Indian pediatrics · 2021
Association of Vitamin A Status With Under-Five Mortality in India.
СтатьяМетаанализНазвание и аннотация: Перевод в очереди
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Thomas Tinku, Sachdev Harshpal S, Ghosh Santu, Kapil Umesh, Kurpad Anura V
Аннотация
OBJECTIVE: To re-estimate the survival benefit from Vitamin A supplementation (VAS) in India using meta-analysis and to correlate mortality and vitamin A deficiency (VAD) in children aged 6 month to 5 year.
METHODS: Pooled risk ratio (fixed effects model) for mortality reduction with VAS was calculated from available Indian studies. Computed mortality rates in 6 months to 5 years children in Indian states were regressed on VAD prevalence estimates of the states.
RESULTS: There was no reduction in risk of all-cause mortality with VAS (RR=0.96; 95% CI: 0.89, 1.03). When regressing mortality on VAD in high or low VAD prevalence states, the regression coefficients were discordant.
CONCLUSION: No survival benefit was observed for VAS in India from the available literature. The targeting of VAS programs should be given serious consideration.
METHODS: Pooled risk ratio (fixed effects model) for mortality reduction with VAS was calculated from available Indian studies. Computed mortality rates in 6 months to 5 years children in Indian states were regressed on VAD prevalence estimates of the states.
RESULTS: There was no reduction in risk of all-cause mortality with VAS (RR=0.96; 95% CI: 0.89, 1.03). When regressing mortality on VAD in high or low VAD prevalence states, the regression coefficients were discordant.
CONCLUSION: No survival benefit was observed for VAS in India from the available literature. The targeting of VAS programs should be given serious consideration.