International journal of cardiology · 2026
Recurrent pericarditis in children: Clinical and therapeutic differences from adults.
СтатьяМногоцентровое исследованиеНаблюдательное исследованиеСравнительное исследованиеНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Mauro A, Mascolo R, Bizzi E, Sandini M, Collini V, Caorsi R, La Torre F, Celani C, Cattalini M, Giani T, Del Giudice E, Rigante D, Maggio M C, Trotta L, Pancrazi M, Ceriani E, Berra S, Agozzino F, Mannarino S, Pasquinucci M, Insalaco A, Lubrano R, Simonini G, Gattorno M, Bernardo L, Imazio M, Brucato A
Аннотация
BACKGROUND AND OBJECTIVES: Recurrent pericarditis (RP) guidelines are based on adult studies. We aimed to compare RP in pediatric and adult patients.
METHODS: This observational longitudinal multicentric cohort study studied 442 patients with idiopathic or post-pericardiotomy RP: 133 pediatric (<18 years) and 309 adult (≥18 years) patients.
RESULTS: Children showed a male predominance (90 males, 67.7%). Chest pain was most common in children [129/133 (97%) vs. 217/309 (70.2%) p < 0.001], as fever and pleural effusion [85/133 (63.9%) vs. 136/309 (44%), p < 0.05; 68/133 (51.1%) vs. 106/309 (34.3%), p < 0.001], while pericardial effusion occurred with a similar frequency: 99/133 (74.4%) vs. 249/309 (80.6%). Children exhibited a pronounced inflammatory response, with higher neutrophilia (p = 0.031). The clinical course was more favorable with a lower recurrence rate [median (IQR) 0.5 (0.27 to 0.87) vs. 0.87 (0.43 to 1.56) episodes/year, p < 0.001] and a longer disease-free interval, with a median (IQR) of 20.5 (11 to 30.6) months vs. 12.3 (7.4 to 23.6) months (p < 0.001). Glucocorticoid use was more frequent in adults [231/309 (74.8%) vs. 66/133 (49.6%), p < 0.001], as well as colchicine [306/309 (99%) vs. 120/133 (90%), p < 0.001]. Anakinra was more frequently prescribed in pediatric patients [60/133 (45.1%) vs. 73/309 (23.6%), p < 0.001]. Only 5/60 (8.3%) pediatric subjects were able to stop anakinra. Eleven patients (8.3%) had disease onset before 6 years.
CONCLUSIONS: Pediatric idiopathic RP exhibits distinct features compared to adult cases, with a more intense inflammatory profile but a more favorable clinical course. IL-1 inhibitors were more commonly used in pediatric subjects.
METHODS: This observational longitudinal multicentric cohort study studied 442 patients with idiopathic or post-pericardiotomy RP: 133 pediatric (<18 years) and 309 adult (≥18 years) patients.
RESULTS: Children showed a male predominance (90 males, 67.7%). Chest pain was most common in children [129/133 (97%) vs. 217/309 (70.2%) p < 0.001], as fever and pleural effusion [85/133 (63.9%) vs. 136/309 (44%), p < 0.05; 68/133 (51.1%) vs. 106/309 (34.3%), p < 0.001], while pericardial effusion occurred with a similar frequency: 99/133 (74.4%) vs. 249/309 (80.6%). Children exhibited a pronounced inflammatory response, with higher neutrophilia (p = 0.031). The clinical course was more favorable with a lower recurrence rate [median (IQR) 0.5 (0.27 to 0.87) vs. 0.87 (0.43 to 1.56) episodes/year, p < 0.001] and a longer disease-free interval, with a median (IQR) of 20.5 (11 to 30.6) months vs. 12.3 (7.4 to 23.6) months (p < 0.001). Glucocorticoid use was more frequent in adults [231/309 (74.8%) vs. 66/133 (49.6%), p < 0.001], as well as colchicine [306/309 (99%) vs. 120/133 (90%), p < 0.001]. Anakinra was more frequently prescribed in pediatric patients [60/133 (45.1%) vs. 73/309 (23.6%), p < 0.001]. Only 5/60 (8.3%) pediatric subjects were able to stop anakinra. Eleven patients (8.3%) had disease onset before 6 years.
CONCLUSIONS: Pediatric idiopathic RP exhibits distinct features compared to adult cases, with a more intense inflammatory profile but a more favorable clinical course. IL-1 inhibitors were more commonly used in pediatric subjects.