Journal of cataract and refractive surgery · 2025
Outcomes of intralenticular lens aspiration with glued scleral-fixated intraocular lens for ectopia lentis in Marfan syndrome.
СтатьяНаблюдательное исследованиеНазвание и аннотация: Перевод в очереди
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Tripathi Manasi, Kaur Manpreet, Sinha Rajesh, Titiyal Jeewan S
Аннотация
PURPOSE: To evaluate visual and anatomical outcomes of intralenticular lens aspiration (ILLA) with fibrin glue-assisted intrascleral haptic fixation of intraocular lens (glued SFIOL) in Marfan syndrome patients with ectopia lentis.
SETTING: Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi.
DESIGN: Ambispective observational case series.
METHODS: Patients with Marfan syndrome and ectopia lentis who underwent ILLA with glued SFIOL from August 2021 to September 2022 were retrospectively enrolled in the study. Intraoperative surgical details were recorded, and patients were prospectively followed up. Primary outcome measure was postoperative corrected distance visual acuity (CDVA) at 12 months. Secondary outcome measures were postoperative complications and residual refractive error at 12 months.
RESULTS: 44 eyes of 25 patients were enrolled. Mean age of patients was 12.52 ± 6.6 years (14 male and 11 female patients). CDVA improved from 1.08 ± 0.53 logMAR preoperatively to 0.68 ± 0.49 logMAR on postoperative day 1 ( P = .012), 0.3 ± 0.2 at 3 months ( P = .004), and 0.14 ± 0.18 at 12 months ( P = .001). Moderate negative correlation was observed between age of presentation and postoperative CDVA at 12 months ( r = -0.36, P = .017). Group 2 (age >10 years) had better CDVA than Group 1 (age ≤10 years) at 3 months ( P = .016) and 12 months ( P = .033). Postoperative complications included vitreous hemorrhage (11.36%), hypotony (4.34%), pupillary capture of IOL (6.5%), haptic extrusion through sclera (2.27%) and posterior dislocation of IOL (2.27%). No eye had clinically apparent pseudophacodonesis.
CONCLUSIONS: ILLA with glued SFIOL is a promising surgical technique for managing ectopia lentis with Marfan syndrome. Younger age of presentation is associated with poorer postoperative visual outcomes.
SETTING: Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi.
DESIGN: Ambispective observational case series.
METHODS: Patients with Marfan syndrome and ectopia lentis who underwent ILLA with glued SFIOL from August 2021 to September 2022 were retrospectively enrolled in the study. Intraoperative surgical details were recorded, and patients were prospectively followed up. Primary outcome measure was postoperative corrected distance visual acuity (CDVA) at 12 months. Secondary outcome measures were postoperative complications and residual refractive error at 12 months.
RESULTS: 44 eyes of 25 patients were enrolled. Mean age of patients was 12.52 ± 6.6 years (14 male and 11 female patients). CDVA improved from 1.08 ± 0.53 logMAR preoperatively to 0.68 ± 0.49 logMAR on postoperative day 1 ( P = .012), 0.3 ± 0.2 at 3 months ( P = .004), and 0.14 ± 0.18 at 12 months ( P = .001). Moderate negative correlation was observed between age of presentation and postoperative CDVA at 12 months ( r = -0.36, P = .017). Group 2 (age >10 years) had better CDVA than Group 1 (age ≤10 years) at 3 months ( P = .016) and 12 months ( P = .033). Postoperative complications included vitreous hemorrhage (11.36%), hypotony (4.34%), pupillary capture of IOL (6.5%), haptic extrusion through sclera (2.27%) and posterior dislocation of IOL (2.27%). No eye had clinically apparent pseudophacodonesis.
CONCLUSIONS: ILLA with glued SFIOL is a promising surgical technique for managing ectopia lentis with Marfan syndrome. Younger age of presentation is associated with poorer postoperative visual outcomes.