Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy · 2026
Clinical Usefulness of Selective Plasma Exchange for Treating Pediatric Autoimmune Neurological Diseases.
СтатьяНазвание и аннотация: Перевод в очереди
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Nakamizo Tomoya, Kanamori Toru, Kaneda Tomoya, Osaka Kei, Murakoshi Miki, Okutsu Mika, Ohkubo Atsushi, Udagawa Tomohiro, Mizuno Tomoko, Naito Shotaro, Takagi Masatoshi, Shimizu Masaki
Аннотация
INTRODUCTION: Selective plasma exchange (SePE) using the Evacure Plus EC-4A10D selective membrane separator is a useful therapeutic option for removing immunoglobulin G (IgG) in autoimmune diseases while retaining coagulation factors, including fibrinogen. This study aimed to clarify the clinical usefulness of SePE in pediatric autoimmune neurological disorders.
METHODS: We reported five pediatric patients with pediatric autoimmune neurological disorders successfully treated with SePE. We analyzed the removal rates of IgG and fibrinogen in a total of 29 SePE sessions and 3 conventional plasma exchange (PE) sessions performed on five pediatric patients.
RESULTS: Clinical symptoms improved in all patients without coagulation factor supplementation, and no severe adverse events of SePE/PE were observed. The mean IgG removal rates were similar for SePE and PE, at 55.5% and 61.8%, respectively. In contrast, the mean fibrinogen removal rate was lower for SePE than for PE, at 17.9% and 61.3%, respectively.
CONCLUSIONS: SePE might be effective for pediatric autoimmune neurological disorders.
METHODS: We reported five pediatric patients with pediatric autoimmune neurological disorders successfully treated with SePE. We analyzed the removal rates of IgG and fibrinogen in a total of 29 SePE sessions and 3 conventional plasma exchange (PE) sessions performed on five pediatric patients.
RESULTS: Clinical symptoms improved in all patients without coagulation factor supplementation, and no severe adverse events of SePE/PE were observed. The mean IgG removal rates were similar for SePE and PE, at 55.5% and 61.8%, respectively. In contrast, the mean fibrinogen removal rate was lower for SePE than for PE, at 17.9% and 61.3%, respectively.
CONCLUSIONS: SePE might be effective for pediatric autoimmune neurological disorders.