Journal of affective disorders · 2026
Resting-state functional connectome correlates of suicide attempt history and childhood trauma in major depressive disorder.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Jung Minjee, Park Jihoon, Kang Youbin, Shin Daun, Kang June, Jung JeYoung, Kaiser Marcus, Auer Dorothee P, Ham Byung-Joo, Han Kyu-Man
Аннотация
BACKGROUND: A prior suicide attempt is the strongest predictor of subsequent suicide mortality in major depressive disorder (MDD); however, the functional network architecture distinguishing individuals with and without a history of suicide attempts remains incompletely characterized. We applied a connectome-wide functional connectivity (FC) framework to identify FC alterations associated with suicide attempt history in MDD and examine their relationships with suicidal ideation and childhood trauma.
METHODS: Resting-state functional magnetic resonance imaging data were obtained from 204 participants (suicidal depression [SD] = 61, non-suicidal depression [NSD] = 62, healthy controls [HC] = 81). FC matrices were constructed using the Schaefer 400-node atlas. Group differences were examined using network-based statistics (NBS) and graph-theoretical measures.
RESULTS: NBS identified a significant subnetwork exhibiting lower FC in the SD group than in the NSD group (pFWE = 0.038), spanning the visual (VIS), somatomotor (SMN), dorsal attention (DAN), frontoparietal (FPN), and default mode (DMN) networks. Compared with the HC group, the SD group exhibited hypo- and hyperconnected subnetworks, whereas the NSD group showed no significant differences in FC. Graph-theoretical analyses revealed reduced strength, global efficiency, and betweenness centrality within the SD < NSD subnetwork. In the MDD group, mean subnetwork FC, SMN-VIS, and DMN-DMN FC were negatively correlated with suicidal ideation. In the SD group, SMN-SMN FC correlated inversely with childhood sexual abuse.
CONCLUSIONS: These findings suggest that hypoconnectivity across sensory, attentional, and self-referential systems may represent a connectome-level signature of suicide vulnerability in MDD and link childhood sexual abuse to suicide risk.
METHODS: Resting-state functional magnetic resonance imaging data were obtained from 204 participants (suicidal depression [SD] = 61, non-suicidal depression [NSD] = 62, healthy controls [HC] = 81). FC matrices were constructed using the Schaefer 400-node atlas. Group differences were examined using network-based statistics (NBS) and graph-theoretical measures.
RESULTS: NBS identified a significant subnetwork exhibiting lower FC in the SD group than in the NSD group (pFWE = 0.038), spanning the visual (VIS), somatomotor (SMN), dorsal attention (DAN), frontoparietal (FPN), and default mode (DMN) networks. Compared with the HC group, the SD group exhibited hypo- and hyperconnected subnetworks, whereas the NSD group showed no significant differences in FC. Graph-theoretical analyses revealed reduced strength, global efficiency, and betweenness centrality within the SD < NSD subnetwork. In the MDD group, mean subnetwork FC, SMN-VIS, and DMN-DMN FC were negatively correlated with suicidal ideation. In the SD group, SMN-SMN FC correlated inversely with childhood sexual abuse.
CONCLUSIONS: These findings suggest that hypoconnectivity across sensory, attentional, and self-referential systems may represent a connectome-level signature of suicide vulnerability in MDD and link childhood sexual abuse to suicide risk.