of a plant species to successfully prevent colonization by any given member of a pathogen species. White blister rust caused by Albugo species can overcome non-host resistance and enable secondary infection and reproduction of usually non-virulent pathogens, including the potato late blight pathogen Phytophthora infestans on Arabidopsis thaliana. However, the molecular basis of host defense suppression in this complex pla

[Double-lung transplantation in 15 patients with pulmonary hypertension].

BACKGROUND: Pulmonary hypertension is a serious disease that, in its terminal phase, requires lung transplantation. PATIENTS AND METHODS: A retrospective study was undertaken of 15 patients with pulmonary hypertension who underwent lung transplantation between 1994 and 2004. Clinical data recorded before the procedure and during follow-up were reviewed. RESULTS: Pulmonary hypertension was reported as idiopathic in 8 patients (53%) and related to consumption of toxic oil in 2. The remaining causes were documented as chronic peripheral pulmonary embolism, histiocytosis X, venoocclusive disease

THE SO-CALLED RHYTHMS OF GROWTH-ENERGY IN MOUSE CANCER.

IN CONCLUSION WE MAY SUMMARIZE THE ABOVE BIOLOGICAL OBSERVATIONS IN A SERIES OF THESES AS FOLLOWS: 1. Cancer cells differ from other epithel … f some possible organism within the cancer cell; some organism which, acting as does Plasmodiophora brassicae within vegetable cells, underlies the infectivity of cancer cells and provides the stimulus for their continued proliferation. Upon such an assumption the numerous cases of cage infection find their explanation. 9. The various inclusions of the can …

Biochanin A Mitigates Atherosclerosis by Inhibiting Lipid Accumulation and Inflammatory Response.

Biochanin A (BCA), a dietary isoflavone extracted from red clover and cabbage, has been shown to antagonize hypertension and myocardial ischemia/reperfusion injury. However, very little is known about its role in atherogenesis. The aim of this study was to observe the effects of BCA on atherosclerosis and explore the underlying mechanisms. Our results showed that administration of BCA promoted reverse cholesterol transport (RCT), improved plasma lipid profile, and decreased serum proinflammatory cytokine levels and atherosclerotic lesion area in apoE-/- mice fed a Western diet. In THP-1 macrop

Всеобъемлющий анализ two Китайские геномы огурцов и мутантов как ресурсы для точного размножения.

Cumuis sativus L., известный как огурец, является важным овощным растениеводством во всем мире, крупнейшим производителем которого является Китай, в особенности северный и южно-китайский типы. В то время как обширные геномные исследования были сосредоточены на Северном Китае, особенно на китайском Лонге. 9930, исследования по Южно-Китайскому типу остаются ограниченными. В этом исследовании мы собрали высококачественные геномы two широко культивируемые и репрезентативные родные разновидности: S36 (тип Северной Китая) и H19 (тип Южной Китая) и провели анализ мутагенезов. Сравнительный анализ ген

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… Impacts of allopolyploidization and structural variation on intraspecific diversification in Brassica rapa. Genome Biol. 2021;22:166. 8. Li H, Wang S, Chai S. et al. Graph-based pan-genome reveals structural and sequence variations related to agronomic traits and domestication in cucumber. … Development and screening of EMS mutants with altered seed oil content or fatty acid composition in Brassica napus. Plant J. 2020;104:1410–22 46. Zhang T, Dong X, Yuan X. et al. Identification and characterization of CsSRP43, a major gene controlling leaf yellowing in cucumber. …

Risk factors for pulmonary arterial hypertension.

The present limitations in knowledge of the potential risk factors for PPH undoubtedly are attributable to the facts that PPH is a rare disease with an unknown pathogenesis and lacking large case series. Moreover, definite epidemiologic data are rare and ideally should be obtained from epidemiologic surveys such as large case-control studies. The increased incidence of the disease in young women, the familial cases, the association with autoimmune disorders, and the recent discovery that mutation of the PPH1 gene may not be restricted to familial PPH support the hypothesis that the development

Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination.

Vitamin C (L-ascorbic acid) has been known as an antioxidant for most people. However, its physiological role is much larger and encompasses very different processes ranging from facilitation of iron absorption through involvement in hormones and carnitine synthesis for important roles in epigenetic processes. Contrarily, high doses act as a pro-oxidant than an anti-oxidant. This may also be the reason why plasma levels are meticulously regulated on the level of absorption and excretion in the kidney. Interestingly, most cells contain vitamin C in millimolar concentrations, which is much highe

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… . | Rosaceae | Pear | 7–29 a | [ 46 ] Vegetables | | | | Brassica oleracea var. italica Plenck. | Brassicaceae | Broccoli | 25–130 a | [ 26 ] Brassica oleracea var. acephala (DC.)Alef. | Brassicaceae | Kale | 51–120 a | [ 26 ] Capsicum annuum L. | Solanaceae | Pepper | 107–154 a | [ 27 ] Solanum … Brassica foods as a dietary source of vitamin C: A review. Crit. Rev. Food Sci. Nutr. 2014;54:1076–1091. doi: 10.1080/10408398.2011.626873. 27. Martínez S., López M., González-Raurich M., Bernardo Alvarez A. …

The Burden of Cancer, Government Strategic Policies, and Challenges in Pakistan: A Comprehensive Review.

Cancer is a severe condition characterized by uncontrolled cell division and increasing reported mortality and diagnostic cases. In 2040, an estimated 28.4 million cancer cases are expected to happen globally. In 2020, an estimated 19.3 million new cancer cases (18.1 million excluding non-melanoma skin cancer) had been diagnosed worldwide, with around 10.0 million cancer deaths. Breast cancer cases have increased by 2.26 million, lung cancer by 2.21 million, stomach by 1.089 million, liver by 0.96 million, and colon cancer by 1.93 million. Cancer is becoming more prevalent in Pakistan, with 19

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… Cabbage ( Brassica oleracea L. var capitata) phytochemicals with antioxidant and anti-inflammatory potential Asian Pacific . J Cancer Prevent. ( 2013 ) 14 : 6657 – 62 . 10.7314/APJCP.2013.14.11.6657 24377584 61. Craig WJ . Nutrition concerns and health effects of vegetarian diets . … Inhibition of DNA oxidative damage and antimutagenic activity by dichloromethane extract of Brassica rapa var. rapa L seeds . Indus Crops Prod. ( 2015 ) 74 : 585 – 91 . 10.1016/j.indcrop.2015.05.038 69. Ren W Qiao Z Wang H Zhu L Zhang L . Flavonoids: promising anticancer agents . …

Angioprevention of Urologic Cancers by Plant-Derived Foods.

The number of cancer cases worldwide keeps growing unstoppably, despite the undeniable advances achieved by basic research and clinical practice. Urologic tumors, including some as prevalent as prostate, bladder or kidney tumors, are no exceptions to this rule. Moreover, the fact that many of these tumors are detected in early stages lengthens the duration of their treatment, with a significant increase in health care costs. In this scenario, prevention offers the most cost-effective long-term strategy for the global control of these diseases. Although specialized diets are not the only way to

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… Similar to other examples of dietary intervention for cancer prevention, there are conflicting data in the literature regarding the efficacy of consumption of brassica vegetables in reducing cancer risk. … The richest plant sources of kaempferol are kale ( Brassica oleracea ), Chinese cabbage ( Brassica rapa ), broccoli, spinach and herbs such as dill, chives and tarragon [ 185 ]. …

Phytochemical-Based Nanomedicine for Advanced Cancer Theranostics: Perspectives on Clinical Trials to Clinical Use.

In the current chapter, a new strategic compilation of phytochemicals with potent antitumor properties has been addressed, most importantly focusing on cell cycle arrest and apoptotic signaling mechanism. A promising approach in tumor prevention is to eliminate cancer cells preferably via cell cycle arrest and programmed cell death with lesser harm to neighboring normal cells. Cancer cells have a survival advantage to escape apoptosis and relentlessly divide to proliferate, gearing up the cell cycle process. Recently, the use of phytochemical-derived conjugated chemotherapeutic agents has incr

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… g/mol | | [ 33 ] NCT03569345 NCT00108121 NCT02723721 Betulinic acid | Betula pubescens (Betulaceae) | C 30 H 48 O 3 | 456.7 g/mol | | [ 34 ] NCT00701987 Maytansine | Maytenusovatus (Celastraceae) | C 34 H 46 ClN 3 O 10 | 692.2 g/mol | | [ 35 ] NCT02289833 NCT00934856 NCT01641939 Sulforaphane | ‎ Brassica … Sulforaphane Sulforaphane is a natural isothiocyanate isolated from crucifer plant Brassica oleracea (Brassicaceae), with potent anticancer effects. It is a secondary plant metabolite having antioxidant, antimitotic, and antiangiogenic properties. …

Clinical Evaluation of a Topical Unani Polyherbal Formulation in the Management of Photodamaged Facial skin: An open-label Standard Controlled Trial.

INTRODUCTION: Ageing is a natural process of life. With increasing age, the skin suffers progressive morphological and physiological decreme … lgare), Nakhud (Cicer arietinum),Masoor (Lens esculenta), Tukhm e turb (Raphanus sativus), Khardal (Brassica nigra), Haldi (Curcuma longa), Kateera (Cochlospermum religiosum). METHODS: This was a randomized open-label standard controlled study. 82 eligible subjects were allocated equally into test and control groups by computer-generated random numbers. I …

Biosynthesis of anticancer phytochemical compounds and their chemistry.

Cancer is a severe health issue, and cancer cases are rising yearly. New anticancer drugs have been developed as our understanding of the molecular mechanisms behind diverse solid tumors, and metastatic malignancies have increased. Plant-derived phytochemical compounds target different oncogenes, tumor suppressor genes, protein channels, immune cells, protein channels, and pumps, which have attracted much attention for treating cancer in preclinical studies. Despite the anticancer capabilities of these phytochemical compounds, systemic toxicity, medication resistance, and limited absorption re

TNFα inhibitors as targets for protective therapies in MSA: a viewpoint.

Multiple system atrophy (MSA) is a unique and fatal α-synucleinopathy associated with oligodendroglial inclusions and secondary neurodegeneration affecting striatum, substantia nigra, pons, and cerebellum. The pathogenesis remains elusive; however, there is emerging evidence suggesting a prominent role of neuroinflammation. Here, we critically review the relationship between αS and microglial activation depending on its aggregation state and its role in neuroinflammation to explore the potential of TNFα inhibitors as a treatment strategy for MSA and other neurodegenerative diseases.

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… Other recent studies demonstrated the neuroprotective and anti-inflammatory activities of allyl isothiocyanate (AITC), an aliphatic isothiocyanate derived from the precursor sinigrin present in vegetables of the Brassica family, on microglial cells through attenuation of JNK/NF-κB/TNFα signaling, which …

Разграничение Genotype X Environment Cooperation for Green Yeeld в Весне Барли в условиях необработанной и фунгицидной среды.

Барли (Hordeul vulgare L.) — четвёртый по величине урожай зерновых культур, выращиваемый на основе производства и возделывания. Биотические стрессы, особенно грибковые заболевания в ячменях, являются разрушительными и сопряжены с высокой вероятностью абсолютной потери урожайности. Для удовлетворения растущего спроса на ячмень решающее значение имеет выявление более высоких и стабильных генотипов. Вместе с тем выявление и рекомендация генотипов высшего сорта сопряжены с трудностями из-за взаимосвязи между генотипом и окружающей средой. Таким образом, настоящее исследование было направлено на оц

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… Oilseed Brassica 2016 1 66 74 37. Dehghani H. Ebadi A. Yousefi A. Biplot analysis of genotype by environment interaction for barley yield in Iran Agron. J. 2006 98 388 393 10.2134/agronj2004.0310 38. Sarkar B. Sharma R. Verma R.P.S. Sarkar A. Sharma I. …

Re-Cellularised Kidney Scaffold for Chikungunya Virus Propagation: A Novel Approach.

BACKGROUND: Re-emerging viral attacks are catastrophic for health and economy. It is crucial to grasp the viral life cycle, replication and mutation policies and attack strategies. It is also absolute to fathom the cost-efficient antiviral remedies earliest possible. METHODS: We propose to use a lab-grown organ (re-cellularized scaffold of sheep kidney) for viral culture and understand its interaction with extra-cellular matrices of the host tissue. RESULTS: Our findings showed that the chikungunya virus (CHIKV) could be better replicated in tissue-engineered bio models than cell culture. A

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… Walawalkar S Almelkar S Fabricating a pre-vascularized large-sized metabolically-supportive scaffold using Brassica oleracea leaf J Biomater Appl 2021 36 165 178 10.1177/0885328220968388 33135573 22. …

Clinical Practice Guidelines for management of Sexual Disorders in Elderly.

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… These include ginger ( Zingiberofficinale ), almond ( Amygdaluscommunis ), spice commonly known as ‘grains of paradise; Melegueta pepper’ ( Aframomummelegueta ), and certain brassica species and seed of garden cress (Lepidium sp). …

Regulation of microRNAs by natural agents: new strategies in cancer therapies.

MicroRNAs (miRNAs) are short noncoding RNA which regulate gene expression by messenger RNA (mRNA) degradation or translation repression. The plethora of published reports in recent years demonstrated that they play fundamental roles in many biological processes, such as carcinogenesis, angiogenesis, programmed cell death, cell proliferation, invasion, migration, and differentiation by acting as tumour suppressor or oncogene, and aberrations in their expressions have been linked to onset and progression of various cancers. Furthermore, each miRNA is capable of regulating the expression of many

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… Indole-3-Carbinol (I3C) and 3,3′-Diindolylmethane (DIM) The indole-3-carbinol (I3C) is a naturally occurring glucosinolates found in the Brassica vegetables such as cabbage, broccoli, cauliflower, kale, radish, turnip, and brussels sprouts, while 3,3′-diindolylmethane (DIM) is a prominent product obtained …

The Effects of Artificial Sweeteners on Intestinal Nutrient-Sensing Receptors: Dr. Jekyll or Mr. Hyde?

The consumption of artificial and low-calorie sweeteners (ASs, LCSs) is an important component of the Western diet. ASs play a role in the pathogenesis of metabolic syndrome, dysbiosis, inflammatory bowel diseases (IBDs), and various inflammatory conditions. Intestinal nutrient-sensing receptors act as a crosstalk between dietary components, the gut microbiota, and the regulation of immune, endocrinological, and neurological responses. This narrative review aimed to summarize the possible effects of ASs and LCSs on intestinal nutrient-sensing receptors and their related functions. Based on the

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… It could lead to the avoidance of some vegetables and fruits (e.g., Brassica ssp., spinach, bitter citrus, and green tea) and increased consumption of sweet and fatty food, thereby increasing the risk for chronic metabolic and inflammatory diseases [ 13 ]. …

Current Perspectives of the Applications of Polyphenols and Flavonoids in Cancer Therapy.

The development of anticancer therapies that involve natural drugs has undergone exponential growth in recent years. Among the natural compounds that produce beneficial effects on human health, polyphenols have shown potential therapeutic applications in cancer due to their protective functions in plants, their use as food additives, and their excellent antioxidant properties. The possibility of combining conventional drugs-which are usually more aggressive than natural compounds-with polyphenols offers very valuable advantages such as the building of more efficient anticancer therapies with l

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… The term anthocyanin was coined in 1835 by Ludwig Clamor Marquart, a German pharmacist, to denote the blue pigment of red cabbage ( Brassica oleracea ) [ 151 ]. …