European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology · 2026
Promising treatment options for cerebellopontine angle meningiomas: a longitudinal retrospective cohort study.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
He Wen-Bo, Tang Lian-Sha, Chen Zhou-Hao-Ran, Hou Jing-Xuan, Zheng Da-Tong, Chen Yu-Chen, Zheng Yan, Chen Rui-Lian, Liu Zhi-Yong, Hu Yu, Xu Jian-Guo
Аннотация
BACKGROUND: Although gross total resection (GTR) is the standard treatment for meningiomas, its application in the cerebellopontine angle (CPA) remains controversial. Previous studies have not systematically compared long-term tumor control and functional outcomes between surgical resection and Gamma Knife radiosurgery (GKRS) for CPA meningiomas.
MATERIALS AND METHODS: CPA meningioma cases were extracted from a cohort of 10,392 patients diagnosed with meningiomas. Two strategies were used: a tumor-free approach (GTR) to ensure complete tumor resection, and a tumor-reduced approach (upfront GKRS or subtotal resection plus adjuvant GKRS) to reduce tumor burden. Outcomes were assessed by progression-free survival, Karnofsky Performance Status (KPS) scores, and neurological function recovery.
RESULTS: This study followed 158 patients for a median of 85.4 months. The tumor-free group had a progression rate of 5.7%, significantly lower than the 22.7% (p = 0.002) in the tumor-reduced group. Kaplan-Meier analysis showed significantly better tumor control in the tumor-free group (p = 0.043), especially in posterior tumors (p = 0.008). Regarding functional outcomes, the overall cranial nerve improvement rate was 54.2%, with a neurological deterioration rate of 7.6%. ΔKPS indicated better functional recovery in the tumor-reduced group (+12.95 vs. tumor-free group: +7.57, p = 0.005), especially for anterior tumors (+14.76 vs. +0.71, p < 0.001).
CONCLUSION: For posterior CPA meningiomas, prioritizing surgical GTR may lead to optimal tumor control. For anterior meningiomas, a tumor-reduced approach (either upfront GKRS or STR followed by adjuvant GKRS) may be preferred to achieve a better functional outcome. The selection between upfront GKRS and STR + GKRS should be guided by tumor size and the presence of neural compression symptoms.
MATERIALS AND METHODS: CPA meningioma cases were extracted from a cohort of 10,392 patients diagnosed with meningiomas. Two strategies were used: a tumor-free approach (GTR) to ensure complete tumor resection, and a tumor-reduced approach (upfront GKRS or subtotal resection plus adjuvant GKRS) to reduce tumor burden. Outcomes were assessed by progression-free survival, Karnofsky Performance Status (KPS) scores, and neurological function recovery.
RESULTS: This study followed 158 patients for a median of 85.4 months. The tumor-free group had a progression rate of 5.7%, significantly lower than the 22.7% (p = 0.002) in the tumor-reduced group. Kaplan-Meier analysis showed significantly better tumor control in the tumor-free group (p = 0.043), especially in posterior tumors (p = 0.008). Regarding functional outcomes, the overall cranial nerve improvement rate was 54.2%, with a neurological deterioration rate of 7.6%. ΔKPS indicated better functional recovery in the tumor-reduced group (+12.95 vs. tumor-free group: +7.57, p = 0.005), especially for anterior tumors (+14.76 vs. +0.71, p < 0.001).
CONCLUSION: For posterior CPA meningiomas, prioritizing surgical GTR may lead to optimal tumor control. For anterior meningiomas, a tumor-reduced approach (either upfront GKRS or STR followed by adjuvant GKRS) may be preferred to achieve a better functional outcome. The selection between upfront GKRS and STR + GKRS should be guided by tumor size and the presence of neural compression symptoms.