Journal of gastroenterology and hepatology · 2026
Five-Year Outcomes and Disease Trajectories in Moderate-to-Severe Ulcerative Colitis: A Korean Multicenter Inception Cohort.
СтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Ye Byong Duk, Kim Hyo Jong, Park Dong Il, Park Young Sook, Lee Kang-Moon, Im Jong Pil, Jung Sung-Ae, Jeen Yoon Tae, Cha Jae Myung, Cheon Jae Hee, Hong Sung Noh, Kim Youngdoe, Choi Jong Min, Lee YoungJa, Lee Chang Kyun
Аннотация
BACKGROUND AND AIM: The incidence of ulcerative colitis (UC) has been increasing in Asia. Comprehensive data on the long-term course of moderate-to-severe UC remain scarce. This study investigated the clinical outcomes and factors associated with a disabling disease course in Korean patients with moderate-to-severe UC.
METHODS: The moderate-to-severe ulcerative colitis in Korea study was a prospective, multicenter, hospital-based inception cohort study that enrolled patients with newly diagnosed moderate-to-severe UC between August 2014 and February 2017. Clinical outcomes and factors associated with a disabling disease course were evaluated over 5 years.
RESULTS: Among 353 patients included, the median follow-up duration was 4.9 (interquartile range, 2.1-5.0) years, and 214 patients (60.6%) completed the 5-year follow-up. At 5 years, the cumulative rates of outcomes were clinical relapses, 62.9%; proximal disease extension, 29.5%; and UC-related hospitalization, 22.4%. Colectomy was required in two patients (0.6%), without mortality. A disabling disease course occurred in 171 patients (48.4%), with cumulative probabilities of 41.0%, 51.1%, and 53.9% at 12, 36, and 60 months, respectively. Elevated baseline white blood cell count was independently associated with a disabling disease course (adjusted hazard ratio: 1.06; 95% confidence interval: 1.00-1.12; p = 0.035). Five distinct partial Mayo score-based disease trajectory clusters were identified, demonstrating clear prognostic separation.
CONCLUSIONS: While Korean patients with moderate-to-severe UC showed a benign structural disease course with minimal colectomy rates, approximately half experienced a disabling disease course. The identified disease trajectories provide a novel framework for risk stratification and personalized management.
METHODS: The moderate-to-severe ulcerative colitis in Korea study was a prospective, multicenter, hospital-based inception cohort study that enrolled patients with newly diagnosed moderate-to-severe UC between August 2014 and February 2017. Clinical outcomes and factors associated with a disabling disease course were evaluated over 5 years.
RESULTS: Among 353 patients included, the median follow-up duration was 4.9 (interquartile range, 2.1-5.0) years, and 214 patients (60.6%) completed the 5-year follow-up. At 5 years, the cumulative rates of outcomes were clinical relapses, 62.9%; proximal disease extension, 29.5%; and UC-related hospitalization, 22.4%. Colectomy was required in two patients (0.6%), without mortality. A disabling disease course occurred in 171 patients (48.4%), with cumulative probabilities of 41.0%, 51.1%, and 53.9% at 12, 36, and 60 months, respectively. Elevated baseline white blood cell count was independently associated with a disabling disease course (adjusted hazard ratio: 1.06; 95% confidence interval: 1.00-1.12; p = 0.035). Five distinct partial Mayo score-based disease trajectory clusters were identified, demonstrating clear prognostic separation.
CONCLUSIONS: While Korean patients with moderate-to-severe UC showed a benign structural disease course with minimal colectomy rates, approximately half experienced a disabling disease course. The identified disease trajectories provide a novel framework for risk stratification and personalized management.