Is segmental/multifocal onset a distinct presentation of idiopathic adult-onset dystonia?
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
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Velucci Vittorio, Terranova Carmen, Bono Francesco, Squintani Giovanna, Esposito Marcello, Avanzino Laura, Belvisi Daniele, Pellicciari Roberta, Artusi Carlo Alberto, Altavista Maria Concetta, Castagna Anna, Scaglione Cesa Lorella Maria, Cotelli Maria Sofia, Lettieri Christian, Erro Roberto, Petracca Martina, Schirinzi Tommaso, Ceravolo Roberto, Gigante Angelo Fabio, Tambasco Nicola, Mascia Marcello Mario, Muroni Antonella, Marinelli Lucio, Pisani Antonio, Romano Marcello, Coletti Moja Mario, Rizzo Vincenzo, Giaco Antonio, Tomas Carmelo, Barillari Maria Paola, Di Vico Ilaria Antonella, Di Biasio Francesca, Terranova Sara, Turla Marinella, Manzo Nicoletta, Liguori Rocco, Tinazzi Michele, Berardelli Alfredo, Defazio Giovanni
Аннотация
OBJECTIVES: To determine whether segmental/multifocal onset represents a distinct presentation of IAOD and to assess whether these patients differ from those with focal onset.
METHODS: We analyzed dystonia body distribution at first neurological evaluation in 863 patients from the Italian Dystonia Registry, all examined by expert neurologists within one year of symptom onset to minimize recall bias.
RESULTS: Segmental or multifocal onset occurred in 10 % of cases. This proportion remained stable across increasing intervals between symptom onset and first evaluation, arguing against recall bias. Patients with segmental/multifocal onset did not differ from those with focal onset in sex, age at onset, family history of dystonia, frequency of thyroid disease, or subsequent spread to additional body regions.
CONCLUSIONS: IAOD can present with segmental or multifocal onset, and this is unlikely to reflect recall bias. Moreover, patients with segmental/multifocal onset do not differ in factors potentially linked to disease initiation or subsequent spread compared with those with focal onset. These findings may have implications for prognostic counseling in IAOD.