JPMA. The Journal of the Pakistan Medical Association · 2026
Relationship between serum immunological biomarkers and small airway obstruction in patients with mild-to-moderate asthma and allergic rhinitis and their prognostic value.
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Xue Jing, Liu Xin, Bai Cairong, Zuo Yali, Hao Wendong
Аннотация
OBJECTIVE: To evaluate the correlation between various serum immunological biomarkers and small airway obstruction in children, and the prognostic value of the markers.
METHODS: This study was conducted at the First Affiliated Hospital of Xi'an Jiaotong University, Yulin, China, from February 2023 to March 2024, and comprised children aged 4-15 years diagnosed with asthma, who were divided into asthma group A and asthma with allergic rhinitis group B. Peripheral venous blood was collected from all the subjects to measure serum levels of total immunoglobulin E, C-reactive protein, eosinophil and interleukin-6 using enzyme-linked immunosorbent assay and standardised laboratory assays. Al participants underwent pulmonary function testing, including forced expiratory volume in 1 second, forced vital capacity, forced expiratory volume in 1 second/forced vital capacity ratio, and peak expiratory flow measurements. Data was analysed using SPSS 19 and GraphPad Prism 5.
RESULTS: Of the 295 patients, 178(60.3%) were in group A; 105(59%) girls and 73(41%) boys with mean age 8.5±1.8 years. The other 117(39.7%) patients were in group B; 72(61.5%) girls and 45(38.5%) boys with mean age 8.9±2.2 years (p>0.05). A significant negative correlation was found between serum interleukin-6 levels and the smal airway obstruction parameters mean mid-expiratory flow between 25-75% of forced vital capacity % predicted (r=-0.564, p<0.05) and forced expiratory flow % 50 predicted (r=-0.521, p<0.05) in group B. The cut-off values for total immunoglobulin E, C-reactive protein and interleukin-6 were 337.80IU/mL, 24.51mg/L and 38.75pg/mL, respectively. The area under the curve, sensitivity and specificity values of the combined diagnosis of total immunoglobulin E, C-reactive protein and interleukin-6 were 0.885, 78.51% and 89.26%, respectively.
CONCLUSIONS: Biomarkers total immunoglobulin E, C-reactive protein and interleukin-6 were found to be associated with small airway obstruction, and their combination demonstrated high diagnostic power for identifying paediatric patients with both asthma and allergic rhinitis.
METHODS: This study was conducted at the First Affiliated Hospital of Xi'an Jiaotong University, Yulin, China, from February 2023 to March 2024, and comprised children aged 4-15 years diagnosed with asthma, who were divided into asthma group A and asthma with allergic rhinitis group B. Peripheral venous blood was collected from all the subjects to measure serum levels of total immunoglobulin E, C-reactive protein, eosinophil and interleukin-6 using enzyme-linked immunosorbent assay and standardised laboratory assays. Al participants underwent pulmonary function testing, including forced expiratory volume in 1 second, forced vital capacity, forced expiratory volume in 1 second/forced vital capacity ratio, and peak expiratory flow measurements. Data was analysed using SPSS 19 and GraphPad Prism 5.
RESULTS: Of the 295 patients, 178(60.3%) were in group A; 105(59%) girls and 73(41%) boys with mean age 8.5±1.8 years. The other 117(39.7%) patients were in group B; 72(61.5%) girls and 45(38.5%) boys with mean age 8.9±2.2 years (p>0.05). A significant negative correlation was found between serum interleukin-6 levels and the smal airway obstruction parameters mean mid-expiratory flow between 25-75% of forced vital capacity % predicted (r=-0.564, p<0.05) and forced expiratory flow % 50 predicted (r=-0.521, p<0.05) in group B. The cut-off values for total immunoglobulin E, C-reactive protein and interleukin-6 were 337.80IU/mL, 24.51mg/L and 38.75pg/mL, respectively. The area under the curve, sensitivity and specificity values of the combined diagnosis of total immunoglobulin E, C-reactive protein and interleukin-6 were 0.885, 78.51% and 89.26%, respectively.
CONCLUSIONS: Biomarkers total immunoglobulin E, C-reactive protein and interleukin-6 were found to be associated with small airway obstruction, and their combination demonstrated high diagnostic power for identifying paediatric patients with both asthma and allergic rhinitis.