Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
Neuropsychiatric symptoms and emerging dementia in people with Down syndrome and older adults.
СтатьяПоддержка NIH: внешняя программаНазвание и аннотация: Перевод в очереди
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Magana-Ramirez Christina M, Gillen Daniel L, Hom Christy L, Jaimes Lidio, Chilukuri Srisai Saavarni, McMahon Noah, Lin Casie, Kuhlman Ryan, Hu Tiffany, Head Elizabeth, Lott Ira T, Sultzer David L
Аннотация
INTRODUCTION: Neuropsychiatric symptoms (NPS) are common as Alzheimer's disease (AD) dementia emerges, both in older adults (OA) and in individuals with Down syndrome (DS).
METHODS: We compared neuropsychiatric inventory (NPI) scores and NPI score trajectories in large cohorts of individuals with DS and OA. Participants were stratified as cognitively normal/stable, mild cognitive impairment, or dementia.
RESULTS: The pattern of NPI domain scores in cohorts with DS (n = 396) or OA (n = 35,217) were qualitatively similar across the cognitive groups. The relationships between cognitive group and both the NPI total score and the rate of NPI score change over time were similar in the two cohorts (multivariate Wald test, p = 0.28 and p = 0.52, respectively).
DISCUSSION: These findings support a conjecture that the shared pathophysiology among individuals with DS and OA may be reflected in the similar clinical profiles and clinical trajectories. NPS are important considerations in the early diagnosis and clinical management.
HIGHLIGHTS: Neuropsychiatric symptoms (NPS) often precede cognitive decline in late-onset AD. People with Down syndrome (DS) are a vulnerable population for AD. Psychiatric symptoms in people with DS and emergent dementia are poorly understood. Symptoms in people with DS and older adults (OA) were similar across cognitive groups. Similar symptoms in the two groups may reflect shared amyloid or related pathology.
METHODS: We compared neuropsychiatric inventory (NPI) scores and NPI score trajectories in large cohorts of individuals with DS and OA. Participants were stratified as cognitively normal/stable, mild cognitive impairment, or dementia.
RESULTS: The pattern of NPI domain scores in cohorts with DS (n = 396) or OA (n = 35,217) were qualitatively similar across the cognitive groups. The relationships between cognitive group and both the NPI total score and the rate of NPI score change over time were similar in the two cohorts (multivariate Wald test, p = 0.28 and p = 0.52, respectively).
DISCUSSION: These findings support a conjecture that the shared pathophysiology among individuals with DS and OA may be reflected in the similar clinical profiles and clinical trajectories. NPS are important considerations in the early diagnosis and clinical management.
HIGHLIGHTS: Neuropsychiatric symptoms (NPS) often precede cognitive decline in late-onset AD. People with Down syndrome (DS) are a vulnerable population for AD. Psychiatric symptoms in people with DS and emergent dementia are poorly understood. Symptoms in people with DS and older adults (OA) were similar across cognitive groups. Similar symptoms in the two groups may reflect shared amyloid or related pathology.