Unemployment, work hour reduction, and income loss: An international, multicentered, cross-sectional study of neuromyelitis optica spectrum disorder.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Ham Andrew Siyoon, Gomez Hjerthen Isabella, Tian De-Cai, Gu Hongfei, Gao Wen, Sudhir Akshatha, Pandit Lekha, Reddy Y Muralidhar, Murthy Jagarlapudi Muralikrishna, Eskandarieh Sharareh, Sahraian Mohammad Ali, Ayoubi Saeideh, Rodríguez-Rivas Roberto, González-González Francisco, Flores Rivera José de Jesús, Oliveira Enedina Maria Lobato, Portugal Raquel Paiva, Zaidan Paloma Peter Travassos, Viswanathan Shanthi, Koh Karina, Lim Su-Yin, Kosiyakul Punchika, Jitprapaikulsan Jiraporn, Siritho Sasitorn, Reyes Saúl, Toro Jaime, Gaitán Jairo, Ramirez Navarro Deyanira, Comme-Debroth Raúl, Báez Josmarlin Patricia Medina, Castillo Maria, Ibis Soto de Castillo, Mendoza de Salazar Sandra, Molina Omaira, Ragab Amany Hussein, Fouad Amr Mohamed, Kishk Nirmeen Adel, Rojas Juan Ignacio, Cristiano Edgardo, Patrucco Liliana, Gülec Bade, Uygunoglu Ugur, Tutuncu Melih, Siva Aksel, Aw Amelia Yun Yi, Tan Kevin, Yeo Tianrong, Alroughani Raed, Farouk Ahmed Samar, Almojel Malak, Kruja Jera, Verlaku Ariola, Qirjako Olga, Estiasari Riwanti, Maharani Kartika, Huda Saif, Kelly Patricia, Iorio Raffaele, Sabatelli Eleonora, Cobo-Calvo Álvaro, Arrambide Georgina, Villacieros Álvarez Javier, Broadley Simon, Leitner Unnah, Abass Cissé Fodé, Lamine Touré Mohamed, Conde Kab, Mateen Farrah J
Аннотация
METHODS: An investigator-designed survey was administered to adults ages 18-70 years with NMOSD and distributed by neurologists in 23 countries, July 2022 to September 2023.
RESULTS: There were 897 participants (635 aquaporin-4 antibody positive, 262 double-seronegative/untested; 81.4% female, average age 42.5 years, average disease duration 7.6 years, median 2 disease attacks since diagnosis). NMOSD impact was visual loss (34.0% unilateral; 28.2% bilateral), 61.8% with spinal cord disease, 55.6% with pain, 43.6% with fatigue, 38.2% with depressed mood, and 25.0% with gait aid use. In total, 92.6% took immunosuppressive therapy. Employment rates were 62.6% before and 36.3% after NMOSD diagnosis. In a multivariable model, statistically significant independent associations with unemployment in NMOSD were older age (odds ratio (OR) = 0.97, p < 0.001), being female (OR = 0.48, p < 0.001), bilateral visual loss (OR = 0.61, p = 0.02), highest frequency of depressed mood (OR = 0.29, p < 0.001), and walking aid use (OR = 0.38, p < 0.001).
DISCUSSION: Approximately 1/3 of people living with NMOSD of potential working age are in the workforce. Unemployment in NMOSD is associated with previously recognized factors but also self-reported low mood, gait aid use, and bilateral visual loss.