Clinical neuropathology · 2009
Neuroanatomical mapping of rabies nucleocapsid viral antigen distribution and apoptosis in pathogenesis in street dog rabies--an immunohistochemical study.
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Suja M S, Mahadevan A, Madhusudhana S N, Vijayasarathi S K, Shankar S K
Аннотация
BACKGROUND: Urinary tract infection (UTI) is a significant issue in childhood due to its high prevalence and potential long-term complications. Several studies have suggested that vitamin D deficiency is an influential factor in the progression of infection. This study aims to determine the value of serum vitamin D levels in predicting renal scarring among children with febrile UTIs.
METHODS: This study was conducted through a census sampling method from September 2019 to November 2021, with a 6-month follow-up period to survey children with their first febrile UTI who were referred to the nephrology clinic of a tertiary academic hospital. Out of 193 referred children, 55 met the inclusion criteria. Patients were excluded if they had a previous history of UTI, recurrent or breakthrough infection, delay in treatment initiation, hospitalization, ultrasonographic abnormality, hypertension, neurogenic bladder, or renal failure. Five additional cases were excluded due to incomplete follow-up. The study was completed with 50 participants, aged between 3 and 98 months. The main outcomes were measuring serum vitamin D levels during the acute phase of UTIs and conducting dimercaptosuccinic acid (DMSA) scans four to six months later. Logistic regression was used to determine the correlation between vitamin D levels and DMSA findings.
RESULTS: Levels of 25-hydroxyvitamin D were significantly associated with renal scarring (p = 0.0001); mean serum concentrations were significantly lower in patients with renal scarring (20.7 ± 7.8 ng/mL) than in those without renal scarring (37.1 ± 11.4 ng/mL). A serum vitamin D concentration of less than 30 ng/mL was determined as the best predictor of post-UTI renal scarring (positive LR 4.25, Youden's j index 0.676).
CONCLUSIONS: The study showed a negative correlation between renal scarring and serum vitamin D levels. It has been found that serum vitamin D level is a good predictor of renal scarring.
METHODS: This study was conducted through a census sampling method from September 2019 to November 2021, with a 6-month follow-up period to survey children with their first febrile UTI who were referred to the nephrology clinic of a tertiary academic hospital. Out of 193 referred children, 55 met the inclusion criteria. Patients were excluded if they had a previous history of UTI, recurrent or breakthrough infection, delay in treatment initiation, hospitalization, ultrasonographic abnormality, hypertension, neurogenic bladder, or renal failure. Five additional cases were excluded due to incomplete follow-up. The study was completed with 50 participants, aged between 3 and 98 months. The main outcomes were measuring serum vitamin D levels during the acute phase of UTIs and conducting dimercaptosuccinic acid (DMSA) scans four to six months later. Logistic regression was used to determine the correlation between vitamin D levels and DMSA findings.
RESULTS: Levels of 25-hydroxyvitamin D were significantly associated with renal scarring (p = 0.0001); mean serum concentrations were significantly lower in patients with renal scarring (20.7 ± 7.8 ng/mL) than in those without renal scarring (37.1 ± 11.4 ng/mL). A serum vitamin D concentration of less than 30 ng/mL was determined as the best predictor of post-UTI renal scarring (positive LR 4.25, Youden's j index 0.676).
CONCLUSIONS: The study showed a negative correlation between renal scarring and serum vitamin D levels. It has been found that serum vitamin D level is a good predictor of renal scarring.