Медицинская библиотека · Clinical immunology (Orlando, Fla.) · 2021

Adverse reactions in a large cohort of patients with inborn errors of immunity receiving intravenous immunoglobulin.

Esmaeilzadeh Hossein, Askarisarvestani Aida, Hosseini Nazanin, Samimi Sahar, Shafiei Alireza, Mahdaviani Seyed Alireza, Eslami Narges, Chavoshzadeh Zahra, Fallahi Mazdak, Khakbazanfard Nasrin, Shabestari Mahnaz Sadeghi, Aleyasin Soheila, Nabavizadeh Seyed Hesamedin, Cheraghi Taher, Kalantari Arash, Ahmadiafshar Akefeh, Safari Mojgan, Eslamian Mohammad Hossein, Molatefi Rasol, Shirkani Afshin, Heidarzadeh Arani Marzieh, Tavakol Marzieh, Bemanian Mohammad Hassan, Arshi Saba, Nabavi Mohammad, Shokri Sima, Shahhosseini Babak, Mortazavi Negar, Nakhaei Pooria, Nazari Farzad, Fallahpour Morteza, Ahanchian Hamid, Moazzen Nasrin, Khoshkhui Maryam, Motlagh Ahmad Vosughi, Aghamohammadi Asghar, Abolhassani Hassan, Yazdani Reza, Rezaei Nima

СтатьяМногоцентровое исследованиеПоддержка исследования: вне правительства СШАПеревод в очереди

Аннотация

BACKGROUND

Intravenous immunoglobulins (IVIg) are the major treatment in inborn errors of immunity (IEI) disorders; However, IVIg infusions show some adverse effects. We aimed to assess the adverse reactions of IVIg infusions.

METHODS

Data of IVIg infusions in IEI patients were collected from 2011 to 2021. Totally, 363 IEI patients received IVIg regularly in Iran entered the study. The adverse reactions are classified regarding their severity and chronicity.

RESULTS

22,667 IVIg infusions were performed in the study. 157 patients (43.2%) and 1349 (5.9%) infusions were associated with at least one type of adverse reaction. The highest rates of adverse reactions were seen in severe combined immunodeficiency. Myalgia, chills, headache, fever, and hypotension were the most frequent adverse effects of IVIg.

CONCLUSION

The reactions affect almost half of the patients mainly in the first infusions which necessitate the close observation of IEI patients receiving IVIg.

Для цитирования: Esmaeilzadeh Hossein, Askarisarvestani Aida, Hosseini Nazanin, Samimi Sahar, Shafiei Alireza, Mahdaviani Seyed Alireza, Eslami Narges, Chavoshzadeh Zahra, Fallahi Mazdak, Khakbazanfard Nasrin, Shabestari Mahnaz Sadeghi, Aleyasin Soheila, Nabavizadeh Seyed Hesamedin, Cheraghi Taher, Kalantari Arash, Ahmadiafshar Akefeh, Safari Mojgan, Eslamian Mohammad Hossein, Molatefi Rasol, Shirkani Afshin, Heidarzadeh Arani Marzieh, Tavakol Marzieh, Bemanian Mohammad Hassan, Arshi Saba, Nabavi Mohammad, Shokri Sima, Shahhosseini Babak, Mortazavi Negar, Nakhaei Pooria, Nazari Farzad, Fallahpour Morteza, Ahanchian Hamid, Moazzen Nasrin, Khoshkhui Maryam, Motlagh Ahmad Vosughi, Aghamohammadi Asghar, Abolhassani Hassan, Yazdani Reza, Rezaei Nima. Adverse reactions in a large cohort of patients with inborn errors of immunity receiving intravenous immunoglobulin.. Clinical immunology (Orlando, Fla.). 2021. DOI: 10.1016/j.clim.2021.108826.

Предметные рубрики MeSH

Adolescent Adult Agammaglobulinemia Aged Ataxia Telangiectasia Child Child, Preschool Cohort Studies Common Variable Immunodeficiency Female Humans Immunoglobulins, Intravenous Immunologic Deficiency Syndromes Infant Infusions, Intravenous Male Middle Aged Young Adult

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