Movement disorders : official journal of the Movement Disorder Society · 2013
Onset latency of segmental dystonia after deep brain stimulation cessation: a randomized, double-blind crossover trial.
СтатьяРандомизированное исследованиеПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Levin Johannes, Singh Arun, Feddersen Berend, Mehrkens Jan-Hinnerk, Bötzel Kai
Аннотация
BACKGROUND: Deep brain stimulation (DBS) of the globus pallidus internus is an effective treatment for cervical dystonia (CD). Interestingly, the onset of initial DBS effects is significantly prolonged compared with that in other diseases, such as Parkinson's disease. The return of symptoms after cessation of DBS could be delayed as well, but this has not been studied systematically.
METHODS: In patients who were treated for CD using DBS and had a good treatment effect, we compared interruption of DBS with sham-OFF in a randomized, double-blind crossover trial.
RESULTS: We observed that dystonic features appeared within a few minutes at almost full intensity in all patients after the cessation of DBS.
CONCLUSIONS: The almost immediate onset of dystonic features in our sample seems to exclude mechanisms with long time constants from the pathophysiology of dystonia. Thus, it is likely that, in these patients, an aberrant pattern of neural activity representing an inappropriate set point value for the position of the head is responsible for dystonia.
METHODS: In patients who were treated for CD using DBS and had a good treatment effect, we compared interruption of DBS with sham-OFF in a randomized, double-blind crossover trial.
RESULTS: We observed that dystonic features appeared within a few minutes at almost full intensity in all patients after the cessation of DBS.
CONCLUSIONS: The almost immediate onset of dystonic features in our sample seems to exclude mechanisms with long time constants from the pathophysiology of dystonia. Thus, it is likely that, in these patients, an aberrant pattern of neural activity representing an inappropriate set point value for the position of the head is responsible for dystonia.