Wounds : a compendium of clinical research and practice · 2026
Efficacy of Rhizophora mangle cream in venous ulcer: a randomized controlled clinical trial.
СтатьяРандомизированное исследованиеНазвание и аннотация: Перевод в очереди
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Sá Jéssica Guido de Araújo, Cardoso Vieira Jeymesson Raphael, Silva Jerrar Janedson Xavier, Lopes Natalia Araújo, Pinheiro Guilherme Rêis de Carvalho, Crusco Vinícius Salcedo, Segatti Camila Brito, Freitas Filho Luiz Eugênio Peres de, Carneiro Pedro Henrique Vanderley da Silva, Santana Eduarda Santos de, Lins Esdras Marques
Аннотация
BACKGROUND: Compression therapy is the primary treatment for venous ulcers (VU). Topical treatments are used as an adjunct to accelerate healing, but they can be costly, and there is currently no standard medication.
OBJECTIVE: To evaluate reduction in venous ulcer area in patients treated with 5% aqueous extract of Rhizophora mangle L. leaves in cream form.
METHODS: Patients were randomized into 2 groups: the experimental group (EG) (55 ulcers) received 5% Rhizophora mangle cream, and the control group (CG) (45 ulcers) received medium chain triglyceride oil. Ulcers were evaluated using the MEASURE (measurement, exudate, appearance, suffering, weakening, reassess, edge) methodology, and area was measured using software on day 1, 4 weeks, 8 weeks, and 12 weeks.
RESULTS: At 12 weeks, the EG showed a mean 51.69% reduction in ulcer area (mean [SD] 3.97 [6.18] cm²), whereas the CG exhibited lesion worsening, with a mean increase in ulcer area corresponding to a -187.82% variation (mean [SD], 12.17 [20.17] cm²). Complete healing was observed in 34.5% of ulcers in the EG compared with 15.6% in the CG (P = .002). Furthermore, the EG demonstrated greater improvement across all clinical ulcer parameters than the CG.
CONCLUSION: The 5% Rhizophora mangle cream was effective in venous ulcer area reduction and clinical healing, which suggests that it may be an effective an alternative treatment for venous ulcers in the lower limbs.
OBJECTIVE: To evaluate reduction in venous ulcer area in patients treated with 5% aqueous extract of Rhizophora mangle L. leaves in cream form.
METHODS: Patients were randomized into 2 groups: the experimental group (EG) (55 ulcers) received 5% Rhizophora mangle cream, and the control group (CG) (45 ulcers) received medium chain triglyceride oil. Ulcers were evaluated using the MEASURE (measurement, exudate, appearance, suffering, weakening, reassess, edge) methodology, and area was measured using software on day 1, 4 weeks, 8 weeks, and 12 weeks.
RESULTS: At 12 weeks, the EG showed a mean 51.69% reduction in ulcer area (mean [SD] 3.97 [6.18] cm²), whereas the CG exhibited lesion worsening, with a mean increase in ulcer area corresponding to a -187.82% variation (mean [SD], 12.17 [20.17] cm²). Complete healing was observed in 34.5% of ulcers in the EG compared with 15.6% in the CG (P = .002). Furthermore, the EG demonstrated greater improvement across all clinical ulcer parameters than the CG.
CONCLUSION: The 5% Rhizophora mangle cream was effective in venous ulcer area reduction and clinical healing, which suggests that it may be an effective an alternative treatment for venous ulcers in the lower limbs.