Drug design, development and therapy · 2018
A targeted therapy for melanoma by graphene oxide composite with microRNA carrier.
СтатьяНазвание и аннотация: Перевод в очереди
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Liu Can, Xie Huiqing, Yu Jingang, Chen Xiaoqing, Tang Shijie, Sun Lichun, Chen Xiang, Peng Defei, Zhang Xiangyan, Zhou Jianda
Аннотация
BACKGROUND: Nowadays, the combination of microRNA (miR) is attracting increased attention in clinical cancer trials. However, the clinical use of miR is highly limited because of certain properties such as instability, low-specificity distribution, and metabolic toxicity.
METHODS: In order to improve the anti-tumor efficacy and reduce the side effects of miR in treating melanoma, a combination of graphene oxide (GO), chitosan (CS), and a cellular penetrating peptide, MPG, was prepared with solid dispersion method in this research. The research has analyzed the specific components of nano drug-loading complexes GO-CS and GO-CS-MPG through characterization research and confirmed the bio-safety of the carrier material GO-CS-MPG.
RESULTS: The GO-CS-MPG-miR33a/miR199a nano drug-loading complex was successfully constructed and its medical effectiveness was verified. Through the subcutaneous tumor implantation experiment, an evident effect of the drug-loading complex in inhibiting melanoma cells was proven.
CONCLUSION: Results suggest that GO-CS-MPG may have potential applications in melanoma therapy.
METHODS: In order to improve the anti-tumor efficacy and reduce the side effects of miR in treating melanoma, a combination of graphene oxide (GO), chitosan (CS), and a cellular penetrating peptide, MPG, was prepared with solid dispersion method in this research. The research has analyzed the specific components of nano drug-loading complexes GO-CS and GO-CS-MPG through characterization research and confirmed the bio-safety of the carrier material GO-CS-MPG.
RESULTS: The GO-CS-MPG-miR33a/miR199a nano drug-loading complex was successfully constructed and its medical effectiveness was verified. Through the subcutaneous tumor implantation experiment, an evident effect of the drug-loading complex in inhibiting melanoma cells was proven.
CONCLUSION: Results suggest that GO-CS-MPG may have potential applications in melanoma therapy.