JPMA. The Journal of the Pakistan Medical Association · 2026
Clinical spectrum and outcomes of autoimmune hepatitis in children: a quaternary centre experience.
СтатьяНазвание и аннотация: Перевод в очереди
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Iqbal Nazia, Seerat Iqtadar, Noureen Sobia, Bashir Hassan
Аннотация
OBJECTIVE: To analyse paediatric autoimmune hepatitis with respect to disease severity, treatment response, and clinical outcomes, including progression to liver failure and transplant survival.
METHODS: The retro-prospective study was conducted at the Pakistan Kidney and Liver Institute and Research Centre, Lahore, Pakistan, and comprised data from July 2019 to December 2024 of paediatric patients aged <15 years diagnosed with autoimmune hepatitis. Demographic characteristics, clinical manifestations as well as laboratory and imaging findings were noted. Data was analysed using SPSS 27.
RESULTS: Of the 56 patients, 30(53.6%) were girls with mean age 9.94±2.63 years, and 26(46.4%) were boys with mean age 9.24±2.90 years. Autoimmune hepatitis type 1 was the predominant type 46(82.1%), while type 2 was found in 1(1.8%) patient and 9(16.1%) were seronegative. Jaundice was the most common symptom found in 54(96.4%) followed by ascites 28(50%) and abdominal pain 18(32.1%). Histopathology of liver biopsies revealed features consistent with autoimmune hepatitis including statistically significant hepatocyte rosette formation (p value= 0.100). Overall, 8 (14.3%) patients required liver transplantation.
CONCLUSION: The clinical spectrum of autoimmune hepatitis and its outcomes in children indicated there were significant diagnostic and therapeutic challenges that needed to be overcome.
METHODS: The retro-prospective study was conducted at the Pakistan Kidney and Liver Institute and Research Centre, Lahore, Pakistan, and comprised data from July 2019 to December 2024 of paediatric patients aged <15 years diagnosed with autoimmune hepatitis. Demographic characteristics, clinical manifestations as well as laboratory and imaging findings were noted. Data was analysed using SPSS 27.
RESULTS: Of the 56 patients, 30(53.6%) were girls with mean age 9.94±2.63 years, and 26(46.4%) were boys with mean age 9.24±2.90 years. Autoimmune hepatitis type 1 was the predominant type 46(82.1%), while type 2 was found in 1(1.8%) patient and 9(16.1%) were seronegative. Jaundice was the most common symptom found in 54(96.4%) followed by ascites 28(50%) and abdominal pain 18(32.1%). Histopathology of liver biopsies revealed features consistent with autoimmune hepatitis including statistically significant hepatocyte rosette formation (p value= 0.100). Overall, 8 (14.3%) patients required liver transplantation.
CONCLUSION: The clinical spectrum of autoimmune hepatitis and its outcomes in children indicated there were significant diagnostic and therapeutic challenges that needed to be overcome.