West African journal of medicine · 2026
Posterior Urethral Valves at the University College Hospital Ibadan: A Seven-Year Review.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Ademola A D, Asinobi A O, Olulana D I, Takure A O, Adebayo S A, Alao M A, Tongo O O, Ayede A I, Akinmoladun J A, Adenigba P T, Olatunji R B, Lawal T A, Lawal T A, Ogundoyin O O, Olapade-Olaopa E O, Shittu O B
Аннотация
BACKGROUND: Posterior urethral valve (PUV) is the most common severe obstructive uropathy in boys. We reviewed patients with PUV in our hospital to provide an update on the presentation, management and outcome of PUV in our setting.
METHODOLOGY: A retrospective study of patients with PUV admitted in our hospital between January 1, 2016 - December 31, 2022.
RESULTS: Fifty-one patients were included, seven (median age 6.4 IQR 2.3, 10.8 years) had undergone valve ablation before presentation, while 44 (median age 1.3 IQR 0.1, 2.9 years) had not. Among the 44, four (9.1%) had abnormal features on antenatal ultrasound. 15.9% and 56.9% presented in the neonatal period and after one year of age respectively. The main complaints were voiding symptoms (45.5%), abdominal swelling (40.9%) and history of fever (38.6%). Wasting occurred in 43.9%. Serum creatinine ranged from 0.2-25.5 (median 1.4, IQR 0.8-3.0) mg/dl. Thiry seven children underwent valve ablation. Additionally, four of the 51 patients underwent repeat valve ablation. End-stage kidney disease (ESKD) occurred in five (9.8%). Dialysis was carried out in six patients (11.7%) including two patients with acute kidney injury. None underwent kidney transplantation. Mortality occurred in 10 (19.6%) and was due to sepsis (n=5) and ESKD (n= 4).
CONCLUSION: Posterior urethral valve is an important cause of morbidity and mortality in low resource settings and has 19.6% mortality in our centre over a 7-year period. Enhanced access to antenatal detection, early diagnosis and treatment, and kidney transplantation have the potential to improve outcomes.
METHODOLOGY: A retrospective study of patients with PUV admitted in our hospital between January 1, 2016 - December 31, 2022.
RESULTS: Fifty-one patients were included, seven (median age 6.4 IQR 2.3, 10.8 years) had undergone valve ablation before presentation, while 44 (median age 1.3 IQR 0.1, 2.9 years) had not. Among the 44, four (9.1%) had abnormal features on antenatal ultrasound. 15.9% and 56.9% presented in the neonatal period and after one year of age respectively. The main complaints were voiding symptoms (45.5%), abdominal swelling (40.9%) and history of fever (38.6%). Wasting occurred in 43.9%. Serum creatinine ranged from 0.2-25.5 (median 1.4, IQR 0.8-3.0) mg/dl. Thiry seven children underwent valve ablation. Additionally, four of the 51 patients underwent repeat valve ablation. End-stage kidney disease (ESKD) occurred in five (9.8%). Dialysis was carried out in six patients (11.7%) including two patients with acute kidney injury. None underwent kidney transplantation. Mortality occurred in 10 (19.6%) and was due to sepsis (n=5) and ESKD (n= 4).
CONCLUSION: Posterior urethral valve is an important cause of morbidity and mortality in low resource settings and has 19.6% mortality in our centre over a 7-year period. Enhanced access to antenatal detection, early diagnosis and treatment, and kidney transplantation have the potential to improve outcomes.