Nephrologie & therapeutique · 2026
[The value of immuno-histochemical analysis of renal glucocorticoid receptor expression in idiopathic nephrotic syndrome].
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Riguen Mouna, Chaker Hanen, Dammak Najla, Ben Hmida Mohamed, Boudawara Tahya, Agrebi Ikram, Kammoun Khawla
Аннотация
INTRODUCTION: The response to corticosteroid therapy in idiopathic nephrotic syndrome (INS) is variable. Glucocorticoid receptors (GR), which are essential for steroid action, may partly explain this variability.
OBJECTIVE: To investigate the relationship between podocyte glucocorticoid receptor expression assessed by immunohistochemistry and the response to corticosteroid therapy in INS.
PATIENTS AND METHODS: This was a retrospective study conducted over a 22-year period, including 29 patients with minimal change disease or primary focal segmental glomerulosclerosis. Podocyte GR expression was evaluated by immunohistochemistry and correlated with treatment response.
RESULTS: In total, 18 patients were steroid-sensitive, 6 were steroid-dependent, and 5 were steroid-resistant. No conventional clinical, laboratory, or histological factor was predictive. However, GR expression was higher in steroid-sensitive than in steroid-resistant patients (p = 0.046).
CONCLUSION: Podocyte glucocorticoid receptor expression may predict the response to corticosteroid therapy in idiopathic nephrotic syndrome.
OBJECTIVE: To investigate the relationship between podocyte glucocorticoid receptor expression assessed by immunohistochemistry and the response to corticosteroid therapy in INS.
PATIENTS AND METHODS: This was a retrospective study conducted over a 22-year period, including 29 patients with minimal change disease or primary focal segmental glomerulosclerosis. Podocyte GR expression was evaluated by immunohistochemistry and correlated with treatment response.
RESULTS: In total, 18 patients were steroid-sensitive, 6 were steroid-dependent, and 5 were steroid-resistant. No conventional clinical, laboratory, or histological factor was predictive. However, GR expression was higher in steroid-sensitive than in steroid-resistant patients (p = 0.046).
CONCLUSION: Podocyte glucocorticoid receptor expression may predict the response to corticosteroid therapy in idiopathic nephrotic syndrome.